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In response to oxidative stress, interacts with the ECF sigma factor SigH and, in conjunction with SigH, binds to an auxiliary promoter upstream of mec-cysO-cysM, leading to the transcriptional activation of these genes encoding a non-canonical actinomycete-specific cysteine biosynthesis pathway. Increased transcription of mec-cysO-cysM results in enhanced production of L-cysteine and cysteine-derived antioxidant molecules. Increased production of cysteine protects mycobacteria cells from host phagocyte-derived oxidative and nitrosative stress, thus facilitating the mycobacterial growth in the host"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P9WM25"}],"value":"Activity is modulated by the formation of a disulfide bound within the N-terminal Cys-X-X-X-Cys (CXXXC) motif. This intramolecular disulfide bond is formed in response to oxidative stress, and results in oxidative stress-dependent interaction with the sigma factor SigH"}],"commentType":"ACTIVITY REGULATION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P9WM25"}],"value":"Homodimer. 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