{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P84309","secondaryAccessions":["Q3TU67","Q3UH09","Q5BL06"],"uniProtkbId":"ADCY5_MOUSE","entryAudit":{"firstPublicDate":"2004-12-21","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2007-01-09","entryVersion":171,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Mus musculus","commonName":"Mouse","taxonId":10090,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Glires","Rodentia","Myomorpha","Muroidea","Muridae","Murinae","Mus","Mus"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Adenylate cyclase type 5"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"O95622"}],"value":"4.6.1.1"}]},"alternativeNames":[{"fullName":{"value":"ATP pyrophosphate-lyase 5"}},{"fullName":{"value":"Adenylate cyclase type V"}},{"fullName":{"value":"Adenylyl cyclase 5"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"MGI","id":"MGI:99673"}],"value":"Adcy5"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"O95622"}],"value":"Catalyzes the formation of the signaling molecule cAMP in response to G protein signaling. Mediates signaling downstream of ADRB1. Regulates the increase of free cytosolic Ca(2+) in response to increased blood glucose levels and contributes to the regulation of Ca(2+)-dependent insulin secretion"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"ATP = 3',5'-cyclic AMP + diphosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:15389"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:33019"},{"database":"ChEBI","id":"CHEBI:58165"}],"ecNumber":"4.6.1.1","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"O95622"}]}},{"commentType":"COFACTOR","cofactors":[{"name":"Mg(2+)","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P30803"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:18420"}},{"name":"Mn(2+)","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P30803"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:29035"}}],"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P30803"}],"value":"Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro)."}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"O95622"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P30803"}],"value":"Activated by G(s) G alpha protein GNAS (By similarity). Inhibited by G(i) G alpha protein GNAI1 (By similarity). Activity is further increased by interaction with the G protein beta and gamma subunit complex formed by GNB1 and GNG2 (By similarity). Activated by forskolin (By similarity). Is not activated by calmodulin. Inhibited by adenosine and ATP analogs (By similarity). Inhibited by calcium ions, already at micromolar concentrations (By similarity). Phosphorylation by RAF1 results in its activation (By similarity)"}],"commentType":"ACTIVITY REGULATION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"O95622"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21670265"}],"value":"Interacts with GNAS, GNB1 and GNG2 (By similarity). Part of a complex containing AKAP5, ADCY6, PDE4C and PKD2 (PubMed:21670265). Interacts with RAF1 (By similarity)"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P30803"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P30803"}],"value":"Multi-pass membrane protein","id":"SL-9909"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21670265"}],"value":"Cell projection, cilium","id":"SL-0066"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["P84309-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["P84309-2"],"sequenceIds":["VSP_022224"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P30803"}],"value":"The protein contains two modules with six transmembrane helices each; both are required for catalytic activity. Isolated N-terminal or C-terminal guanylate cyclase domains have no catalytic activity, but when they are brought together, enzyme activity is restored. The active site is at the interface of the two domains. Both contribute substrate-binding residues, but the catalytic metal ions are bound exclusively via the N-terminal guanylate cyclase domain"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Phosphorylated by RAF1"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00099"}],"value":"Belongs to the adenylyl cyclase class-4/guanylyl cyclase family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1262,"modifier":"EXACT"}},"description":"Adenylate cyclase type 5","featureId":"PRO_0000195695"},{"type":"Topological domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":196,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":197,"modifier":"EXACT"},"end":{"value":217,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":243,"modifier":"EXACT"},"end":{"value":263,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":269,"modifier":"EXACT"},"end":{"value":289,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":300,"modifier":"EXACT"},"end":{"value":320,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":326,"modifier":"EXACT"},"end":{"value":346,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":375,"modifier":"EXACT"},"end":{"value":395,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":396,"modifier":"EXACT"},"end":{"value":763,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":764,"modifier":"EXACT"},"end":{"value":784,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":790,"modifier":"EXACT"},"end":{"value":810,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":837,"modifier":"EXACT"},"end":{"value":857,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":858,"modifier":"EXACT"},"end":{"value":910,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":911,"modifier":"EXACT"},"end":{"value":931,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":936,"modifier":"EXACT"},"end":{"value":956,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":985,"modifier":"EXACT"},"end":{"value":1005,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":1006,"modifier":"EXACT"},"end":{"value":1262,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Domain","location":{"start":{"value":470,"modifier":"EXACT"},"end":{"value":597,"modifier":"EXACT"}},"description":"Guanylate cyclase 1","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00099"}]},{"type":"Domain","location":{"start":{"value":1072,"modifier":"EXACT"},"end":{"value":1211,"modifier":"EXACT"}},"description":"Guanylate cyclase 2","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00099"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":194,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Coiled coil","location":{"start":{"value":1019,"modifier":"EXACT"},"end":{"value":1045,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Compositional bias","location":{"start":{"value":25,"modifier":"EXACT"},"end":{"value":37,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":47,"modifier":"EXACT"},"end":{"value":59,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":129,"modifier":"EXACT"},"end":{"value":150,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":152,"modifier":"EXACT"},"end":{"value":172,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Binding site","location":{"start":{"value":475,"modifier":"EXACT"},"end":{"value":480,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P30803"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616"}},{"type":"Binding site","location":{"start":{"value":475,"modifier":"EXACT"},"end":{"value":475,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:18420"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00099"}],"ligand":{"name":"Mg(2+)","id":"ChEBI:CHEBI:18420","label":"1","note":"catalytic"}},{"type":"Binding site","location":{"start":{"value":475,"modifier":"EXACT"},"end":{"value":475,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:18420"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00099"}],"ligand":{"name":"Mg(2+)","id":"ChEBI:CHEBI:18420","label":"2","note":"catalytic"}},{"type":"Binding site","location":{"start":{"value":476,"modifier":"EXACT"},"end":{"value":476,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:18420"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00099"}],"ligand":{"name":"Mg(2+)","id":"ChEBI:CHEBI:18420","label":"2","note":"catalytic"}},{"type":"Binding site","location":{"start":{"value":517,"modifier":"EXACT"},"end":{"value":519,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P30803"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616"}},{"type":"Binding site","location":{"start":{"value":519,"modifier":"EXACT"},"end":{"value":519,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:18420"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00099"}],"ligand":{"name":"Mg(2+)","id":"ChEBI:CHEBI:18420","label":"1","note":"catalytic"}},{"type":"Binding site","location":{"start":{"value":519,"modifier":"EXACT"},"end":{"value":519,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:18420"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00099"}],"ligand":{"name":"Mg(2+)","id":"ChEBI:CHEBI:18420","label":"2","note":"catalytic"}},{"type":"Binding site","location":{"start":{"value":563,"modifier":"EXACT"},"end":{"value":563,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P30803"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616"}},{"type":"Binding site","location":{"start":{"value":1124,"modifier":"EXACT"},"end":{"value":1124,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P26769"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616"}},{"type":"Binding site","location":{"start":{"value":1198,"modifier":"EXACT"},"end":{"value":1200,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P26769"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616"}},{"type":"Binding site","location":{"start":{"value":1205,"modifier":"EXACT"},"end":{"value":1209,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P26769"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616"}},{"type":"Binding site","location":{"start":{"value":1245,"modifier":"EXACT"},"end":{"value":1245,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P26769"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616"}},{"type":"Modified residue","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":23,"modifier":"EXACT"}},"description":"Omega-N-methylarginine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24129315"}]},{"type":"Modified residue","location":{"start":{"value":97,"modifier":"EXACT"},"end":{"value":97,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21183079"}]},{"type":"Modified residue","location":{"start":{"value":156,"modifier":"EXACT"},"end":{"value":156,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21183079"}]},{"type":"Modified residue","location":{"start":{"value":667,"modifier":"EXACT"},"end":{"value":667,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"O43306"}]},{"type":"Modified residue","location":{"start":{"value":755,"modifier":"EXACT"},"end":{"value":755,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q03343"}]},{"type":"Modified residue","location":{"start":{"value":1012,"modifier":"EXACT"},"end":{"value":1012,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q03343"}]},{"type":"Glycosylation","location":{"start":{"value":239,"modifier":"EXACT"},"end":{"value":239,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":834,"modifier":"EXACT"},"end":{"value":834,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":871,"modifier":"EXACT"},"end":{"value":871,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":888,"modifier":"EXACT"},"end":{"value":888,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":973,"modifier":"EXACT"},"end":{"value":973,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Alternative sequence","location":{"start":{"value":1259,"modifier":"EXACT"},"end":{"value":1262,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"featureId":"VSP_022224","alternativeSequence":{"originalSequence":"PPLS","alternativeSequences":["LGHDGVVGKLKAGLGVSMELKGLLFHCGEVTPPHNVWGTGTGRRVACAILSPHLHAQRQCPVRETGLLTREARGHQARSSGSEQKKIFIK"]}},{"type":"Sequence conflict","location":{"start":{"value":25,"modifier":"EXACT"},"end":{"value":25,"modifier":"EXACT"}},"description":"in Ref. 2; AAH90846","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"G","alternativeSequences":["S"]}},{"type":"Sequence conflict","location":{"start":{"value":686,"modifier":"EXACT"},"end":{"value":686,"modifier":"EXACT"}},"description":"in Ref. 1; BAE28048","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"G","alternativeSequences":["D"]}},{"type":"Sequence conflict","location":{"start":{"value":924,"modifier":"EXACT"},"end":{"value":924,"modifier":"EXACT"}},"description":"in Ref. 2; AAH90846","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"V","alternativeSequences":["M"]}}],"keywords":[{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"id":"KW-0115","category":"Biological process","name":"cAMP biosynthesis"},{"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"id":"KW-0966","category":"Cellular component","name":"Cell projection"},{"id":"KW-0969","category":"Cellular component","name":"Cilium"},{"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"id":"KW-0456","category":"Molecular function","name":"Lyase"},{"id":"KW-0460","category":"Ligand","name":"Magnesium"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"id":"KW-0488","category":"PTM","name":"Methylation"},{"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0677","category":"Domain","name":"Repeat"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"16141072","citationType":"journal article","authors":["Carninci P.","Kasukawa T.","Katayama S.","Gough J.","Frith M.C.","Maeda N.","Oyama R.","Ravasi T.","Lenhard B.","Wells C.","Kodzius R.","Shimokawa K.","Bajic V.B.","Brenner S.E.","Batalov S.","Forrest A.R.","Zavolan M.","Davis M.J.","Wilming L.G.","Aidinis V.","Allen J.E.","Ambesi-Impiombato A.","Apweiler R.","Aturaliya R.N.","Bailey T.L.","Bansal M.","Baxter L.","Beisel K.W.","Bersano T.","Bono H.","Chalk A.M.","Chiu K.P.","Choudhary V.","Christoffels A.","Clutterbuck D.R.","Crowe M.L.","Dalla E.","Dalrymple B.P.","de Bono B.","Della Gatta G.","di Bernardo D.","Down T.","Engstrom P.","Fagiolini M.","Faulkner G.","Fletcher C.F.","Fukushima T.","Furuno M.","Futaki S.","Gariboldi M.","Georgii-Hemming P.","Gingeras T.R.","Gojobori T.","Green R.E.","Gustincich S.","Harbers M.","Hayashi Y.","Hensch T.K.","Hirokawa N.","Hill D.","Huminiecki L.","Iacono M.","Ikeo K.","Iwama A.","Ishikawa T.","Jakt M.","Kanapin A.","Katoh M.","Kawasawa Y.","Kelso J.","Kitamura H.","Kitano H.","Kollias G.","Krishnan S.P.","Kruger A.","Kummerfeld S.K.","Kurochkin I.V.","Lareau L.F.","Lazarevic D.","Lipovich L.","Liu J.","Liuni S.","McWilliam S.","Madan Babu M.","Madera M.","Marchionni L.","Matsuda H.","Matsuzawa S.","Miki H.","Mignone F.","Miyake S.","Morris K.","Mottagui-Tabar S.","Mulder N.","Nakano N.","Nakauchi H.","Ng P.","Nilsson R.","Nishiguchi S.","Nishikawa S.","Nori F.","Ohara O.","Okazaki Y.","Orlando V.","Pang K.C.","Pavan W.J.","Pavesi G.","Pesole G.","Petrovsky N.","Piazza S.","Reed J.","Reid J.F.","Ring B.Z.","Ringwald M.","Rost B.","Ruan Y.","Salzberg S.L.","Sandelin A.","Schneider C.","Schoenbach C.","Sekiguchi K.","Semple C.A.","Seno S.","Sessa L.","Sheng Y.","Shibata Y.","Shimada H.","Shimada K.","Silva D.","Sinclair B.","Sperling S.","Stupka E.","Sugiura K.","Sultana R.","Takenaka Y.","Taki K.","Tammoja K.","Tan S.L.","Tang S.","Taylor M.S.","Tegner J.","Teichmann S.A.","Ueda H.R.","van Nimwegen E.","Verardo R.","Wei C.L.","Yagi K.","Yamanishi H.","Zabarovsky E.","Zhu S.","Zimmer A.","Hide W.","Bult C.","Grimmond S.M.","Teasdale R.D.","Liu E.T.","Brusic V.","Quackenbush J.","Wahlestedt C.","Mattick J.S.","Hume D.A.","Kai C.","Sasaki D.","Tomaru Y.","Fukuda S.","Kanamori-Katayama M.","Suzuki M.","Aoki J.","Arakawa T.","Iida J.","Imamura K.","Itoh M.","Kato T.","Kawaji H.","Kawagashira N.","Kawashima T.","Kojima M.","Kondo S.","Konno H.","Nakano K.","Ninomiya N.","Nishio T.","Okada M.","Plessy C.","Shibata K.","Shiraki T.","Suzuki S.","Tagami M.","Waki K.","Watahiki A.","Okamura-Oho Y.","Suzuki H.","Kawai J.","Hayashizaki Y."],"citationCrossReferences":[{"database":"PubMed","id":"16141072"},{"database":"DOI","id":"10.1126/science.1112014"}],"title":"The transcriptional landscape of the mammalian genome.","publicationDate":"2005","journal":"Science","firstPage":"1559","lastPage":"1563","volume":"309"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"},{"value":"Head","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15489334"}],"value":"C57BL/6J","type":"STRAIN"},{"value":"Brain","type":"TISSUE"},{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15489334"}],"value":"Retina","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000305"}]},{"referenceNumber":3,"citation":{"id":"21183079","citationType":"journal article","authors":["Huttlin E.L.","Jedrychowski M.P.","Elias J.E.","Goswami T.","Rad R.","Beausoleil S.A.","Villen J.","Haas W.","Sowa M.E.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"21183079"},{"database":"DOI","id":"10.1016/j.cell.2010.12.001"}],"title":"A tissue-specific atlas of mouse protein phosphorylation and expression.","publicationDate":"2010","journal":"Cell","firstPage":"1174","lastPage":"1189","volume":"143"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-97 AND SER-156","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Brain","type":"TISSUE"},{"value":"Kidney","type":"TISSUE"}]},{"referenceNumber":4,"citation":{"id":"21670265","citationType":"journal article","authors":["Choi Y.H.","Suzuki A.","Hajarnis S.","Ma Z.","Chapin H.C.","Caplan M.J.","Pontoglio M.","Somlo S.","Igarashi P."],"citationCrossReferences":[{"database":"PubMed","id":"21670265"},{"database":"DOI","id":"10.1073/pnas.1016214108"}],"title":"Polycystin-2 and phosphodiesterase 4C are components of a ciliary A-kinase anchoring protein complex that is disrupted in cystic kidney diseases.","publicationDate":"2011","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"10679","lastPage":"10684","volume":"108"},"referencePositions":["SUBCELLULAR LOCATION","INTERACTION WITH AKAP5; ADCY6; PDE4C AND PKD2"]},{"referenceNumber":5,"citation":{"id":"24129315","citationType":"journal article","authors":["Guo A.","Gu H.","Zhou J.","Mulhern D.","Wang Y.","Lee K.A.","Yang V.","Aguiar M.","Kornhauser J.","Jia X.","Ren J.","Beausoleil S.A.","Silva J.C.","Vemulapalli V.","Bedford M.T.","Comb M.J."],"citationCrossReferences":[{"database":"PubMed","id":"24129315"},{"database":"DOI","id":"10.1074/mcp.o113.027870"}],"title":"Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.","publicationDate":"2014","journal":"Mol. Cell. Proteomics","firstPage":"372","lastPage":"387","volume":"13"},"referencePositions":["METHYLATION [LARGE SCALE ANALYSIS] AT ARG-23","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AK147649","properties":[{"key":"ProteinId","value":"BAE28048.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK160942","properties":[{"key":"ProteinId","value":"BAE36104.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC035550","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC090846","properties":[{"key":"ProteinId","value":"AAH90846.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS37322.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P84309-1"},{"database":"RefSeq","id":"NP_001012783.3","properties":[{"key":"NucleotideSequenceId","value":"NM_001012765.6"}],"isoformId":"P84309-1"},{"database":"AlphaFoldDB","id":"P84309","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P84309","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"230250","properties":[{"key":"Interactions","value":"2"}]},{"database":"CORUM","id":"P84309","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"P84309","properties":[{"key":"Number of interactors","value":"998"}]},{"database":"STRING","id":"10090.ENSMUSP00000110563","properties":[{"key":"Description","value":"-"}]},{"database":"GlyCosmos","id":"P84309","properties":[{"key":"glycosylation","value":"5 sites, No reported glycans"}]},{"database":"GlyGen","id":"P84309","properties":[{"key":"glycosylation","value":"8 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)"}]},{"database":"iPTMnet","id":"P84309","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"P84309","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"P84309","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"P84309","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"10090-ENSMUSP00000110563","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"P84309","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"285762","properties":[{"key":"Description","value":"-"}],"isoformId":"P84309-1"},{"database":"ProteomicsDB","id":"285763","properties":[{"key":"Description","value":"-"}],"isoformId":"P84309-2"},{"database":"Antibodypedia","id":"2807","properties":[{"key":"antibodies","value":"164 antibodies from 29 providers"}]},{"database":"DNASU","id":"224129","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENSMUST00000114913.3","properties":[{"key":"ProteinId","value":"ENSMUSP00000110563.2"},{"key":"GeneId","value":"ENSMUSG00000022840.10"}],"isoformId":"P84309-1"},{"database":"GeneID","id":"224129","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"mmu:224129","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"uc007zbj.1","properties":[{"key":"OrganismName","value":"mouse"}],"isoformId":"P84309-1"},{"database":"AGR","id":"MGI:99673","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"111","properties":[{"key":"Description","value":"-"}]},{"database":"MGI","id":"MGI:99673","properties":[{"key":"GeneName","value":"Adcy5"}]},{"database":"VEuPathDB","id":"HostDB:ENSMUSG00000022840","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG3619","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000158054","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_001072_2_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P84309","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"HNSSHWT","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"64271at9989","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"P84309","properties":[{"key":"Description","value":"-"}]},{"database":"BRENDA","id":"4.6.1.1","properties":[{"key":"OrganismId","value":"3474"}]},{"database":"Reactome","id":"R-MMU-163615","properties":[{"key":"PathwayName","value":"PKA activation"}]},{"database":"Reactome","id":"R-MMU-170660","properties":[{"key":"PathwayName","value":"Adenylate cyclase activating pathway"}]},{"database":"Reactome","id":"R-MMU-170670","properties":[{"key":"PathwayName","value":"Adenylate cyclase inhibitory pathway"}]},{"database":"Reactome","id":"R-MMU-400042","properties":[{"key":"PathwayName","value":"Adrenaline,noradrenaline inhibits insulin secretion"}]},{"database":"Reactome","id":"R-MMU-418597","properties":[{"key":"PathwayName","value":"G alpha (z) signalling events"}]},{"database":"Reactome","id":"R-MMU-5610787","properties":[{"key":"PathwayName","value":"Hedgehog 'off' state"}]},{"database":"BioGRID-ORCS","id":"224129","properties":[{"key":"hits","value":"3 hits in 76 CRISPR screens"}]},{"database":"CD-CODE","id":"CE726F99","properties":[{"key":"EntryName","value":"Postsynaptic density"}]},{"database":"PRO","id":"PR:P84309","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000589","properties":[{"key":"Component","value":"Chromosome 16"}]},{"database":"RNAct","id":"P84309","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSMUSG00000022840","properties":[{"key":"ExpressionPatterns","value":"Expressed in caudate-putamen and 198 other cell types or tissues"}]},{"database":"GO","id":"GO:0005929","properties":[{"key":"GoTerm","value":"C:cilium"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"21670265"}]},{"database":"GO","id":"GO:0005768","properties":[{"key":"GoTerm","value":"C:endosome"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17593019"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18164588"}]},{"database":"GO","id":"GO:0042383","properties":[{"key":"GoTerm","value":"C:sarcolemma"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0004016","properties":[{"key":"GoTerm","value":"F:adenylate cyclase activity"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17593019"}]},{"database":"GO","id":"GO:0008179","properties":[{"key":"GoTerm","value":"F:adenylate cyclase binding"},{"key":"GoEvidenceType","value":"IPI:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"18164588"}]},{"database":"GO","id":"GO:0008294","properties":[{"key":"GoTerm","value":"F:calcium- and calmodulin-responsive adenylate cyclase activity"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0097110","properties":[{"key":"GoTerm","value":"F:scaffold protein binding"},{"key":"GoEvidenceType","value":"IPI:MGI"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"19574217"}]},{"database":"GO","id":"GO:0007191","properties":[{"key":"GoTerm","value":"P:adenylate cyclase-activating dopamine receptor signaling pathway"},{"key":"GoEvidenceType","value":"IGI:MGI"}],"evidences":[{"evidenceCode":"ECO:0000316","source":"PubMed","id":"12223546"}]},{"database":"GO","id":"GO:0007189","properties":[{"key":"GoTerm","value":"P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"},{"key":"GoEvidenceType","value":"IGI:MGI"}],"evidences":[{"evidenceCode":"ECO:0000316","source":"PubMed","id":"12223546"}]},{"database":"GO","id":"GO:0007195","properties":[{"key":"GoTerm","value":"P:adenylate cyclase-inhibiting dopamine receptor signaling pathway"},{"key":"GoEvidenceType","value":"IGI:MGI"}],"evidences":[{"evidenceCode":"ECO:0000316","source":"PubMed","id":"12223546"}]},{"database":"GO","id":"GO:0006171","properties":[{"key":"GoTerm","value":"P:cAMP biosynthetic process"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:1904322","properties":[{"key":"GoTerm","value":"P:cellular response to forskolin"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0001973","properties":[{"key":"GoTerm","value":"P:G protein-coupled adenosine receptor signaling pathway"},{"key":"GoEvidenceType","value":"IGI:MGI"}],"evidences":[{"evidenceCode":"ECO:0000316","source":"PubMed","id":"12223546"}]},{"database":"GO","id":"GO:0035556","properties":[{"key":"GoTerm","value":"P:intracellular signal transduction"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0007626","properties":[{"key":"GoTerm","value":"P:locomotory behavior"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"12665504"}]},{"database":"GO","id":"GO:0050885","properties":[{"key":"GoTerm","value":"P:neuromuscular process controlling balance"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"12665504"}]},{"database":"GO","id":"GO:0007204","properties":[{"key":"GoTerm","value":"P:positive regulation of cytosolic calcium ion concentration"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0061178","properties":[{"key":"GoTerm","value":"P:regulation of insulin secretion involved in cellular response to glucose stimulus"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"CDD","id":"cd07302","properties":[{"key":"EntryName","value":"CHD"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd07556","properties":[{"key":"EntryName","value":"Nucleotidyl_cyc_III"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.70.1230:FF:000001","properties":[{"key":"EntryName","value":"Adenylate cyclase"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.70.1230:FF:000002","properties":[{"key":"EntryName","value":"Adenylate cyclase"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.70.1230","properties":[{"key":"EntryName","value":"Nucleotide cyclase"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR001054","properties":[{"key":"EntryName","value":"A/G_cyclase"}]},{"database":"InterPro","id":"IPR018297","properties":[{"key":"EntryName","value":"A/G_cyclase_CS"}]},{"database":"InterPro","id":"IPR032628","properties":[{"key":"EntryName","value":"AC_N"}]},{"database":"InterPro","id":"IPR030672","properties":[{"key":"EntryName","value":"Adcy"}]},{"database":"InterPro","id":"IPR009398","properties":[{"key":"EntryName","value":"Adcy_conserved_dom"}]},{"database":"InterPro","id":"IPR029787","properties":[{"key":"EntryName","value":"Nucleotide_cyclase"}]},{"database":"PANTHER","id":"PTHR45627","properties":[{"key":"EntryName","value":"ADENYLATE CYCLASE TYPE 1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR45627:SF7","properties":[{"key":"EntryName","value":"ADENYLATE CYCLASE TYPE 5"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF16214","properties":[{"key":"EntryName","value":"AC_N"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF06327","properties":[{"key":"EntryName","value":"Adcy_cons_dom"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00211","properties":[{"key":"EntryName","value":"Guanylate_cyc"},{"key":"MatchStatus","value":"2"}]},{"database":"PIRSF","id":"PIRSF039050","properties":[{"key":"EntryName","value":"Ade_cyc"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00044","properties":[{"key":"EntryName","value":"CYCc"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF55073","properties":[{"key":"EntryName","value":"Nucleotide cyclase"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS00452","properties":[{"key":"EntryName","value":"GUANYLATE_CYCLASE_1"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS50125","properties":[{"key":"EntryName","value":"GUANYLATE_CYCLASE_2"},{"key":"MatchStatus","value":"2"}]}],"sequence":{"value":"MSGSKSVSPPGYAAQTAASPAPRGGPEHRAAWGEADSRANGYPHAPGGSTRGSTKRSGGAVTPQQQQRLASRWRGGDDDEDPPLSGDDPLAGGFGFSFRSKSAWQERGGDDGGRGSRRQRRGAAGGGSTRAPPAGGSGSSAAAAAAAGGTEVRPRSVELGLEERRGKGRAAEELEPGTGIVEDGDGSEDGGSSVASGSGTGAVLSLGACCLALLQIFRSKKFPSDKLERLYQRYFFRLNQSSLTMLMAVLVLVCLVMLAFHAARPPLQIAYLAVLAAAVGVILIMAVLCNRAAFHQDHMGLACYALIAVVLAVQVVGLLLPQPRSASEGIWWTVFFIYTIYTLLPVRMRAAVLSGVLLSALHLAISLHTNSQDQFLLKQLVSNVLIFSCTNIVGVCTHYPAEVSQRQAFQETRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLNGDYEVEPGCGGDRNAYLKEHSIETFLILSCTQKRKEEKAMIAKMNRQRTNSIGHNPPHWGAERPFYNHLGGNQVSKEMKRMGFEDPKDKNAQESANPEDEVDEFLGRAIDARSIDRLRSEHVRKFLLTFREPDLEKKYSKQVDDRFGAYVACASLVFLFICFVQITIVPHSLFMLSFYLSCFLLLALVVFVSVIYACVKLFPTPLQTLSRKIVRSKKNSTLVGVFTITLVFLSAFVNMFMCNSKNLVGCLAEEHNITVNQVNACHVMESAFNYSLGDEQGFCGSPQPNCNFPEYFTYSVLLSLLACSVFLQISCIGKLVLMLAIEFIYVLIVEVPGVTLFDNADLLVTANAIDFSNNGTSQCPEHATKVALKVVTPIIISVFVLALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTYDKAGKTHIKAIADFAMKLMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLECRGVVKVKGKGEMMTYFLNGGPPLS","length":1262,"molWeight":139122,"crc64":"342966E7CA67E28D","md5":"04F287B3EB7E9E4A3F0995FB886B3065"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"COFACTOR":1,"ACTIVITY REGULATION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":2,"DOMAIN":1,"PTM":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Topological domain":4,"Transmembrane":12,"Domain":2,"Region":1,"Coiled coil":1,"Compositional bias":4,"Binding site":12,"Modified residue":6,"Glycosylation":5,"Alternative sequence":1,"Sequence conflict":3},"uniParcId":"UPI00001E37D7"}}