{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P9WKM1","secondaryAccessions":["L0T5B3","P71544"],"uniProtkbId":"Y966_MYCTU","entryAudit":{"firstPublicDate":"2014-04-16","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2014-04-16","entryVersion":43,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)","taxonId":83332,"lineage":["Bacteria","Bacillati","Actinomycetota","Actinomycetes","Mycobacteriales","Mycobacteriaceae","Mycobacterium","Mycobacterium tuberculosis complex"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Uncharacterized protein Rv0966c"}}},"genes":[{"orderedLocusNames":[{"value":"Rv0966c"}],"orfNames":[{"value":"MTCY10D7.08"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16586367"}],"value":"Highly up-regulated during the early stages of invasion of the human blood-brain barrier"}],"commentType":"INDUCTION"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":200,"modifier":"EXACT"}},"description":"Uncharacterized protein Rv0966c","featureId":"PRO_0000103764"},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":21,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":7,"modifier":"EXACT"},"end":{"value":21,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"9634230","citationType":"journal article","authors":["Cole S.T.","Brosch R.","Parkhill J.","Garnier T.","Churcher C.M.","Harris D.E.","Gordon S.V.","Eiglmeier K.","Gas S.","Barry C.E. III","Tekaia F.","Badcock K.","Basham D.","Brown D.","Chillingworth T.","Connor R.","Davies R.M.","Devlin K.","Feltwell T.","Gentles S.","Hamlin N.","Holroyd S.","Hornsby T.","Jagels K.","Krogh A.","McLean J.","Moule S.","Murphy L.D.","Oliver S.","Osborne J.","Quail M.A.","Rajandream M.A.","Rogers J.","Rutter S.","Seeger K.","Skelton S.","Squares S.","Squares R.","Sulston J.E.","Taylor K.","Whitehead S.","Barrell B.G."],"citationCrossReferences":[{"database":"PubMed","id":"9634230"},{"database":"DOI","id":"10.1038/31159"}],"title":"Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.","publicationDate":"1998","journal":"Nature","firstPage":"537","lastPage":"544","volume":"393"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"ATCC 25618 / H37Rv","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"16586367","citationType":"journal article","authors":["Jain S.K.","Paul-Satyaseela M.","Lamichhane G.","Kim K.S.","Bishai W.R."],"citationCrossReferences":[{"database":"PubMed","id":"16586367"},{"database":"DOI","id":"10.1086/502631"}],"title":"Mycobacterium tuberculosis invasion and traversal across an in vitro human blood-brain barrier as a pathogenic mechanism for central nervous system tuberculosis.","publicationDate":"2006","journal":"J. Infect. Dis.","firstPage":"1287","lastPage":"1295","volume":"193"},"referencePositions":["INDUCTION"],"referenceComments":[{"value":"ATCC 25618 / H37Rv","type":"STRAIN"}]},{"referenceNumber":3,"citation":{"id":"21969609","citationType":"journal article","authors":["Kelkar D.S.","Kumar D.","Kumar P.","Balakrishnan L.","Muthusamy B.","Yadav A.K.","Shrivastava P.","Marimuthu A.","Anand S.","Sundaram H.","Kingsbury R.","Harsha H.C.","Nair B.","Prasad T.S.","Chauhan D.S.","Katoch K.","Katoch V.M.","Kumar P.","Chaerkady R.","Ramachandran S.","Dash D.","Pandey A."],"citationCrossReferences":[{"database":"PubMed","id":"21969609"},{"database":"DOI","id":"10.1074/mcp.m111.011445"}],"title":"Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.","publicationDate":"2011","journal":"Mol. Cell. Proteomics","firstPage":"M111.011627","lastPage":"M111.011627","volume":"10"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"ATCC 25618 / H37Rv","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL123456","properties":[{"key":"ProteinId","value":"CCP43715.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"D70718","properties":[{"key":"EntryName","value":"D70718"}]},{"database":"RefSeq","id":"NP_215481.2","properties":[{"key":"NucleotideSequenceId","value":"NC_000962.3"}]},{"database":"RefSeq","id":"WP_010886096.1","properties":[{"key":"NucleotideSequenceId","value":"NC_000962.3"}]},{"database":"AlphaFoldDB","id":"P9WKM1","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P9WKM1","properties":[{"key":"Description","value":"-"}]},{"database":"STRING","id":"83332.Rv0966c","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"83332-Rv0966c","properties":[{"key":"Description","value":"-"}]},{"database":"DNASU","id":"885043","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"885043","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"mtu:Rv0966c","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"mtv:RVBD_0966c","properties":[{"key":"Description","value":"-"}]},{"database":"TubercuList","id":"Rv0966c","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"COG4758","properties":[{"key":"ToxonomicScope","value":"Bacteria"}]},{"database":"InParanoid","id":"P9WKM1","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"3625082at2","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"P9WKM1","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000001584","properties":[{"key":"Component","value":"Chromosome"}]},{"database":"AbasyAtlas","id":"P9WKM1","properties":[{"key":"Description","value":"-"}]},{"database":"InterPro","id":"IPR012551","properties":[{"key":"EntryName","value":"DUF1707_SHOCT-like"}]},{"database":"PANTHER","id":"PTHR40763:SF4","properties":[{"key":"EntryName","value":"DUF1707 DOMAIN-CONTAINING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR40763","properties":[{"key":"EntryName","value":"MEMBRANE PROTEIN-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08044","properties":[{"key":"EntryName","value":"DUF1707"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSNSAQRDARNSRDESARASDTDRIQIAQLLAYAAEQGRLQLTDYEDRLARAYAATTYQELDRLRADLPGAAIGPRRGGECNPAPSTLLLALLGGFERRGRWNVPKKLTTFTLWGSGVLDLRYADFTSTEVDIRAYSIMGAQTILLPPEVNVEIHGHRVMGGFDRKVVGEGTRGVPTVRIRGFSLWGDVGIKRKPRKPRK","length":200,"molWeight":22210,"crc64":"752F8CFBE9BB3C02","md5":"9FE8F2CF088B2246E71B8545FB2D2D1A"},"extraAttributes":{"countByCommentType":{"INDUCTION":1},"countByFeatureType":{"Chain":1,"Region":1,"Compositional bias":1},"uniParcId":"UPI0000139E8F"}}