{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P9WKS7","secondaryAccessions":["L0T611","P64729","P96918"],"uniProtkbId":"Y628_MYCTU","entryAudit":{"firstPublicDate":"2014-04-16","lastAnnotationUpdateDate":"2026-06-10","lastSequenceUpdateDate":"2014-04-16","entryVersion":44,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)","taxonId":83332,"lineage":["Bacteria","Bacillati","Actinomycetota","Actinomycetes","Mycobacteriales","Mycobacteriaceae","Mycobacterium","Mycobacterium tuberculosis complex"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Uncharacterized protein Rv0628c"}}},"genes":[{"orderedLocusNames":[{"value":"Rv0628c"}],"orfNames":[{"value":"MTCY20H10.09c"}]}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"To M.tuberculosis Rv0874c"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":383,"modifier":"EXACT"}},"description":"Uncharacterized protein Rv0628c","featureId":"PRO_0000103714"},{"type":"Transmembrane","location":{"start":{"value":49,"modifier":"EXACT"},"end":{"value":69,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":347,"modifier":"EXACT"},"end":{"value":367,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}],"keywords":[{"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"9634230","citationType":"journal article","authors":["Cole S.T.","Brosch R.","Parkhill J.","Garnier T.","Churcher C.M.","Harris D.E.","Gordon S.V.","Eiglmeier K.","Gas S.","Barry C.E. III","Tekaia F.","Badcock K.","Basham D.","Brown D.","Chillingworth T.","Connor R.","Davies R.M.","Devlin K.","Feltwell T.","Gentles S.","Hamlin N.","Holroyd S.","Hornsby T.","Jagels K.","Krogh A.","McLean J.","Moule S.","Murphy L.D.","Oliver S.","Osborne J.","Quail M.A.","Rajandream M.A.","Rogers J.","Rutter S.","Seeger K.","Skelton S.","Squares S.","Squares R.","Sulston J.E.","Taylor K.","Whitehead S.","Barrell B.G."],"citationCrossReferences":[{"database":"PubMed","id":"9634230"},{"database":"DOI","id":"10.1038/31159"}],"title":"Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.","publicationDate":"1998","journal":"Nature","firstPage":"537","lastPage":"544","volume":"393"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"ATCC 25618 / H37Rv","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"21969609","citationType":"journal article","authors":["Kelkar D.S.","Kumar D.","Kumar P.","Balakrishnan L.","Muthusamy B.","Yadav A.K.","Shrivastava P.","Marimuthu A.","Anand S.","Sundaram H.","Kingsbury R.","Harsha H.C.","Nair B.","Prasad T.S.","Chauhan D.S.","Katoch K.","Katoch V.M.","Kumar P.","Chaerkady R.","Ramachandran S.","Dash D.","Pandey A."],"citationCrossReferences":[{"database":"PubMed","id":"21969609"},{"database":"DOI","id":"10.1074/mcp.m111.011445"}],"title":"Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.","publicationDate":"2011","journal":"Mol. Cell. Proteomics","firstPage":"M111.011627","lastPage":"M111.011627","volume":"10"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"ATCC 25618 / H37Rv","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL123456","properties":[{"key":"ProteinId","value":"CCP43369.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"A70612","properties":[{"key":"EntryName","value":"A70612"}]},{"database":"RefSeq","id":"NP_215142.1","properties":[{"key":"NucleotideSequenceId","value":"NC_000962.3"}]},{"database":"RefSeq","id":"WP_003403248.1","properties":[{"key":"NucleotideSequenceId","value":"NC_000962.3"}]},{"database":"AlphaFoldDB","id":"P9WKS7","properties":[{"key":"Description","value":"-"}]},{"database":"STRING","id":"83332.Rv0628c","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"83332-Rv0628c","properties":[{"key":"Description","value":"-"}]},{"database":"DNASU","id":"887986","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"887986","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"mtu:Rv0628c","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"mtv:RVBD_0628c","properties":[{"key":"Description","value":"-"}]},{"database":"TubercuList","id":"Rv0628c","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"COG4398","properties":[{"key":"ToxonomicScope","value":"Bacteria"}]},{"database":"InParanoid","id":"P9WKS7","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"9770435at2","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"P9WKS7","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000001584","properties":[{"key":"Component","value":"Chromosome"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"InterPro","id":"IPR019494","properties":[{"key":"EntryName","value":"FIST_C"}]},{"database":"InterPro","id":"IPR013702","properties":[{"key":"EntryName","value":"FIST_domain_N"}]},{"database":"InterPro","id":"IPR016741","properties":[{"key":"EntryName","value":"Mb0898c-like"}]},{"database":"PANTHER","id":"PTHR14939","properties":[{"key":"EntryName","value":"F-BOX ONLY PROTEIN 22"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR14939:SF5","properties":[{"key":"EntryName","value":"F-BOX ONLY PROTEIN 22"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08495","properties":[{"key":"EntryName","value":"FIST"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF10442","properties":[{"key":"EntryName","value":"FIST_C"},{"key":"MatchStatus","value":"1"}]},{"database":"PIRSF","id":"PIRSF018953","properties":[{"key":"EntryName","value":"UCP018953"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00897","properties":[{"key":"EntryName","value":"FIST"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM01204","properties":[{"key":"EntryName","value":"FIST_C"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MRIGVGVSTAPDVRRAAAEAAAHAREELAGGTPALAVLLGSRSHTDQAVDLLAAVQASVEPAALIGCVAQGIVAGRHELENEPAVAVWLASGPPAETFHLDFVRTGSGALITGYRFDRTAHDLHLLLPDPYSFPSNLLIEHLNTDLPGTTVVGGVVSGGRRRGDTRLFRDRDVLTSGLVGVRLPGAHSVSVVSQGCRPIGEPYIVTGADGAVITELGGRPPLHRLREIVLGMAPDEQELVSRGLQIGIVVDEHLAVPGQGDFLIRGLLGADPTTGAIGIGEVVEVGATVQFQVRDAAAADKDLRLAVERAAAELPGPPVGGLLFTCNGRGRRMFGVTDHDASTIEDLLGGIPLAGFFAAGEIGPVAGHNALHGFTASMALFVD","length":383,"molWeight":39606,"crc64":"8C3E68C39426A699","md5":"657A7A68595A928288CB27B83FB8D01D"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Transmembrane":2},"uniParcId":"UPI0000139B4F"}}