{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P9WL69","secondaryAccessions":["L0TA52","Q50622"],"uniProtkbId":"Y2599_MYCTU","entryAudit":{"firstPublicDate":"2014-04-16","lastAnnotationUpdateDate":"2026-06-10","lastSequenceUpdateDate":"2014-04-16","entryVersion":40,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)","taxonId":83332,"lineage":["Bacteria","Bacillati","Actinomycetota","Actinomycetes","Mycobacteriales","Mycobacteriaceae","Mycobacterium","Mycobacterium tuberculosis complex"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Uncharacterized protein Rv2599"}},"flag":"Precursor"},"genes":[{"orderedLocusNames":[{"value":"Rv2599"}],"orfNames":[{"value":"MTCY227.02c"}]}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33636152"}],"value":"In silico docking and molecular dynamics simulation studies suggest that this protein can act as a potential antigenic vaccine candidate against tuberculosis"}],"commentType":"BIOTECHNOLOGY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":16,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Chain","location":{"start":{"value":17,"modifier":"EXACT"},"end":{"value":143,"modifier":"EXACT"}},"description":"Uncharacterized protein Rv2599","featureId":"PRO_0000014143"}],"keywords":[{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"9634230","citationType":"journal article","authors":["Cole S.T.","Brosch R.","Parkhill J.","Garnier T.","Churcher C.M.","Harris D.E.","Gordon S.V.","Eiglmeier K.","Gas S.","Barry C.E. III","Tekaia F.","Badcock K.","Basham D.","Brown D.","Chillingworth T.","Connor R.","Davies R.M.","Devlin K.","Feltwell T.","Gentles S.","Hamlin N.","Holroyd S.","Hornsby T.","Jagels K.","Krogh A.","McLean J.","Moule S.","Murphy L.D.","Oliver S.","Osborne J.","Quail M.A.","Rajandream M.A.","Rogers J.","Rutter S.","Seeger K.","Skelton S.","Squares S.","Squares R.","Sulston J.E.","Taylor K.","Whitehead S.","Barrell B.G."],"citationCrossReferences":[{"database":"PubMed","id":"9634230"},{"database":"DOI","id":"10.1038/31159"}],"title":"Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.","publicationDate":"1998","journal":"Nature","firstPage":"537","lastPage":"544","volume":"393"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"ATCC 25618 / H37Rv","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"21969609","citationType":"journal article","authors":["Kelkar D.S.","Kumar D.","Kumar P.","Balakrishnan L.","Muthusamy B.","Yadav A.K.","Shrivastava P.","Marimuthu A.","Anand S.","Sundaram H.","Kingsbury R.","Harsha H.C.","Nair B.","Prasad T.S.","Chauhan D.S.","Katoch K.","Katoch V.M.","Kumar P.","Chaerkady R.","Ramachandran S.","Dash D.","Pandey A."],"citationCrossReferences":[{"database":"PubMed","id":"21969609"},{"database":"DOI","id":"10.1074/mcp.m111.011445"}],"title":"Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.","publicationDate":"2011","journal":"Mol. Cell. Proteomics","firstPage":"M111.011627","lastPage":"M111.011627","volume":"10"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"ATCC 25618 / H37Rv","type":"STRAIN"}]},{"referenceNumber":3,"citation":{"id":"33636152","citationType":"journal article","authors":["Arega A.M.","Pattanaik K.P.","Nayak S.","Mahapatra R.K."],"citationCrossReferences":[{"database":"PubMed","id":"33636152"},{"database":"DOI","id":"10.1016/j.actatropica.2021.105870"}],"title":"Computational discovery and ex-vivo validation study of novel antigenic vaccine candidates against tuberculosis.","publicationDate":"2021","journal":"Acta Trop.","firstPage":"105870","lastPage":"105870","volume":"217"},"referencePositions":["BIOTECHNOLOGY"],"referenceComments":[{"value":"H37Rv","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL123456","properties":[{"key":"ProteinId","value":"CCP45395.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"F70727","properties":[{"key":"EntryName","value":"F70727"}]},{"database":"RefSeq","id":"NP_217115.1","properties":[{"key":"NucleotideSequenceId","value":"NC_000962.3"}]},{"database":"RefSeq","id":"WP_003899390.1","properties":[{"key":"NucleotideSequenceId","value":"NC_000962.3"}]},{"database":"AlphaFoldDB","id":"P9WL69","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P9WL69","properties":[{"key":"Description","value":"-"}]},{"database":"STRING","id":"83332.Rv2599","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"83332-Rv2599","properties":[{"key":"Description","value":"-"}]},{"database":"DNASU","id":"887832","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"887832","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"mtu:Rv2599","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"mtv:RVBD_2599","properties":[{"key":"Description","value":"-"}]},{"database":"TubercuList","id":"Rv2599","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG5032994","properties":[{"key":"ToxonomicScope","value":"Bacteria"}]},{"database":"InParanoid","id":"P9WL69","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"3783200at2","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000001584","properties":[{"key":"Component","value":"Chromosome"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"HDA:MTBBASE"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"21148733"}]},{"database":"InterPro","id":"IPR025341","properties":[{"key":"EntryName","value":"DUF4247"}]},{"database":"Pfam","id":"PF14042","properties":[{"key":"EntryName","value":"DUF4247"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSRNRLFLVAGSLAVAAAVSLISGITLLNRDVGSYIASHYRQESRDVNGTRYLCTGSPKQVATTLVKYQTPAARASHTDTEYLRYRNNIVTVGPDGTYPCIIRVENLSAGYNHGAYVFLGPGFTPGSPSGGSGGSPGGPGGSK","length":143,"molWeight":14955,"crc64":"62ECCF049826B588","md5":"5FFA733CECFEBD0459CCCB77BAEBDA60"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"BIOTECHNOLOGY":1},"countByFeatureType":{"Signal":1,"Chain":1},"uniParcId":"UPI000013BD80"}}