{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P61981","secondaryAccessions":["O70457","P35214","Q6FH52","Q9UDP2","Q9UN99"],"uniProtkbId":"1433G_HUMAN","entryAudit":{"firstPublicDate":"2004-06-07","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2007-01-23","entryVersion":206,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"14-3-3 protein gamma"}},"alternativeNames":[{"fullName":{"value":"Protein kinase C inhibitor protein 1"},"shortNames":[{"value":"KCIP-1"}]}],"contains":[{"recommendedName":{"fullName":{"value":"14-3-3 protein gamma, N-terminally processed"}}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:12852"}],"value":"YWHAG"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15696159"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16511572"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22532927"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29121962"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29678907"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36732624"}],"value":"Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:15696159, PubMed:16511572, PubMed:36732624). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:15696159, PubMed:16511572, PubMed:36732624). Binding generally results in the modulation of the activity of the binding partner (PubMed:16511572). Promotes inactivation of WDR24 component of the GATOR2 complex by binding to phosphorylated WDR24 (PubMed:36732624). Participates in the positive regulation of NMDA glutamate receptor activity by promoting the L-glutamate secretion through interaction with BEST1 (PubMed:29121962). Reduces keratinocyte intercellular adhesion, via interacting with PKP1 and sequestering it in the cytoplasm, thereby reducing its incorporation into desmosomes (PubMed:29678907). Plays a role in mitochondrial protein catabolic process (also named MALM) that promotes the degradation of damaged proteins inside mitochondria (PubMed:22532927)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P61982"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10433554"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11427721"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15159416"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15454081"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15696159"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16511572"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16959763"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17085597"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18249187"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19172738"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19640509"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22532927"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23572552"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26047703"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27030597"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28202711"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29121962"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29678907"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31835537"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33473107"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36732624"}],"value":"Homodimer (PubMed:17085597). Forms heterodimers with SFN, YWHAB or YWHAQ (By similarity). Part of a complex that contains DSG3, PKP1, YAP1 and YWHAG; the complex is required for localization of DSG3 and YAP1 to the cell membrane in keratinocytes (PubMed:31835537). Interacts with YAP1 (By similarity). Interacts with SAMSN1 (By similarity). Interacts with RAF1, SSH1 and CRTC2/TORC2 (PubMed:10433554, PubMed:15159416, PubMed:15454081). Interacts with ABL1 (phosphorylated form); the interaction retains it in the cytoplasm (PubMed:15696159). Interacts with GAB2 (PubMed:19172738). Interacts with MDM4 (phosphorylated); negatively regulates MDM4 activity toward TP53 (PubMed:16511572). Interacts with PKA-phosphorylated AANAT and SIRT2 (PubMed:11427721, PubMed:18249187). Interacts with the 'Thr-369' phosphorylated form of DAPK2 (PubMed:26047703). Interacts with PI4KB, TBC1D22A and TBC1D22B (PubMed:23572552). Interacts with SLITRK1 (PubMed:19640509). Interacts with LRRK2; this interaction is dependent on LRRK2 phosphorylation (PubMed:28202711). Interacts with MARK2 and MARK3 (PubMed:16959763). Interacts with MEFV (PubMed:27030597). Interacts with ENDOG, TSC2 and PIK3C3; interaction with ENDOG weakens its interaction with TSC2 and PIK3C3 (PubMed:33473107). Interacts with (phosphorylated) WDR24 (PubMed:36732624). Interacts with BEST1; this interaction promotes L-glutamate channel activity leading to the positive regulation of NMDA glutamate receptor activity through the L-glutamate secretion (PubMed:29121962). Interacts with PKP1 (when phosphorylated); the interaction results in translocation of PKP1 to the cytoplasm and loss of intercellular adhesion in keratinocytes (PubMed:29678907). Interacts with SPATA18/MIEAP (isoforms 1 and 2); a protein that also plays a role in MALM (PubMed:22532927)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P61981","intActId":"EBI-359832"},"interactantTwo":{"uniProtKBAccession":"P00519","geneName":"ABL1","intActId":"EBI-375543"},"numberOfExperiments":8,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P61981","intActId":"EBI-359832"},"interactantTwo":{"uniProtKBAccession":"Q15027","geneName":"ACAP1","intActId":"EBI-751746"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P61981","intActId":"EBI-359832"},"interactantTwo":{"uniProtKBAccession":"Q9NPJ3","geneName":"ACOT13","intActId":"EBI-1045357"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P61981","intActId":"EBI-359832"},"interactantTwo":{"uniProtKBAccession":"Q8IWZ3-3","geneName":"ANKHD1","intActId":"EBI-25833200"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P61981","intActId":"EBI-359832"},"interactantTwo":{"uniProtKBAccession":"O43307","geneName":"ARHGEF9","intActId":"EBI-3447299"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P61981","intActId":"EBI-359832"},"interactantTwo":{"uniProtKBAccession":"Q66PJ3-4","geneName":"ARL6IP4","intActId":"EBI-5280499"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P61981","intActId":"EBI-359832"},"interactantTwo":{"uniProtKBAccession":"Q9Y576","geneName":"ASB1","intActId":"EBI-2323092"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P61981","intActId":"EBI-359832"},"interactantTwo":{"uniProtKBAccession":"Q14032","geneName":"BAAT","intActId":"EBI-8994378"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P61981","intActId":"EBI-359832"},"interactantTwo":{"uniProtKBAccession":"Q92934","geneName":"BAD","intActId":"EBI-700771"},"numberOfExperiments":7,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P61981","intActId":"EBI-359832"},"interactantTwo":{"uniProtKBAccession":"Q13072","geneName":"BAGE","intActId":"EBI-25884811"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P61981","intActId":"EBI-359832"},"interactantTwo":{"uniProtKBAccession":"Q8N9N5-2","geneName":"BANP","intActId":"EBI-11524452"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P61981","intActId":"EBI-359832"},"interactantTwo":{"uniProtKBAccession":"Q6PH81","geneName":"C16orf87","intActId":"EBI-6598617"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P61981","intActId":"EBI-359832"},"interactantTwo":{"uniProtKBAccession":"P42574","geneName":"CASP3","intActId":"EBI-524064"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P61981","intActId":"EBI-359832"},"interactantTwo":{"uniProtKBAccession":"P22681","geneName":"CBL","intActId":"EBI-518228"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P61981","intActId":"EBI-359832"},"interactantTwo":{"uniProtKBAccession":"Q96HJ3-2","geneName":"CCDC34","intActId":"EBI-17641690"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P61981","intActId":"EBI-359832"},"interactantTwo":{"uniProtKBAccession":"Q96A33","geneName":"CCDC47","intActId":"EBI-720151"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P61981","intActId":"EBI-359832"},"interactantTwo":{"uniProtKBAccession":"Q96LY2-2","geneName":"CCDC74B","intActId":"EBI-17967022"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P61981","intActId":"EBI-359832"},"interactantTwo":{"uniProtKBAccession":"Q9GZT6","geneName":"CCDC90B","intActId":"EBI-713148"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P61981","intActId":"EBI-359832"},"interactantTwo":{"uniProtKBAccession":"P30305","geneName":"CDC25B","intActId":"EBI-1051746"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P61981","intActId":"EBI-359832"},"interactantTwo":{"uniProtKBAccession":"Q7Z7K6","geneName":"CENPV","intActId":"EBI-1210604"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P61981","intActId":"EBI-359832"},"interactantTwo":{"uniProtKBAccession":"Q8TAP6","geneName":"CEP76","intActId":"EBI-742887"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P61981","intActId":"EBI-359832"},"interactantTwo":{"uniProtKBAccession":"Q96GE4","geneName":"CEP95","intActId":"EBI-372775"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P61981","intActId":"EBI-359832"},"interactantTwo":{"uniProtKBAccession":"Q0VF96","geneName":"CGNL1","intActId":"EBI-3388952"}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