{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P75767","uniProtkbId":"GNGF_ECOLI","entryAudit":{"firstPublicDate":"1998-07-15","lastAnnotationUpdateDate":"2026-01-28","lastSequenceUpdateDate":"1997-02-01","entryVersion":154,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Escherichia coli (strain K12)","taxonId":83333,"lineage":["Bacteria","Pseudomonadati","Pseudomonadota","Gammaproteobacteria","Enterobacterales","Enterobacteriaceae","Escherichia"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_00973"}],"value":"Putative gluconeogenesis factor"}}},"genes":[{"geneName":{"value":"ybhK"},"orderedLocusNames":[{"value":"b0780"},{"value":"JW0763"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Required for morphogenesis under gluconeogenic growth conditions"}],"commentType":"FUNCTION"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P75767","intActId":"EBI-550390"},"interactantTwo":{"uniProtKBAccession":"P0AEW6","geneName":"gsk","intActId":"EBI-548746"},"numberOfExperiments":5,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_00973"}],"value":"Cytoplasm","id":"SL-0086"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"16272399"}],"value":"Was shown to partially rescue a mgfK mutant in B.subtilis, suggesting that the function of this protein is conserved in different bacteria"}],"commentType":"MISCELLANEOUS"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_00973"}],"value":"Belongs to the gluconeogenesis factor family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":302,"modifier":"EXACT"}},"description":"Putative gluconeogenesis factor","featureId":"PRO_0000107797"}],"keywords":[{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"8905232","citationType":"journal article","authors":["Oshima T.","Aiba H.","Baba T.","Fujita K.","Hayashi K.","Honjo A.","Ikemoto K.","Inada T.","Itoh T.","Kajihara M.","Kanai K.","Kashimoto K.","Kimura S.","Kitagawa M.","Makino K.","Masuda S.","Miki T.","Mizobuchi K.","Mori H.","Motomura K.","Nakamura Y.","Nashimoto H.","Nishio Y.","Saito N.","Sampei G.","Seki Y.","Tagami H.","Takemoto K.","Wada C.","Yamamoto Y.","Yano M.","Horiuchi T."],"citationCrossReferences":[{"database":"PubMed","id":"8905232"},{"database":"DOI","id":"10.1093/dnares/3.3.137"}],"title":"A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map.","publicationDate":"1996","journal":"DNA Res.","firstPage":"137","lastPage":"155","volume":"3"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"K12 / W3110 / ATCC 27325 / DSM 5911","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"9278503","citationType":"journal article","authors":["Blattner F.R.","Plunkett G. III","Bloch C.A.","Perna N.T.","Burland V.","Riley M.","Collado-Vides J.","Glasner J.D.","Rode C.K.","Mayhew G.F.","Gregor J.","Davis N.W.","Kirkpatrick H.A.","Goeden M.A.","Rose D.J.","Mau B.","Shao Y."],"citationCrossReferences":[{"database":"PubMed","id":"9278503"},{"database":"DOI","id":"10.1126/science.277.5331.1453"}],"title":"The complete genome sequence of Escherichia coli K-12.","publicationDate":"1997","journal":"Science","firstPage":"1453","lastPage":"1462","volume":"277"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"K12 / MG1655 / ATCC 47076","type":"STRAIN"}]},{"referenceNumber":3,"citation":{"id":"16738553","citationType":"journal article","authors":["Hayashi K.","Morooka N.","Yamamoto Y.","Fujita K.","Isono K.","Choi S.","Ohtsubo E.","Baba T.","Wanner B.L.","Mori H.","Horiuchi T."],"citationCrossReferences":[{"database":"PubMed","id":"16738553"},{"database":"DOI","id":"10.1038/msb4100049"}],"title":"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.","publicationDate":"2006","journal":"Mol. Syst. Biol.","firstPage":"E1","lastPage":"E5","volume":"2"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"K12 / W3110 / ATCC 27325 / DSM 5911","type":"STRAIN"}]},{"referenceNumber":4,"citation":{"id":"16272399","citationType":"journal article","authors":["Gorke B.","Foulquier E.","Galinier A."],"citationCrossReferences":[{"database":"PubMed","id":"16272399"},{"database":"DOI","id":"10.1099/mic.0.28172-0"}],"title":"YvcK of Bacillus subtilis is required for a normal cell shape and for growth on Krebs cycle intermediates and substrates of the pentose phosphate pathway.","publicationDate":"2005","journal":"Microbiology","firstPage":"3777","lastPage":"3791","volume":"151"},"referencePositions":["PUTATIVE FUNCTION"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"U00096","properties":[{"key":"ProteinId","value":"AAC73867.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AP009048","properties":[{"key":"ProteinId","value":"BAA35438.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"D64814","properties":[{"key":"EntryName","value":"D64814"}]},{"database":"RefSeq","id":"NP_415301.1","properties":[{"key":"NucleotideSequenceId","value":"NC_000913.3"}]},{"database":"RefSeq","id":"WP_001295302.1","properties":[{"key":"NucleotideSequenceId","value":"NZ_CP009789.1"}]},{"database":"AlphaFoldDB","id":"P75767","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P75767","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"4259958","properties":[{"key":"Interactions","value":"23"}]},{"database":"BioGRID","id":"849765","properties":[{"key":"Interactions","value":"10"}]},{"database":"DIP","id":"DIP-11414N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"P75767","properties":[{"key":"Number of interactors","value":"101"}]},{"database":"IntAct","id":"P75767","properties":[{"key":"Interactions","value":"44"}]},{"database":"STRING","id":"511145.b0780","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"P75767","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"511145-b0780","properties":[{"key":"Description","value":"-"}]},{"database":"EnsemblBacteria","id":"AAC73867","properties":[{"key":"ProteinId","value":"AAC73867"},{"key":"GeneId","value":"b0780"}]},{"database":"GeneID","id":"93776650","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"945390","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"ecj:JW0763","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"eco:b0780","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"ecoc:C3026_04950","properties":[{"key":"Description","value":"-"}]},{"database":"PATRIC","id":"fig|1411691.4.peg.1498","properties":[{"key":"GeneDesignation","value":"-"}]},{"database":"EchoBASE","id":"EB3431","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"COG0391","properties":[{"key":"ToxonomicScope","value":"Bacteria"}]},{"database":"HOGENOM","id":"CLU_044041_2_0_6","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P75767","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"LCGDDDW","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"9783842at2","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"P75767","properties":[{"key":"Description","value":"-"}]},{"database":"BioCyc","id":"EcoCyc:G6402-MONOMER","properties":[{"key":"Description","value":"-"}]},{"database":"PRO","id":"PR:P75767","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000625","properties":[{"key":"Component","value":"Chromosome"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0043743","properties":[{"key":"GoTerm","value":"F:LPPG:FO 2-phospho-L-lactate transferase activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0008360","properties":[{"key":"GoTerm","value":"P:regulation of cell shape"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"CDD","id":"cd07187","properties":[{"key":"EntryName","value":"YvcK_like"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.10680","properties":[{"key":"EntryName","value":"CofD-like domains"},{"key":"MatchStatus","value":"1"}]},{"database":"HAMAP","id":"MF_00973","properties":[{"key":"EntryName","value":"Gluconeogen_factor"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR002882","properties":[{"key":"EntryName","value":"CofD"}]},{"database":"InterPro","id":"IPR038136","properties":[{"key":"EntryName","value":"CofD-like_dom_sf"}]},{"database":"InterPro","id":"IPR010119","properties":[{"key":"EntryName","value":"Gluconeogen_factor"}]},{"database":"NCBIfam","id":"TIGR01826","properties":[{"key":"EntryName","value":"CofD_related"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR30135:SF3","properties":[{"key":"EntryName","value":"GLUCONEOGENESIS FACTOR-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR30135","properties":[{"key":"EntryName","value":"UNCHARACTERIZED PROTEIN YVCK-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01933","properties":[{"key":"EntryName","value":"CofD"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF142338","properties":[{"key":"EntryName","value":"CofD-like"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MRNRTLADLDRVVALGGGHGLGRVLSSLSSLGSRLTGIVTTTDNGGSTGRIRRSEGGIAWGDMRNCLNQLITEPSVASAMFEYRFGGNGELSGHNLGNLMLKALDHLSVRPLEAINLIRNLLKVDTHLIPMSEHPVDLMAIDDQGHEVYGEVNIDQLTTPIQELLLTPNVPATREAVHAINEADLIIIGPGSFYTSLMPILLLKEIAQALRRTPAPMVYIGNLGRELSLPAANLKLESKLAIMEQYVGKKVIDAVIVGPKVDVSAVKERIVIQEVLEASDIPYRHDRQLLHNALEKALQALG","length":302,"molWeight":32788,"crc64":"4E88D67B89576874","md5":"1ECFFDE042EB451537578D672B06669E"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"INTERACTION":1,"SUBCELLULAR LOCATION":1,"MISCELLANEOUS":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1},"uniParcId":"UPI000013A356"}}