{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P86044","uniProtkbId":"ANO9_MOUSE","entryAudit":{"firstPublicDate":"2008-11-04","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2008-11-04","entryVersion":98,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Mus musculus","commonName":"Mouse","taxonId":10090,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Glires","Rodentia","Myomorpha","Muroidea","Muridae","Murinae","Mus","Mus"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A1A5B4"}],"value":"Anoctamin-9"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A1A5B4"}],"value":"Transmembrane protein 16J"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A1A5B4"}],"value":"Ano9"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A1A5B4"}],"value":"Tmem16j"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A1A5B4"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23532839"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29604966"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36330924"}],"value":"PKA-activated nonselective cation channel (PubMed:29604966, PubMed:36330924). 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Expressed in the kidney (at protein level) (PubMed:36520003). Predominant expression seen in epithelial tissues (PubMed:20056604, PubMed:23532839). Highly expressed in the small intestine, colon and stomach (PubMed:29604966)"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18729231"}],"value":"In the developing respiratory system, expression is restricted to the lung epithelium at 14.5 dpc. At 14.5 dpc and 16.5 dpc, expressed in the epithelium of the esophagus, small intestine, stomach and pancreas. At 16.5 dpc, detected in bronchial epithelium. In the developing skeleton, expressed in the perichondria of developing ribs at 14.5 dpc. 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