{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P72194","uniProtkbId":"KGP38_PORGN","entryAudit":{"firstPublicDate":"2010-07-13","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1997-02-01","entryVersion":94,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Porphyromonas gingivalis","commonName":"Bacteroides gingivalis","taxonId":837,"lineage":["Bacteria","Pseudomonadati","Bacteroidota","Bacteroidia","Bacteroidales","Porphyromonadaceae","Porphyromonas"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15297553"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"8889827"},{"evidenceCode":"ECO:0000312","source":"EMBL","id":"BAA11870.1"}],"value":"Lys-gingipain 381"},"ecNumbers":[{"value":"3.4.22.47"}]},"contains":[{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"B2RLK2"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q51817"}],"value":"Lys-gingipain catalytic subunit"}}},{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q51817"}],"value":"39 kDa adhesin"}}},{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q51817"}],"value":"15 kDa adhesin"}}},{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q51817"}],"value":"44 kDa adhesin"}}}],"flag":"Precursor"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"EMBL","id":"BAA11870.1"}],"value":"kgp"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"B2RLK2"}],"value":"Cysteine proteinase with a strong preference for substrates with Lys in the P1 position. Hydrolyzes bovine hemoglobin, bovine serum albumin, casein, human placental type I collagen and human IgA and IgG. Disrupts the functions of polymorphonuclear leukocytes. May act as a virulence factor in the development of peridontal disease. Involved in the coaggregation of P.gingivalis with other oral bacteria (By similarity)"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"Endopeptidase with strict specificity for lysyl bonds.","ecNumber":"3.4.22.47","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"B2RLK2"}]}},{"commentType":"SUBCELLULAR LOCATION","molecule":"Lys-gingipain catalytic subunit","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8889827"}],"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q51817"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8889827"}],"value":"Proteolytically cleaved into a catalytic subunit and three adhesins. Arg-gingipain is involved in this post-translational processing"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15297553"}],"value":"Several forms of kgp with differences at the C-terminus exist in different P.gingivalis strains"}],"commentType":"POLYMORPHISM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255"}],"value":"Belongs to the peptidase C25 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":24,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Propeptide","location":{"start":{"value":25,"modifier":"EXACT"},"end":{"value":228,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8889827"}],"featureId":"PRO_0000395369"},{"type":"Chain","location":{"start":{"value":229,"modifier":"EXACT"},"end":{"value":1723,"modifier":"EXACT"}},"description":"Lys-gingipain 381","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"8889827"}],"featureId":"PRO_0000395370"},{"type":"Chain","location":{"start":{"value":229,"modifier":"EXACT"},"end":{"value":null,"modifier":"UNKNOWN"}},"description":"Lys-gingipain catalytic subunit","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"8889827"}],"featureId":"PRO_0000395371"},{"type":"Chain","location":{"start":{"value":738,"modifier":"EXACT"},"end":{"value":null,"modifier":"UNKNOWN"}},"description":"39 kDa adhesin","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q51817"}],"featureId":"PRO_0000395372"},{"type":"Chain","location":{"start":{"value":1156,"modifier":"EXACT"},"end":{"value":null,"modifier":"UNKNOWN"}},"description":"15 kDa adhesin","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q51817"}],"featureId":"PRO_0000395373"},{"type":"Chain","location":{"start":{"value":1291,"modifier":"EXACT"},"end":{"value":null,"modifier":"UNKNOWN"}},"description":"44 kDa adhesin","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q51817"}],"featureId":"PRO_0000395374"},{"type":"Region","location":{"start":{"value":964,"modifier":"EXACT"},"end":{"value":985,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Active site","location":{"start":{"value":444,"modifier":"EXACT"},"end":{"value":444,"modifier":"EXACT"}},"description":"Proton donor","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P95493"}]},{"type":"Active site","location":{"start":{"value":477,"modifier":"EXACT"},"end":{"value":477,"modifier":"EXACT"}},"description":"Nucleophile","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P95493"}]},{"type":"Binding site","location":{"start":{"value":313,"modifier":"EXACT"},"end":{"value":313,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q51817"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"1"}},{"type":"Binding site","location":{"start":{"value":337,"modifier":"EXACT"},"end":{"value":337,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q51817"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"2"}},{"type":"Binding site","location":{"start":{"value":339,"modifier":"EXACT"},"end":{"value":339,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q51817"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"2"}},{"type":"Binding site","location":{"start":{"value":341,"modifier":"EXACT"},"end":{"value":341,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q51817"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"2"}},{"type":"Binding site","location":{"start":{"value":343,"modifier":"EXACT"},"end":{"value":343,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q51817"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"2"}},{"type":"Binding site","location":{"start":{"value":482,"modifier":"EXACT"},"end":{"value":482,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q51817"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"1"}},{"type":"Binding site","location":{"start":{"value":491,"modifier":"EXACT"},"end":{"value":491,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q51817"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"1"}},{"type":"Binding site","location":{"start":{"value":987,"modifier":"EXACT"},"end":{"value":987,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q51817"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"3"}},{"type":"Binding site","location":{"start":{"value":989,"modifier":"EXACT"},"end":{"value":989,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q51817"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"3"}},{"type":"Binding site","location":{"start":{"value":1000,"modifier":"EXACT"},"end":{"value":1000,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q51817"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"4"}},{"type":"Binding site","location":{"start":{"value":1002,"modifier":"EXACT"},"end":{"value":1002,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q51817"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"4"}},{"type":"Binding site","location":{"start":{"value":1004,"modifier":"EXACT"},"end":{"value":1004,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q51817"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"4"}},{"type":"Binding site","location":{"start":{"value":1006,"modifier":"EXACT"},"end":{"value":1006,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q51817"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"4"}},{"type":"Binding site","location":{"start":{"value":1021,"modifier":"EXACT"},"end":{"value":1021,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q51817"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"3"}},{"type":"Binding site","location":{"start":{"value":1023,"modifier":"EXACT"},"end":{"value":1023,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q51817"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"3"}},{"type":"Binding site","location":{"start":{"value":1042,"modifier":"EXACT"},"end":{"value":1042,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q51817"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"4"}},{"type":"Binding site","location":{"start":{"value":1145,"modifier":"EXACT"},"end":{"value":1145,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q51817"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"3"}},{"type":"Binding site","location":{"start":{"value":1146,"modifier":"EXACT"},"end":{"value":1146,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q51817"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"3"}},{"type":"Binding site","location":{"start":{"value":1430,"modifier":"EXACT"},"end":{"value":1430,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q51817"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"5"}},{"type":"Binding site","location":{"start":{"value":1432,"modifier":"EXACT"},"end":{"value":1432,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q51817"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"5"}},{"type":"Binding site","location":{"start":{"value":1444,"modifier":"EXACT"},"end":{"value":1444,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q51817"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"6"}},{"type":"Binding site","location":{"start":{"value":1446,"modifier":"EXACT"},"end":{"value":1446,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q51817"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"6"}},{"type":"Binding site","location":{"start":{"value":1448,"modifier":"EXACT"},"end":{"value":1448,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q51817"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"6"}},{"type":"Binding site","location":{"start":{"value":1450,"modifier":"EXACT"},"end":{"value":1450,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q51817"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"6"}},{"type":"Binding site","location":{"start":{"value":1480,"modifier":"EXACT"},"end":{"value":1480,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q51817"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"5"}},{"type":"Binding site","location":{"start":{"value":1495,"modifier":"EXACT"},"end":{"value":1495,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q51817"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"6"}},{"type":"Binding site","location":{"start":{"value":1585,"modifier":"EXACT"},"end":{"value":1585,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q51817"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"5"}},{"type":"Site","location":{"start":{"value":228,"modifier":"EXACT"},"end":{"value":229,"modifier":"EXACT"}},"description":"Cleavage; site 1","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q51817"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8889827"}]},{"type":"Site","location":{"start":{"value":737,"modifier":"EXACT"},"end":{"value":738,"modifier":"EXACT"}},"description":"Cleavage; site 2","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q51817"}]},{"type":"Site","location":{"start":{"value":1155,"modifier":"EXACT"},"end":{"value":1156,"modifier":"EXACT"}},"description":"Cleavage; site 3","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q51817"}]},{"type":"Site","location":{"start":{"value":1290,"modifier":"EXACT"},"end":{"value":1291,"modifier":"EXACT"}},"description":"Cleavage; site 4","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q51817"}]}],"keywords":[{"id":"KW-0106","category":"Ligand","name":"Calcium"},{"id":"KW-0903","category":"Technical term","name":"Direct protein sequencing"},{"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"id":"KW-0645","category":"Molecular function","name":"Protease"},{"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"id":"KW-0732","category":"Domain","name":"Signal"},{"id":"KW-0788","category":"Molecular function","name":"Thiol protease"},{"id":"KW-0843","category":"Biological process","name":"Virulence"},{"id":"KW-0865","category":"PTM","name":"Zymogen"}],"references":[{"referenceNumber":1,"citation":{"id":"8889827","citationType":"journal article","authors":["Okamoto K.","Kadowaki T.","Nakayama K.","Yamamoto K."],"citationCrossReferences":[{"database":"PubMed","id":"8889827"},{"database":"DOI","id":"10.1093/oxfordjournals.jbchem.a021426"}],"title":"Cloning and sequencing of the gene encoding a novel lysine-specific cysteine proteinase (Lys-gingipain) in Porphyromonas gingivalis: structural relationship with the arginine-specific cysteine proteinase (Arg-gingipain).","publicationDate":"1996","journal":"J. Biochem.","firstPage":"398","lastPage":"406","volume":"120"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]","PROTEIN SEQUENCE OF 229-253","SUBCELLULAR LOCATION","POST-TRANSLATIONAL PROCESSING"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000312","source":"EMBL","id":"BAA11870.1"}],"value":"ATCC BAA-1703 / FDC 381","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000305"},{"evidenceCode":"ECO:0000312","source":"EMBL","id":"BAA11870.1"}]},{"referenceNumber":2,"citation":{"id":"15297553","citationType":"journal article","authors":["Nadkarni M.A.","Nguyen K.A.","Chapple C.C.","DeCarlo A.A.","Jacques N.A.","Hunter N."],"citationCrossReferences":[{"database":"PubMed","id":"15297553"},{"database":"DOI","id":"10.1128/jcm.42.8.3873-3876.2004"}],"title":"Distribution of Porphyromonas gingivalis biotypes defined by alleles of the kgp (Lys-gingipain) gene.","publicationDate":"2004","journal":"J. Clin. Microbiol.","firstPage":"3873","lastPage":"3876","volume":"42"},"referencePositions":["POLYMORPHISM"],"evidences":[{"evidenceCode":"ECO:0000305"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"D83258","properties":[{"key":"ProteinId","value":"BAA11870.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"P72194","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P72194","properties":[{"key":"Description","value":"-"}]},{"database":"MEROPS","id":"C25.002","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"29256891","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8889827"}]},{"database":"GO","id":"GO:0005509","properties":[{"key":"GoTerm","value":"F:calcium ion binding"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0004197","properties":[{"key":"GoTerm","value":"F:cysteine-type endopeptidase activity"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0044179","properties":[{"key":"GoTerm","value":"P:hemolysis in another organism"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0006508","properties":[{"key":"GoTerm","value":"P:proteolysis"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"FunFam","id":"2.60.40.3800:FF:000002","properties":[{"key":"EntryName","value":"Lys-gingipain W83"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.1460:FF:000023","properties":[{"key":"EntryName","value":"Lys-gingipain W83"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.120.200","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"3"}]},{"database":"Gene3D","id":"2.60.40.3800","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.1460","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.10390","properties":[{"key":"EntryName","value":"Gingipain r, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"4"}]},{"database":"InterPro","id":"IPR029030","properties":[{"key":"EntryName","value":"Caspase-like_dom_sf"}]},{"database":"InterPro","id":"IPR011628","properties":[{"key":"EntryName","value":"Cleaved_adhesin"}]},{"database":"InterPro","id":"IPR001769","properties":[{"key":"EntryName","value":"Gingipain"}]},{"database":"InterPro","id":"IPR029031","properties":[{"key":"EntryName","value":"Gingipain_N_sf"}]},{"database":"InterPro","id":"IPR038490","properties":[{"key":"EntryName","value":"Gingipain_propep_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR018832","properties":[{"key":"EntryName","value":"Pept_C25_gingipain_C"}]},{"database":"InterPro","id":"IPR005536","properties":[{"key":"EntryName","value":"Peptidase_C25_Ig-like_domain"}]},{"database":"InterPro","id":"IPR012600","properties":[{"key":"EntryName","value":"Propeptide_C25"}]},{"database":"NCBIfam","id":"NF038128","properties":[{"key":"EntryName","value":"choice_anch_J"},{"key":"MatchStatus","value":"3"}]},{"database":"Pfam","id":"PF07675","properties":[{"key":"EntryName","value":"Cleaved_Adhesin"},{"key":"MatchStatus","value":"3"}]},{"database":"Pfam","id":"PF10365","properties":[{"key":"EntryName","value":"DUF2436"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01364","properties":[{"key":"EntryName","value":"Peptidase_C25"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF03785","properties":[{"key":"EntryName","value":"Peptidase_C25_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08126","properties":[{"key":"EntryName","value":"Propeptide_C25"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52129","properties":[{"key":"EntryName","value":"Caspase-like"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MRKLLLLIAASLLGVGLYAQSAKIKLDAPTTRTTCTNNSFKQFDASFSFNEVELTKVETKGGTFASVSIPGAFPTGEVGSPEVPAVRKLIAVPVGATPVVRVKSFTEQVYSLNQYGSEKLMPHQPSMSKSDDPEKVPFVYNAAAYARKGFVGQELTQVEMLGTMRGVRIAALTINPVQYDVVANQLKVRNNIEIEVSFQGADEVATQRLYDASFSPYFETAYKQLFNRDVYTDHGDLYNTPVRMLVVAGAKFKEALKPWLTWKAQKGFYLDVHYTDEAEVGTTNASIKAFIHKKYNDGLAASAAPVFLALVGDTDVISGEKGKKTKKVTDLYYSAVDGDYFPEMYTFRMSASSPEELTNIIDKVLMYEKATMPDKSYLEKALLIAGADSYWNPKIGQQTIKYAVQYYYNQDHGYTDVYSYPKAPYTGCYSHLNTGVGFANYTAHGSETSWADPSLTATQVKALTNKDKYFLAIGNCCVTAQFDYPQPCFGEVMTRVKEKGAYAYIGSSPNSYWGEDYYWSVGANAVFGVQPTFEGTSMGSYDATFLEDSYNTVNSIMWAGNLAATHAGNIGNITHIGAHYYWEAYHVLGDGSVMPYRAMPKTNTYTLPASLPQNQASYSIQASAGSYVAISKDGVLYGTGVANASGVATVNMTKQITENGNYDVVITRSNYLPVIKQIQAGEPSPYQPVSNLTATTQGQKVTLKWDAPSAKKAEASREVKRIGDGLFVTIEPANDVRANEAKVVLAADNVWGDNTGYQFLLDADHNTFGSVIPATGPLFTGTASSNLYSANFEYLIPANADPVVTTQNIIVTGQGEVVIPGGVYDYCITNPEPASGKMWIAGDGGNQPARYDDFTFEAGKKYTFTMRRAGMGDGTDMEVEDDSPASYTYTVYRDGTKIQEGLTATTFEEDGVAAGNHEYCVEVKYTAGVSPKVCKDVTVEGSNEFAPVQNLTGSAVGQKVTLKWDAPNGTPNPNPNPNPGTTTLSESFENGIPASWKTIDADGDGHGWKPGNAPGIAGYNSNGCVYSESFGLGGIGVLTPDNYLITPALDLPNGGKLTFWVCAQDANYASEHYAVYASSTGNDASNFTNALLEETITAKGVRSPEAIRGRIQGTWRQKTVDLPAGTKYVAFRHFQSTDMFYIDLDEVEIKANGKRADFTETFESSTHGEAPAEWTTIDADGDGQDWLCLSSGQLDWLTAHGGTNVVASFSWNGMALNPDNYLISKDVTGATKVKYYYAVNDGFPGDHYAVMISKTGTNAGDFTVVFEETPNGINKGGARFGLSTEANGAKPQSVWIERTVDLPAGTKYVAFRHYNCSDLNYILLDDIQFTMGGSPTPTDYTYTVYRDGTKIKEGLTETTFEEDGVATGNHEYCVEVKYTAGVSPKVCVNVTINPTQFNPVKNLKAQPDGGDVVLKWEAPSGKRGELLNEDFEGDAIPTGWTALDADGDGNNWDITLNEFTRGERHVLSPLRASNVAISYSSLLQGQEYLPLTPNNFLITPKVEGAKKITYKVGSPGLPQWSHDHYALCISKSGTAAADFEVIFEETMTYTQGGANLTREKDLPAGTKYVAFRHYNCTDVLGIMIDDVVITGEGEGPSYTYTVYRDGTKIQEGLTETTYRDAGMSAQSHEYCVEVKYAAGVSPKVCVDYIPDGVADVTAQKPYTLTVVGKTITVTCQGEAMIYDMNGRRLAAGRNTVVYTAQGGYYAVMVVVDGKSYVEKLAIK","length":1723,"molWeight":187262,"crc64":"5628963D251493EB","md5":"57FA77C333F09D63F33A1E2D841AF022"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"SUBCELLULAR LOCATION":1,"PTM":1,"POLYMORPHISM":1,"SIMILARITY":1},"countByFeatureType":{"Signal":1,"Propeptide":1,"Chain":5,"Region":1,"Active site":2,"Binding site":27,"Site":4},"uniParcId":"UPI00000B4822"}}