{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P87236","uniProtkbId":"MU154_SCHPO","entryAudit":{"firstPublicDate":"2007-02-20","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1997-07-01","entryVersion":112,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Schizosaccharomyces pombe (strain 972 / ATCC 24843)","commonName":"Fission yeast","taxonId":284812,"lineage":["Eukaryota","Fungi","Dikarya","Ascomycota","Taphrinomycotina","Schizosaccharomycetes","Schizosaccharomycetales","Schizosaccharomycetaceae","Schizosaccharomyces"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Meiotically up-regulated gene 154 protein"}}},"genes":[{"geneName":{"value":"mug154"},"orfNames":[{"value":"SPCC4G3.11"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16303567"}],"value":"Has a role in meiosis"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16823372"}],"value":"Endoplasmic reticulum membrane","id":"SL-0097"},"topology":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16823372"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":316,"modifier":"EXACT"}},"description":"Meiotically up-regulated gene 154 protein","featureId":"PRO_0000278509"},{"type":"Transmembrane","location":{"start":{"value":41,"modifier":"EXACT"},"end":{"value":61,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":88,"modifier":"EXACT"},"end":{"value":108,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":159,"modifier":"EXACT"},"end":{"value":179,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":186,"modifier":"EXACT"},"end":{"value":206,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Region","location":{"start":{"value":291,"modifier":"EXACT"},"end":{"value":316,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"id":"KW-0256","category":"Cellular component","name":"Endoplasmic reticulum"},{"id":"KW-0469","category":"Biological process","name":"Meiosis"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"11859360","citationType":"journal article","authors":["Wood V.","Gwilliam R.","Rajandream M.A.","Lyne M.H.","Lyne R.","Stewart A.","Sgouros J.G.","Peat N.","Hayles J.","Baker S.G.","Basham D.","Bowman S.","Brooks K.","Brown D.","Brown S.","Chillingworth T.","Churcher C.M.","Collins M.","Connor R.","Cronin A.","Davis P.","Feltwell T.","Fraser A.","Gentles S.","Goble A.","Hamlin N.","Harris D.E.","Hidalgo J.","Hodgson G.","Holroyd S.","Hornsby T.","Howarth S.","Huckle E.J.","Hunt S.","Jagels K.","James K.D.","Jones L.","Jones M.","Leather S.","McDonald S.","McLean J.","Mooney P.","Moule S.","Mungall K.L.","Murphy L.D.","Niblett D.","Odell C.","Oliver K.","O'Neil S.","Pearson D.","Quail M.A.","Rabbinowitsch E.","Rutherford K.M.","Rutter S.","Saunders D.","Seeger K.","Sharp S.","Skelton J.","Simmonds M.N.","Squares R.","Squares S.","Stevens K.","Taylor K.","Taylor R.G.","Tivey A.","Walsh S.V.","Warren T.","Whitehead S.","Woodward J.R.","Volckaert G.","Aert R.","Robben J.","Grymonprez B.","Weltjens I.","Vanstreels E.","Rieger M.","Schaefer M.","Mueller-Auer S.","Gabel C.","Fuchs M.","Duesterhoeft A.","Fritzc C.","Holzer E.","Moestl D.","Hilbert H.","Borzym K.","Langer I.","Beck A.","Lehrach H.","Reinhardt R.","Pohl T.M.","Eger P.","Zimmermann W.","Wedler H.","Wambutt R.","Purnelle B.","Goffeau A.","Cadieu E.","Dreano S.","Gloux S.","Lelaure V.","Mottier S.","Galibert F.","Aves S.J.","Xiang Z.","Hunt C.","Moore K.","Hurst S.M.","Lucas M.","Rochet M.","Gaillardin C.","Tallada V.A.","Garzon A.","Thode G.","Daga R.R.","Cruzado L.","Jimenez J.","Sanchez M.","del Rey F.","Benito J.","Dominguez A.","Revuelta J.L.","Moreno S.","Armstrong J.","Forsburg S.L.","Cerutti L.","Lowe T.","McCombie W.R.","Paulsen I.","Potashkin J.","Shpakovski G.V.","Ussery D.","Barrell B.G.","Nurse P."],"citationCrossReferences":[{"database":"PubMed","id":"11859360"},{"database":"DOI","id":"10.1038/nature724"}],"title":"The genome sequence of Schizosaccharomyces pombe.","publicationDate":"2002","journal":"Nature","firstPage":"871","lastPage":"880","volume":"415"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"972 / ATCC 24843","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"16303567","citationType":"journal article","authors":["Martin-Castellanos C.","Blanco M.","Rozalen A.E.","Perez-Hidalgo L.","Garcia A.I.","Conde F.","Mata J.","Ellermeier C.","Davis L.","San-Segundo P.","Smith G.R.","Moreno S."],"citationCrossReferences":[{"database":"PubMed","id":"16303567"},{"database":"DOI","id":"10.1016/j.cub.2005.10.038"}],"title":"A large-scale screen in S. pombe identifies seven novel genes required for critical meiotic events.","publicationDate":"2005","journal":"Curr. Biol.","firstPage":"2056","lastPage":"2062","volume":"15"},"referencePositions":["FUNCTION IN MEIOSIS"]},{"referenceNumber":3,"citation":{"id":"16823372","citationType":"journal article","authors":["Matsuyama A.","Arai R.","Yashiroda Y.","Shirai A.","Kamata A.","Sekido S.","Kobayashi Y.","Hashimoto A.","Hamamoto M.","Hiraoka Y.","Horinouchi S.","Yoshida M."],"citationCrossReferences":[{"database":"PubMed","id":"16823372"},{"database":"DOI","id":"10.1038/nbt1222"}],"title":"ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.","publicationDate":"2006","journal":"Nat. Biotechnol.","firstPage":"841","lastPage":"847","volume":"24"},"referencePositions":["SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"CU329672","properties":[{"key":"ProteinId","value":"CAB09766.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"T41365","properties":[{"key":"EntryName","value":"T41365"}]},{"database":"RefSeq","id":"NP_587827.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001022820.3"}]},{"database":"AlphaFoldDB","id":"P87236","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"275941","properties":[{"key":"Interactions","value":"247"}]},{"database":"FunCoup","id":"P87236","properties":[{"key":"Number of interactors","value":"44"}]},{"database":"STRING","id":"284812.P87236","properties":[{"key":"Description","value":"-"}]},{"database":"iPTMnet","id":"P87236","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"284812-P87236","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"2539375","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"spo:2539375","properties":[{"key":"Description","value":"-"}]},{"database":"PomBase","id":"SPCC4G3.11","properties":[{"key":"GeneName","value":"mug154"}]},{"database":"VEuPathDB","id":"FungiDB:SPCC4G3.11","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502QV5S","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"HOGENOM","id":"CLU_839665_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P87236","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"SERWSIP","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"PhylomeDB","id":"P87236","properties":[{"key":"Description","value":"-"}]},{"database":"PRO","id":"PR:P87236","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000002485","properties":[{"key":"Component","value":"Chromosome III"}]},{"database":"GO","id":"GO:0061638","properties":[{"key":"GoTerm","value":"C:CENP-A containing chromatin"},{"key":"GoEvidenceType","value":"IDA:PomBase"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"27451393"}]},{"database":"GO","id":"GO:0034506","properties":[{"key":"GoTerm","value":"C:chromosome, centromeric core domain"},{"key":"GoEvidenceType","value":"IDA:CACAO"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"27451393"}]},{"database":"GO","id":"GO:0005783","properties":[{"key":"GoTerm","value":"C:endoplasmic reticulum"},{"key":"GoEvidenceType","value":"HDA:PomBase"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"16823372"}]},{"database":"GO","id":"GO:0005789","properties":[{"key":"GoTerm","value":"C:endoplasmic reticulum membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"NAS:PomBase"}]},{"database":"GO","id":"GO:0070828","properties":[{"key":"GoTerm","value":"P:heterochromatin organization"},{"key":"GoEvidenceType","value":"EXP:PomBase"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27451393"}]},{"database":"GO","id":"GO:0043007","properties":[{"key":"GoTerm","value":"P:maintenance of rDNA"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0007096","properties":[{"key":"GoTerm","value":"P:regulation of exit from mitosis"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"InterPro","id":"IPR018819","properties":[{"key":"EntryName","value":"Nur1/Mug154"}]},{"database":"PANTHER","id":"PTHR28293","properties":[{"key":"EntryName","value":"NUCLEAR RIM PROTEIN 1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR28293:SF1","properties":[{"key":"EntryName","value":"NUCLEAR RIM PROTEIN 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF10332","properties":[{"key":"EntryName","value":"DUF2418"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MGKLIRRTSLTSKIINLPIDYFIYVCEQFDSVEWDKVSDRYSIPFSLAVNFIFLLMRIYIKSTHVPVQRNQLFVDKQSINTSRSWFRAFLSFLSICFLFISFLNFIFSTRFQNKLYRTLPQDKRTTTSTPNVKPVFQHSNNDDGDEQVFELKVWSPNQFLLNFACLFSPAHALILWFYSTSLRVTLLTFLLSFTTLHFVNKFSLLLKDQQYLHRQVFFEYDKKFVEPRLSVVKRDVAINTTRGPTTASIEYFTPRKPIDTFLEHRSSSHDHLTSTPRTPIALQRRSVHHLHDSGISRDSSSPFKRFPHLSDGSSRF","length":316,"molWeight":37138,"crc64":"2C7BF3A9AFE06B58","md5":"6C5E15D4B34340276F38FCBB92D8C624"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Chain":1,"Transmembrane":4,"Region":1},"uniParcId":"UPI0000069FB4"}}