{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P9WLQ5","secondaryAccessions":["L0T860","P95269"],"uniProtkbId":"Y1945_MYCTU","entryAudit":{"firstPublicDate":"2014-04-16","lastAnnotationUpdateDate":"2026-06-10","lastSequenceUpdateDate":"2014-04-16","entryVersion":47,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)","taxonId":83332,"lineage":["Bacteria","Bacillati","Actinomycetota","Actinomycetes","Mycobacteriales","Mycobacteriaceae","Mycobacterium","Mycobacterium tuberculosis complex"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Uncharacterized protein Rv1945"}}},"genes":[{"orderedLocusNames":[{"value":"Rv1945"}],"orfNames":[{"value":"MTCY09F9.19c"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the Rv1128c/1148c/1588c/1702c/1945/3466 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":454,"modifier":"EXACT"}},"description":"Uncharacterized protein Rv1945","featureId":"PRO_0000103914"},{"type":"Domain","location":{"start":{"value":364,"modifier":"EXACT"},"end":{"value":405,"modifier":"EXACT"}},"description":"HNH"},{"type":"Region","location":{"start":{"value":415,"modifier":"EXACT"},"end":{"value":434,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"9634230","citationType":"journal article","authors":["Cole S.T.","Brosch R.","Parkhill J.","Garnier T.","Churcher C.M.","Harris D.E.","Gordon S.V.","Eiglmeier K.","Gas S.","Barry C.E. III","Tekaia F.","Badcock K.","Basham D.","Brown D.","Chillingworth T.","Connor R.","Davies R.M.","Devlin K.","Feltwell T.","Gentles S.","Hamlin N.","Holroyd S.","Hornsby T.","Jagels K.","Krogh A.","McLean J.","Moule S.","Murphy L.D.","Oliver S.","Osborne J.","Quail M.A.","Rajandream M.A.","Rogers J.","Rutter S.","Seeger K.","Skelton S.","Squares S.","Squares R.","Sulston J.E.","Taylor K.","Whitehead S.","Barrell B.G."],"citationCrossReferences":[{"database":"PubMed","id":"9634230"},{"database":"DOI","id":"10.1038/31159"}],"title":"Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.","publicationDate":"1998","journal":"Nature","firstPage":"537","lastPage":"544","volume":"393"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"ATCC 25618 / H37Rv","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"21969609","citationType":"journal article","authors":["Kelkar D.S.","Kumar D.","Kumar P.","Balakrishnan L.","Muthusamy B.","Yadav A.K.","Shrivastava P.","Marimuthu A.","Anand S.","Sundaram H.","Kingsbury R.","Harsha H.C.","Nair B.","Prasad T.S.","Chauhan D.S.","Katoch K.","Katoch V.M.","Kumar P.","Chaerkady R.","Ramachandran S.","Dash D.","Pandey A."],"citationCrossReferences":[{"database":"PubMed","id":"21969609"},{"database":"DOI","id":"10.1074/mcp.m111.011445"}],"title":"Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.","publicationDate":"2011","journal":"Mol. Cell. Proteomics","firstPage":"M111.011627","lastPage":"M111.011627","volume":"10"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"ATCC 25618 / H37Rv","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL123456","properties":[{"key":"ProteinId","value":"CCP44712.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"E70637","properties":[{"key":"EntryName","value":"E70637"}]},{"database":"RefSeq","id":"NP_216461.1","properties":[{"key":"NucleotideSequenceId","value":"NC_000962.3"}]},{"database":"RefSeq","id":"WP_003903691.1","properties":[{"key":"NucleotideSequenceId","value":"NC_000962.3"}]},{"database":"AlphaFoldDB","id":"P9WLQ5","properties":[{"key":"Description","value":"-"}]},{"database":"STRING","id":"83332.Rv1945","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"83332-Rv1945","properties":[{"key":"Description","value":"-"}]},{"database":"DNASU","id":"885980","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"885980","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"mtu:Rv1945","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"mtv:RVBD_1945","properties":[{"key":"Description","value":"-"}]},{"database":"TubercuList","id":"Rv1945","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"COG1403","properties":[{"key":"ToxonomicScope","value":"Bacteria"}]},{"database":"InParanoid","id":"P9WLQ5","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"4419061at2","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"P9WLQ5","properties":[{"key":"Description","value":"-"}]},{"database":"PRO","id":"PR:P9WLQ5","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000001584","properties":[{"key":"Component","value":"Chromosome"}]},{"database":"AbasyAtlas","id":"P9WLQ5","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0004519","properties":[{"key":"GoTerm","value":"F:endonuclease activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0003676","properties":[{"key":"GoTerm","value":"F:nucleic acid binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0008270","properties":[{"key":"GoTerm","value":"F:zinc ion binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd00085","properties":[{"key":"EntryName","value":"HNHc"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR003870","properties":[{"key":"EntryName","value":"DUF222"}]},{"database":"InterPro","id":"IPR002711","properties":[{"key":"EntryName","value":"HNH"}]},{"database":"InterPro","id":"IPR003615","properties":[{"key":"EntryName","value":"HNH_nuc"}]},{"database":"Pfam","id":"PF02720","properties":[{"key":"EntryName","value":"DUF222"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01844","properties":[{"key":"EntryName","value":"HNH"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00507","properties":[{"key":"EntryName","value":"HNHc"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MRSDTREEISAALDAYHASLSRVLDLKCDALTTPELLACLQRLEVERRRQGAAEHALINQLAGQACEEELGGTLRTALANRLHITPGEASRRIAEAEDLGERRALTGEPLPAQLTATAAAQREGKIGREHIKEIQAFFKELSAAVDLGIREAAEAQLAELATSRRPDHLHGLATQLMDWLHPDGNFSDQERARKRGITMGKQEFDGMSRISGLLTPELRATIEAVLAKLAAPGACNPDDQTPVVDDTPDADAVRRDTRSQAQRHHDGLLAGLRGLLASGELGQHRGLPVTVVVSTTLKELEAATGKGVTGGGSRVPMSDLIRMASNAHHYLALFDGAKPLALYHTKRLASPAQRIMLYAKDRGCSRPGCDAPAYHSEVHHVTPWTTTHRTDINDLTLACGPDNRLVEKGWKTRKNAKGDTEWLPPAHLDHGQPRINRYHHPEKILCEPDDDEPH","length":454,"molWeight":49671,"crc64":"63D8EB2D4A3A9534","md5":"DAC8638C5BC13F505C0DD2BF3098A52B"},"extraAttributes":{"countByCommentType":{"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Domain":1,"Region":1},"uniParcId":"UPI000013B4BA"}}