{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P76498","secondaryAccessions":["Q2MAL7"],"uniProtkbId":"YFCO_ECOLI","entryAudit":{"firstPublicDate":"2000-05-30","lastAnnotationUpdateDate":"2026-01-28","lastSequenceUpdateDate":"2000-05-30","entryVersion":124,"sequenceVersion":2},"annotationScore":3.0,"organism":{"scientificName":"Escherichia coli (strain K12)","taxonId":83333,"lineage":["Bacteria","Pseudomonadati","Pseudomonadota","Gammaproteobacteria","Enterobacterales","Enterobacteriaceae","Escherichia"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"value":"Uncharacterized protein YfcO"}},"flag":"Precursor"},"genes":[{"geneName":{"value":"yfcO"},"orderedLocusNames":[{"value":"b2332"},{"value":"JW2329"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20345943"}],"value":"Part of the yfcOPQRSUV fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim genes"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20345943"}],"value":"Expression is negatively regulated by H-NS and subjected to cAMP receptor protein (CRP)-mediated catabolite repression"}],"commentType":"INDUCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20345943"}],"value":"Deletion of the operon under classical laboratory conditions does not result in any major effect on E.coli capacity to form biofilms compared with the wild-type strain"}],"commentType":"DISRUPTION PHENOTYPE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"20345943"}],"value":"The operon is cryptic under classical laboratory conditions, but is functional when constitutively expressed"}],"commentType":"MISCELLANEOUS"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"To S.typhimurium YadU"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":21,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Chain","location":{"start":{"value":22,"modifier":"EXACT"},"end":{"value":273,"modifier":"EXACT"}},"description":"Uncharacterized protein YfcO","featureId":"PRO_0000013879"}],"keywords":[{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"9278503","citationType":"journal article","authors":["Blattner F.R.","Plunkett G. III","Bloch C.A.","Perna N.T.","Burland V.","Riley M.","Collado-Vides J.","Glasner J.D.","Rode C.K.","Mayhew G.F.","Gregor J.","Davis N.W.","Kirkpatrick H.A.","Goeden M.A.","Rose D.J.","Mau B.","Shao Y."],"citationCrossReferences":[{"database":"PubMed","id":"9278503"},{"database":"DOI","id":"10.1126/science.277.5331.1453"}],"title":"The complete genome sequence of Escherichia coli K-12.","publicationDate":"1997","journal":"Science","firstPage":"1453","lastPage":"1462","volume":"277"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"K12 / MG1655 / ATCC 47076","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"16738553","citationType":"journal article","authors":["Hayashi K.","Morooka N.","Yamamoto Y.","Fujita K.","Isono K.","Choi S.","Ohtsubo E.","Baba T.","Wanner B.L.","Mori H.","Horiuchi T."],"citationCrossReferences":[{"database":"PubMed","id":"16738553"},{"database":"DOI","id":"10.1038/msb4100049"}],"title":"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.","publicationDate":"2006","journal":"Mol. Syst. Biol.","firstPage":"E1","lastPage":"E5","volume":"2"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"K12 / W3110 / ATCC 27325 / DSM 5911","type":"STRAIN"}]},{"referenceNumber":3,"citation":{"id":"20345943","citationType":"journal article","authors":["Korea C.G.","Badouraly R.","Prevost M.C.","Ghigo J.M.","Beloin C."],"citationCrossReferences":[{"database":"PubMed","id":"20345943"},{"database":"DOI","id":"10.1111/j.1462-2920.2010.02202.x"}],"title":"Escherichia coli K-12 possesses multiple cryptic but functional chaperone-usher fimbriae with distinct surface specificities.","publicationDate":"2010","journal":"Environ. Microbiol.","firstPage":"1957","lastPage":"1977","volume":"12"},"referencePositions":["FUNCTION","INDUCTION","DISRUPTION PHENOTYPE"],"referenceComments":[{"value":"K12 / MG1655 / ATCC 47076","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"U00096","properties":[{"key":"ProteinId","value":"AAC75392.2"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AP009048","properties":[{"key":"ProteinId","value":"BAE76689.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"B65006","properties":[{"key":"EntryName","value":"B65006"}]},{"database":"RefSeq","id":"NP_416835.2","properties":[{"key":"NucleotideSequenceId","value":"NC_000913.3"}]},{"database":"RefSeq","id":"WP_000698745.1","properties":[{"key":"NucleotideSequenceId","value":"NZ_CP009789.1"}]},{"database":"AlphaFoldDB","id":"P76498","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"4260939","properties":[{"key":"Interactions","value":"10"}]},{"database":"FunCoup","id":"P76498","properties":[{"key":"Number of interactors","value":"23"}]},{"database":"STRING","id":"511145.b2332","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"511145-b2332","properties":[{"key":"Description","value":"-"}]},{"database":"EnsemblBacteria","id":"AAC75392","properties":[{"key":"ProteinId","value":"AAC75392"},{"key":"GeneId","value":"b2332"}]},{"database":"GeneID","id":"946620","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"ecj:JW2329","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"eco:b2332","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"ecoc:C3026_12990","properties":[{"key":"Description","value":"-"}]},{"database":"PATRIC","id":"fig|511145.12.peg.2428","properties":[{"key":"GeneDesignation","value":"-"}]},{"database":"EchoBASE","id":"EB3871","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG503064I","properties":[{"key":"ToxonomicScope","value":"Bacteria"}]},{"database":"HOGENOM","id":"CLU_095265_0_0_6","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P76498","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"HGCPWLV","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"6595070at2","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"P76498","properties":[{"key":"Description","value":"-"}]},{"database":"BioCyc","id":"EcoCyc:G7203-MONOMER","properties":[{"key":"Description","value":"-"}]},{"database":"PHI-base","id":"PHI:6598","properties":[{"key":"Description","value":"-"}]},{"database":"PRO","id":"PR:P76498","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000625","properties":[{"key":"Component","value":"Chromosome"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IDA:EcoCyc"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17309111"}]},{"database":"InterPro","id":"IPR021407","properties":[{"key":"EntryName","value":"DUF2544"}]},{"database":"Pfam","id":"PF11245","properties":[{"key":"EntryName","value":"DUF2544"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MKILRWLFALVMLIATTEAMAAGHSVDVYYGYNGDSRNIATFNLKIMMPSAVYVGEYKSSQWLMTGEILQNVSWSGPPPAPSVKLIGYHQNINKASCPGLPSGWNCGYYTFEVIVSAEIESYFSCPWLVIMNDSEASPGGVTYQGPDSHDTICPSVSVQPYDVSWNENYVSKSKLLTLQSTGGVVEKTLSTYLMKDGKLCDSTQMNETGGYCRWVAQMITFTASGCDKAEVSVTPNRHPITDKQLHDMVVRVDTSSMQPIDSTCRFQYILNEL","length":273,"molWeight":30260,"crc64":"9D1D9C22959823DC","md5":"1EE8B6345D15BCEF9D70DA9B47E8AE17"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"INDUCTION":1,"DISRUPTION PHENOTYPE":1,"MISCELLANEOUS":1,"SIMILARITY":1},"countByFeatureType":{"Signal":1,"Chain":1},"uniParcId":"UPI000013AE14"}}