{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q01105","secondaryAccessions":["A5A5H4","A6NGV1","B4DUE2","Q15541","Q5VXV1","Q5VXV2","Q6FHZ5"],"uniProtkbId":"SET_HUMAN","entryAudit":{"firstPublicDate":"1993-04-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2004-04-13","entryVersion":235,"sequenceVersion":3},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Protein SET"}},"alternativeNames":[{"fullName":{"value":"HLA-DR-associated protein II"}},{"fullName":{"value":"Inhibitor of granzyme A-activated DNase"},"shortNames":[{"value":"IGAAD"}]},{"fullName":{"value":"PHAPII"}},{"fullName":{"value":"Phosphatase 2A inhibitor I2PP2A"},"shortNames":[{"value":"I-2PP2A"}]},{"fullName":{"value":"Template-activating factor I"},"shortNames":[{"value":"TAF-I"}]}]},"genes":[{"geneName":{"value":"SET"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11555662"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12628186"}],"value":"Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 specific activity is higher"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11231286"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11555662"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11909973"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12628186"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16541025"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16818237"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17360516"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19343227"}],"value":"Headphone-shaped homodimer. Isoforms 1 and 2 interact directly with each other and with ANP32A within the tripartite INHAT (inhibitor of acetyltransferases) complex. Isoform 1 and isoform 2 interact also with histones. Isoform 2 is a component of the SET complex, composed of at least ANP32A, APEX1, HMGB2, NME1, SET and TREX1, but not NME2 or TREX2. Within this complex, directly interacts with ANP32A, NME1, HMGB2 and TREX1; the interaction with ANP32A is enhanced after cleavage. Interacts with APBB1, CHTOP, SETBP1, SGO1"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12917472"}],"value":"(Microbial infection) Interacts with herpes simplex virus 1 VP22"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q01105","intActId":"EBI-1053182"},"interactantTwo":{"uniProtKBAccession":"P68400","geneName":"CSNK2A1","intActId":"EBI-347804"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q01105","intActId":"EBI-1053182"},"interactantTwo":{"uniProtKBAccession":"Q6SJ93","geneName":"FAM111B","intActId":"EBI-6309082"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q01105","intActId":"EBI-1053182"},"interactantTwo":{"uniProtKBAccession":"Q12778","geneName":"FOXO1","intActId":"EBI-1108782"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q01105","intActId":"EBI-1053182"},"interactantTwo":{"uniProtKBAccession":"Q00987","geneName":"MDM2","intActId":"EBI-389668"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q01105","intActId":"EBI-1053182"},"interactantTwo":{"uniProtKBAccession":"P50222","geneName":"MEOX2","intActId":"EBI-748397"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q01105","intActId":"EBI-1053182"},"interactantTwo":{"uniProtKBAccession":"P10644","geneName":"PRKAR1A","intActId":"EBI-476431"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q01105","intActId":"EBI-1053182"},"interactantTwo":{"uniProtKBAccession":"P63000","geneName":"RAC1","intActId":"EBI-413628"},"numberOfExperiments":8,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q01105","intActId":"EBI-1053182"},"interactantTwo":{"uniProtKBAccession":"O00560","geneName":"SDCBP","intActId":"EBI-727004"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q01105","intActId":"EBI-1053182"},"interactantTwo":{"uniProtKBAccession":"Q15573","geneName":"TAF1A","intActId":"EBI-2510647"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q01105","intActId":"EBI-1053182"},"interactantTwo":{"uniProtKBAccession":"Q53T94","geneName":"TAF1B","intActId":"EBI-1560239"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q01105","intActId":"EBI-1053182"},"interactantTwo":{"uniProtKBAccession":"Q15572","geneName":"TAF1C","intActId":"EBI-2510659"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q01105","intActId":"EBI-1053182"},"interactantTwo":{"uniProtKBAccession":"P20226","geneName":"TBP","intActId":"EBI-355371"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q01105","intActId":"EBI-1053182"},"interactantTwo":{"uniProtKBAccession":"Q9BT49","geneName":"THAP7","intActId":"EBI-741350"},"numberOfExperiments":7,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q01105","intActId":"EBI-1053182"},"interactantTwo":{"uniProtKBAccession":"P17480","geneName":"UBTF","intActId":"EBI-396235"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q01105-2","intActId":"EBI-7481343"},"interactantTwo":{"uniProtKBAccession":"Q53HL2","geneName":"CDCA8","intActId":"EBI-979174"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q01105-2","intActId":"EBI-7481343"},"interactantTwo":{"uniProtKBAccession":"Q6SJ93","geneName":"FAM111B","intActId":"EBI-6309082"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q01105-2","intActId":"EBI-7481343"},"interactantTwo":{"uniProtKBAccession":"Q92993","geneName":"KAT5","intActId":"EBI-399080"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q01105-2","intActId":"EBI-7481343"},"interactantTwo":{"uniProtKBAccession":"Q8TAP4-4","geneName":"LMO3","intActId":"EBI-11742507"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q01105-2","intActId":"EBI-7481343"},"interactantTwo":{"uniProtKBAccession":"P26367","geneName":"PAX6","intActId":"EBI-747278"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q01105-2","intActId":"EBI-7481343"},"interactantTwo":{"uniProtKBAccession":"P17252","geneName":"PRKCA","intActId":"EBI-1383528"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q01105-2","intActId":"EBI-7481343"},"interactantTwo":{"uniProtKBAccession":"Q9BWE0-4","geneName":"REPIN1","intActId":"EBI-24236508"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q01105-2","intActId":"EBI-7481343"},"interactantTwo":{"uniProtKBAccession":"O00560","geneName":"SDCBP","intActId":"EBI-727004"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q01105-2","intActId":"EBI-7481343"},"interactantTwo":{"uniProtKBAccession":"Q15047-2","geneName":"SETDB1","intActId":"EBI-9090795"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q01105-2","intActId":"EBI-7481343"},"interactantTwo":{"uniProtKBAccession":"Q562F6-3","geneName":"SGO2","intActId":"EBI-12111430"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q01105-2","intActId":"EBI-7481343"},"interactantTwo":{"uniProtKBAccession":"Q7Z699","geneName":"SPRED1","intActId":"EBI-5235340"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q01105-2","intActId":"EBI-7481343"},"interactantTwo":{"uniProtKBAccession":"Q5T0J7-2","geneName":"TEX35","intActId":"EBI-12833746"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q01105-2","intActId":"EBI-7481343"},"interactantTwo":{"uniProtKBAccession":"Q9BT49","geneName":"THAP7","intActId":"EBI-741350"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q01105-2","intActId":"EBI-7481343"},"interactantTwo":{"uniProtKBAccession":"Q08117-2","geneName":"TLE5","intActId":"EBI-11741437"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q01105-2","intActId":"EBI-7481343"},"interactantTwo":{"uniProtKBAccession":"P61981","geneName":"YWHAG","intActId":"EBI-359832"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q01105-2","intActId":"EBI-7481343"},"interactantTwo":{"uniProtKBAccession":"P17021","geneName":"ZNF17","intActId":"EBI-1105334"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q01105-2","intActId":"EBI-7481343"},"interactantTwo":{"uniProtKBAccession":"Q7Z4V0","geneName":"ZNF438","intActId":"EBI-11962468"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q01105-2","intActId":"EBI-7481343"},"interactantTwo":{"uniProtKBAccession":"Q49A12","geneName":"ZNF85","intActId":"EBI-18141506"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"value":"In the cytoplasm, found both in the cytosol and associated with the endoplasmic reticulum. The SET complex is associated with the endoplasmic reticulum. Following CTL attack and cleavage by GZMA, moves rapidly to the nucleus, where it is found in the nucleoplasm, avoiding the nucleolus. Similar translocation to the nucleus is also observed for lymphocyte-activated killer cells after the addition of calcium"}]},"subcellularLocations":[{"location":{"value":"Cytoplasm, cytosol","id":"SL-0091"}},{"location":{"value":"Endoplasmic reticulum","id":"SL-0095"}},{"location":{"value":"Nucleus, nucleoplasm","id":"SL-0190"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"synonyms":[{"value":"TAF-I alpha"}],"isoformIds":["Q01105-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"synonyms":[{"value":"TAF-I beta"}],"isoformIds":["Q01105-2"],"sequenceIds":["VSP_009868"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"isoformIds":["Q01105-3"],"sequenceIds":["VSP_045175"],"isoformSequenceStatus":"Described"},{"name":{"value":"4"},"isoformIds":["Q01105-4"],"sequenceIds":["VSP_046741"],"isoformSequenceStatus":"Described"}]},{"texts":[{"value":"Widely expressed. Low levels in quiescent cells during serum starvation, contact inhibition or differentiation. Highly expressed in Wilms' tumor"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17360516"}],"value":"A long alpha helix in the N-terminus mediates dimerization, while the earmuff domain is responsible for core histone and dsDNA binding. The C-terminal acidic domain mediates the inhibition of histone acetyltransferases and is required for the DNA replication stimulatory activity"}],"commentType":"DOMAIN"},{"texts":[{"value":"Isoform 2 is phosphorylated on Ser-15 and Ser-24"}],"commentType":"PTM"},{"texts":[{"value":"Isoform 2 is acetylated on Lys-11"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Some glutamate residues are glycylated by TTLL8. This modification occurs exclusively on glutamate residues and results in a glycine chain on the gamma-carboxyl group (By similarity)"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"N-terminus of isoform 1 is methylated by METTL11A/NTM1. Mainly trimethylated (By similarity)"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11555662"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12628186"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16818237"}],"value":"Cleaved after Lys-176 by GZMA. The cleavage inhibits its nucleosome assembly activity and disrupts the inhibition on NME1"}],"commentType":"PTM","molecule":"Isoform 2"},{"commentType":"DISEASE","note":{"texts":[{"value":"A chromosomal aberration involving SET is found in some cases of acute undifferentiated leukemia (AUL). Translocation t(6;9)(q21;q34.1) with NUP214/CAN"}]}},{"commentType":"DISEASE","disease":{"diseaseId":"Intellectual developmental disorder, autosomal dominant 58","diseaseAccession":"DI-05326","acronym":"MRD58","description":"A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRD58 patients show delayed development, intellectual disability, language delay and speech impairment. Some patients have motor delay or incoordination, and minor dysmorphic features.","diseaseCrossReference":{"database":"MIM","id":"618106"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25356899"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29688601"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the nucleosome assembly protein (NAP) family"}],"commentType":"SIMILARITY"},{"commentType":"WEB RESOURCE","resourceName":"Atlas of Genetics and Cytogenetics in Oncology and Haematology","resourceUrl":"https://atlasgeneticsoncology.org/gene/42272/SET","ftp":false}],"features":[{"type":"Initiator methionine","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"Removed","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9EQU5"}]},{"type":"Chain","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":290,"modifier":"EXACT"}},"description":"Protein SET","featureId":"PRO_0000185662"},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":45,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":31,"modifier":"EXACT"},"end":{"value":78,"modifier":"EXACT"}},"description":"Dimerization"},{"type":"Region","location":{"start":{"value":79,"modifier":"EXACT"},"end":{"value":225,"modifier":"EXACT"}},"description":"Earmuff domain"},{"type":"Region","location":{"start":{"value":158,"modifier":"EXACT"},"end":{"value":207,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":236,"modifier":"EXACT"},"end":{"value":290,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":35,"modifier":"EXACT"},"end":{"value":45,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":169,"modifier":"EXACT"},"end":{"value":181,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":237,"modifier":"EXACT"},"end":{"value":290,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Site","location":{"start":{"value":283,"modifier":"EXACT"},"end":{"value":284,"modifier":"EXACT"}},"description":"Breakpoint for translocation to form SET-CAN oncogene"},{"type":"Modified residue","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":2,"modifier":"EXACT"}},"description":"N,N,N-trimethylalanine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9EQU5"}]},{"type":"Modified residue","location":{"start":{"value":7,"modifier":"EXACT"},"end":{"value":7,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"17081983"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"17924679"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]},{"type":"Modified residue","location":{"start":{"value":28,"modifier":"EXACT"},"end":{"value":28,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":63,"modifier":"EXACT"},"end":{"value":63,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":68,"modifier":"EXACT"},"end":{"value":68,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9EQU5"}]},{"type":"Modified residue","location":{"start":{"value":146,"modifier":"EXACT"},"end":{"value":146,"modifier":"EXACT"}},"description":"Phosphotyrosine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9EQU5"}]},{"type":"Modified residue","location":{"start":{"value":150,"modifier":"EXACT"},"end":{"value":150,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19608861"}]},{"type":"Modified residue","location":{"start":{"value":172,"modifier":"EXACT"},"end":{"value":172,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19608861"}]},{"type":"Cross-link","location":{"start":{"value":154,"modifier":"EXACT"},"end":{"value":154,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)"},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":37,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15642345"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"1630450"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"7753797"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"8192856"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"8626647"},{"evidenceCode":"ECO:0000303","source":"Reference","id":"Ref.12"},{"evidenceCode":"ECO:0000303","source":"Reference","id":"Ref.6"},{"evidenceCode":"ECO:0000303","source":"Reference","id":"Ref.7"}],"featureId":"VSP_009868","alternativeSequence":{"originalSequence":"MAPKRQSPLPPQKKKPRPPPALGPEETSASAGLPKKG","alternativeSequences":["MSAPAAKVSKKELNSNHDGADETS"]}},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":37,"modifier":"EXACT"}},"description":"in isoform 3","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"}],"featureId":"VSP_045175","alternativeSequence":{"originalSequence":"MAPKRQSPLPPQKKKPRPPPALGPEETSASAGLPKKG","alternativeSequences":["MPRSHQPPPPPH"]}},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":37,"modifier":"EXACT"}},"description":"in isoform 4","evidences":[{"evidenceCode":"ECO:0000305"}],"featureId":"VSP_046741","alternativeSequence":{"originalSequence":"MAPKRQSPLPPQKKKPRPPPALGPEETSASAGLPKKG","alternativeSequences":["MGCRDLLPSLKPTLL"]}},{"type":"Natural variant","location":{"start":{"value":95,"modifier":"EXACT"},"end":{"value":95,"modifier":"EXACT"}},"description":"in MRD58; dbSNP:rs1554776500","featureCrossReferences":[{"database":"dbSNP","id":"rs1554776500"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29688601"}],"featureId":"VAR_081147","alternativeSequence":{"originalSequence":"W","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":118,"modifier":"EXACT"},"end":{"value":118,"modifier":"EXACT"}},"description":"in MRD58; dbSNP:rs1564360978","featureCrossReferences":[{"database":"dbSNP","id":"rs1564360978"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29688601"}],"featureId":"VAR_081148","alternativeSequence":{"originalSequence":"H","alternativeSequences":["Y"]}},{"type":"Natural variant","location":{"start":{"value":233,"modifier":"EXACT"},"end":{"value":290,"modifier":"EXACT"}},"description":"in MRD58","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25356899"}],"featureId":"VAR_078653","alternativeSequence":{}},{"type":"Helix","location":{"start":{"value":38,"modifier":"EXACT"},"end":{"value":88,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7MTO"}]},{"type":"Helix","location":{"start":{"value":94,"modifier":"EXACT"},"end":{"value":100,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7MTO"}]},{"type":"Turn","location":{"start":{"value":103,"modifier":"EXACT"},"end":{"value":105,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7MTO"}]},{"type":"Helix","location":{"start":{"value":106,"modifier":"EXACT"},"end":{"value":108,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7MTO"}]},{"type":"Helix","location":{"start":{"value":111,"modifier":"EXACT"},"end":{"value":117,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7MTO"}]},{"type":"Beta strand","location":{"start":{"value":120,"modifier":"EXACT"},"end":{"value":127,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7MTO"}]},{"type":"Beta strand","location":{"start":{"value":135,"modifier":"EXACT"},"end":{"value":141,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7MTO"}]},{"type":"Beta strand","location":{"start":{"value":145,"modifier":"EXACT"},"end":{"value":147,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7MTO"}]},{"type":"Beta strand","location":{"start":{"value":150,"modifier":"EXACT"},"end":{"value":158,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7MTO"}]},{"type":"Beta strand","location":{"start":{"value":164,"modifier":"EXACT"},"end":{"value":168,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7MTO"}]},{"type":"Helix","location":{"start":{"value":169,"modifier":"EXACT"},"end":{"value":171,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7MTO"}]},{"type":"Helix","location":{"start":{"value":199,"modifier":"EXACT"},"end":{"value":201,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7MTO"}]},{"type":"Helix","location":{"start":{"value":202,"modifier":"EXACT"},"end":{"value":207,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7MTO"}]},{"type":"Turn","location":{"start":{"value":210,"modifier":"EXACT"},"end":{"value":214,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7MTO"}]},{"type":"Helix","location":{"start":{"value":216,"modifier":"EXACT"},"end":{"value":220,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7MTO"}]},{"type":"Helix","location":{"start":{"value":221,"modifier":"EXACT"},"end":{"value":225,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7MTO"}]},{"type":"Helix","location":{"start":{"value":230,"modifier":"EXACT"},"end":{"value":233,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7MTO"}]},{"type":"Modified residue","location":{"start":{"value":11,"modifier":"EXACT"},"end":{"value":11,"modifier":"EXACT"},"sequence":"Q01105-2"},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19608861"}]},{"type":"Modified residue","location":{"start":{"value":15,"modifier":"EXACT"},"end":{"value":15,"modifier":"EXACT"},"sequence":"Q01105-2"},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"}]},{"type":"Modified residue","location":{"start":{"value":24,"modifier":"EXACT"},"end":{"value":24,"modifier":"EXACT"},"sequence":"Q01105-2"},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"}]},{"type":"Natural variant","location":{"start":{"value":4,"modifier":"EXACT"},"end":{"value":4,"modifier":"EXACT"},"sequence":"Q01105-2"},"description":"in dbSNP:rs1141138","featureCrossReferences":[{"database":"dbSNP","id":"rs1141138"}],"evidences":[{"evidenceCode":"ECO:0000305"}],"featureId":"VAR_082865","alternativeSequence":{"originalSequence":"P","alternativeSequences":["Q"]}}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0007","category":"PTM","name":"Acetylation"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0143","category":"Molecular function","name":"Chaperone"},{"id":"KW-0160","category":"Coding sequence diversity","name":"Chromosomal rearrangement"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0903","category":"Technical term","name":"Direct protein sequencing"},{"id":"KW-0225","category":"Disease","name":"Disease variant"},{"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"id":"KW-0256","category":"Cellular component","name":"Endoplasmic reticulum"},{"id":"KW-0945","category":"Biological process","name":"Host-virus interaction"},{"id":"KW-0991","category":"Disease","name":"Intellectual disability"},{"id":"KW-1017","category":"PTM","name":"Isopeptide bond"},{"id":"KW-0488","category":"PTM","name":"Methylation"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-0656","category":"Disease","name":"Proto-oncogene"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0832","category":"PTM","name":"Ubl conjugation"}],"references":[{"referenceNumber":1,"citation":{"id":"1630450","citationType":"journal article","authors":["von Lindern M.","van Baal S.","Wiegant J.","Raap A.","Hagemeijer A.","Grosveld G."],"citationCrossReferences":[{"database":"PubMed","id":"1630450"},{"database":"DOI","id":"10.1128/mcb.12.8.3346-3355.1992"}],"title":"Can, a putative oncogene associated with myeloid leukemogenesis, may be activated by fusion of its 3' half to different genes: characterization of the set gene.","publicationDate":"1992","journal":"Mol. Cell. Biol.","firstPage":"3346","lastPage":"3355","volume":"12"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)"]},{"referenceNumber":2,"citation":{"id":"8192856","citationType":"journal article","authors":["Vaesen M.","Barnikol-Watanabe S.","Goetz H.","Adil Awni L.","Cole T.","Zimmermann B.","Kratzin H.D.","Hilschmann N."],"citationCrossReferences":[{"database":"PubMed","id":"8192856"},{"database":"DOI","id":"10.1515/bchm3.1994.375.2.113"}],"title":"Purification and characterization of two putative HLA class II associated proteins: PHAPI and PHAPII.","publicationDate":"1994","journal":"Biol. Chem. Hoppe-Seyler","firstPage":"113","lastPage":"126","volume":"375"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)","PARTIAL PROTEIN SEQUENCE"]},{"referenceNumber":3,"citation":{"id":"7753797","citationType":"journal article","authors":["Nagata K.","Kawase H.","Handa H.","Yano K.","Yamasaki M.","Ishimi Y.","Okuda A.","Kikuchi A.","Matsumoto K."],"citationCrossReferences":[{"database":"PubMed","id":"7753797"},{"database":"DOI","id":"10.1073/pnas.92.10.4279"}],"title":"Replication factor encoded by a putative oncogene, set, associated with myeloid leukemogenesis.","publicationDate":"1995","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"4279","lastPage":"4283","volume":"92"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2)","PROTEIN SEQUENCE OF 14-35; 40-60; 75-90 AND 155-167","ACTIVATION OF DNA REPLICATION"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":4,"citation":{"id":"8626647","citationType":"journal article","authors":["Li M.","Makkinje A.","Damuni Z."],"citationCrossReferences":[{"database":"PubMed","id":"8626647"},{"database":"DOI","id":"10.1074/jbc.271.19.11059"}],"title":"The myeloid leukemia-associated protein SET is a potent inhibitor of protein phosphatase 2A.","publicationDate":"1996","journal":"J. Biol. Chem.","firstPage":"11059","lastPage":"11062","volume":"271"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)"],"referenceComments":[{"value":"Kidney","type":"TISSUE"}]},{"referenceNumber":5,"citation":{"id":"15642345","citationType":"journal article","authors":["Tsujio I.","Zaidi T.","Xu J.","Kotula L.","Grundke-Iqbal I.","Iqbal K."],"citationCrossReferences":[{"database":"PubMed","id":"15642345"},{"database":"DOI","id":"10.1016/j.febslet.2004.11.097"}],"title":"Inhibitors of protein phosphatase-2A from human brain structures, immunocytological localization and activities towards dephosphorylation of the Alzheimer type hyperphosphorylated tau.","publicationDate":"2005","journal":"FEBS Lett.","firstPage":"363","lastPage":"372","volume":"579"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":6,"citation":{"id":"CI-65UA89QGSSD50","citationType":"submission","authors":["Halleck A.","Ebert L.","Mkoundinya M.","Schick M.","Eisenstein S.","Neubert P.","Kstrang K.","Schatten R.","Shen B.","Henze S.","Mar W.","Korn B.","Zuo D.","Hu Y.","LaBaer J."],"title":"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201).","publicationDate":"JUN-2004","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)"]},{"referenceNumber":7,"citation":{"id":"CI-58UKVFP8TE70J","citationType":"submission","authors":["Totoki Y.","Toyoda A.","Takeda T.","Sakaki Y.","Tanaka A.","Yokoyama S."],"publicationDate":"APR-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":8,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)"]},{"referenceNumber":9,"citation":{"id":"15164053","citationType":"journal article","authors":["Humphray S.J.","Oliver K.","Hunt A.R.","Plumb R.W.","Loveland J.E.","Howe K.L.","Andrews T.D.","Searle S.","Hunt S.E.","Scott C.E.","Jones M.C.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Ashwell R.I.S.","Babbage A.K.","Babbage S.","Bagguley C.L.","Bailey J.","Banerjee R.","Barker D.J.","Barlow K.F.","Bates K.","Beasley H.","Beasley O.","Bird C.P.","Bray-Allen S.","Brown A.J.","Brown J.Y.","Burford D.","Burrill W.","Burton J.","Carder C.","Carter N.P.","Chapman J.C.","Chen Y.","Clarke G.","Clark S.Y.","Clee C.M.","Clegg S.","Collier R.E.","Corby N.","Crosier M.","Cummings A.T.","Davies J.","Dhami P.","Dunn M.","Dutta I.","Dyer L.W.","Earthrowl M.E.","Faulkner L.","Fleming C.J.","Frankish A.","Frankland J.A.","French L.","Fricker D.G.","Garner P.","Garnett J.","Ghori J.","Gilbert J.G.R.","Glison C.","Grafham D.V.","Gribble S.","Griffiths C.","Griffiths-Jones S.","Grocock R.","Guy J.","Hall R.E.","Hammond S.","Harley J.L.","Harrison E.S.I.","Hart E.A.","Heath P.D.","Henderson C.D.","Hopkins B.L.","Howard P.J.","Howden P.J.","Huckle E.","Johnson C.","Johnson D.","Joy A.A.","Kay M.","Keenan S.","Kershaw J.K.","Kimberley A.M.","King A.","Knights A.","Laird G.K.","Langford C.","Lawlor S.","Leongamornlert D.A.","Leversha M.","Lloyd C.","Lloyd D.M.","Lovell J.","Martin S.","Mashreghi-Mohammadi M.","Matthews L.","McLaren S.","McLay K.E.","McMurray A.","Milne S.","Nickerson T.","Nisbett J.","Nordsiek G.","Pearce A.V.","Peck A.I.","Porter K.M.","Pandian R.","Pelan S.","Phillimore B.","Povey S.","Ramsey Y.","Rand V.","Scharfe M.","Sehra H.K.","Shownkeen R.","Sims S.K.","Skuce C.D.","Smith M.","Steward C.A.","Swarbreck D.","Sycamore N.","Tester J.","Thorpe A.","Tracey A.","Tromans A.","Thomas D.W.","Wall M.","Wallis J.M.","West A.P.","Whitehead S.L.","Willey D.L.","Williams S.A.","Wilming L.","Wray P.W.","Young L.","Ashurst J.L.","Coulson A.","Blocker H.","Durbin R.M.","Sulston J.E.","Hubbard T.","Jackson M.J.","Bentley D.R.","Beck S.","Rogers J.","Dunham I."],"citationCrossReferences":[{"database":"PubMed","id":"15164053"},{"database":"DOI","id":"10.1038/nature02465"}],"title":"DNA sequence and analysis of human chromosome 9.","publicationDate":"2004","journal":"Nature","firstPage":"369","lastPage":"374","volume":"429"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":10,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)"],"referenceComments":[{"value":"Testis","type":"TISSUE"}]},{"referenceNumber":11,"citation":{"id":"8294483","citationType":"journal article","authors":["Adachi Y.","Pavlaki G.N.","Copeland T.D."],"citationCrossReferences":[{"database":"PubMed","id":"8294483"},{"database":"DOI","id":"10.1016/s0021-9258(17)42162-4"}],"title":"Identification and characterization of SET, a nuclear phosphoprotein encoded by the translocation break point in acute undifferentiated leukemia.","publicationDate":"1994","journal":"J. Biol. Chem.","firstPage":"2258","lastPage":"2262","volume":"269"},"referencePositions":["PARTIAL PROTEIN SEQUENCE","CHARACTERIZATION"]},{"referenceNumber":12,"citation":{"id":"CI-DE560QSKKG48G","citationType":"submission","authors":["Wang L.C.","Chen Y."],"title":"A relative factor in human rectum carcinoma.","publicationDate":"APR-2007","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] OF 1-241 (ISOFORM 2)"]},{"referenceNumber":13,"citation":{"id":"9773788","citationType":"journal article","authors":["Carlson S.G.","Eng E.","Kim E.-G.","Perlman E.J.","Copeland T.D.","Ballermann B.J."],"citationCrossReferences":[{"database":"PubMed","id":"9773788"},{"database":"DOI","id":"10.1681/asn.v9101873"}],"title":"Expression of SET, an inhibitor of protein phosphatase 2A, in renal development and Wilms' tumor.","publicationDate":"1998","journal":"J. Am. Soc. Nephrol.","firstPage":"1873","lastPage":"1880","volume":"9"},"referencePositions":["EXPRESSION IN THE KIDNEY"]},{"referenceNumber":14,"citation":{"id":"11163245","citationType":"journal article","authors":["Seo S.-B.","McNamara P.","Heo S.","Turner A.","Lane W.S.","Chakravarti D."],"citationCrossReferences":[{"database":"PubMed","id":"11163245"},{"database":"DOI","id":"10.1016/s0092-8674(01)00196-9"}],"title":"Regulation of histone acetylation and transcription by INHAT, a human cellular complex containing the Set oncoprotein.","publicationDate":"2001","journal":"Cell","firstPage":"119","lastPage":"130","volume":"104"},"referencePositions":["INHIBITION OF HISTONE ACETYLATION"]},{"referenceNumber":15,"citation":{"id":"11231286","citationType":"journal article","authors":["Minakuchi M.","Kakazu N.","Gorrin-Rivas M.J.","Abe T.","Copeland T.D.","Ueda K.","Adachi Y."],"citationCrossReferences":[{"database":"PubMed","id":"11231286"},{"database":"DOI","id":"10.1046/j.1432-1327.2001.02000.x"}],"title":"Identification and characterization of SEB, a novel protein that binds to the acute undifferentiated leukemia-associated protein SET.","publicationDate":"2001","journal":"Eur. J. Biochem.","firstPage":"1340","lastPage":"1351","volume":"268"},"referencePositions":["INTERACTION WITH SETBP1"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":16,"citation":{"id":"11555662","citationType":"journal article","authors":["Beresford P.J.","Zhang D.","Oh D.Y.","Fan Z.","Greer E.L.","Russo M.L.","Jaju M.","Lieberman J."],"citationCrossReferences":[{"database":"PubMed","id":"11555662"},{"database":"DOI","id":"10.1074/jbc.m108137200"}],"title":"Granzyme A activates an endoplasmic reticulum-associated caspase-independent nuclease to induce single-stranded DNA nicks.","publicationDate":"2001","journal":"J. Biol. Chem.","firstPage":"43285","lastPage":"43293","volume":"276"},"referencePositions":["FUNCTION","INTERACTION WITH ANP32A","PROTEOLYTIC CLEAVAGE AT LYS-179 BY GZMA (ISOFORM 2)","SUBCELLULAR LOCATION"]},{"referenceNumber":17,"citation":{"id":"11909973","citationType":"journal article","authors":["Fan Z.","Beresford P.J.","Zhang D.","Lieberman J."],"citationCrossReferences":[{"database":"PubMed","id":"11909973"},{"database":"DOI","id":"10.1128/mcb.22.8.2810-2820.2002"}],"title":"HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A.","publicationDate":"2002","journal":"Mol. Cell. Biol.","firstPage":"2810","lastPage":"2820","volume":"22"},"referencePositions":["INTERACTION WITH HMGB2","IDENTIFICATION IN THE SET COMPLEX"]},{"referenceNumber":18,"citation":{"id":"12628186","citationType":"journal article","authors":["Fan Z.","Beresford P.J.","Oh D.Y.","Zhang D.","Lieberman J."],"citationCrossReferences":[{"database":"PubMed","id":"12628186"},{"database":"DOI","id":"10.1016/s0092-8674(03)00150-8"}],"title":"Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor.","publicationDate":"2003","journal":"Cell","firstPage":"659","lastPage":"672","volume":"112"},"referencePositions":["FUNCTION IN NME1 INHIBITION","INTERACTION WITH NME1","SUBCELLULAR LOCATION","DESCRIPTION OF THE SET COMPLEX","PROTEOLYTIC CLEAVAGE BY GZMA"]},{"referenceNumber":19,"citation":{"id":"CI-9L09O6G3L7ERS","citationType":"journal article","authors":["Fan Z.","Beresford P.J.","Oh D.Y.","Zhang D.","Lieberman J."],"publicationDate":"2003","journal":"Cell","firstPage":"241","lastPage":"241","volume":"115"},"referencePositions":["ERRATUM OF PUBMED:12628186"]},{"referenceNumber":20,"citation":{"id":"12917472","citationType":"journal article","authors":["van Leeuwen H.","Okuwaki M.","Hong R.","Chakravarti D.","Nagata K.","O'Hare P."],"citationCrossReferences":[{"database":"PubMed","id":"12917472"},{"database":"DOI","id":"10.1099/vir.0.19326-0"}],"title":"Herpes simplex virus type 1 tegument protein VP22 interacts with TAF-I proteins and inhibits nucleosome assembly but not regulation of histone acetylation by INHAT.","publicationDate":"2003","journal":"J. Gen. Virol.","firstPage":"2501","lastPage":"2510","volume":"84"},"referencePositions":["INTERACTION WITH HERPES SIMPLEX VIRUS 1 VP22 (MICROBIAL INFECTION)"]},{"referenceNumber":21,"citation":{"id":"12524539","citationType":"journal article","authors":["Fan Z.","Beresford P.J.","Zhang D.","Xu Z.","Novina C.D.","Yoshida A.","Pommier Y.","Lieberman J."],"citationCrossReferences":[{"database":"PubMed","id":"12524539"},{"database":"DOI","id":"10.1038/ni885"}],"title":"Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A.","publicationDate":"2003","journal":"Nat. Immunol.","firstPage":"145","lastPage":"153","volume":"4"},"referencePositions":["SUBCELLULAR LOCATION"]},{"referenceNumber":22,"citation":{"id":"17081983","citationType":"journal article","authors":["Olsen J.V.","Blagoev B.","Gnad F.","Macek B.","Kumar C.","Mortensen P.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"17081983"},{"database":"DOI","id":"10.1016/j.cell.2006.09.026"}],"title":"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.","publicationDate":"2006","journal":"Cell","firstPage":"635","lastPage":"648","volume":"127"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-7","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":23,"citation":{"id":"16818237","citationType":"journal article","authors":["Chowdhury D.","Beresford P.J.","Zhu P.","Zhang D.","Sung J.S.","Demple B.","Perrino F.W.","Lieberman J."],"citationCrossReferences":[{"database":"PubMed","id":"16818237"},{"database":"DOI","id":"10.1016/j.molcel.2006.06.005"}],"title":"The exonuclease TREX1 is in the SET complex and acts in concert with NM23-H1 to degrade DNA during granzyme A-mediated cell death.","publicationDate":"2006","journal":"Mol. Cell","firstPage":"133","lastPage":"142","volume":"23"},"referencePositions":["INTERACTION WITH TREX1","IDENTIFICATION IN THE SET COMPLEX","PROTEOLYTIC CLEAVAGE BY GZMA","SUBCELLULAR LOCATION"]},{"referenceNumber":24,"citation":{"id":"16541025","citationType":"journal article","authors":["Kitajima T.S.","Sakuno T.","Ishiguro K.","Iemura S.","Natsume T.","Kawashima S.A.","Watanabe Y."],"citationCrossReferences":[{"database":"PubMed","id":"16541025"},{"database":"DOI","id":"10.1038/nature04663"}],"title":"Shugoshin collaborates with protein phosphatase 2A to protect cohesin.","publicationDate":"2006","journal":"Nature","firstPage":"46","lastPage":"52","volume":"441"},"referencePositions":["INTERACTION WITH SGO1"]},{"referenceNumber":25,"citation":{"id":"17924679","citationType":"journal article","authors":["Yu L.R.","Zhu Z.","Chan K.C.","Issaq H.J.","Dimitrov D.S.","Veenstra T.D."],"citationCrossReferences":[{"database":"PubMed","id":"17924679"},{"database":"DOI","id":"10.1021/pr070152u"}],"title":"Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.","publicationDate":"2007","journal":"J. Proteome Res.","firstPage":"4150","lastPage":"4162","volume":"6"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-7","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":26,"citation":{"id":"18669648","citationType":"journal article","authors":["Dephoure N.","Zhou C.","Villen J.","Beausoleil S.A.","Bakalarski C.E.","Elledge S.J.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"18669648"},{"database":"DOI","id":"10.1073/pnas.0805139105"}],"title":"A quantitative atlas of mitotic phosphorylation.","publicationDate":"2008","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"10762","lastPage":"10767","volume":"105"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":27,"citation":{"id":"19343227","citationType":"journal article","authors":["Kajiwara Y.","Akram A.","Katsel P.","Haroutunian V.","Schmeidler J.","Beecham G.","Haines J.L.","Pericak-Vance M.A.","Buxbaum J.D."],"citationCrossReferences":[{"database":"PubMed","id":"19343227"},{"database":"DOI","id":"10.1371/journal.pone.0005071"}],"title":"FE65 binds Teashirt, inhibiting expression of the primate-specific caspase-4.","publicationDate":"2009","journal":"PLoS ONE","firstPage":"E5071","lastPage":"E5071","volume":"4"},"referencePositions":["INTERACTION WITH APBB1"]},{"referenceNumber":28,"citation":{"id":"19608861","citationType":"journal article","authors":["Choudhary C.","Kumar C.","Gnad F.","Nielsen M.L.","Rehman M.","Walther T.C.","Olsen J.V.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"19608861"},{"database":"DOI","id":"10.1126/science.1175371"}],"title":"Lysine acetylation targets protein complexes and co-regulates major cellular functions.","publicationDate":"2009","journal":"Science","firstPage":"834","lastPage":"840","volume":"325"},"referencePositions":["ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-150 AND LYS-172","ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-11 (ISOFORM 2)","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":29,"citation":{"id":"20068231","citationType":"journal article","authors":["Olsen J.V.","Vermeulen M.","Santamaria A.","Kumar C.","Miller M.L.","Jensen L.J.","Gnad F.","Cox J.","Jensen T.S.","Nigg E.A.","Brunak S.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"20068231"},{"database":"DOI","id":"10.1126/scisignal.2000475"}],"title":"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.","publicationDate":"2010","journal":"Sci. Signal.","firstPage":"RA3","lastPage":"RA3","volume":"3"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-7","PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-15 AND SER-24 (ISOFORM 2)","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":30,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Buerckstuemmer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":31,"citation":{"id":"21406692","citationType":"journal article","authors":["Rigbolt K.T.","Prokhorova T.A.","Akimov V.","Henningsen J.","Johansen P.T.","Kratchmarova I.","Kassem M.","Mann M.","Olsen J.V.","Blagoev B."],"citationCrossReferences":[{"database":"PubMed","id":"21406692"},{"database":"DOI","id":"10.1126/scisignal.2001570"}],"title":"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.","publicationDate":"2011","journal":"Sci. Signal.","firstPage":"RS3","lastPage":"RS3","volume":"4"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-15 AND SER-24 (ISOFORM 2)","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":32,"citation":{"id":"23186163","citationType":"journal article","authors":["Zhou H.","Di Palma S.","Preisinger C.","Peng M.","Polat A.N.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"23186163"},{"database":"DOI","id":"10.1021/pr300630k"}],"title":"Toward a comprehensive characterization of a human cancer cell phosphoproteome.","publicationDate":"2013","journal":"J. Proteome Res.","firstPage":"260","lastPage":"271","volume":"12"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-28 AND SER-63","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"},{"value":"Erythroleukemia","type":"TISSUE"}]},{"referenceNumber":33,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-7","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":34,"citation":{"id":"25944712","citationType":"journal article","authors":["Vaca Jacome A.S.","Rabilloud T.","Schaeffer-Reiss C.","Rompais M.","Ayoub D.","Lane L.","Bairoch A.","Van Dorsselaer A.","Carapito C."],"citationCrossReferences":[{"database":"PubMed","id":"25944712"},{"database":"DOI","id":"10.1002/pmic.201400617"}],"title":"N-terminome analysis of the human mitochondrial proteome.","publicationDate":"2015","journal":"Proteomics","firstPage":"2519","lastPage":"2524","volume":"15"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":35,"citation":{"id":"25356899","citationType":"journal article","authors":["Hamdan F.F.","Srour M.","Capo-Chichi J.M.","Daoud H.","Nassif C.","Patry L.","Massicotte C.","Ambalavanan A.","Spiegelman D.","Diallo O.","Henrion E.","Dionne-Laporte A.","Fougerat A.","Pshezhetsky A.V.","Venkateswaran S.","Rouleau G.A.","Michaud J.L."],"citationCrossReferences":[{"database":"PubMed","id":"25356899"},{"database":"DOI","id":"10.1371/journal.pgen.1004772"}],"title":"De novo mutations in moderate or severe intellectual disability.","publicationDate":"2014","journal":"PLoS Genet.","firstPage":"E1004772","lastPage":"E1004772","volume":"10"},"referencePositions":["INVOLVEMENT IN MRD58","VARIANT MRD58 233-TYR--ASP-290 DEL"]},{"referenceNumber":36,"citation":{"id":"29688601","citationType":"journal article","authoringGroup":["CAUSES Study"],"authors":["Stevens S.J.C.","van der Schoot V.","Leduc M.S.","Rinne T.","Lalani S.R.","Weiss M.M.","van Hagen J.M.","Lachmeijer A.M.A.","Stockler-Ipsiroglu S.G.","Lehman A.","Brunner H.G."],"citationCrossReferences":[{"database":"PubMed","id":"29688601"},{"database":"DOI","id":"10.1002/humu.23541"}],"title":"De novo mutations in the SET nuclear proto-oncogene, encoding a component of the inhibitor of histone acetyltransferases (INHAT) complex in patients with nonsyndromic intellectual disability.","publicationDate":"2018","journal":"Hum. Mutat.","firstPage":"1014","lastPage":"1023","volume":"39"},"referencePositions":["INVOLVEMENT IN MRD58","VARIANTS MRD58 GLY-95 AND TYR-118"]},{"referenceNumber":37,"citation":{"id":"17360516","citationType":"journal article","authors":["Muto S.","Senda M.","Akai Y.","Sato L.","Suzuki T.","Nagai R.","Senda T.","Horikoshi M."],"citationCrossReferences":[{"database":"PubMed","id":"17360516"},{"database":"DOI","id":"10.1073/pnas.0603762104"}],"title":"Relationship between the structure of SET/TAF-Ibeta/INHAT and its histone chaperone activity.","publicationDate":"2007","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"4285","lastPage":"4290","volume":"104"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 38-238","DNA-BINDING","DOMAINS","SUBUNIT"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"M93651","properties":[{"key":"ProteinId","value":"AAA60318.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"X75091","properties":[{"key":"ProteinId","value":"CAA52982.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"D45198","properties":[{"key":"ProteinId","value":"BAA08139.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"U51924","properties":[{"key":"ProteinId","value":"AAC50460.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AY349172","properties":[{"key":"ProteinId","value":"AAQ79833.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"CR536543","properties":[{"key":"ProteinId","value":"CAG38780.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"CR542050","properties":[{"key":"ProteinId","value":"CAG46847.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK223556","properties":[{"key":"ProteinId","value":"BAD97276.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK300609","properties":[{"key":"ProteinId","value":"BAG62304.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AL356481","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL359678","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC032749","properties":[{"key":"ProteinId","value":"AAH32749.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"EF534308","properties":[{"key":"ProteinId","value":"ABP96841.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS48037.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q01105-1"},{"database":"CCDS","id":"CCDS59149.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q01105-4"},{"database":"CCDS","id":"CCDS6907.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q01105-2"},{"database":"PIR","id":"A57984","properties":[{"key":"EntryName","value":"A45018"}]},{"database":"PIR","id":"I59377","properties":[{"key":"EntryName","value":"I59377"}]},{"database":"RefSeq","id":"NP_001116293.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001122821.2"}],"isoformId":"Q01105-1"},{"database":"RefSeq","id":"NP_001234929.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001248000.2"}],"isoformId":"Q01105-4"},{"database":"RefSeq","id":"NP_001234930.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001248001.2"}]},{"database":"RefSeq","id":"NP_001361255.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001374326.1"}],"isoformId":"Q01105-1"},{"database":"RefSeq","id":"NP_003002.2","properties":[{"key":"NucleotideSequenceId","value":"NM_003011.4"}],"isoformId":"Q01105-2"},{"database":"RefSeq","id":"XP_054219489.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054363514.1"}],"isoformId":"Q01105-1"},{"database":"PDB","id":"2E50","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.30 A"},{"key":"Chains","value":"A/B/P/Q=25-238"}]},{"database":"PDB","id":"7MTO","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.79 A"},{"key":"Chains","value":"A=37-238"}]},{"database":"PDB","id":"9I15","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.47 A"},{"key":"Chains","value":"A/Q=32-238"}]},{"database":"PDBsum","id":"2E50","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7MTO","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9I15","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"Q01105","properties":[{"key":"Description","value":"-"}]},{"database":"SASBDB","id":"Q01105","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q01105","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"112316","properties":[{"key":"Interactions","value":"319"}]},{"database":"ComplexPortal","id":"CPX-26714","properties":[{"key":"EntryName","value":"Inhibitor of acetyltransferases complex"}],"isoformId":"Q01105-2"},{"database":"ComplexPortal","id":"CPX-26715","properties":[{"key":"EntryName","value":"SET complex"}],"isoformId":"Q01105-2"},{"database":"CORUM","id":"Q01105","properties":[{"key":"Description","value":"-"}]},{"database":"DIP","id":"DIP-33561N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q01105","properties":[{"key":"Number of interactors","value":"4438"}]},{"database":"IntAct","id":"Q01105","properties":[{"key":"Interactions","value":"193"}]},{"database":"MINT","id":"Q01105","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-SET","properties":[{"key":"Evidences","value":"5 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000361777","properties":[{"key":"Description","value":"-"}]},{"database":"BindingDB","id":"Q01105","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL4295798","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"Q01105","properties":[{"key":"glycosylation","value":"2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)"}]},{"database":"iPTMnet","id":"Q01105","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q01105","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"Q01105","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"SET","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"46397790","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q01105","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q01105","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000361777","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q01105","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"1156","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"57917","properties":[{"key":"Description","value":"-"}],"isoformId":"Q01105-1"},{"database":"ProteomicsDB","id":"57918","properties":[{"key":"Description","value":"-"}],"isoformId":"Q01105-2"},{"database":"ProteomicsDB","id":"65617","properties":[{"key":"Description","value":"-"}]},{"database":"Pumba","id":"Q01105","properties":[{"key":"Description","value":"-"}]},{"database":"TopDownProteomics","id":"Q01105-1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q01105-1"},{"database":"TopDownProteomics","id":"Q01105-2","properties":[{"key":"Description","value":"-"}],"isoformId":"Q01105-2"},{"database":"Antibodypedia","id":"3931","properties":[{"key":"antibodies","value":"397 antibodies from 41 providers"}]},{"database":"DNASU","id":"6418","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000322030.13","properties":[{"key":"ProteinId","value":"ENSP00000318012.9"},{"key":"GeneId","value":"ENSG00000119335.19"}],"isoformId":"Q01105-2"},{"database":"Ensembl","id":"ENST00000372692.8","properties":[{"key":"ProteinId","value":"ENSP00000361777.4"},{"key":"GeneId","value":"ENSG00000119335.19"}],"isoformId":"Q01105-1"},{"database":"Ensembl","id":"ENST00000409104.7","properties":[{"key":"ProteinId","value":"ENSP00000387321.3"},{"key":"GeneId","value":"ENSG00000119335.19"}],"isoformId":"Q01105-4"},{"database":"Ensembl","id":"ENST00000686840.1","properties":[{"key":"ProteinId","value":"ENSP00000509032.1"},{"key":"GeneId","value":"ENSG00000119335.19"}],"isoformId":"Q01105-1"},{"database":"Ensembl","id":"ENST00000921998.1","properties":[{"key":"ProteinId","value":"ENSP00000592057.1"},{"key":"GeneId","value":"ENSG00000119335.19"}],"isoformId":"Q01105-2"},{"database":"GeneID","id":"6418","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:6418","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000322030.13","properties":[{"key":"ProteinId","value":"ENSP00000318012.9"},{"key":"RefSeqNucleotideId","value":"NM_003011.4"},{"key":"RefSeqProteinId","value":"NP_003002.2"}],"isoformId":"Q01105-2"},{"database":"UCSC","id":"uc004bvu.5","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"Q01105-1"},{"database":"AGR","id":"HGNC:10760","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA35678","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"6418","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"6418","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"SET","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:10760","properties":[{"key":"GeneName","value":"SET"}]},{"database":"HPA","id":"ENSG00000119335","properties":[{"key":"ExpressionPatterns","value":"Low tissue specificity"}]},{"database":"MalaCards","id":"SET","properties":[{"key":"Description","value":"-"}]},{"database":"MIM","id":"600960","properties":[{"key":"Type","value":"gene"}]},{"database":"MIM","id":"618106","properties":[{"key":"Type","value":"phenotype"}]},{"database":"OpenTargets","id":"ENSG00000119335","properties":[{"key":"Description","value":"-"}]},{"database":"Orphanet","id":"178469","properties":[{"key":"Disease","value":"Autosomal dominant non-syndromic intellectual disability"}]},{"database":"Orphanet","id":"99861","properties":[{"key":"Disease","value":"Precursor T-cell acute lymphoblastic leukemia"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000119335","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG1508","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000153877","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_051687_4_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q01105","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"WPVALMN","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"19419at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q01105","properties":[{"key":"Number of GO annotations","value":"4 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q01105","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"Q01105","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-2299718","properties":[{"key":"PathwayName","value":"Condensation of Prophase Chromosomes"}]},{"database":"Reactome","id":"R-HSA-450520","properties":[{"key":"PathwayName","value":"HuR (ELAVL1) binds and stabilizes mRNA"}]},{"database":"SignaLink","id":"Q01105","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"Q01105","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000119335","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"6418","properties":[{"key":"hits","value":"167 hits in 1165 CRISPR screens"}]},{"database":"CD-CODE","id":"91857CE7","properties":[{"key":"EntryName","value":"Nucleolus"}]},{"database":"ChiTaRS","id":"SET","properties":[{"key":"OrganismName","value":"human"}]},{"database":"EvolutionaryTrace","id":"Q01105","properties":[{"key":"Description","value":"-"}]},{"database":"GeneWiki","id":"Protein_SET","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"6418","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q01105","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:Q01105","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 9"}]},{"database":"RNAct","id":"Q01105","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000119335","properties":[{"key":"ExpressionPatterns","value":"Expressed in ganglionic eminence and 219 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q01105","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0000785","properties":[{"key":"GoTerm","value":"C:chromatin"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11909973"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12524539"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005783","properties":[{"key":"GoTerm","value":"C:endoplasmic reticulum"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11555662"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12524539"}]},{"database":"GO","id":"GO:0005811","properties":[{"key":"GoTerm","value":"C:lipid droplet"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11555662"}]},{"database":"GO","id":"GO:0048471","properties":[{"key":"GoTerm","value":"C:perinuclear region of cytoplasm"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11555662"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12524539"}]},{"database":"GO","id":"GO:0032991","properties":[{"key":"GoTerm","value":"C:protein-containing complex"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11909973"}]},{"database":"GO","id":"GO:0005667","properties":[{"key":"GoTerm","value":"C:transcription regulator complex"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}]},{"database":"GO","id":"GO:0042393","properties":[{"key":"GoTerm","value":"F:histone binding"},{"key":"GoEvidenceType","value":"TAS:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"11555662"}]},{"database":"GO","id":"GO:0004864","properties":[{"key":"GoTerm","value":"F:protein phosphatase inhibitor activity"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"8626647"}]},{"database":"GO","id":"GO:0019888","properties":[{"key":"GoTerm","value":"F:protein phosphatase regulator activity"},{"key":"GoEvidenceType","value":"TAS:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"11555662"}]},{"database":"GO","id":"GO:0006284","properties":[{"key":"GoTerm","value":"P:base-excision repair"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}]},{"database":"GO","id":"GO:0006260","properties":[{"key":"GoTerm","value":"P:DNA replication"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"7753797"}]},{"database":"GO","id":"GO:0008626","properties":[{"key":"GoTerm","value":"P:granzyme-mediated apoptotic signaling pathway"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}]},{"database":"GO","id":"GO:0045892","properties":[{"key":"GoTerm","value":"P:negative regulation of DNA-templated transcription"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19343227"}]},{"database":"GO","id":"GO:0043524","properties":[{"key":"GoTerm","value":"P:negative regulation of neuron apoptotic process"},{"key":"GoEvidenceType","value":"IGI:MGI"}],"evidences":[{"evidenceCode":"ECO:0000316","source":"PubMed","id":"18374643"}]},{"database":"GO","id":"GO:0006334","properties":[{"key":"GoTerm","value":"P:nucleosome assembly"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006337","properties":[{"key":"GoTerm","value":"P:nucleosome disassembly"},{"key":"GoEvidenceType","value":"TAS:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"11555662"}]},{"database":"GO","id":"GO:0051338","properties":[{"key":"GoTerm","value":"P:regulation of transferase activity"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}]},{"database":"DisProt","id":"DP04119","properties":[{"key":"Description","value":"-"}],"isoformId":"Q01105-2"},{"database":"FunFam","id":"1.20.5.1500:FF:000003","properties":[{"key":"EntryName","value":"SET isoform 2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.1120.90:FF:000002","properties":[{"key":"EntryName","value":"Testis-specific Y-encoded-like protein 2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.5.1500","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.1120.90","properties":[{"key":"EntryName","value":"Nucleosome assembly protein"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR002164","properties":[{"key":"EntryName","value":"NAP"}]},{"database":"InterPro","id":"IPR037231","properties":[{"key":"EntryName","value":"NAP-like_sf"}]},{"database":"PANTHER","id":"PTHR11875","properties":[{"key":"EntryName","value":"TESTIS-SPECIFIC Y-ENCODED PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00956","properties":[{"key":"EntryName","value":"NAP"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF143113","properties":[{"key":"EntryName","value":"NAP-like"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MAPKRQSPLPPQKKKPRPPPALGPEETSASAGLPKKGEKEQQEAIEHIDEVQNEIDRLNEQASEEILKVEQKYNKLRQPFFQKRSELIAKIPNFWVTTFVNHPQVSALLGEEDEEALHYLTRVEVTEFEDIKSGYRIDFYFDENPYFENKVLSKEFHLNESGDPSSKSTEIKWKSGKDLTKRSSQTQNKASRKRQHEEPESFFTWFTDHSDAGADELGEVIKDDIWPNPLQYYLVPDMDDEEGEGEEDDDDDEEEEGLEDIDEEGDEDEGEEDEDDDEGEEGEEDEGEDD","length":290,"molWeight":33489,"crc64":"F4664118171EF230","md5":"DF5843C8CDE656C2A550871BA21A2CB4"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":2,"INTERACTION":32,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":4,"TISSUE SPECIFICITY":1,"DOMAIN":1,"PTM":5,"DISEASE":2,"SIMILARITY":1,"WEB RESOURCE":1},"countByFeatureType":{"Initiator methionine":1,"Chain":1,"Region":5,"Compositional bias":3,"Site":1,"Modified residue":11,"Cross-link":1,"Alternative sequence":3,"Natural variant":4,"Helix":10,"Turn":2,"Beta strand":5},"uniParcId":"UPI000006D7FF"}}