{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P75883","secondaryAccessions":["Q9Z3A3"],"uniProtkbId":"GFCC_ECOLI","entryAudit":{"firstPublicDate":"1997-11-01","lastAnnotationUpdateDate":"2026-01-28","lastSequenceUpdateDate":"1997-02-01","entryVersion":140,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Escherichia coli (strain K12)","taxonId":83333,"lineage":["Bacteria","Pseudomonadati","Pseudomonadota","Gammaproteobacteria","Enterobacterales","Enterobacteriaceae","Escherichia"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"value":"Uncharacterized protein GfcC"}},"alternativeNames":[{"fullName":{"value":"Group 4 capsule protein C homolog"}}],"flag":"Precursor"},"genes":[{"geneName":{"value":"gfcC"},"synonyms":[{"value":"ymcB"}],"orderedLocusNames":[{"value":"b0985"},{"value":"JW0968"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"To E.coli YjbG"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"In E.coli K12 / MG1655 and K12 / W3110 this operon is silenced by an IS1D insertion in the promoter region"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":22,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Chain","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":248,"modifier":"EXACT"}},"description":"Uncharacterized protein GfcC","featureId":"PRO_0000013816"}],"keywords":[{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"8905232","citationType":"journal article","authors":["Oshima T.","Aiba H.","Baba T.","Fujita K.","Hayashi K.","Honjo A.","Ikemoto K.","Inada T.","Itoh T.","Kajihara M.","Kanai K.","Kashimoto K.","Kimura S.","Kitagawa M.","Makino K.","Masuda S.","Miki T.","Mizobuchi K.","Mori H.","Motomura K.","Nakamura Y.","Nashimoto H.","Nishio Y.","Saito N.","Sampei G.","Seki Y.","Tagami H.","Takemoto K.","Wada C.","Yamamoto Y.","Yano M.","Horiuchi T."],"citationCrossReferences":[{"database":"PubMed","id":"8905232"},{"database":"DOI","id":"10.1093/dnares/3.3.137"}],"title":"A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map.","publicationDate":"1996","journal":"DNA Res.","firstPage":"137","lastPage":"155","volume":"3"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"K12 / W3110 / ATCC 27325 / DSM 5911","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"9278503","citationType":"journal article","authors":["Blattner F.R.","Plunkett G. III","Bloch C.A.","Perna N.T.","Burland V.","Riley M.","Collado-Vides J.","Glasner J.D.","Rode C.K.","Mayhew G.F.","Gregor J.","Davis N.W.","Kirkpatrick H.A.","Goeden M.A.","Rose D.J.","Mau B.","Shao Y."],"citationCrossReferences":[{"database":"PubMed","id":"9278503"},{"database":"DOI","id":"10.1126/science.277.5331.1453"}],"title":"The complete genome sequence of Escherichia coli K-12.","publicationDate":"1997","journal":"Science","firstPage":"1453","lastPage":"1462","volume":"277"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"K12 / MG1655 / ATCC 47076","type":"STRAIN"}]},{"referenceNumber":3,"citation":{"id":"16738553","citationType":"journal article","authors":["Hayashi K.","Morooka N.","Yamamoto Y.","Fujita K.","Isono K.","Choi S.","Ohtsubo E.","Baba T.","Wanner B.L.","Mori H.","Horiuchi T."],"citationCrossReferences":[{"database":"PubMed","id":"16738553"},{"database":"DOI","id":"10.1038/msb4100049"}],"title":"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.","publicationDate":"2006","journal":"Mol. Syst. Biol.","firstPage":"E1","lastPage":"E5","volume":"2"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"K12 / W3110 / ATCC 27325 / DSM 5911","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"U00096","properties":[{"key":"ProteinId","value":"AAC74070.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AP009048","properties":[{"key":"ProteinId","value":"BAA35750.2"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"G64839","properties":[{"key":"EntryName","value":"G64839"}]},{"database":"RefSeq","id":"NP_415505.1","properties":[{"key":"NucleotideSequenceId","value":"NC_000913.3"}]},{"database":"RefSeq","id":"WP_001038079.1","properties":[{"key":"NucleotideSequenceId","value":"NZ_CP009789.1"}]},{"database":"AlphaFoldDB","id":"P75883","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P75883","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"4261410","properties":[{"key":"Interactions","value":"21"}]},{"database":"BioGRID","id":"849375","properties":[{"key":"Interactions","value":"3"}]},{"database":"DIP","id":"DIP-12708N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"P75883","properties":[{"key":"Number of interactors","value":"53"}]},{"database":"IntAct","id":"P75883","properties":[{"key":"Interactions","value":"5"}]},{"database":"STRING","id":"511145.b0985","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"511145-b0985","properties":[{"key":"Description","value":"-"}]},{"database":"EnsemblBacteria","id":"AAC74070","properties":[{"key":"ProteinId","value":"AAC74070"},{"key":"GeneId","value":"b0985"}]},{"database":"GeneID","id":"944978","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"ecj:JW0968","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"eco:b0985","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"ecoc:C3026_06005","properties":[{"key":"Description","value":"-"}]},{"database":"PATRIC","id":"fig|511145.12.peg.1020","properties":[{"key":"GeneDesignation","value":"-"}]},{"database":"EchoBASE","id":"EB3494","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG5030EE4","properties":[{"key":"ToxonomicScope","value":"Bacteria"}]},{"database":"HOGENOM","id":"CLU_080984_2_0_6","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P75883","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"TWWPGTA","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"5592890at2","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"P75883","properties":[{"key":"Description","value":"-"}]},{"database":"BioCyc","id":"EcoCyc:G6506-MONOMER","properties":[{"key":"Description","value":"-"}]},{"database":"PRO","id":"PR:P75883","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000625","properties":[{"key":"Component","value":"Chromosome"}]},{"database":"Gene3D","id":"3.10.20.700","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"6.10.250.2280","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.10.560.10","properties":[{"key":"EntryName","value":"Outer membrane lipoprotein wza domain like"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR046459","properties":[{"key":"EntryName","value":"Caps_syn_GfcC_N"}]},{"database":"InterPro","id":"IPR010425","properties":[{"key":"EntryName","value":"Caps_synth_GfcC-like_C"}]},{"database":"Pfam","id":"PF06251","properties":[{"key":"EntryName","value":"Caps_syn_GfcC_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF20616","properties":[{"key":"EntryName","value":"Caps_syn_GfcC_N"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MNKLQSYFIASVLYVMTPHAFAQGTVTIYLPGEQQTLSVGPVENVVQLVTQPQLRDRLWWPGALLTDSAAKAKALKDYQHVMAQLASWEAEADDDVAATIKSVRQQLLNLNITGRLPVKLDPDFVRVDENSNPPLVGDYTLYTVQRPVTITLLGAVSGAGQLPWQAGRSVTDYLQDHPRLAGADKNNVMVITPEGETVVAPVALWNKRHVEPPPGSQLWLGFSAHVLPEKYADLNDQIVSVLTQRVPD","length":248,"molWeight":27296,"crc64":"74F5B38825C4587B","md5":"95C1E9E66D0834C4960ED6E96CC07B99"},"extraAttributes":{"countByCommentType":{"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1},"uniParcId":"UPI000013B97E"}}