{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P63208","secondaryAccessions":["D3DQ97","D3DQ98","P34991","Q8TAY2"],"uniProtkbId":"SKP1_HUMAN","entryAudit":{"firstPublicDate":"2004-09-27","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2007-01-23","entryVersion":209,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"S-phase kinase-associated protein 1"}},"alternativeNames":[{"fullName":{"value":"Cyclin-A/CDK2-associated protein p19"},"shortNames":[{"value":"p19A"}]},{"fullName":{"value":"Organ of Corti protein 2"},"shortNames":[{"value":"OCP-2"}]},{"fullName":{"value":"Organ of Corti protein II"},"shortNames":[{"value":"OCP-II"}]},{"fullName":{"value":"RNA polymerase II elongation factor-like protein"}},{"fullName":{"value":"SIII"}},{"fullName":{"value":"Transcription elongation factor B polypeptide 1-like"}},{"fullName":{"value":"p19skp1"}}]},"genes":[{"geneName":{"value":"SKP1"},"synonyms":[{"value":"EMC19"},{"value":"OCP2"},{"value":"SKP1A"},{"value":"TCEB1L"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16209941"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20181953"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22113614"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23431138"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25704143"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28727686"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35982156"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36896912"}],"value":"Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5, CEP68 and probably NFKB2 (PubMed:25704143). SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1. SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination of MYOD1. SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO11) directs ubiquitination of BCL6 and DTL but does not seem to direct ubiquitination of TP53. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(CCNF) directs ubiquitination of CCP110. SCF(FBXL3) and SCF(FBXL21) direct ubiquitination of CRY1 and CRY2. SCF(FBXO9) directs ubiquitination of TTI1 and TELO2. SCF(FBXO10) directs ubiquitination of BCL2. Core component of the Cul7-RING(FBXW8) ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:35982156). Also acts as a core component of the Cul1-RING(FBXL4) ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of BNIP3 and BNI3L (PubMed:36896912)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9WTX5"}],"value":"In oocytes and preimplantation embryos, SCF ubiquitin ligase complexes are maintained inactive by cytoplasmic lattices"}],"commentType":"ACTIVITY REGULATION"},{"texts":[{"value":"Protein modification; protein ubiquitination"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9WTX5"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11389839"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12481031"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12820959"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16209941"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16880511"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17389369"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17434132"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18203720"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20181953"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20596027"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22113614"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23431138"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25503564"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27568929"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28727686"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29149593"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30033217"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31209342"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31413110"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35982156"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36896912"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38342987"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"39880951"}],"value":"Interacts with KDM2B, forming heterodimers (PubMed:27568929). The KDM2B-SKP1 heterodimeric complex interacts with the PCGF1-BCORL heterodimeric complex to form a homotetrameric polycomb repression complex 1 (PRC1.1) (PubMed:27568929). Component of multiple SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes formed of CUL1, SKP1, RBX1 and a variable F-box domain-containing protein as substrate-specific subunit (PubMed:31413110). Component of the SCF(FBXW11) complex containing FBXW11. Component of the SCF(SKP2) complex containing SKP2, in which it interacts directly with SKP1, SKP2 and RBX1. Component of the SCF(FBXW2) complex containing FBXW2. Component of the SCF(FBXO32) complex containing FBXO32. Component of the probable SCF(FBXO7) complex containing FBXO7. Component of the SCF(FBXO10) complex containing FBXO10. Component of the SCF(FBXO11) complex containing FBXO11. Component of the SCF(FBXO25) complex containing FBXO25. Component of the SCF(FBXO33) complex containing FBXO33. Component of the probable SCF(FBXO4) complex containing FBXO4. Component of the SCF(FBXO44) complex, composed of SKP1, CUL1 and FBXO44. Component of the SCF(BTRC) complex, composed of SKP1, CUL1 and BTRC. This complex binds phosphorylated NFKBIA. Part of a SCF complex consisting of CUL1, RBX1, SKP1 and FBXO2. Component of a SCF(SKP2)-like complex containing CUL1, SKP1, TRIM21 and SKP2. Component of the SCF(FBXO17) complex, composed of SKP1, CUL1 and FBXO17. Component of the SCF(FBXO27) complex, composed of SKP1, CUL1 and FBXO27. Component of the SCF(CCNF) complex consisting of CUL1, RBX1, SKP1 and CCNF. Component of the SCF(FBXL3) complex composed of CUL1, SKP1, RBX1 and FBXL3. Component of the SCF(FBXL21) complex composed of CUL1, SKP1, RBX1 and FBXL21. Component of the SCF(FBXO9) complex composed of CUL1, SKP1, RBX1 and FBXO9. Component of the SCF(FBXW7) complex composed of CUL1, SKP1, RBX1 and FBXW7 (PubMed:28727686). Component of the SCF(FBXO31) complex composed of CUL1, SKP1, RBX1 and FBXO31 (PubMed:39880951). Component of the SCF(FBXW15) complex composed of CUL1, SKP1, RBX1 and FBXW15 (By similarity). Component of the SCF(FBXL2) complex composed of CUL1, SKP1, RBX1 and FBXL2 (PubMed:31209342). Interacts with CEP68 (PubMed:25503564). Interacts with NOTCH2 (PubMed:29149593). Interacts with FBXW15 (By similarity). The SKP1-KDM2A and SKP1-KDM2B complexes interact with UBB (PubMed:30033217). Component of the Cul7-RING(FBXW8) complex consisting of CUL7, RBX1, SKP1 and FBXW8; within the complex interacts with FBXW8 (PubMed:35982156). Interacts with BCORL1 (PubMed:38342987). Interacts with FBXL4 (PubMed:36896912)"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29444943"}],"value":"(Microbial infection) Interacts with vaccinia virus protein C9L"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P63208","intActId":"EBI-307486"},"interactantTwo":{"uniProtKBAccession":"Q96IX9","geneName":"ANKRD36BP1","intActId":"EBI-744859"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P63208","intActId":"EBI-307486"},"interactantTwo":{"uniProtKBAccession":"Q96GX9","geneName":"APIP","intActId":"EBI-359248"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P63208","intActId":"EBI-307486"},"interactantTwo":{"uniProtKBAccession":"P54253","geneName":"ATXN1","intActId":"EBI-930964"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P63208","intActId":"EBI-307486"},"interactantTwo":{"uniProtKBAccession":"Q9Y297","geneName":"BTRC","intActId":"EBI-307461"},"numberOfExperiments":25,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P63208","intActId":"EBI-307486"},"interactantTwo":{"uniProtKBAccession":"P41002","geneName":"CCNF","intActId":"EBI-1207574"},"numberOfExperiments":10,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P63208","intActId":"EBI-307486"},"interactantTwo":{"uniProtKBAccession":"P38936","geneName":"CDKN1A","intActId":"EBI-375077"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P63208","intActId":"EBI-307486"},"interactantTwo":{"uniProtKBAccession":"Q13616","geneName":"CUL1","intActId":"EBI-359390"},"numberOfExperiments":21,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P63208","intActId":"EBI-307486"},"interactantTwo":{"uniProtKBAccession":"Q9NXK8","geneName":"FBXL12","intActId":"EBI-719790"},"numberOfExperiments":11,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P63208","intActId":"EBI-307486"},"interactantTwo":{"uniProtKBAccession":"Q8N1E6","geneName":"FBXL14","intActId":"EBI-6425532"},"numberOfExperiments":7,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P63208","intActId":"EBI-307486"},"interactantTwo":{"uniProtKBAccession":"Q9UF56","geneName":"FBXL17","intActId":"EBI-8835653"},"numberOfExperiments":17,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P63208","intActId":"EBI-307486"},"interactantTwo":{"uniProtKBAccession":"Q9UKC9","geneName":"FBXL2","intActId":"EBI-724253"},"numberOfExperiments":14,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P63208","intActId":"EBI-307486"},"interactantTwo":{"uniProtKBAccession":"Q96IG2","geneName":"FBXL20","intActId":"EBI-8835647"},"numberOfExperiments":8,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P63208","intActId":"EBI-307486"},"interactantTwo":{"uniProtKBAccession":"Q6P050","geneName":"FBXL22","intActId":"EBI-24224082"},"numberOfExperiments":7,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P63208","intActId":"EBI-307486"},"interactantTwo":{"uniProtKBAccession":"Q9UKA1","geneName":"FBXL5","intActId":"EBI-2692340"},"numberOfExperiments":15,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P63208","intActId":"EBI-307486"},"interactantTwo":{"uniProtKBAccession":"Q8N531","geneName":"FBXL6","intActId":"EBI-2322696"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P63208","intActId":"EBI-307486"},"interactantTwo":{"uniProtKBAccession":"Q96CD0","geneName":"FBXL8","intActId":"EBI-2321097"},"numberOfExperiments":18,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P63208","intActId":"EBI-307486"},"interactantTwo":{"uniProtKBAccession":"Q86XK2","geneName":"FBXO11","intActId":"EBI-1047804"},"numberOfExperiments":12,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P63208","intActId":"EBI-307486"},"interactantTwo":{"uniProtKBAccession":"Q96EF6","geneName":"FBXO17","intActId":"EBI-2510157"},"numberOfExperiments":20,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P63208","intActId":"EBI-307486"},"interactantTwo":{"uniProtKBAccession":"Q9UK22","geneName":"FBXO2","intActId":"EBI-4287196"},"numberOfExperiments":15,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P63208","intActId":"EBI-307486"},"interactantTwo":{"uniProtKBAccession":"O94952","geneName":"FBXO21","intActId":"EBI-311435"},"numberOfExperiments":11,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P63208","intActId":"EBI-307486"},"interactantTwo":{"uniProtKBAccession":"Q8NEZ5","geneName":"FBXO22","intActId":"EBI-2510137"},"numberOfExperiments":11,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P63208","intActId":"EBI-307486"},"interactantTwo":{"uniProtKBAccession":"Q8TCJ0-3","geneName":"FBXO25","intActId":"EBI-6262578"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P63208","intActId":"EBI-307486"},"interactantTwo":{"uniProtKBAccession":"Q8NI29","geneName":"FBXO27","intActId":"EBI-6425694"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P63208","intActId":"EBI-307486"},"interactantTwo":{"uniProtKBAccession":"Q9NVF7","geneName":"FBXO28","intActId":"EBI-740282"},"numberOfExperiments":15,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P63208","intActId":"EBI-307486"},"interactantTwo":{"uniProtKBAccession":"Q9UK99","geneName":"FBXO3","intActId":"EBI-2509901"},"numberOfExperiments":13,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P63208","intActId":"EBI-307486"},"interactantTwo":{"uniProtKBAccession":"Q5XUX0","geneName":"FBXO31","intActId":"EBI-6162477"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P63208","intActId":"EBI-307486"},"interactantTwo":{"uniProtKBAccession":"Q7Z6M2","geneName":"FBXO33","intActId":"EBI-8555452"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P63208","intActId":"EBI-307486"},"interactantTwo":{"uniProtKBAccession":"Q9UKT5","geneName":"FBXO4","intActId":"EBI-960409"},"numberOfExperiments":20,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P63208","intActId":"EBI-307486"},"interactantTwo":{"uniProtKBAccession":"Q4G163","geneName":"FBXO43","intActId":"EBI-12053217"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P63208","intActId":"EBI-307486"},"interactantTwo":{"uniProtKBAccession":"Q9H4M3","geneName":"FBXO44","intActId":"EBI-2322644"},"numberOfExperiments":8,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P63208","intActId":"EBI-307486"},"interactantTwo":{"uniProtKBAccession":"Q9H4M3-2","geneName":"FBXO44","intActId":"EBI-12104696"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P63208","intActId":"EBI-307486"},"interactantTwo":{"uniProtKBAccession":"Q6PJ61","geneName":"FBXO46","intActId":"EBI-2322982"},"numberOfExperiments":8,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P63208","intActId":"EBI-307486"},"interactantTwo":{"uniProtKBAccession":"Q5FWF7","geneName":"FBXO48","intActId":"EBI-11961122"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P63208","intActId":"EBI-307486"},"interactantTwo":{"uniProtKBAccession":"Q9UKT4","geneName":"FBXO5","intActId":"EBI-852298"},"numberOfExperiments":9,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P63208","intActId":"EBI-307486"},"interactantTwo":{"uniProtKBAccession":"Q9NRD1","geneName":"FBXO6","intActId":"EBI-3938499"},"numberOfExperiments":10,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P63208","intActId":"EBI-307486"},"interactantTwo":{"uniProtKBAccession":"Q9Y3I1","geneName":"FBXO7","intActId":"EBI-1161222"},"numberOfExperiments":12,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P63208","intActId":"EBI-307486"},"interactantTwo":{"uniProtKBAccession":"Q9UK97","geneName":"FBXO9","intActId":"EBI-2869927"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P63208","intActId":"EBI-307486"},"interactantTwo":{"uniProtKBAccession":"Q9UK97-2","geneName":"FBXO9","intActId":"EBI-11023199"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P63208","intActId":"EBI-307486"},"interactantTwo":{"uniProtKBAccession":"Q9UKB1","geneName":"FBXW11","intActId":"EBI-355189"},"numberOfExperiments":14,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P63208","intActId":"EBI-307486"},"interactantTwo":{"uniProtKBAccession":"Q9UKT8","geneName":"FBXW2","intActId":"EBI-914727"},"numberOfExperiments":8,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P63208","intActId":"EBI-307486"},"interactantTwo":{"uniProtKBAccession":"P57775","geneName":"FBXW4","intActId":"EBI-2372268"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P63208","intActId":"EBI-307486"},"interactantTwo":{"uniProtKBAccession":"Q969U6","geneName":"FBXW5","intActId":"EBI-741068"},"numberOfExperiments":8,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P63208","intActId":"EBI-307486"},"interactantTwo":{"uniProtKBAccession":"Q969H0","geneName":"FBXW7","intActId":"EBI-359574"},"numberOfExperiments":12,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P63208","intActId":"EBI-307486"},"interactantTwo":{"uniProtKBAccession":"Q8N3Y1","geneName":"FBXW8","intActId":"EBI-914770"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P63208","intActId":"EBI-307486"},"interactantTwo":{"uniProtKBAccession":"Q5XUX1","geneName":"FBXW9","intActId":"EBI-2322729"},"numberOfExperiments":8,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P63208","intActId":"EBI-307486"},"interactantTwo":{"uniProtKBAccession":"Q7L273","geneName":"KCTD9","intActId":"EBI-4397613"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P63208","intActId":"EBI-307486"},"interactantTwo":{"uniProtKBAccession":"Q9Y2K7","geneName":"KDM2A","intActId":"EBI-765758"},"numberOfExperiments":7,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P63208","intActId":"EBI-307486"},"interactantTwo":{"uniProtKBAccession":"Q8NHM5","geneName":"KDM2B","intActId":"EBI-3955564"},"numberOfExperiments":8,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P63208","intActId":"EBI-307486"},"interactantTwo":{"uniProtKBAccession":"P25791","geneName":"LMO2","intActId":"EBI-739696"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P63208","intActId":"EBI-307486"},"interactantTwo":{"uniProtKBAccession":"Q6FHY5","geneName":"MEOX2","intActId":"EBI-16439278"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P63208","intActId":"EBI-307486"},"interactantTwo":{"uniProtKBAccession":"Q9ULD2-3","geneName":"MTUS1","intActId":"EBI-18051665"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P63208","intActId":"EBI-307486"},"interactantTwo":{"uniProtKBAccession":"Q14901","geneName":"MYC","intActId":"EBI-7982457"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P63208","intActId":"EBI-307486"},"interactantTwo":{"uniProtKBAccession":"P62136","geneName":"PPP1CA","intActId":"EBI-357253"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P63208","intActId":"EBI-307486"},"interactantTwo":{"uniProtKBAccession":"Q13309","geneName":"SKP2","intActId":"EBI-456291"},"numberOfExperiments":19,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P63208","intActId":"EBI-307486"},"interactantTwo":{"uniProtKBAccession":"Q13309-2","geneName":"SKP2","intActId":"EBI-7791408"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P63208","intActId":"EBI-307486"},"interactantTwo":{"uniProtKBAccession":"Q9Y2Z0","geneName":"SUGT1","intActId":"EBI-307008"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P63208","intActId":"EBI-307486"},"interactantTwo":{"uniProtKBAccession":"Q9Y2Z0-2","geneName":"SUGT1","intActId":"EBI-10768076"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P63208","intActId":"EBI-307486"},"interactantTwo":{"uniProtKBAccession":"A0A0B4J1Y2","geneName":"TTC21A","intActId":"EBI-10220701"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P63208","intActId":"EBI-307486"},"interactantTwo":{"uniProtKBAccession":"Q8N5M4","geneName":"TTC9C","intActId":"EBI-2851213"},"numberOfExperiments":14,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P63208","intActId":"EBI-307486"},"interactantTwo":{"uniProtKBAccession":"Q8BFZ4","geneName":"Fbxl21","intActId":"EBI-6898235"},"numberOfExperiments":3,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"P63208","intActId":"EBI-307486"},"interactantTwo":{"uniProtKBAccession":"Q8C4V4","geneName":"Fbxl3","intActId":"EBI-1266589"},"numberOfExperiments":3,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"P63208-1","intActId":"EBI-307497"},"interactantTwo":{"uniProtKBAccession":"P41002","geneName":"CCNF","intActId":"EBI-1207574"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P63208-1","intActId":"EBI-307497"},"interactantTwo":{"uniProtKBAccession":"Q86XK2","geneName":"FBXO11","intActId":"EBI-1047804"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P63208-1","intActId":"EBI-307497"},"interactantTwo":{"uniProtKBAccession":"Q969U6-1","geneName":"FBXW5","intActId":"EBI-16031873"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P63208-1","intActId":"EBI-307497"},"interactantTwo":{"uniProtKBAccession":"Q969H0","geneName":"FBXW7","intActId":"EBI-359574"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P63208-1","intActId":"EBI-307497"},"interactantTwo":{"uniProtKBAccession":"Q13503","geneName":"MED21","intActId":"EBI-394678"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P63208-1","intActId":"EBI-307497"},"interactantTwo":{"uniProtKBAccession":"Q13309-1","geneName":"SKP2","intActId":"EBI-15490084"},"numberOfExperiments":7,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P63208-1","intActId":"EBI-307497"},"interactantTwo":{"uniProtKBAccession":"Q80UW2","geneName":"Fbxo2","intActId":"EBI-2314714"},"numberOfExperiments":4,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"P63208-1","intActId":"EBI-307497"},"interactantTwo":{"uniProtKBAccession":"Q6TVJ2","intActId":"EBI-15718764"},"numberOfExperiments":2,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"P63208-1","intActId":"EBI-307497"},"interactantTwo":{"uniProtKBAccession":"Q6TVJ4","intActId":"EBI-15718558"},"numberOfExperiments":2,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"P63208-1","intActId":"EBI-307497"},"interactantTwo":{"uniProtKBAccession":"Q6TVJ7","intActId":"EBI-15718586"},"numberOfExperiments":2,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"P63208-1","intActId":"EBI-307497"},"interactantTwo":{"uniProtKBAccession":"Q6TVW2","intActId":"EBI-15718527"},"numberOfExperiments":5,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"P63208-2","intActId":"EBI-25930963"},"interactantTwo":{"uniProtKBAccession":"Q7Z699","geneName":"SPRED1","intActId":"EBI-5235340"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["P63208-1","P34991-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["P63208-2","P34991-2"],"sequenceIds":["VSP_007555"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9WTX5"}],"value":"Undergoes autophagy-mediated degradation in the liver in a time-dependent manner"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the SKP1 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Initiator methionine","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"Removed","evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.5"}]},{"type":"Chain","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":163,"modifier":"EXACT"}},"description":"S-phase kinase-associated protein 1","featureId":"PRO_0000187251"},{"type":"Region","location":{"start":{"value":63,"modifier":"EXACT"},"end":{"value":83,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":104,"modifier":"EXACT"},"end":{"value":163,"modifier":"EXACT"}},"description":"Interaction with the F-box domain of F-box proteins","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35982156"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7Z8B"}]},{"type":"Modified residue","location":{"start":{"value":131,"modifier":"EXACT"},"end":{"value":131,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"}]},{"type":"Cross-link","location":{"start":{"value":142,"modifier":"EXACT"},"end":{"value":142,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"25114211"}]},{"type":"Alternative sequence","location":{"start":{"value":154,"modifier":"EXACT"},"end":{"value":163,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"featureId":"VSP_007555","alternativeSequence":{"originalSequence":"RKENQWCEEK","alternativeSequences":["GSTQFCL"]}},{"type":"Beta strand","location":{"start":{"value":3,"modifier":"EXACT"},"end":{"value":7,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1FS1"}]},{"type":"Beta strand","location":{"start":{"value":9,"modifier":"EXACT"},"end":{"value":11,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6M90"}]},{"type":"Beta strand","location":{"start":{"value":13,"modifier":"EXACT"},"end":{"value":17,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1FS1"}]},{"type":"Helix","location":{"start":{"value":18,"modifier":"EXACT"},"end":{"value":22,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1FS1"}]},{"type":"Helix","location":{"start":{"value":25,"modifier":"EXACT"},"end":{"value":33,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1FS1"}]},{"type":"Beta strand","location":{"start":{"value":38,"modifier":"EXACT"},"end":{"value":40,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6O60"}]},{"type":"Beta strand","location":{"start":{"value":44,"modifier":"EXACT"},"end":{"value":46,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1FS1"}]},{"type":"Beta strand","location":{"start":{"value":47,"modifier":"EXACT"},"end":{"value":50,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1LDK"}]},{"type":"Helix","location":{"start":{"value":52,"modifier":"EXACT"},"end":{"value":65,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1FS1"}]},{"type":"Helix","location":{"start":{"value":68,"modifier":"EXACT"},"end":{"value":72,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5JH5"}]},{"type":"Helix","location":{"start":{"value":75,"modifier":"EXACT"},"end":{"value":79,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8BYL"}]},{"type":"Beta strand","location":{"start":{"value":80,"modifier":"EXACT"},"end":{"value":82,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5XYL"}]},{"type":"Beta strand","location":{"start":{"value":83,"modifier":"EXACT"},"end":{"value":85,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6WNX"}]},{"type":"Helix","location":{"start":{"value":87,"modifier":"EXACT"},"end":{"value":92,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1FS1"}]},{"type":"Helix","location":{"start":{"value":97,"modifier":"EXACT"},"end":{"value":110,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1FS1"}]},{"type":"Helix","location":{"start":{"value":113,"modifier":"EXACT"},"end":{"value":127,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1FS1"}]},{"type":"Beta strand","location":{"start":{"value":128,"modifier":"EXACT"},"end":{"value":130,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1FQV"}]},{"type":"Helix","location":{"start":{"value":132,"modifier":"EXACT"},"end":{"value":138,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1FS1"}]},{"type":"Helix","location":{"start":{"value":141,"modifier":"EXACT"},"end":{"value":143,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5IBK"}]},{"type":"Helix","location":{"start":{"value":147,"modifier":"EXACT"},"end":{"value":155,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6M90"}]},{"type":"Turn","location":{"start":{"value":157,"modifier":"EXACT"},"end":{"value":159,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2AST"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0903","category":"Technical term","name":"Direct protein sequencing"},{"id":"KW-0945","category":"Biological process","name":"Host-virus interaction"},{"id":"KW-1017","category":"PTM","name":"Isopeptide bond"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0832","category":"PTM","name":"Ubl conjugation"},{"id":"KW-0833","category":"Biological process","name":"Ubl conjugation pathway"}],"references":[{"referenceNumber":1,"citation":{"id":"7553852","citationType":"journal article","authors":["Zhang H.","Kobayashi R.","Galaktionov K.","Beach D."],"citationCrossReferences":[{"database":"PubMed","id":"7553852"},{"database":"DOI","id":"10.1016/0092-8674(95)90271-6"}],"title":"p19Skp1 and p45Skp2 are essential elements of the cyclin A-CDK2 S phase kinase.","publicationDate":"1995","journal":"Cell","firstPage":"915","lastPage":"925","volume":"82"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)"]},{"referenceNumber":2,"citation":{"id":"8530064","citationType":"journal article","authors":["Sowden J.","Morrison K.","Schofield J.","Putt W.","Edwards Y."],"citationCrossReferences":[{"database":"PubMed","id":"8530064"},{"database":"DOI","id":"10.1006/geno.1995.1225"}],"title":"A novel cDNA with homology to an RNA polymerase II elongation factors maps to human chromosome 5q31 (TCEB1L) and to mouse chromosome 11 (Tceb1l).","publicationDate":"1995","journal":"Genomics","firstPage":"145","lastPage":"151","volume":"29"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)"]},{"referenceNumber":3,"citation":{"id":"CI-5GBD0VIIJ7C63","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"SEP-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":4,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)"],"referenceComments":[{"value":"Lung","type":"TISSUE"},{"value":"Skin","type":"TISSUE"},{"value":"Uterus","type":"TISSUE"}]},{"referenceNumber":5,"citation":{"id":"CI-5P03I4HUOE7TF","citationType":"submission","authors":["Golaz O.","Hughes G.J.","Frutiger S.","Paquet N.","Bairoch A.","Pasquali C.","Sanchez J.-C.","Tissot J.-D.","Appel R.D.","Walzer C.","Balant L.","Hochstrasser D.F."],"publicationDate":"FEB-1994","submissionDatabase":"UniProtKB"},"referencePositions":["PROTEIN SEQUENCE OF 2-11"],"referenceComments":[{"value":"Erythrocyte","type":"TISSUE"}]},{"referenceNumber":6,"citation":{"id":"20068231","citationType":"journal article","authors":["Olsen J.V.","Vermeulen M.","Santamaria A.","Kumar C.","Miller M.L.","Jensen L.J.","Gnad F.","Cox J.","Jensen T.S.","Nigg E.A.","Brunak S.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"20068231"},{"database":"DOI","id":"10.1126/scisignal.2000475"}],"title":"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.","publicationDate":"2010","journal":"Sci. Signal.","firstPage":"RA3","lastPage":"RA3","volume":"3"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-131","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":7,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Buerckstuemmer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":8,"citation":{"id":"21406692","citationType":"journal article","authors":["Rigbolt K.T.","Prokhorova T.A.","Akimov V.","Henningsen J.","Johansen P.T.","Kratchmarova I.","Kassem M.","Mann M.","Olsen J.V.","Blagoev B."],"citationCrossReferences":[{"database":"PubMed","id":"21406692"},{"database":"DOI","id":"10.1126/scisignal.2001570"}],"title":"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.","publicationDate":"2011","journal":"Sci. Signal.","firstPage":"RS3","lastPage":"RS3","volume":"4"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-131","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":9,"citation":{"id":"23431138","citationType":"journal article","authors":["Chiorazzi M.","Rui L.","Yang Y.","Ceribelli M.","Tishbi N.","Maurer C.W.","Ranuncolo S.M.","Zhao H.","Xu W.","Chan W.C.","Jaffe E.S.","Gascoyne R.D.","Campo E.","Rosenwald A.","Ott G.","Delabie J.","Rimsza L.M.","Shaham S.","Staudt L.M."],"citationCrossReferences":[{"database":"PubMed","id":"23431138"},{"database":"DOI","id":"10.1073/pnas.1217271110"}],"title":"Related F-box proteins control cell death in Caenorhabditis elegans and human lymphoma.","publicationDate":"2013","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"3943","lastPage":"3948","volume":"110"},"referencePositions":["FUNCTION IN UBIQUITINATION OF BCL2","IDENTIFICATION IN THE SCF(FBXO10) COMPLEX"]},{"referenceNumber":10,"citation":{"id":"9031623","citationType":"journal article","authors":["Liang Y.","Chen H.","Asher J.H. Jr.","Chang C.-C.","Friedman T.B."],"citationCrossReferences":[{"database":"PubMed","id":"9031623"},{"database":"DOI","id":"10.1016/s0378-1119(96)00590-2"}],"title":"Human inner ear OCP2 cDNA maps to 5q22-5q35.2 with related sequences on chromosomes 4p16.2-4p14, 5p13-5q22, 7pter-q22, 10 and 12p13-12qter.","publicationDate":"1997","journal":"Gene","firstPage":"163","lastPage":"167","volume":"184"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] OF 14-163 (ISOFORM 1)"],"referenceComments":[{"value":"Inner ear","type":"TISSUE"}]},{"referenceNumber":11,"citation":{"id":"12481031","citationType":"journal article","authors":["Dias D.C.","Dolios G.","Wang R.","Pan Z.Q."],"citationCrossReferences":[{"database":"PubMed","id":"12481031"},{"database":"DOI","id":"10.1073/pnas.252646399"}],"title":"CUL7: a DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex.","publicationDate":"2002","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"16601","lastPage":"16606","volume":"99"},"referencePositions":["INTERACTION WITH FBXW8","IDENTIFICATION IN SCF-LIKE COMPLEX"]},{"referenceNumber":12,"citation":{"id":"11389839","citationType":"journal article","authors":["Matsuzawa S.","Reed J.C."],"citationCrossReferences":[{"database":"PubMed","id":"11389839"},{"database":"DOI","id":"10.1016/s1097-2765(01)00242-8"}],"title":"Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses.","publicationDate":"2001","journal":"Mol. Cell","firstPage":"915","lastPage":"926","volume":"7"},"referencePositions":["SUBUNIT OF A COMPLEX WITH SIAH1; CACYBP; UBE2D1; APC AND TBL1X"]},{"referenceNumber":13,"citation":{"id":"16880511","citationType":"journal article","authors":["Sabile A.","Meyer A.M.","Wirbelauer C.","Hess D.","Kogel U.","Scheffner M.","Krek W."],"citationCrossReferences":[{"database":"PubMed","id":"16880511"},{"database":"DOI","id":"10.1128/mcb.01630-05"}],"title":"Regulation of p27 degradation and S-phase progression by Ro52 RING finger protein.","publicationDate":"2006","journal":"Mol. Cell. Biol.","firstPage":"5994","lastPage":"6004","volume":"26"},"referencePositions":["INTERACTION WITH THE SCF(SKP2)-LIKE COMPLEX","INTERACTION WITH TRIM21"]},{"referenceNumber":14,"citation":{"id":"18203720","citationType":"journal article","authors":["Glenn K.A.","Nelson R.F.","Wen H.M.","Mallinger A.J.","Paulson H.L."],"citationCrossReferences":[{"database":"PubMed","id":"18203720"},{"database":"DOI","id":"10.1074/jbc.m709508200"}],"title":"Diversity in tissue expression, substrate binding, and SCF complex formation for a lectin family of ubiquitin ligases.","publicationDate":"2008","journal":"J. Biol. Chem.","firstPage":"12717","lastPage":"12729","volume":"283"},"referencePositions":["INTERACTION WITH FBXO44; FBXO17 AND FBXO27","IDENTIFICATION IN SCF-COMPLEX"]},{"referenceNumber":15,"citation":{"id":"20596027","citationType":"journal article","authors":["D'Angiolella V.","Donato V.","Vijayakumar S.","Saraf A.","Florens L.","Washburn M.P.","Dynlacht B.","Pagano M."],"citationCrossReferences":[{"database":"PubMed","id":"20596027"},{"database":"DOI","id":"10.1038/nature09140"}],"title":"SCF(Cyclin F) controls centrosome homeostasis and mitotic fidelity through CP110 degradation.","publicationDate":"2010","journal":"Nature","firstPage":"138","lastPage":"142","volume":"466"},"referencePositions":["IDENTIFICATION IN THE SCF(CCNF) COMPLEX"]},{"referenceNumber":16,"citation":{"id":"22113614","citationType":"journal article","authors":["Duan S.","Cermak L.","Pagan J.K.","Rossi M.","Martinengo C.","di Celle P.F.","Chapuy B.","Shipp M.","Chiarle R.","Pagano M."],"citationCrossReferences":[{"database":"PubMed","id":"22113614"},{"database":"DOI","id":"10.1038/nature10688"}],"title":"FBXO11 targets BCL6 for degradation and is inactivated in diffuse large B-cell lymphomas.","publicationDate":"2012","journal":"Nature","firstPage":"90","lastPage":"93","volume":"481"},"referencePositions":["FUNCTION IN UBIQUITINATION OF BCL6","IDENTIFICATION IN THE SCF(FBXO11) COMPLEX"]},{"referenceNumber":17,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":18,"citation":{"id":"25114211","citationType":"journal article","authors":["Impens F.","Radoshevich L.","Cossart P.","Ribet D."],"citationCrossReferences":[{"database":"PubMed","id":"25114211"},{"database":"DOI","id":"10.1073/pnas.1413825111"}],"title":"Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.","publicationDate":"2014","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"12432","lastPage":"12437","volume":"111"},"referencePositions":["SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-142","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":19,"citation":{"id":"25704143","citationType":"journal article","authors":["Man X.","Megraw T.L.","Lim Y.P."],"citationCrossReferences":[{"database":"PubMed","id":"25704143"},{"database":"DOI","id":"10.1016/j.ejcb.2015.01.004"}],"title":"Cep68 can be regulated by Nek2 and SCF complex.","publicationDate":"2015","journal":"Eur. J. Cell Biol.","firstPage":"162","lastPage":"172","volume":"94"},"referencePositions":["FUNCTION"]},{"referenceNumber":20,"citation":{"id":"25503564","citationType":"journal article","authors":["Pagan J.K.","Marzio A.","Jones M.J.","Saraf A.","Jallepalli P.V.","Florens L.","Washburn M.P.","Pagano M."],"citationCrossReferences":[{"database":"PubMed","id":"25503564"},{"database":"DOI","id":"10.1038/ncb3076"}],"title":"Degradation of Cep68 and PCNT cleavage mediate Cep215 removal from the PCM to allow centriole separation, disengagement and licensing.","publicationDate":"2015","journal":"Nat. Cell Biol.","firstPage":"31","lastPage":"43","volume":"17"},"referencePositions":["INTERACTION WITH CEP68"]},{"referenceNumber":21,"citation":{"id":"25944712","citationType":"journal article","authors":["Vaca Jacome A.S.","Rabilloud T.","Schaeffer-Reiss C.","Rompais M.","Ayoub D.","Lane L.","Bairoch A.","Van Dorsselaer A.","Carapito C."],"citationCrossReferences":[{"database":"PubMed","id":"25944712"},{"database":"DOI","id":"10.1002/pmic.201400617"}],"title":"N-terminome analysis of the human mitochondrial proteome.","publicationDate":"2015","journal":"Proteomics","firstPage":"2519","lastPage":"2524","volume":"15"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":22,"citation":{"id":"29149593","citationType":"journal article","authors":["Fukushima H.","Shimizu K.","Watahiki A.","Hoshikawa S.","Kosho T.","Oba D.","Sakano S.","Arakaki M.","Yamada A.","Nagashima K.","Okabe K.","Fukumoto S.","Jimi E.","Bigas A.","Nakayama K.I.","Nakayama K.","Aoki Y.","Wei W.","Inuzuka H."],"citationCrossReferences":[{"database":"PubMed","id":"29149593"},{"database":"DOI","id":"10.1016/j.molcel.2017.10.018"}],"title":"NOTCH2 Hajdu-Cheney mutations escape SCFFBW7-dependent proteolysis to promote osteoporosis.","publicationDate":"2017","journal":"Mol. Cell","firstPage":"645","lastPage":"658","volume":"68"},"referencePositions":["INTERACTION WITH NOTCH2"]},{"referenceNumber":23,"citation":{"id":"29444943","citationType":"journal article","authors":["Liu R.","Moss B."],"citationCrossReferences":[{"database":"PubMed","id":"29444943"},{"database":"DOI","id":"10.1128/jvi.00053-18"}],"title":"Vaccinia Virus C9 Ankyrin Repeat/F-Box Protein Is a Newly Identified Antagonist of the Type I Interferon-Induced Antiviral State.","publicationDate":"2018","journal":"J. Virol.","firstPage":"0","lastPage":"0","volume":"92"},"referencePositions":["INTERACTION WITH VACCINIA VIRUS PROTEIN C9L (MICROBIAL INFECTION)"]},{"referenceNumber":24,"citation":{"id":"31413110","citationType":"journal article","authors":["Dutta P.","Islam S.","Choppara S.","Sengupta P.","Kumar A.","Kumar A.","Wani M.R.","Chatterjee S.","Santra M.K."],"citationCrossReferences":[{"database":"PubMed","id":"31413110"},{"database":"DOI","id":"10.1074/jbc.ra118.007055"}],"title":"The tumor suppressor FBXO31 preserves genomic integrity by regulating DNA replication and segregation through precise control of cyclin A levels.","publicationDate":"2019","journal":"J. Biol. Chem.","firstPage":"14879","lastPage":"14895","volume":"294"},"referencePositions":["IDENTIFICATION IN A SCF PROTEIN LIGASE COMPLEX"]},{"referenceNumber":25,"citation":{"id":"36896912","citationType":"journal article","authors":["Cao Y.","Zheng J.","Wan H.","Sun Y.","Fu S.","Liu S.","He B.","Cai G.","Cao Y.","Huang H.","Li Q.","Ma Y.","Chen S.","Wang F.","Jiang H."],"citationCrossReferences":[{"database":"PubMed","id":"36896912"},{"database":"DOI","id":"10.15252/embj.2022113033"}],"title":"A mitochondrial SCF-FBXL4 ubiquitin E3 ligase complex degrades BNIP3 and NIX to restrain mitophagy and prevent mitochondrial disease.","publicationDate":"2023","journal":"EMBO J.","firstPage":"e113033","lastPage":"e113033","volume":"42"},"referencePositions":["FUNCTION","INTERACTION WITH FBXL4"]},{"referenceNumber":26,"citation":{"id":"38342987","citationType":"journal article","authors":["Luo C.","Chen Z.","Meng L.","Tan C.","He W.","Tu C.","Du J.","Lu G.X.","Lin G.","Tan Y.Q.","Hu T.Y."],"citationCrossReferences":[{"database":"PubMed","id":"38342987"},{"database":"DOI","id":"10.1111/cge.14500"}],"title":"A hemizygous loss-of-function variant in BCORL1 is associated with male infertility and oligoasthenoteratozoospermia.","publicationDate":"2024","journal":"Clin. Genet.","firstPage":"27","lastPage":"36","volume":"106"},"referencePositions":["INTERACTION WITH BCORL1"]},{"referenceNumber":27,"citation":{"id":"39880951","citationType":"journal article","authors":["Muhar M.F.","Farnung J.","Cernakova M.","Hofmann R.","Henneberg L.T.","Pfleiderer M.M.","Denoth-Lippuner A.","Kalcic F.","Nievergelt A.S.","Peters Al-Bayati M.","Sidiropoulos N.D.","Beier V.","Mann M.","Jessberger S.","Jinek M.","Schulman B.A.","Bode J.W.","Corn J.E."],"citationCrossReferences":[{"database":"PubMed","id":"39880951"},{"database":"DOI","id":"10.1038/s41586-024-08475-w"}],"title":"C-terminal amides mark proteins for degradation via SCF-FBXO31.","publicationDate":"2025","journal":"Nature","firstPage":"0","lastPage":"0","volume":"0"},"referencePositions":["IDENTIFICATION IN THE SCF(FBXO31) UBIQUITIN LIGASE COMPLEX"]},{"referenceNumber":28,"citation":{"id":"11099048","citationType":"journal article","authors":["Schulman B.A.","Carrano A.C.","Jeffrey P.D.","Bowen Z.","Kinnucan E.R.E.","Finnin M.S.","Elledge S.J.","Harper J.W.","Pagano M.","Pavletich N.P."],"citationCrossReferences":[{"database":"PubMed","id":"11099048"},{"database":"DOI","id":"10.1038/35042620"}],"title":"Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex.","publicationDate":"2000","journal":"Nature","firstPage":"381","lastPage":"386","volume":"408"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF THE SKP1-SKP2 COMPLEX"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"1FQV"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"1FS1"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"1FS2"}]},{"referenceNumber":29,"citation":{"id":"11961546","citationType":"journal article","authors":["Zheng N.","Schulman B.A.","Song L.","Miller J.J.","Jeffrey P.D.","Wang P.","Chu C.","Koepp D.M.","Elledge S.J.","Pagano M.","Conaway R.C.","Conaway J.W.","Harper J.W.","Pavletich N.P."],"citationCrossReferences":[{"database":"PubMed","id":"11961546"},{"database":"DOI","id":"10.1038/416703a"}],"title":"Structure of the Cul1-Rbx1-Skp1-F box Skp2 SCF ubiquitin ligase complex.","publicationDate":"2002","journal":"Nature","firstPage":"703","lastPage":"709","volume":"416"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) IN SCF COMPLEX WITH CUL1; RBX1 AND SKP2"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"1LDK"}]},{"referenceNumber":30,"citation":{"id":"12820959","citationType":"journal article","authors":["Wu G.","Xu G.","Schulman B.A.","Jeffrey P.D.","Harper J.W.","Pavletich N.P."],"citationCrossReferences":[{"database":"PubMed","id":"12820959"},{"database":"DOI","id":"10.1016/s1097-2765(03)00234-x"}],"title":"Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligase.","publicationDate":"2003","journal":"Mol. Cell","firstPage":"1445","lastPage":"1456","volume":"11"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.95 ANGSTROMS) IN COMPLEX WITH 176-606 OF BTRC AND CTNNB1"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"1P22"}]},{"referenceNumber":31,"citation":{"id":"16209941","citationType":"journal article","authors":["Hao B.","Zheng N.","Schulman B.A.","Wu G.","Miller J.J.","Pagano M.","Pavletich N.P."],"citationCrossReferences":[{"database":"PubMed","id":"16209941"},{"database":"DOI","id":"10.1016/j.molcel.2005.09.003"}],"title":"Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligase.","publicationDate":"2005","journal":"Mol. Cell","firstPage":"9","lastPage":"19","volume":"20"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 3-159 IN COMPLEX WITH SKP2; CKS1B AND CDKN1B PHOSPHOPEPTIDE","SUBUNIT","FUNCTION"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"2ASS"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"2AST"}]},{"referenceNumber":32,"citation":{"id":"17434132","citationType":"journal article","authors":["Hao B.","Oehlmann S.","Sowa M.E.","Harper J.W.","Pavletich N.P."],"citationCrossReferences":[{"database":"PubMed","id":"17434132"},{"database":"DOI","id":"10.1016/j.molcel.2007.02.022"}],"title":"Structure of a Fbw7-Skp1-cyclin E complex: multisite-phosphorylated substrate recognition by SCF ubiquitin ligases.","publicationDate":"2007","journal":"Mol. Cell","firstPage":"131","lastPage":"143","volume":"26"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) IN COMPLEX WITH FBXW7 AND CCNE1 PEPTIDE"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"2OVP"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"2OVQ"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"2OVR"}]},{"referenceNumber":33,"citation":{"id":"17389369","citationType":"journal article","authors":["Mizushima T.","Yoshida Y.","Kumanomidou T.","Hasegawa Y.","Suzuki A.","Yamane T.","Tanaka K."],"citationCrossReferences":[{"database":"PubMed","id":"17389369"},{"database":"DOI","id":"10.1073/pnas.0610312104"}],"title":"Structural basis for the selection of glycosylated substrates by SCF(Fbs1) ubiquitin ligase.","publicationDate":"2007","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"5777","lastPage":"5781","volume":"104"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) IN COMPLEX WITH FBXO2"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"2E31"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"2E32"}]},{"referenceNumber":34,"citation":{"id":"20181953","citationType":"journal article","authors":["Li Y.","Hao B."],"citationCrossReferences":[{"database":"PubMed","id":"20181953"},{"database":"DOI","id":"10.1074/jbc.m110.111518"}],"title":"Structural basis of dimerization-dependent ubiquitination by the SCF(Fbx4) ubiquitin ligase.","publicationDate":"2010","journal":"J. Biol. Chem.","firstPage":"13896","lastPage":"13906","volume":"285"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) IN COMPLEX WITH FBXO4","FUNCTION"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"3L2O"}]},{"referenceNumber":35,"citation":{"id":"27568929","citationType":"journal article","authors":["Wong S.J.","Gearhart M.D.","Taylor A.B.","Nanyes D.R.","Ha D.J.","Robinson A.K.","Artigas J.A.","Lee O.J.","Demeler B.","Hart P.J.","Bardwell V.J.","Kim C.A."],"citationCrossReferences":[{"database":"PubMed","id":"27568929"},{"database":"DOI","id":"10.1016/j.str.2016.07.011"}],"title":"KDM2B Recruitment of the Polycomb Group Complex, PRC1.1, Requires Cooperation between PCGF1 and BCORL1.","publicationDate":"2016","journal":"Structure","firstPage":"1795","lastPage":"1801","volume":"24"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.55 ANGSTROMS) OF 2-163","SUBUNIT"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"5JH5"}]},{"referenceNumber":36,"citation":{"id":"28727686","citationType":"journal article","authors":["Yalla K.","Elliott C.","Day J.P.","Findlay J.","Barratt S.","Hughes Z.A.","Wilson L.","Whiteley E.","Popiolek M.","Li Y.","Dunlop J.","Killick R.","Adams D.R.","Brandon N.J.","Houslay M.D.","Hao B.","Baillie G.S."],"citationCrossReferences":[{"database":"PubMed","id":"28727686"},{"database":"DOI","id":"10.1038/mp.2017.138"}],"title":"FBXW7 regulates DISC1 stability via the ubiquitin-proteosome system.","publicationDate":"2018","journal":"Mol. Psychiatry","firstPage":"1278","lastPage":"1286","volume":"23"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) IN COMPLEX WITH FBXW7","FUNCTION"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"5V4B"}]},{"referenceNumber":37,"citation":{"id":"30033217","citationType":"journal article","authors":["Gorelik M.","Manczyk N.","Pavlenco A.","Kurinov I.","Sidhu S.S.","Sicheri F."],"citationCrossReferences":[{"database":"PubMed","id":"30033217"},{"database":"DOI","id":"10.1016/j.str.2018.06.004"}],"title":"A Structure-Based Strategy for Engineering Selective Ubiquitin Variant Inhibitors of Skp1-Cul1-F-Box Ubiquitin Ligases.","publicationDate":"2018","journal":"Structure","firstPage":"1226","lastPage":"1236.E3","volume":"26"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.61 ANGSTROMS) IN COMPLEX WITH KDM2A; KDM2B AND UBB","INTERACTION OF SKP1-KDM2A AND SKP1-KDM2B COMPLEXES WITH UBB"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"6BVA"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6BYH"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6C16"}]},{"referenceNumber":38,"citation":{"id":"31209342","citationType":"journal article","authors":["Kuchay S.","Wang H.","Marzio A.","Jain K.","Homer H.","Fehrenbacher N.","Philips M.R.","Zheng N.","Pagano M."],"citationCrossReferences":[{"database":"PubMed","id":"31209342"},{"database":"DOI","id":"10.1038/s41594-019-0249-3"}],"title":"GGTase3 is a newly identified geranylgeranyltransferase targeting a ubiquitin ligase.","publicationDate":"2019","journal":"Nat. Struct. Mol. Biol.","firstPage":"628","lastPage":"636","volume":"26"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) IN COMPLEX WITH PTAR1; RABGGTB AND FBXL2","SUBUNIT"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"6O60"}]},{"referenceNumber":39,"citation":{"id":"35982156","citationType":"journal article","authors":["Hopf L.V.M.","Baek K.","Kluegel M.","von Gronau S.","Xiong Y.","Schulman B.A."],"citationCrossReferences":[{"database":"PubMed","id":"35982156"},{"database":"DOI","id":"10.1038/s41594-022-00815-6"}],"title":"Structure of CRL7FBXW8 reveals coupling with CUL1-RBX1/ROC1 for multi-cullin-RING E3-catalyzed ubiquitin ligation.","publicationDate":"2022","journal":"Nat. Struct. Mol. Biol.","firstPage":"854","lastPage":"862","volume":"29"},"referencePositions":["STRUCTURE BY ELECTRON MICROSCOPY (2.80 ANGSTROMS) IN CUL7-RING(FBXW8) COMPLEX","FUNCTION","SUBUNIT","INTERACTION WITH FBXW8"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"7Z8B"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"U33760","properties":[{"key":"ProteinId","value":"AAC50241.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"Z47087","properties":[{"key":"ProteinId","value":"CAA87392.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"CH471062","properties":[{"key":"ProteinId","value":"EAW62270.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471062","properties":[{"key":"ProteinId","value":"EAW62271.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471062","properties":[{"key":"ProteinId","value":"EAW62272.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471062","properties":[{"key":"ProteinId","value":"EAW62276.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC009839","properties":[{"key":"ProteinId","value":"AAH09839.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC020798","properties":[{"key":"ProteinId","value":"AAH20798.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC025673","properties":[{"key":"ProteinId","value":"AAH25673.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC065730","properties":[{"key":"ProteinId","value":"AAH65730.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"U37558","properties":[{"key":"ProteinId","value":"AAA79202.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS4171.1","properties":[{"key":"Description","value":"-"}]},{"database":"CCDS","id":"CCDS4172.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P63208-2"},{"database":"PIR","id":"I39170","properties":[{"key":"EntryName","value":"I39170"}]},{"database":"RefSeq","id":"NP_008861.2","properties":[{"key":"NucleotideSequenceId","value":"NM_006930.4"}],"isoformId":"P63208-2"},{"database":"RefSeq","id":"NP_733779.1","properties":[{"key":"NucleotideSequenceId","value":"NM_170679.3"}],"isoformId":"P63208-1"},{"database":"PDB","id":"1FQV","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.80 A"},{"key":"Chains","value":"B/D/F/H/J/L/N/P=1-163"}]},{"database":"PDB","id":"1FS1","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"B/D=1-147"}]},{"database":"PDB","id":"1FS2","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.90 A"},{"key":"Chains","value":"B/D=1-147"}]},{"database":"PDB","id":"1LDK","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.10 A"},{"key":"Chains","value":"D=2-140"}]},{"database":"PDB","id":"1P22","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.95 A"},{"key":"Chains","value":"B=1-163"}]},{"database":"PDB","id":"29HG","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.00 A"},{"key":"Chains","value":"C=1-163"}]},{"database":"PDB","id":"29HH","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.20 A"},{"key":"Chains","value":"C=1-163"}]},{"database":"PDB","id":"29HI","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"5.90 A"},{"key":"Chains","value":"C=1-163"}]},{"database":"PDB","id":"2ASS","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.00 A"},{"key":"Chains","value":"A=2-160"}]},{"database":"PDB","id":"2AST","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.30 A"},{"key":"Chains","value":"A=2-160"}]},{"database":"PDB","id":"2E31","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.40 A"},{"key":"Chains","value":"B=1-163"}]},{"database":"PDB","id":"2E32","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.52 A"},{"key":"Chains","value":"B/D=1-163"}]},{"database":"PDB","id":"2OVP","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.90 A"},{"key":"Chains","value":"A=1-69, A=82-163"}]},{"database":"PDB","id":"2OVQ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.60 A"},{"key":"Chains","value":"A=1-69, A=82-163"}]},{"database":"PDB","id":"2OVR","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.50 A"},{"key":"Chains","value":"A=1-69, A=82-163"}]},{"database":"PDB","id":"3L2O","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.80 A"},{"key":"Chains","value":"A=1-69, A=82-163"}]},{"database":"PDB","id":"3WSO","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.60 A"},{"key":"Chains","value":"B=1-163"}]},{"database":"PDB","id":"4I6J","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.70 A"},{"key":"Chains","value":"C=1-163"}]},{"database":"PDB","id":"5IBK","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.50 A"},{"key":"Chains","value":"A/D=1-69, A/D=82-163"}]},{"database":"PDB","id":"5JH5","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.55 A"},{"key":"Chains","value":"B=2-163"}]},{"database":"PDB","id":"5K35","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.85 A"},{"key":"Chains","value":"B=1-163"}]},{"database":"PDB","id":"5V4B","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.60 A"},{"key":"Chains","value":"A=1-69, A=82-163"}]},{"database":"PDB","id":"5VZT","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.70 A"},{"key":"Chains","value":"A/C=1-163"}]},{"database":"PDB","id":"5VZU","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.70 A"},{"key":"Chains","value":"A/C=1-163"}]},{"database":"PDB","id":"5XYL","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=1-163"}]},{"database":"PDB","id":"6BVA","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.66 A"},{"key":"Chains","value":"C/D=1-163"}]},{"database":"PDB","id":"6BYH","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.61 A"},{"key":"Chains","value":"A/B/G=1-163"}]},{"database":"PDB","id":"6C16","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.27 A"},{"key":"Chains","value":"A/B=1-163"}]},{"database":"PDB","id":"6M90","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.05 A"},{"key":"Chains","value":"B=2-163"}]},{"database":"PDB","id":"6M91","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.40 A"},{"key":"Chains","value":"B=2-163"}]},{"database":"PDB","id":"6M92","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.35 A"},{"key":"Chains","value":"B=2-163"}]},{"database":"PDB","id":"6M93","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.50 A"},{"key":"Chains","value":"B=2-163"}]},{"database":"PDB","id":"6M94","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.70 A"},{"key":"Chains","value":"B=2-163"}]},{"database":"PDB","id":"6O60","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.50 A"},{"key":"Chains","value":"D=1-163"}]},{"database":"PDB","id":"6TTU","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.70 A"},{"key":"Chains","value":"S=1-163"}]},{"database":"PDB","id":"6VCD","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.00 A"},{"key":"Chains","value":"C=1-163"}]},{"database":"PDB","id":"6W66","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.21 A"},{"key":"Chains","value":"A=1-163"}]},{"database":"PDB","id":"6WCQ","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"8.50 A"},{"key":"Chains","value":"A=1-163"}]},{"database":"PDB","id":"6WNX","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.50 A"},{"key":"Chains","value":"B/E/H=1-163"}]},{"database":"PDB","id":"7B5L","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.80 A"},{"key":"Chains","value":"S=1-163"}]},{"database":"PDB","id":"7B5M","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.91 A"},{"key":"Chains","value":"S=1-163"}]},{"database":"PDB","id":"7B5R","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.80 A"},{"key":"Chains","value":"S=1-163"}]},{"database":"PDB","id":"7T1Y","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.55 A"},{"key":"Chains","value":"A=1-163"}]},{"database":"PDB","id":"7T1Z","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.77 A"},{"key":"Chains","value":"A=1-69, A=89-163"}]},{"database":"PDB","id":"7Z8B","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.80 A"},{"key":"Chains","value":"S=1-163"}]},{"database":"PDB","id":"7Z8T","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.00 A"},{"key":"Chains","value":"S=1-163"}]},{"database":"PDB","id":"7Z8V","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.70 A"},{"key":"Chains","value":"S=1-163"}]},{"database":"PDB","id":"7ZBW","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.50 A"},{"key":"Chains","value":"S=1-163"}]},{"database":"PDB","id":"7ZBZ","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.10 A"},{"key":"Chains","value":"S=1-163"}]},{"database":"PDB","id":"8BYA","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.38 A"},{"key":"Chains","value":"D=1-163"}]},{"database":"PDB","id":"8BYL","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.50 A"},{"key":"Chains","value":"A=1-163"}]},{"database":"PDB","id":"8CDJ","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.40 A"},{"key":"Chains","value":"S=1-163"}]},{"database":"PDB","id":"8CDK","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.32 A"},{"key":"Chains","value":"S=1-163"}]},{"database":"PDB","id":"8OR0","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.10 A"},{"key":"Chains","value":"D=1-163"}]},{"database":"PDB","id":"8OR3","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.90 A"},{"key":"Chains","value":"D=1-163"}]},{"database":"PDB","id":"8OR4","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.80 A"},{"key":"Chains","value":"D=1-163"}]},{"database":"PDB","id":"8S7D","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.20 A"},{"key":"Chains","value":"C=1-163"}]},{"database":"PDB","id":"8S7E","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.40 A"},{"key":"Chains","value":"A=2-163"}]},{"database":"PDB","id":"8UA6","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.90 A"},{"key":"Chains","value":"B=1-160"}]},{"database":"PDB","id":"8UBT","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.10 A"},{"key":"Chains","value":"B=1-163"}]},{"database":"PDB","id":"8UBU","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.60 A"},{"key":"Chains","value":"C/G=1-163"}]},{"database":"PDB","id":"9CB3","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.47 A"},{"key":"Chains","value":"B=1-163"}]},{"database":"PDB","id":"9JKB","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.93 A"},{"key":"Chains","value":"B=1-163"}]},{"database":"PDB","id":"9KBD","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.70 A"},{"key":"Chains","value":"B=1-163"}]},{"database":"PDB","id":"9KBF","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.74 A"},{"key":"Chains","value":"B=1-163"}]},{"database":"PDB","id":"9QO0","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.26 A"},{"key":"Chains","value":"L=1-163"}]},{"database":"PDB","id":"9QO2","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.80 A"},{"key":"Chains","value":"L=1-163"}]},{"database":"PDB","id":"9QO3","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.60 A"},{"key":"Chains","value":"L=1-163"}]},{"database":"PDB","id":"9QO4","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.95 A"},{"key":"Chains","value":"L=1-163"}]},{"database":"PDB","id":"9QO5","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.00 A"},{"key":"Chains","value":"L=1-163"}]},{"database":"PDB","id":"9XZJ","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.13 A"},{"key":"Chains","value":"S=1-163"}]},{"database":"PDB","id":"9XZL","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.00 A"},{"key":"Chains","value":"S=1-163"}]},{"database":"PDBsum","id":"1FQV","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1FS1","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1FS2","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1LDK","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1P22","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"29HG","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"29HH","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"29HI","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2ASS","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2AST","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2E31","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2E32","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2OVP","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2OVQ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2OVR","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3L2O","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3WSO","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4I6J","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5IBK","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5JH5","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5K35","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5V4B","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5VZT","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5VZU","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5XYL","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6BVA","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6BYH","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6C16","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6M90","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6M91","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6M92","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6M93","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6M94","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6O60","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6TTU","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6VCD","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6W66","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6WCQ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6WNX","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7B5L","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7B5M","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7B5R","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7T1Y","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7T1Z","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7Z8B","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7Z8T","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7Z8V","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7ZBW","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7ZBZ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8BYA","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8BYL","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8CDJ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8CDK","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8OR0","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8OR3","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8OR4","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8S7D","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8S7E","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8UA6","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8UBT","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8UBU","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9CB3","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9JKB","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9KBD","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9KBF","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9QO0","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9QO2","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9QO3","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9QO4","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9QO5","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9XZJ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9XZL","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"P63208","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-10585","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-12037","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-12040","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-12048","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-14547","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-14563","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-14564","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-14594","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-14597","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-16325","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-16327","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-16575","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-16576","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-17114","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-17116","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-17117","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-19766","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-19768","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-21149","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-21617","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-3401","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-42051","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-42102","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-42105","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-45413","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-49966","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-53252","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-53254","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-53255","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-53256","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-53257","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-61550","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-62222","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-62223","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-72358","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-72361","properties":[{"key":"Description","value":"-"}]},{"database":"SASBDB","id":"P63208","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P63208","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"112391","properties":[{"key":"Interactions","value":"537"}]},{"database":"ComplexPortal","id":"CPX-2239","properties":[{"key":"EntryName","value":"SCF E3 ubiquitin ligase complex, FBXL5 variant"}]},{"database":"ComplexPortal","id":"CPX-2241","properties":[{"key":"EntryName","value":"SCF E3 ubiquitin ligase complex, FBXL13 variant"}]},{"database":"ComplexPortal","id":"CPX-2272","properties":[{"key":"EntryName","value":"Non-canonical polycomb repressive complex 1.1, RING2-PCGF1-YAF2 variant"}]},{"database":"ComplexPortal","id":"CPX-2319","properties":[{"key":"EntryName","value":"SCF E3 ubiquitin ligase complex, FBXL14 variant"}]},{"database":"ComplexPortal","id":"CPX-2343","properties":[{"key":"EntryName","value":"SCF E3 ubiquitin ligase complex, FBXL16 variant"}]},{"database":"ComplexPortal","id":"CPX-2354","properties":[{"key":"EntryName","value":"Non-canonical polycomb repressive complex 1.1, RING1-PCGF1-RYBP variant"}]},{"database":"ComplexPortal","id":"CPX-2365","properties":[{"key":"EntryName","value":"SCF E3 ubiquitin ligase complex, BTRC variant"}]},{"database":"ComplexPortal","id":"CPX-2438","properties":[{"key":"EntryName","value":"SCF E3 ubiquitin ligase complex, FBXL8 variant"}]},{"database":"ComplexPortal","id":"CPX-2489","properties":[{"key":"EntryName","value":"SCF E3 ubiquitin ligase complex, FBXL22 variant"}]},{"database":"ComplexPortal","id":"CPX-2492","properties":[{"key":"EntryName","value":"SCF E3 ubiquitin ligase complex, FBXL15 variant"}]},{"database":"ComplexPortal","id":"CPX-2512","properties":[{"key":"EntryName","value":"SCF E3 ubiquitin ligase complex, FBXL4 variant"}]},{"database":"ComplexPortal","id":"CPX-2516","properties":[{"key":"EntryName","value":"SCF E3 ubiquitin ligase complex, FBXL6 variant"}]},{"database":"ComplexPortal","id":"CPX-2538","properties":[{"key":"EntryName","value":"SCF E3 ubiquitin ligase complex, KDM2A variant"}]},{"database":"ComplexPortal","id":"CPX-2553","properties":[{"key":"EntryName","value":"SCF E3 ubiquitin ligase complex, FBXL18 variant"}]},{"database":"ComplexPortal","id":"CPX-2554","properties":[{"key":"EntryName","value":"SCF E3 ubiquitin ligase complex, FBXL19 variant"}]},{"database":"ComplexPortal","id":"CPX-2627","properties":[{"key":"EntryName","value":"Non-canonical polycomb repressive complex 1.1, RING2-PCGF1-RYBP variant"}]},{"database":"ComplexPortal","id":"CPX-2658","properties":[{"key":"EntryName","value":"SCF E3 ubiquitin ligase complex, FBXL12 variant"}]},{"database":"ComplexPortal","id":"CPX-2683","properties":[{"key":"EntryName","value":"SCF E3 ubiquitin ligase complex, FBXL7 variant"}]},{"database":"ComplexPortal","id":"CPX-2748","properties":[{"key":"EntryName","value":"SCF E3 ubiquitin ligase complex, FBXL21 variant"}]},{"database":"ComplexPortal","id":"CPX-2773","properties":[{"key":"EntryName","value":"SCF E3 ubiquitin ligase complex, FBXL17 variant"}]},{"database":"ComplexPortal","id":"CPX-2832","properties":[{"key":"EntryName","value":"SCF E3 ubiquitin ligase complex, KDM2B variant"}]},{"database":"ComplexPortal","id":"CPX-2873","properties":[{"key":"EntryName","value":"SCF E3 ubiquitin ligase complex, FBXL20 variant"}]},{"database":"ComplexPortal","id":"CPX-3291","properties":[{"key":"EntryName","value":"SCF E3 ubiquitin ligase complex, FBXL3 variant"}]},{"database":"ComplexPortal","id":"CPX-3292","properties":[{"key":"EntryName","value":"SCF E3 ubiquitin ligase complex, FBXL2 variant"}]},{"database":"ComplexPortal","id":"CPX-3295","properties":[{"key":"EntryName","value":"SCF E3 ubiquitin ligase complex, SKP2 variant"}]},{"database":"ComplexPortal","id":"CPX-7561","properties":[{"key":"EntryName","value":"Non-canonical polycomb repressive complex 1.1, RING1-PCGF1-YAF2 variant"}]},{"database":"ComplexPortal","id":"CPX-7747","properties":[{"key":"EntryName","value":"SCF E3 ubiquitin ligase complex, FBXW2 variant"}]},{"database":"ComplexPortal","id":"CPX-7761","properties":[{"key":"EntryName","value":"SCF E3 ubiquitin ligase complex, FBXW4 variant"}]},{"database":"ComplexPortal","id":"CPX-7762","properties":[{"key":"EntryName","value":"SCF E3 ubiquitin ligase complex, FBXW5 variant"}]},{"database":"ComplexPortal","id":"CPX-7763","properties":[{"key":"EntryName","value":"SCF E3 ubiquitin ligase complex, FBXW7 variant"}]},{"database":"ComplexPortal","id":"CPX-7784","properties":[{"key":"EntryName","value":"SCF E3 ubiquitin ligase complex, FBXW8-CUL7 variant"}]},{"database":"ComplexPortal","id":"CPX-7785","properties":[{"key":"EntryName","value":"SCF E3 ubiquitin ligase complex, FBXW9 variant"}]},{"database":"ComplexPortal","id":"CPX-7786","properties":[{"key":"EntryName","value":"SCF E3 ubiquitin ligase complex, FBXW10 variant"}]},{"database":"ComplexPortal","id":"CPX-7821","properties":[{"key":"EntryName","value":"SCF E3 ubiquitin ligase complex, FBXW11 variant"}]},{"database":"ComplexPortal","id":"CPX-7822","properties":[{"key":"EntryName","value":"SCF E3 ubiquitin ligase complex, FBXW12 variant"}]},{"database":"ComplexPortal","id":"CPX-7846","properties":[{"key":"EntryName","value":"SCF E3 ubiquitin ligase complex, CCNF variant"}]},{"database":"ComplexPortal","id":"CPX-7847","properties":[{"key":"EntryName","value":"SCF E3 ubiquitin ligase complex, FBXO2 variant"}]},{"database":"ComplexPortal","id":"CPX-7881","properties":[{"key":"EntryName","value":"SCF E3 ubiquitin ligase complex, FBXO3 variant"}]},{"database":"ComplexPortal","id":"CPX-7882","properties":[{"key":"EntryName","value":"SCF E3 ubiquitin ligase complex, FBXO4 variant"}]},{"database":"ComplexPortal","id":"CPX-7904","properties":[{"key":"EntryName","value":"SCF E3 ubiquitin ligase complex, FBXO5 variant"}]},{"database":"ComplexPortal","id":"CPX-7905","properties":[{"key":"EntryName","value":"SCF E3 ubiquitin ligase complex, FBXO6 variant"}]},{"database":"ComplexPortal","id":"CPX-7906","properties":[{"key":"EntryName","value":"SCF E3 ubiquitin ligase complex, FBXO7 variant"}]},{"database":"ComplexPortal","id":"CPX-7921","properties":[{"key":"EntryName","value":"SCF E3 ubiquitin ligase complex, FBXO8 variant"}]},{"database":"ComplexPortal","id":"CPX-7922","properties":[{"key":"EntryName","value":"SCF E3 ubiquitin ligase complex, FBXO9 variant"}]},{"database":"ComplexPortal","id":"CPX-7923","properties":[{"key":"EntryName","value":"SCF E3 ubiquitin ligase complex, FBXO10 variant"}]},{"database":"ComplexPortal","id":"CPX-7924","properties":[{"key":"EntryName","value":"SCF E3 ubiquitin ligase complex, FBXO11 variant"}]},{"database":"ComplexPortal","id":"CPX-7925","properties":[{"key":"EntryName","value":"SCF E3 ubiquitin ligase complex, FBXO15 variant"}]},{"database":"ComplexPortal","id":"CPX-7926","properties":[{"key":"EntryName","value":"SCF E3 ubiquitin ligase complex, FBXO16 variant"}]},{"database":"ComplexPortal","id":"CPX-7927","properties":[{"key":"EntryName","value":"SCF E3 ubiquitin ligase complex, FBXO17 variant"}]},{"database":"ComplexPortal","id":"CPX-7928","properties":[{"key":"EntryName","value":"SCF E3 ubiquitin ligase complex, FBH1 variant"}]},{"database":"ComplexPortal","id":"CPX-7929","properties":[{"key":"EntryName","value":"SCF E3 ubiquitin ligase complex, LMO7 variant"}]},{"database":"ComplexPortal","id":"CPX-7930","properties":[{"key":"EntryName","value":"SCF E3 ubiquitin ligase complex, FBXO21 variant"}]},{"database":"ComplexPortal","id":"CPX-7962","properties":[{"key":"EntryName","value":"SCF E3 ubiquitin ligase complex, FBXO22 variant"}]},{"database":"ComplexPortal","id":"CPX-7963","properties":[{"key":"EntryName","value":"SCF E3 ubiquitin ligase complex, FBXO24 variant"}]},{"database":"ComplexPortal","id":"CPX-7965","properties":[{"key":"EntryName","value":"SCF E3 ubiquitin ligase complex, FBXO25 variant"}]},{"database":"ComplexPortal","id":"CPX-7966","properties":[{"key":"EntryName","value":"SCF E3 ubiquitin ligase complex, FBXO27 variant"}]},{"database":"ComplexPortal","id":"CPX-7967","properties":[{"key":"EntryName","value":"SCF E3 ubiquitin ligase complex, FBXO28 variant"}]},{"database":"ComplexPortal","id":"CPX-7968","properties":[{"key":"EntryName","value":"SCF E3 ubiquitin ligase complex, FBXO30 variant"}]},{"database":"ComplexPortal","id":"CPX-7971","properties":[{"key":"EntryName","value":"SCF E3 ubiquitin ligase complex, FBXO31 variant"}]},{"database":"ComplexPortal","id":"CPX-7972","properties":[{"key":"EntryName","value":"SCF E3 ubiquitin ligase complex, FBXO32 variant"}]},{"database":"ComplexPortal","id":"CPX-7973","properties":[{"key":"EntryName","value":"SCF E3 ubiquitin ligase complex, FBXO33 variant"}]},{"database":"ComplexPortal","id":"CPX-7975","properties":[{"key":"EntryName","value":"SCF E3 ubiquitin ligase complex, FBXO34 variant"}]},{"database":"ComplexPortal","id":"CPX-7976","properties":[{"key":"EntryName","value":"SCF E3 ubiquitin ligase complex, FBXO36 variant"}]},{"database":"ComplexPortal","id":"CPX-7977","properties":[{"key":"EntryName","value":"SCF E3 ubiquitin ligase complex, FBXO38 variant"}]},{"database":"ComplexPortal","id":"CPX-7979","properties":[{"key":"EntryName","value":"SCF E3 ubiquitin ligase complex, FBXO39 variant"}]},{"database":"ComplexPortal","id":"CPX-7981","properties":[{"key":"EntryName","value":"SCF E3 ubiquitin ligase complex, FBXO40 variant"}]},{"database":"ComplexPortal","id":"CPX-7982","properties":[{"key":"EntryName","value":"SCF E3 ubiquitin ligase complex, FBXO41 variant"}]},{"database":"ComplexPortal","id":"CPX-7983","properties":[{"key":"EntryName","value":"SCF E3 ubiquitin ligase complex, FBXO42 variant"}]},{"database":"ComplexPortal","id":"CPX-8002","properties":[{"key":"EntryName","value":"SCF E3 ubiquitin ligase complex, FBXO43 variant"}]},{"database":"ComplexPortal","id":"CPX-8003","properties":[{"key":"EntryName","value":"SCF E3 ubiquitin ligase complex, FBXO44 variant"}]},{"database":"ComplexPortal","id":"CPX-8004","properties":[{"key":"EntryName","value":"Non-canonical FBXO45-MYCBP2-SKP1 E3 ubiquitin ligase complex"}]},{"database":"ComplexPortal","id":"CPX-8005","properties":[{"key":"EntryName","value":"SCF E3 ubiquitin ligase complex, FBXO46 variant"}]},{"database":"ComplexPortal","id":"CPX-8006","properties":[{"key":"EntryName","value":"SCF E3 ubiquitin ligase complex, FBXO47 variant"}]},{"database":"ComplexPortal","id":"CPX-8108","properties":[{"key":"EntryName","value":"SCF E3 ubiquitin ligase complex, TSPAN17 variant"}]},{"database":"CORUM","id":"P63208","properties":[{"key":"Description","value":"-"}]},{"database":"DIP","id":"DIP-31606N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"P63208","properties":[{"key":"Number of interactors","value":"3721"}]},{"database":"IntAct","id":"P63208","properties":[{"key":"Interactions","value":"310"}]},{"database":"MINT","id":"P63208","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-SKP1","properties":[{"key":"Evidences","value":"18 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000231487","properties":[{"key":"Description","value":"-"}]},{"database":"DrugBank","id":"DB06980","properties":[{"key":"GenericName","value":"(2S)-2-(1H-indol-3-yl)hexanoic acid"}]},{"database":"DrugBank","id":"DB06981","properties":[{"key":"GenericName","value":"(2S)-2-(1H-indol-3-yl)pentanoic acid"}]},{"database":"DrugBank","id":"DB06982","properties":[{"key":"GenericName","value":"(2S)-8-[(tert-butoxycarbonyl)amino]-2-(1H-indol-3-yl)octanoic acid"}]},{"database":"DrugBank","id":"DB01750","properties":[{"key":"GenericName","value":"1-naphthaleneacetic acid"}]},{"database":"DrugBank","id":"DB07950","properties":[{"key":"GenericName","value":"Indoleacetic acid"}]},{"database":"MoonDB","id":"P63208","properties":[{"key":"Type","value":"Predicted"}]},{"database":"GlyGen","id":"P63208","properties":[{"key":"glycosylation","value":"1 site, 1 O-linked glycan (1 site)"}]},{"database":"iPTMnet","id":"P63208","properties":[{"key":"Description","value":"-"}]},{"database":"MetOSite","id":"P63208","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"P63208","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"P63208","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"SKP1","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"52783797","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"P63208","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"P63208","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000231487","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"P63208","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"57504","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"57505","properties":[{"key":"Description","value":"-"}],"isoformId":"P63208-2"},{"database":"Pumba","id":"P63208","properties":[{"key":"Description","value":"-"}]},{"database":"TopDownProteomics","id":"P63208-1","properties":[{"key":"Description","value":"-"}],"isoformId":"P63208-1"},{"database":"Antibodypedia","id":"4566","properties":[{"key":"antibodies","value":"575 antibodies from 43 providers"}]},{"database":"DNASU","id":"6500","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000353411.11","properties":[{"key":"ProteinId","value":"ENSP00000231487.9"},{"key":"GeneId","value":"ENSG00000113558.20"}],"isoformId":"P63208-1"},{"database":"Ensembl","id":"ENST00000517625.5","properties":[{"key":"ProteinId","value":"ENSP00000429961.1"},{"key":"GeneId","value":"ENSG00000113558.20"}],"isoformId":"P63208-1"},{"database":"Ensembl","id":"ENST00000522552.5","properties":[{"key":"ProteinId","value":"ENSP00000429472.1"},{"key":"GeneId","value":"ENSG00000113558.20"}],"isoformId":"P63208-2"},{"database":"Ensembl","id":"ENST00000522855.5","properties":[{"key":"ProteinId","value":"ENSP00000429686.1"},{"key":"GeneId","value":"ENSG00000113558.20"}],"isoformId":"P63208-1"},{"database":"Ensembl","id":"ENST00000880996.1","properties":[{"key":"ProteinId","value":"ENSP00000551055.1"},{"key":"GeneId","value":"ENSG00000113558.20"}],"isoformId":"P63208-1"},{"database":"Ensembl","id":"ENST00000880997.1","properties":[{"key":"ProteinId","value":"ENSP00000551056.1"},{"key":"GeneId","value":"ENSG00000113558.20"}],"isoformId":"P63208-1"},{"database":"Ensembl","id":"ENST00000881000.1","properties":[{"key":"ProteinId","value":"ENSP00000551059.1"},{"key":"GeneId","value":"ENSG00000113558.20"}],"isoformId":"P63208-1"},{"database":"Ensembl","id":"ENST00000934651.1","properties":[{"key":"ProteinId","value":"ENSP00000604710.1"},{"key":"GeneId","value":"ENSG00000113558.20"}],"isoformId":"P63208-1"},{"database":"Ensembl","id":"ENST00000934653.1","properties":[{"key":"ProteinId","value":"ENSP00000604712.1"},{"key":"GeneId","value":"ENSG00000113558.20"}],"isoformId":"P63208-1"},{"database":"Ensembl","id":"ENST00000934654.1","properties":[{"key":"ProteinId","value":"ENSP00000604713.1"},{"key":"GeneId","value":"ENSG00000113558.20"}],"isoformId":"P63208-1"},{"database":"Ensembl","id":"ENST00000968700.1","properties":[{"key":"ProteinId","value":"ENSP00000638759.1"},{"key":"GeneId","value":"ENSG00000113558.20"}],"isoformId":"P63208-1"},{"database":"GeneID","id":"6500","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:6500","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000353411.11","properties":[{"key":"ProteinId","value":"ENSP00000231487.9"},{"key":"RefSeqNucleotideId","value":"NM_170679.3"},{"key":"RefSeqProteinId","value":"NP_733779.1"}]},{"database":"UCSC","id":"uc003kzc.5","properties":[{"key":"OrganismName","value":"human"}]},{"database":"AGR","id":"HGNC:10899","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA162403424","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"6500","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"6500","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"SKP1","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:10899","properties":[{"key":"GeneName","value":"SKP1"}]},{"database":"HPA","id":"ENSG00000113558","properties":[{"key":"ExpressionPatterns","value":"Low tissue specificity"}]},{"database":"MIM","id":"601434","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000113558","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000113558","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG1724","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00390000012652","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P63208","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"DKYTASM","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"2342932at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"P63208","properties":[{"key":"Number of GO annotations","value":"4 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"P63208","properties":[{"key":"Description","value":"-"}]},{"database":"BioCyc","id":"MetaCyc:ENSG00000113558-MONOMER","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"P63208","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-1169091","properties":[{"key":"PathwayName","value":"Activation of NF-kappaB in B cells"}]},{"database":"Reactome","id":"R-HSA-1170546","properties":[{"key":"PathwayName","value":"Prolactin receptor signaling"}]},{"database":"Reactome","id":"R-HSA-174113","properties":[{"key":"PathwayName","value":"SCF-beta-TrCP mediated degradation of Emi1"}]},{"database":"Reactome","id":"R-HSA-180534","properties":[{"key":"PathwayName","value":"Vpu mediated degradation of CD4"}]},{"database":"Reactome","id":"R-HSA-187577","properties":[{"key":"PathwayName","value":"SCF(Skp2)-mediated degradation of p27/p21"}]},{"database":"Reactome","id":"R-HSA-195253","properties":[{"key":"PathwayName","value":"Degradation of beta-catenin by the destruction complex"}]},{"database":"Reactome","id":"R-HSA-202424","properties":[{"key":"PathwayName","value":"Downstream TCR signaling"}]},{"database":"Reactome","id":"R-HSA-2122947","properties":[{"key":"PathwayName","value":"NOTCH1 Intracellular Domain Regulates Transcription"}]},{"database":"Reactome","id":"R-HSA-2565942","properties":[{"key":"PathwayName","value":"Regulation of PLK1 Activity at G2/M Transition"}]},{"database":"Reactome","id":"R-HSA-2644606","properties":[{"key":"PathwayName","value":"Constitutive Signaling by NOTCH1 PEST Domain Mutants"}]},{"database":"Reactome","id":"R-HSA-2644607","properties":[{"key":"PathwayName","value":"Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling"}]},{"database":"Reactome","id":"R-HSA-2871837","properties":[{"key":"PathwayName","value":"FCERI mediated NF-kB activation"}]},{"database":"Reactome","id":"R-HSA-2894862","properties":[{"key":"PathwayName","value":"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants"}]},{"database":"Reactome","id":"R-HSA-5607761","properties":[{"key":"PathwayName","value":"Dectin-1 mediated noncanonical NF-kB signaling"}]},{"database":"Reactome","id":"R-HSA-5607764","properties":[{"key":"PathwayName","value":"CLEC7A (Dectin-1) signaling"}]},{"database":"Reactome","id":"R-HSA-5610780","properties":[{"key":"PathwayName","value":"Degradation of GLI1 by the proteasome"}]},{"database":"Reactome","id":"R-HSA-5610783","properties":[{"key":"PathwayName","value":"Degradation of GLI2 by the proteasome"}]},{"database":"Reactome","id":"R-HSA-5610785","properties":[{"key":"PathwayName","value":"GLI3 is processed to GLI3R by the proteasome"}]},{"database":"Reactome","id":"R-HSA-5676590","properties":[{"key":"PathwayName","value":"NIK-->noncanonical NF-kB signaling"}]},{"database":"Reactome","id":"R-HSA-5684264","properties":[{"key":"PathwayName","value":"MAP3K8 (TPL2)-dependent MAPK1/3 activation"}]},{"database":"Reactome","id":"R-HSA-68949","properties":[{"key":"PathwayName","value":"Orc1 removal from chromatin"}]},{"database":"Reactome","id":"R-HSA-69231","properties":[{"key":"PathwayName","value":"Cyclin D associated events in G1"}]},{"database":"Reactome","id":"R-HSA-69601","properties":[{"key":"PathwayName","value":"Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A"}]},{"database":"Reactome","id":"R-HSA-8854050","properties":[{"key":"PathwayName","value":"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis"}]},{"database":"Reactome","id":"R-HSA-8939902","properties":[{"key":"PathwayName","value":"Regulation of RUNX2 expression and activity"}]},{"database":"Reactome","id":"R-HSA-8951664","properties":[{"key":"PathwayName","value":"Neddylation"}]},{"database":"Reactome","id":"R-HSA-9020702","properties":[{"key":"PathwayName","value":"Interleukin-1 signaling"}]},{"database":"Reactome","id":"R-HSA-917937","properties":[{"key":"PathwayName","value":"Iron uptake and transport"}]},{"database":"Reactome","id":"R-HSA-9604323","properties":[{"key":"PathwayName","value":"Negative regulation of NOTCH4 signaling"}]},{"database":"Reactome","id":"R-HSA-9708530","properties":[{"key":"PathwayName","value":"Regulation of BACH1 activity"}]},{"database":"Reactome","id":"R-HSA-9725371","properties":[{"key":"PathwayName","value":"Nuclear events stimulated by ALK signaling in cancer"}]},{"database":"Reactome","id":"R-HSA-9762114","properties":[{"key":"PathwayName","value":"GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2"}]},{"database":"Reactome","id":"R-HSA-983168","properties":[{"key":"PathwayName","value":"Antigen processing: Ubiquitination & Proteasome degradation"}]},{"database":"Reactome","id":"R-HSA-9929356","properties":[{"key":"PathwayName","value":"GSK3B-mediated proteasomal degradation of PD-L1(CD274)"}]},{"database":"Reactome","id":"R-HSA-9932298","properties":[{"key":"PathwayName","value":"Degradation of CRY and PER proteins"}]},{"database":"SignaLink","id":"P63208","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"P63208","properties":[{"key":"Description","value":"-"}]},{"database":"UniPathway","id":"UPA00143","properties":[{"key":"RectionId","value":"-"}]},{"database":"Agora","id":"ENSG00000113558","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"6500","properties":[{"key":"hits","value":"684 hits in 1135 CRISPR screens"}]},{"database":"CD-CODE","id":"8C2F96ED","properties":[{"key":"EntryName","value":"Centrosome"}]},{"database":"CD-CODE","id":"91857CE7","properties":[{"key":"EntryName","value":"Nucleolus"}]},{"database":"ChiTaRS","id":"SKP1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"EvolutionaryTrace","id":"P63208","properties":[{"key":"Description","value":"-"}]},{"database":"GeneWiki","id":"SKP1A","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"6500","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"P63208","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:P63208","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 5"}]},{"database":"RNAct","id":"P63208","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000113558","properties":[{"key":"ExpressionPatterns","value":"Expressed in prefrontal cortex and 211 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"P63208","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005813","properties":[{"key":"GoTerm","value":"C:centrosome"},{"key":"GoEvidenceType","value":"NAS:UniProt"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"20596027"}]},{"database":"GO","id":"GO:0000785","properties":[{"key":"GoTerm","value":"C:chromatin"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"22325352"}]},{"database":"GO","id":"GO:0031467","properties":[{"key":"GoTerm","value":"C:Cul7-RING ubiquitin ligase complex"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18498745"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"21572988"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IDA:ParkinsonsUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18929646"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"21378169"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IDA:ParkinsonsUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18929646"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"21378169"}]},{"database":"GO","id":"GO:0031519","properties":[{"key":"GoTerm","value":"C:PcG protein complex"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16943429"}]},{"database":"GO","id":"GO:0035102","properties":[{"key":"GoTerm","value":"C:PRC1 complex"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"22325352"}]},{"database":"GO","id":"GO:0019005","properties":[{"key":"GoTerm","value":"C:SCF ubiquitin ligase complex"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11956208"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15103331"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15145941"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16880511"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20347421"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20596027"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"21572392"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"21725316"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"23263282"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"25585578"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"28007894"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"31413110"}]},{"database":"GO","id":"GO:0000151","properties":[{"key":"GoTerm","value":"C:ubiquitin ligase complex"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"34445249"}]},{"database":"GO","id":"GO:0008013","properties":[{"key":"GoTerm","value":"F:beta-catenin binding"},{"key":"GoEvidenceType","value":"IDA:ParkinsonsUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12820959"}]},{"database":"GO","id":"GO:0097602","properties":[{"key":"GoTerm","value":"F:cullin family protein binding"},{"key":"GoEvidenceType","value":"IPI:ParkinsonsUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"18929646"}]},{"database":"GO","id":"GO:1990444","properties":[{"key":"GoTerm","value":"F:F-box domain binding"},{"key":"GoEvidenceType","value":"IPI:ParkinsonsUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"12820959"}]},{"database":"GO","id":"GO:0140677","properties":[{"key":"GoTerm","value":"F:molecular function activator activity"},{"key":"GoEvidenceType","value":"IDA:UniProt"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"29997255"}]},{"database":"GO","id":"GO:0019904","properties":[{"key":"GoTerm","value":"F:protein domain specific binding"},{"key":"GoEvidenceType","value":"IPI:CAFA"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"15996101"}]},{"database":"GO","id":"GO:1990757","properties":[{"key":"GoTerm","value":"F:ubiquitin ligase activator activity"},{"key":"GoEvidenceType","value":"IDA:ParkinsonsUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12820959"}]},{"database":"GO","id":"GO:0160072","properties":[{"key":"GoTerm","value":"F:ubiquitin ligase complex scaffold activity"},{"key":"GoEvidenceType","value":"IDA:UniProt"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15145941"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"23263282"}]},{"database":"GO","id":"GO:1990756","properties":[{"key":"GoTerm","value":"F:ubiquitin-like ligase-substrate adaptor activity"},{"key":"GoEvidenceType","value":"IDA:ParkinsonsUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12820959"}]},{"database":"GO","id":"GO:0051298","properties":[{"key":"GoTerm","value":"P:centrosome duplication"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"34388369"}]},{"database":"GO","id":"GO:0006338","properties":[{"key":"GoTerm","value":"P:chromatin remodeling"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16943429"}]},{"database":"GO","id":"GO:0060271","properties":[{"key":"GoTerm","value":"P:cilium assembly"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"34368969"}]},{"database":"GO","id":"GO:0000082","properties":[{"key":"GoTerm","value":"P:G1/S transition of mitotic cell cycle"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"11961546"}]},{"database":"GO","id":"GO:0031507","properties":[{"key":"GoTerm","value":"P:heterochromatin formation"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"22325352"}]},{"database":"GO","id":"GO:0006879","properties":[{"key":"GoTerm","value":"P:intracellular iron ion homeostasis"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"19762597"}]},{"database":"GO","id":"GO:0060173","properties":[{"key":"GoTerm","value":"P:limb development"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"10471509"}]},{"database":"GO","id":"GO:0051457","properties":[{"key":"GoTerm","value":"P:maintenance of protein location in nucleus"},{"key":"GoEvidenceType","value":"IPI:ParkinsonsUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"21378169"}]},{"database":"GO","id":"GO:0045892","properties":[{"key":"GoTerm","value":"P:negative regulation of DNA-templated transcription"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"22325352"}]},{"database":"GO","id":"GO:0014033","properties":[{"key":"GoTerm","value":"P:neural crest cell differentiation"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"30190310"}]},{"database":"GO","id":"GO:0043161","properties":[{"key":"GoTerm","value":"P:proteasome-mediated ubiquitin-dependent protein catabolic process"},{"key":"GoEvidenceType","value":"IDA:UniProt"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15145941"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"34480022"}]},{"database":"GO","id":"GO:0070936","properties":[{"key":"GoTerm","value":"P:protein K48-linked ubiquitination"},{"key":"GoEvidenceType","value":"IDA:UniProt"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15145941"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"23263282"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"29997255"}]},{"database":"GO","id":"GO:0000209","properties":[{"key":"GoTerm","value":"P:protein polyubiquitination"},{"key":"GoEvidenceType","value":"IDA:ParkinsonsUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12820959"}]},{"database":"GO","id":"GO:0016567","properties":[{"key":"GoTerm","value":"P:protein ubiquitination"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15103331"}]},{"database":"GO","id":"GO:0042981","properties":[{"key":"GoTerm","value":"P:regulation of apoptotic process"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"25654763"}]},{"database":"GO","id":"GO:0030510","properties":[{"key":"GoTerm","value":"P:regulation of BMP signaling pathway"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"21572392"}]},{"database":"GO","id":"GO:0051726","properties":[{"key":"GoTerm","value":"P:regulation of cell cycle"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"33234069"}]},{"database":"GO","id":"GO:0010564","properties":[{"key":"GoTerm","value":"P:regulation of cell cycle process"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"31424118"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"34445249"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"35414786"}]},{"database":"GO","id":"GO:0010824","properties":[{"key":"GoTerm","value":"P:regulation of centrosome duplication"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"29348145"}]},{"database":"GO","id":"GO:0042752","properties":[{"key":"GoTerm","value":"P:regulation of circadian rhythm"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"17463251"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"23452855"}]},{"database":"GO","id":"GO:2000001","properties":[{"key":"GoTerm","value":"P:regulation of DNA damage checkpoint"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"33784509"}]},{"database":"GO","id":"GO:0006355","properties":[{"key":"GoTerm","value":"P:regulation of DNA-templated transcription"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"36372232"}]},{"database":"GO","id":"GO:0050727","properties":[{"key":"GoTerm","value":"P:regulation of inflammatory response"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"23542741"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"35127719"}]},{"database":"GO","id":"GO:1901524","properties":[{"key":"GoTerm","value":"P:regulation of mitophagy"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"36135912"}]},{"database":"GO","id":"GO:0007346","properties":[{"key":"GoTerm","value":"P:regulation of mitotic cell cycle"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"36395886"}]},{"database":"GO","id":"GO:0032006","properties":[{"key":"GoTerm","value":"P:regulation of TOR signaling"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"23263282"}]},{"database":"GO","id":"GO:1904415","properties":[{"key":"GoTerm","value":"P:regulation of xenophagy"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"34515398"}]},{"database":"GO","id":"GO:0031146","properties":[{"key":"GoTerm","value":"P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15103331"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20347421"}]},{"database":"GO","id":"GO:0051124","properties":[{"key":"GoTerm","value":"P:synaptic assembly at neuromuscular junction"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"35535869"}]},{"database":"CDD","id":"cd18322","properties":[{"key":"EntryName","value":"BTB_POZ_SKP1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.710.10:FF:000270","properties":[{"key":"EntryName","value":"S-phase kinase-associated protein 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.710.10","properties":[{"key":"EntryName","value":"Potassium Channel Kv1.1, Chain A"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR016897","properties":[{"key":"EntryName","value":"SKP1"}]},{"database":"InterPro","id":"IPR001232","properties":[{"key":"EntryName","value":"SKP1-like"}]},{"database":"InterPro","id":"IPR036296","properties":[{"key":"EntryName","value":"SKP1-like_dim_sf"}]},{"database":"InterPro","id":"IPR011333","properties":[{"key":"EntryName","value":"SKP1/BTB/POZ_sf"}]},{"database":"InterPro","id":"IPR016072","properties":[{"key":"EntryName","value":"Skp1_comp_dimer"}]},{"database":"InterPro","id":"IPR016073","properties":[{"key":"EntryName","value":"Skp1_comp_POZ"}]},{"database":"PANTHER","id":"PTHR11165","properties":[{"key":"EntryName","value":"SKP1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01466","properties":[{"key":"EntryName","value":"Skp1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF03931","properties":[{"key":"EntryName","value":"Skp1_POZ"},{"key":"MatchStatus","value":"1"}]},{"database":"PIRSF","id":"PIRSF028729","properties":[{"key":"EntryName","value":"E3_ubiquit_lig_SCF_Skp"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00512","properties":[{"key":"EntryName","value":"Skp1"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF54695","properties":[{"key":"EntryName","value":"POZ domain"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF81382","properties":[{"key":"EntryName","value":"Skp1 dimerisation domain-like"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MPSIKLQSSDGEIFEVDVEIAKQSVTIKTMLEDLGMDDEGDDDPVPLPNVNAAILKKVIQWCTHHKDDPPPPEDDENKEKRTDDIPVWDQEFLKVDQGTLFELILAANYLDIKGLLDVTCKTVANMIKGKTPEEIRKTFNIKNDFTEEEEAQVRKENQWCEEK","length":163,"molWeight":18658,"crc64":"C794D62AFB75528A","md5":"CAA4380B0BEAE658CE5D091B8DEBD603"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"ACTIVITY REGULATION":1,"PATHWAY":1,"SUBUNIT":2,"INTERACTION":73,"ALTERNATIVE PRODUCTS":2,"PTM":1,"SIMILARITY":1},"countByFeatureType":{"Initiator methionine":1,"Chain":1,"Region":2,"Modified residue":1,"Cross-link":1,"Alternative sequence":1,"Beta strand":9,"Helix":11,"Turn":1},"uniParcId":"UPI00000002C9"}}