{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P59632","secondaryAccessions":["Q7T6R6","Q7TA10","Q7TA18","Q7TFB0","Q7TLD0","Q80BV5"],"uniProtkbId":"AP3A_SARS","entryAudit":{"firstPublicDate":"2003-04-23","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2003-04-23","entryVersion":124,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Severe acute respiratory syndrome coronavirus","commonName":"SARS-CoV","taxonId":694009,"lineage":["Viruses","Riboviria","Orthornavirae","Pisuviricota","Pisoniviricetes","Nidovirales","Cornidovirineae","Coronaviridae","Orthocoronavirinae","Betacoronavirus","Sarbecovirus","Betacoronavirus pandemicum"]},"organismHosts":[{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606},{"scientificName":"Paguma larvata","commonName":"Masked palm civet","taxonId":9675}],"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"ORF3a protein"}},"alternativeNames":[{"fullName":{"value":"Accessory protein 3a"}},{"fullName":{"value":"Protein 3a"}},{"fullName":{"value":"Protein U274"}},{"fullName":{"value":"Protein X1"}}]},"genes":[{"orfNames":[{"value":"3a"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15958670"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16014971"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16894145"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20020050"}],"value":"Forms homotetrameric potassium sensitive ion channels (viroporin) and may modulate virus release. Up-regulates expression of fibrinogen subunits FGA, FGB and FGG in host lung epithelial cells. Induces apoptosis in cell culture. Down-regulates the type 1 interferon receptor by inducing serine phosphorylation within the IFN alpha-receptor subunit 1 (IFNAR1) degradation motif and increasing IFNAR1 ubiquitination"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15194747"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15763150"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16894145"}],"value":"Homotetramer composed of two homodimers linked non covalently. Interacts with M, S and E proteins. Also interacts with the accessory protein 7a"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P59632","intActId":"EBI-15595051"},"interactantTwo":{"uniProtKBAccession":"P59632","geneName":"3a","intActId":"EBI-15595051"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P59632","intActId":"EBI-15595051"},"interactantTwo":{"uniProtKBAccession":"P59596","geneName":"M","intActId":"EBI-25487824"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P59632","intActId":"EBI-15595051"},"interactantTwo":{"uniProtKBAccession":"P0C6X7","geneName":"rep","chainId":"PRO_0000037310","intActId":"EBI-25474098"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P59632","intActId":"EBI-15595051"},"interactantTwo":{"uniProtKBAccession":"P33724","geneName":"CAV1","intActId":"EBI-79998"},"numberOfExperiments":5,"organismDiffer":true}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"value":"The cell surface expressed protein can undergo endocytosis. The protein is secreted in association with membranous structures"}]},"subcellularLocations":[{"location":{"value":"Virion","id":"SL-0274"}},{"location":{"value":"Host Golgi apparatus membrane","id":"SL-0426"},"topology":{"value":"Multi-pass membrane protein","id":"SL-9909"}},{"location":{"value":"Host cell membrane","id":"SL-0375"},"topology":{"value":"Multi-pass membrane protein","id":"SL-9909"}},{"location":{"value":"Secreted","id":"SL-0243"}},{"location":{"value":"Host cytoplasm","id":"SL-0381"}}]},{"texts":[{"value":"The second or the third transmembrane region are responsible for Golgi localization"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16474139"}],"value":"Exists in both O-glycosylated and non-glycosylated forms. The glycosylated form is associated with the virion"}],"commentType":"PTM"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":274,"modifier":"EXACT"}},"description":"ORF3a protein","featureId":"PRO_0000106131"},{"type":"Topological domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":34,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"15194747"}]},{"type":"Transmembrane","location":{"start":{"value":35,"modifier":"EXACT"},"end":{"value":55,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":56,"modifier":"EXACT"},"end":{"value":78,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":79,"modifier":"EXACT"},"end":{"value":99,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":100,"modifier":"EXACT"},"end":{"value":104,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":105,"modifier":"EXACT"},"end":{"value":125,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":126,"modifier":"EXACT"},"end":{"value":274,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"15194747"}]},{"type":"Domain","location":{"start":{"value":33,"modifier":"EXACT"},"end":{"value":141,"modifier":"EXACT"}},"description":"CoV 3a-like viroporin TM","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01311"}]},{"type":"Domain","location":{"start":{"value":145,"modifier":"EXACT"},"end":{"value":237,"modifier":"EXACT"}},"description":"CoV 3a-like viroporin CD","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01312"}]},{"type":"Site","location":{"start":{"value":133,"modifier":"EXACT"},"end":{"value":133,"modifier":"EXACT"}},"description":"Involved in polymerization"},{"type":"Glycosylation","location":{"start":{"value":27,"modifier":"EXACT"},"end":{"value":27,"modifier":"EXACT"}},"description":"O-linked (GalNAc...) serine; by host","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":28,"modifier":"EXACT"},"end":{"value":28,"modifier":"EXACT"}},"description":"O-linked (GalNAc...) threonine; by host","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"16474139"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":32,"modifier":"EXACT"},"end":{"value":32,"modifier":"EXACT"}},"description":"O-linked (GalNAc...) threonine; by host","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"16474139"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":34,"modifier":"EXACT"},"end":{"value":34,"modifier":"EXACT"}},"description":"O-linked (GalNAc...) threonine; by host","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Natural variant","location":{"start":{"value":11,"modifier":"EXACT"},"end":{"value":11,"modifier":"EXACT"}},"description":"in strain: Isolate Tor2, Isolate BJ02 and Isolate BJ03","featureId":"","alternativeSequence":{"originalSequence":"G","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":20,"modifier":"EXACT"},"end":{"value":20,"modifier":"EXACT"}},"description":"in strain: Isolate Shanghai LY","featureId":"","alternativeSequence":{"originalSequence":"I","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":29,"modifier":"EXACT"},"end":{"value":29,"modifier":"EXACT"}},"description":"in strain: Isolate Shanghai QXC1","featureId":"","alternativeSequence":{"originalSequence":"V","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":101,"modifier":"EXACT"},"end":{"value":101,"modifier":"EXACT"}},"description":"in strain: Isolate HKU-39849","featureId":"","alternativeSequence":{"originalSequence":"M","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":129,"modifier":"EXACT"},"end":{"value":129,"modifier":"EXACT"}},"description":"in strain: Isolate TWK","featureId":"","alternativeSequence":{"originalSequence":"L","alternativeSequences":["F"]}},{"type":"Natural variant","location":{"start":{"value":136,"modifier":"EXACT"},"end":{"value":136,"modifier":"EXACT"}},"description":"in strain: Isolate BJ01","featureId":"","alternativeSequence":{"originalSequence":"K","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":171,"modifier":"EXACT"},"end":{"value":171,"modifier":"EXACT"}},"description":"in strain: Isolate GD01","featureId":"","alternativeSequence":{"originalSequence":"E","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":193,"modifier":"EXACT"},"end":{"value":193,"modifier":"EXACT"}},"description":"in strain: Isolate GD01","featureId":"","alternativeSequence":{"originalSequence":"R","alternativeSequences":["W"]}},{"type":"Natural variant","location":{"start":{"value":222,"modifier":"EXACT"},"end":{"value":222,"modifier":"EXACT"}},"description":"in strain: Isolate Shanghai QXC1","featureId":"","alternativeSequence":{"originalSequence":"D","alternativeSequences":["N"]}},{"type":"Mutagenesis","location":{"start":{"value":27,"modifier":"EXACT"},"end":{"value":27,"modifier":"EXACT"}},"description":"Complete loss of O-glycosylation; when associated with A-28; A-32 and A-34.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16474139"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["G"]}},{"type":"Mutagenesis","location":{"start":{"value":28,"modifier":"EXACT"},"end":{"value":28,"modifier":"EXACT"}},"description":"Complete loss of O-glycosylation; when associated with A-27; A-32 and A-34.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16474139"}],"alternativeSequence":{"originalSequence":"T","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":32,"modifier":"EXACT"},"end":{"value":32,"modifier":"EXACT"}},"description":"Complete loss of O-glycosylation; when associated with A-27; A-28 and A-34.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16474139"}],"alternativeSequence":{"originalSequence":"T","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":34,"modifier":"EXACT"},"end":{"value":34,"modifier":"EXACT"}},"description":"Complete loss of O-glycosylation; when associated with A-27; A-28 and A-32.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16474139"}],"alternativeSequence":{"originalSequence":"T","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":81,"modifier":"EXACT"},"end":{"value":81,"modifier":"EXACT"}},"description":"No effect on polymerization.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16894145"}],"alternativeSequence":{"originalSequence":"C","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":117,"modifier":"EXACT"},"end":{"value":117,"modifier":"EXACT"}},"description":"No effect on polymerization.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16894145"}],"alternativeSequence":{"originalSequence":"C","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":121,"modifier":"EXACT"},"end":{"value":121,"modifier":"EXACT"}},"description":"No effect on polymerization.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16894145"}],"alternativeSequence":{"originalSequence":"C","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":127,"modifier":"EXACT"},"end":{"value":127,"modifier":"EXACT"}},"description":"No effect on polymerization.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16894145"}],"alternativeSequence":{"originalSequence":"C","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":130,"modifier":"EXACT"},"end":{"value":130,"modifier":"EXACT"}},"description":"No effect on polymerization.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16894145"}],"alternativeSequence":{"originalSequence":"C","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":133,"modifier":"EXACT"},"end":{"value":133,"modifier":"EXACT"}},"description":"Almost complete loss of polymerization ability.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16894145"}],"alternativeSequence":{"originalSequence":"C","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":148,"modifier":"EXACT"},"end":{"value":148,"modifier":"EXACT"}},"description":"No effect on polymerization.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16894145"}],"alternativeSequence":{"originalSequence":"C","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":157,"modifier":"EXACT"},"end":{"value":157,"modifier":"EXACT"}},"description":"No effect on polymerization.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16894145"}],"alternativeSequence":{"originalSequence":"C","alternativeSequences":["A"]}},{"type":"Helix","location":{"start":{"value":44,"modifier":"EXACT"},"end":{"value":60,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8EQS"}]},{"type":"Helix","location":{"start":{"value":68,"modifier":"EXACT"},"end":{"value":99,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8EQS"}]},{"type":"Turn","location":{"start":{"value":100,"modifier":"EXACT"},"end":{"value":104,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8EQS"}]},{"type":"Helix","location":{"start":{"value":106,"modifier":"EXACT"},"end":{"value":133,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8EQS"}]},{"type":"Helix","location":{"start":{"value":137,"modifier":"EXACT"},"end":{"value":140,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8EQS"}]},{"type":"Beta strand","location":{"start":{"value":144,"modifier":"EXACT"},"end":{"value":150,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8EQS"}]},{"type":"Beta strand","location":{"start":{"value":155,"modifier":"EXACT"},"end":{"value":162,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8EQS"}]},{"type":"Beta strand","location":{"start":{"value":165,"modifier":"EXACT"},"end":{"value":172,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8EQS"}]},{"type":"Beta strand","location":{"start":{"value":183,"modifier":"EXACT"},"end":{"value":186,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8EQS"}]},{"type":"Beta strand","location":{"start":{"value":189,"modifier":"EXACT"},"end":{"value":192,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8EQS"}]},{"type":"Beta strand","location":{"start":{"value":199,"modifier":"EXACT"},"end":{"value":204,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8EQS"}]},{"type":"Beta strand","location":{"start":{"value":209,"modifier":"EXACT"},"end":{"value":218,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8EQS"}]},{"type":"Helix","location":{"start":{"value":220,"modifier":"EXACT"},"end":{"value":223,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8EQS"}]},{"type":"Beta strand","location":{"start":{"value":229,"modifier":"EXACT"},"end":{"value":235,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8EQS"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0053","category":"Biological process","name":"Apoptosis"},{"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"id":"KW-1032","category":"Cellular component","name":"Host cell membrane"},{"id":"KW-1035","category":"Cellular component","name":"Host cytoplasm"},{"id":"KW-1040","category":"Cellular component","name":"Host Golgi apparatus"},{"id":"KW-1043","category":"Cellular component","name":"Host membrane"},{"id":"KW-0945","category":"Biological process","name":"Host-virus interaction"},{"id":"KW-1090","category":"Biological process","name":"Inhibition of host innate immune response by virus"},{"id":"KW-1091","category":"Biological process","name":"Inhibition of host interferon receptors by virus"},{"id":"KW-1114","category":"Biological process","name":"Inhibition of host interferon signaling pathway by virus"},{"id":"KW-0922","category":"Biological process","name":"Interferon antiviral system evasion"},{"id":"KW-0407","category":"Molecular function","name":"Ion channel"},{"id":"KW-0406","category":"Biological process","name":"Ion transport"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"id":"KW-0813","category":"Biological process","name":"Transport"},{"id":"KW-0899","category":"Biological process","name":"Viral immunoevasion"},{"id":"KW-1182","category":"Molecular function","name":"Viral ion channel"},{"id":"KW-0946","category":"Cellular component","name":"Virion"}],"references":[{"referenceNumber":1,"citation":{"id":"12730500","citationType":"journal article","authors":["Rota P.A.","Oberste M.S.","Monroe S.S.","Nix W.A.","Campagnoli R.","Icenogle J.P.","Penaranda S.","Bankamp B.","Maher K.","Chen M.-H.","Tong S.","Tamin A.","Lowe L.","Frace M.","DeRisi J.L.","Chen Q.","Wang D.","Erdman D.D.","Peret T.C.T.","Burns C.","Ksiazek T.G.","Rollin P.E.","Sanchez A.","Liffick S.","Holloway B.","Limor J.","McCaustland K.","Olsen-Rasmussen M.","Fouchier R.","Guenther S.","Osterhaus A.D.M.E.","Drosten C.","Pallansch M.A.","Anderson L.J.","Bellini W.J."],"citationCrossReferences":[{"database":"PubMed","id":"12730500"},{"database":"DOI","id":"10.1126/science.1085952"}],"title":"Characterization of a novel coronavirus associated with severe acute respiratory syndrome.","publicationDate":"2003","journal":"Science","firstPage":"1394","lastPage":"1399","volume":"300"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC RNA]"],"referenceComments":[{"value":"Isolate Urbani","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"12730501","citationType":"journal article","authors":["Marra M.A.","Jones S.J.M.","Astell C.R.","Holt R.A.","Brooks-Wilson A.","Butterfield Y.S.N.","Khattra J.","Asano J.K.","Barber S.A.","Chan S.Y.","Cloutier A.","Coughlin S.M.","Freeman D.","Girn N.","Griffith O.L.","Leach S.R.","Mayo M.","McDonald H.","Montgomery S.B.","Pandoh P.K.","Petrescu A.S.","Robertson A.G.","Schein J.E.","Siddiqui A.","Smailus D.E.","Stott J.M.","Yang G.S.","Plummer F.","Andonov A.","Artsob H.","Bastien N.","Bernard K.","Booth T.F.","Bowness D.","Czub M.","Drebot M.","Fernando L.","Flick R.","Garbutt M.","Gray M.","Grolla A.","Jones S.","Feldmann H.","Meyers A.","Kabani A.","Li Y.","Normand S.","Stroher U.","Tipples G.A.","Tyler S.","Vogrig R.","Ward D.","Watson B.","Brunham R.C.","Krajden M.","Petric M.","Skowronski D.M.","Upton C.","Roper R.L."],"citationCrossReferences":[{"database":"PubMed","id":"12730501"},{"database":"DOI","id":"10.1126/science.1085953"}],"title":"The genome sequence of the SARS-associated coronavirus.","publicationDate":"2003","journal":"Science","firstPage":"1399","lastPage":"1404","volume":"300"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC RNA]"],"referenceComments":[{"value":"Isolate Tor2","type":"STRAIN"}]},{"referenceNumber":3,"citation":{"id":"12853594","citationType":"journal article","authors":["Tsui S.K.W.","Chim S.S.C.","Lo Y.M.D."],"citationCrossReferences":[{"database":"PubMed","id":"12853594"},{"database":"DOI","id":"10.1056/nejm200307103490216"}],"title":"Coronavirus genomic-sequence variations and the epidemiology of the severe acute respiratory syndrome.","publicationDate":"2003","journal":"N. Engl. J. Med.","firstPage":"187","lastPage":"188","volume":"349"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC RNA]"],"referenceComments":[{"value":"Isolate CUHK-Su10","type":"STRAIN"},{"value":"Isolate CUHK-W1","type":"STRAIN"}]},{"referenceNumber":4,"citation":{"id":"12876307","citationType":"journal article","authors":["Zeng F.Y.","Chan C.W.","Chan M.N.","Chen J.D.","Chow K.Y.C.","Hon C.C.C.","Hui R.K.H.","Li J.","Li V.Y.Y.","Wang C.Y.","Wang P.Y.","Guan Y.","Zheng B.","Poon L.L.M.","Chan K.H.","Yuen K.Y.","Peiris J.S.M.","Leung F.C."],"citationCrossReferences":[{"database":"PubMed","id":"12876307"},{"database":"DOI","id":"10.1177/15353702-0322807-13"}],"title":"The complete genome sequence of severe acute respiratory syndrome coronavirus strain HKU-39849 (HK-39).","publicationDate":"2003","journal":"Exp. Biol. Med.","firstPage":"866","lastPage":"873","volume":"228"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC RNA]"],"referenceComments":[{"value":"Isolate HKU-39849","type":"STRAIN"}]},{"referenceNumber":5,"citation":{"id":"CI-9P5CED02CNU7L","citationType":"submission","authors":["Qin E.","Zhu Q.","Yu M.","Fan B.","Chang G.","Si B.","Yang B.","Peng W.","Jiang T.","Liu B.","Deng Y.","Liu H.","Zhang Y.","Wang C.","Li Y.","Gan Y.","Li X.","Lu F.","Tan G.","Yang R.","Cao W.S.","Wang J.","Chen W.","Cong L.","Deng Y.","Dong W.","Han Y.","Hu W.","Lei M.","Li C.","Li G.","Li G.","Li H.","Li S.","Li S.","Li W.","Li W.","Lin W.","Liu J.","Liu Z.","Lu H.","Ni P.","Qi Q.","Sun Y.","Tang L.","Tong Z.","Wang J.","Wang X.","Wu Q.","Xi Y.","Xu Z.","Yang L.","Ye C.","Ye J.","Zhang B.","Zhang F.","Zhang J.","Zhang X.","Zhou J.","Yang H."],"publicationDate":"APR-2003","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC RNA]"],"referenceComments":[{"value":"Isolate BJ01","type":"STRAIN"},{"value":"Isolate BJ02","type":"STRAIN"},{"value":"Isolate BJ03","type":"STRAIN"},{"value":"Isolate BJ04","type":"STRAIN"},{"value":"Isolate GD01","type":"STRAIN"}]},{"referenceNumber":6,"citation":{"id":"CI-4E36U8J0OCHS4","citationType":"submission","authors":["Yeh S.-H.","Kao C.-L.","Tsai C.-Y.","Liu C.-J.","Chen D.-S.","Chen P.-J."],"title":"The complete genome of SARS coronavirus clone TW1.","publicationDate":"MAY-2003","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC RNA]"],"referenceComments":[{"value":"Isolate TW1","type":"STRAIN"}]},{"referenceNumber":7,"citation":{"id":"CI-F530UAGG60O20","citationType":"submission","authors":["Eickmann M.","Becker S.","Klenk H.-D.","Doerr H.W.","Stadler K.","Censini S.","Guidotti S.","Masignani V.","Scarselli M.","Mora M.","Donati C.","Han J.","Song H.C.","Abrignani S.","Covacci A.","Rappuoli R."],"title":"SARS virus is a close relative of type II coronaviruses.","publicationDate":"MAY-2003","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC RNA]"],"referenceComments":[{"value":"Isolate FRA","type":"STRAIN"}]},{"referenceNumber":8,"citation":{"id":"CI-3V5QVFVEK7VT7","citationType":"submission","authors":["Thiel V.","Hertzig T.","Putics A.","Ivanov K.A.","Schelle B.","Bayer S.","Scheiner B.","Weinand H.","Weissbrich B.","Ziebuhr J."],"publicationDate":"MAY-2003","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC RNA]"],"referenceComments":[{"value":"Isolate Frankfurt 1","type":"STRAIN"}]},{"referenceNumber":9,"citation":{"id":"CI-45FOADNH5HP9A","citationType":"submission","authors":["Chang J.-G.C.","Lin T.-H.","Chen C.-M.","Lin C.-S.","Chan W.-L.","Shih M.-C."],"publicationDate":"JUL-2003","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC RNA]"],"referenceComments":[{"value":"Isolate Taiwan TC1","type":"STRAIN"},{"value":"Isolate Taiwan TC2","type":"STRAIN"},{"value":"Isolate Taiwan TC3","type":"STRAIN"}]},{"referenceNumber":10,"citation":{"id":"CI-ES89E1N4791UE","citationType":"submission","authors":["Shu H.Y.","Wu K.M.","Tsai S.F."],"title":"The complete genome of SARS coronavirus TWH.","publicationDate":"JUL-2003","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC RNA]"],"referenceComments":[{"value":"Isolate TWH","type":"STRAIN"},{"value":"Isolate TWJ","type":"STRAIN"},{"value":"Isolate TWK","type":"STRAIN"},{"value":"Isolate TWS","type":"STRAIN"},{"value":"Isolate TWY","type":"STRAIN"}]},{"referenceNumber":11,"citation":{"id":"CI-6I6OBMD7H4DP3","citationType":"submission","authors":["Canducci F.","Clementi M.","Poli G.","Vicenzi E."],"publicationDate":"JUL-2003","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC RNA]"],"referenceComments":[{"value":"Isolate HSR 1","type":"STRAIN"}]},{"referenceNumber":12,"citation":{"id":"CI-B2G58OKIJFFV","citationType":"submission","authors":["Balotta C.","Corvasce S.","Violin M.","Galli M.","Moroni M.","Vigevani G.M.","Ruan Y.J.","Salemi M."],"publicationDate":"OCT-2003","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC RNA]"],"referenceComments":[{"value":"Isolate AS","type":"STRAIN"}]},{"referenceNumber":13,"citation":{"id":"CI-B4I6SI3859T19","citationType":"submission","authors":["Yuan Z.","Zhang X.","Hu Y.","Lan S.","Wang H.","Zhou Z.","Wen Y."],"title":"Analysis of SARS coronavirus genome in Shanghai isolates.","publicationDate":"JAN-2004","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC RNA]"],"referenceComments":[{"value":"Isolate Shanghai QXC1","type":"STRAIN"}]},{"referenceNumber":14,"citation":{"id":"CI-3DHD93KRH2NDA","citationType":"submission","authors":["Yuan Z.","Zhang X.","Hu Y.","Lan S.","Wang H.","Zhou Z.","Wen Y."],"publicationDate":"JUN-2003","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC RNA] OF 1-125"],"referenceComments":[{"value":"Isolate Shanghai LY","type":"STRAIN"}]},{"referenceNumber":15,"citation":{"id":"15135062","citationType":"journal article","authors":["Yu C.-J.","Chen Y.-C.","Hsiao C.-H.","Kuo T.-C.","Chang S.C.","Lu C.-Y.","Wei W.-C.","Lee C.-H.","Huang L.-M.","Chang M.-F.","Ho H.-N.","Lee F.-J.S."],"citationCrossReferences":[{"database":"PubMed","id":"15135062"},{"database":"DOI","id":"10.1016/j.febslet.2004.03.086"}],"title":"Identification of a novel protein 3a from severe acute respiratory syndrome coronavirus.","publicationDate":"2004","journal":"FEBS Lett.","firstPage":"111","lastPage":"116","volume":"565"},"referencePositions":["IDENTIFICATION"]},{"referenceNumber":16,"citation":{"id":"15194747","citationType":"journal article","authors":["Tan Y.-J.","Teng E.","Shen S.","Tan T.H.P.","Goh P.-Y.","Fielding B.C.","Ooi E.-E.","Tan H.-C.","Lim S.G.","Hong W."],"citationCrossReferences":[{"database":"PubMed","id":"15194747"},{"database":"DOI","id":"10.1128/jvi.78.13.6723-6734.2004"}],"title":"A novel severe acute respiratory syndrome coronavirus protein, U274, is transported to the cell surface and undergoes endocytosis.","publicationDate":"2004","journal":"J. Virol.","firstPage":"6723","lastPage":"6734","volume":"78"},"referencePositions":["SUBCELLULAR LOCATION","TOPOLOGY","INTERACTION WITH M PROTEIN; E PROTEIN; SPIKE GLYCOPROTEIN AND ACCESSORY PROTEIN 7A"]},{"referenceNumber":17,"citation":{"id":"15763150","citationType":"journal article","authors":["Yuan X.","Li J.","Shan Y.","Yang Z.","Zhao Z.","Chen B.","Yao Z.","Dong B.","Wang S.","Chen J.","Cong Y."],"citationCrossReferences":[{"database":"PubMed","id":"15763150"},{"database":"DOI","id":"10.1016/j.virusres.2005.01.001"}],"title":"Subcellular localization and membrane association of SARS-CoV 3a protein.","publicationDate":"2005","journal":"Virus Res.","firstPage":"191","lastPage":"202","volume":"109"},"referencePositions":["SUBCELLULAR LOCATION","INTERACTION WITH M AND E PROTEINS"]},{"referenceNumber":18,"citation":{"id":"15781262","citationType":"journal article","authors":["Shen S.","Lin P.S.","Chao Y.C.","Zhang A.","Yang X.","Lim S.G.","Hong W.","Tan Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"15781262"},{"database":"DOI","id":"10.1016/j.bbrc.2005.02.153"}],"title":"The severe acute respiratory syndrome coronavirus 3a is a novel structural protein.","publicationDate":"2005","journal":"Biochem. Biophys. Res. Commun.","firstPage":"286","lastPage":"292","volume":"330"},"referencePositions":["CHARACTERIZATION"]},{"referenceNumber":19,"citation":{"id":"15709039","citationType":"journal article","authors":["Ito N.","Mossel E.C.","Narayanan K.","Popov V.L.","Huang C.","Inoue T.","Peters C.J.","Makino S."],"citationCrossReferences":[{"database":"PubMed","id":"15709039"},{"database":"DOI","id":"10.1128/jvi.79.5.3182-3186.2005"}],"title":"Severe acute respiratory syndrome coronavirus 3a protein is a viral structural protein.","publicationDate":"2005","journal":"J. Virol.","firstPage":"3182","lastPage":"3186","volume":"79"},"referencePositions":["CHARACTERIZATION","SUBCELLULAR LOCATION"]},{"referenceNumber":20,"citation":{"id":"16014971","citationType":"journal article","authors":["Tan Y.J.","Tham P.Y.","Chan D.Z.","Chou C.-F.","Shen S.","Fielding B.C.","Tan T.H.","Lim S.G.","Hong W."],"citationCrossReferences":[{"database":"PubMed","id":"16014971"},{"database":"DOI","id":"10.1128/jvi.79.15.10083-10087.2005"}],"title":"The severe acute respiratory syndrome coronavirus 3a protein up-regulates expression of fibrinogen in lung epithelial cells.","publicationDate":"2005","journal":"J. Virol.","firstPage":"10083","lastPage":"10087","volume":"79"},"referencePositions":["FUNCTION"]},{"referenceNumber":21,"citation":{"id":"15958670","citationType":"journal article","authors":["Law P.T.","Wong C.H.","Au T.C.","Chuck C.P.","Kong S.K.","Chan P.K.","To K.F.","Lo A.W.","Chan J.Y.","Suen Y.K.","Chan H.Y.","Fung K.P.","Waye M.M.","Sung J.J.","Lo Y.M.D.","Tsui S.K.W."],"citationCrossReferences":[{"database":"PubMed","id":"15958670"},{"database":"DOI","id":"10.1099/vir.0.80813-0"}],"title":"The 3a protein of severe acute respiratory syndrome-associated coronavirus induces apoptosis in Vero E6 cells.","publicationDate":"2005","journal":"J. Gen. Virol.","firstPage":"1921","lastPage":"1930","volume":"86"},"referencePositions":["FUNCTION"]},{"referenceNumber":22,"citation":{"id":"16474139","citationType":"journal article","authors":["Oostra M.","de Haan C.A.","de Groot R.J.","Rottier P.J.M."],"citationCrossReferences":[{"database":"PubMed","id":"16474139"},{"database":"DOI","id":"10.1128/jvi.80.5.2326-2336.2006"}],"title":"Glycosylation of the severe acute respiratory syndrome coronavirus triple-spanning membrane proteins 3a and M.","publicationDate":"2006","journal":"J. Virol.","firstPage":"2326","lastPage":"2336","volume":"80"},"referencePositions":["GLYCOSYLATION","MUTAGENESIS OF SER-27; THR-28; THR-32 AND THR-34"]},{"referenceNumber":23,"citation":{"id":"16352545","citationType":"journal article","authors":["Huang C.","Narayanan K.","Ito N.","Peters C.J.","Makino S."],"citationCrossReferences":[{"database":"PubMed","id":"16352545"},{"database":"DOI","id":"10.1128/jvi.80.1.210-217.2006"}],"title":"Severe acute respiratory syndrome coronavirus 3a protein is released in membranous structures from 3a protein-expressing cells and infected cells.","publicationDate":"2006","journal":"J. Virol.","firstPage":"210","lastPage":"217","volume":"80"},"referencePositions":["SUBCELLULAR LOCATION"]},{"referenceNumber":24,"citation":{"id":"16894145","citationType":"journal article","authors":["Lu W.","Zheng B.-J.","Xu K.","Schwarz W.","Du L.","Wong C.K.L.","Chen J.","Duan S.","Deubel V.","Sun B."],"citationCrossReferences":[{"database":"PubMed","id":"16894145"},{"database":"DOI","id":"10.1073/pnas.0605402103"}],"title":"Severe acute respiratory syndrome-associated coronavirus 3a protein forms an ion channel and modulates virus release.","publicationDate":"2006","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"12540","lastPage":"12545","volume":"103"},"referencePositions":["FUNCTION","SUBUNIT","MUTAGENESIS OF CYS-81; CYS-117; CYS-121; CYS-127; CYS-130; CYS-133; CYS-148 AND CYS-157"]},{"referenceNumber":25,"citation":{"id":"20020050","citationType":"journal article","authors":["Minakshi R.","Padhan K.","Rani M.","Khan N.","Ahmad F.","Jameel S."],"citationCrossReferences":[{"database":"PubMed","id":"20020050"},{"database":"DOI","id":"10.1371/journal.pone.0008342"}],"title":"The SARS Coronavirus 3a protein causes endoplasmic reticulum stress and induces ligand-independent downregulation of the type 1 interferon receptor.","publicationDate":"2009","journal":"PLoS ONE","firstPage":"E8342","lastPage":"E8342","volume":"4"},"referencePositions":["FUNCTION"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AY278741","properties":[{"key":"ProteinId","value":"AAP13446.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_RNA"}]},{"database":"EMBL","id":"AY274119","properties":[{"key":"ProteinId","value":"AAP41038.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_RNA"}]},{"database":"EMBL","id":"AY282752","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_RNA"}]},{"database":"EMBL","id":"AY278554","properties":[{"key":"ProteinId","value":"AAP13568.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_RNA"}]},{"database":"EMBL","id":"AY278491","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_RNA"}]},{"database":"EMBL","id":"AY278487","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_RNA"}]},{"database":"EMBL","id":"AY278488","properties":[{"key":"ProteinId","value":"AAP30031.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_RNA"}]},{"database":"EMBL","id":"AY278489","properties":[{"key":"ProteinId","value":"AAP51228.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_RNA"}]},{"database":"EMBL","id":"AY278490","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_RNA"}]},{"database":"EMBL","id":"AY279354","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_RNA"}]},{"database":"EMBL","id":"AY291451","properties":[{"key":"ProteinId","value":"AAP37018.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_RNA"}]},{"database":"EMBL","id":"AY310120","properties":[{"key":"ProteinId","value":"AAP50486.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_RNA"}]},{"database":"EMBL","id":"AY291315","properties":[{"key":"ProteinId","value":"AAP33698.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_RNA"}]},{"database":"EMBL","id":"AY338174","properties":[{"key":"ProteinId","value":"AAQ01598.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_RNA"}]},{"database":"EMBL","id":"AY338175","properties":[{"key":"ProteinId","value":"AAQ01610.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_RNA"}]},{"database":"EMBL","id":"AY348314","properties":[{"key":"ProteinId","value":"AAP97883.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_RNA"}]},{"database":"EMBL","id":"AP006557","properties":[{"key":"ProteinId","value":"BAC81349.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_RNA"}]},{"database":"EMBL","id":"AP006558","properties":[{"key":"ProteinId","value":"BAC81363.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_RNA"}]},{"database":"EMBL","id":"AP006559","properties":[{"key":"ProteinId","value":"BAC81377.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_RNA"}]},{"database":"EMBL","id":"AP006560","properties":[{"key":"ProteinId","value":"BAC81391.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_RNA"}]},{"database":"EMBL","id":"AP006561","properties":[{"key":"ProteinId","value":"BAC81405.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_RNA"}]},{"database":"EMBL","id":"AY323977","properties":[{"key":"ProteinId","value":"AAP72975.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_RNA"}]},{"database":"EMBL","id":"AY427439","properties":[{"key":"ProteinId","value":"AAQ94061.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_RNA"}]},{"database":"EMBL","id":"AY463059","properties":[{"key":"ProteinId","value":"AAP82984.2"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_RNA"}]},{"database":"EMBL","id":"AH012999","properties":[{"key":"ProteinId","value":"AAP82969.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_RNA"}]},{"database":"PDB","id":"8EQS","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.10 A"},{"key":"Chains","value":"A/B=1-274"}]},{"database":"PDBsum","id":"8EQS","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-28544","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P59632","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"4383917","properties":[{"key":"Interactions","value":"81"}]},{"database":"ComplexPortal","id":"CPX-6095","properties":[{"key":"EntryName","value":"SARS-CoV 3a complex"}]},{"database":"DIP","id":"DIP-61251N","properties":[{"key":"Description","value":"-"}]},{"database":"IntAct","id":"P59632","properties":[{"key":"Interactions","value":"58"}]},{"database":"MINT","id":"P59632","properties":[{"key":"Description","value":"-"}]},{"database":"TCDB","id":"1.A.57.1.1","properties":[{"key":"FamilyName","value":"the human sars coronavirus viroporin (sars-vp) family"}]},{"database":"GlyGen","id":"P59632","properties":[{"key":"glycosylation","value":"4 sites"}]},{"database":"iPTMnet","id":"P59632","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-9678110","properties":[{"key":"PathwayName","value":"Attachment and Entry"}]},{"database":"Reactome","id":"R-HSA-9679509","properties":[{"key":"PathwayName","value":"Virion Assembly and Release"}]},{"database":"Reactome","id":"R-HSA-9683673","properties":[{"key":"PathwayName","value":"Maturation of protein 3a"}]},{"database":"Reactome","id":"R-HSA-9683701","properties":[{"key":"PathwayName","value":"Translation of Structural Proteins"}]},{"database":"Reactome","id":"R-HSA-9686347","properties":[{"key":"PathwayName","value":"Microbial modulation of RIPK1-mediated regulated necrosis"}]},{"database":"Reactome","id":"R-HSA-9692913","properties":[{"key":"PathwayName","value":"SARS-CoV-1-mediated effects on programmed cell death"}]},{"database":"Reactome","id":"R-HSA-9692916","properties":[{"key":"PathwayName","value":"SARS-CoV-1 activates/modulates innate immune responses"}]},{"database":"Reactome","id":"R-HSA-9735871","properties":[{"key":"PathwayName","value":"SARS-CoV-1 targets host intracellular signalling and regulatory pathways"}]},{"database":"SIGNOR","id":"P59632","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000354","properties":[{"key":"Component","value":"Segment"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0044178","properties":[{"key":"GoTerm","value":"C:host cell Golgi membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0020002","properties":[{"key":"GoTerm","value":"C:host cell plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IDA:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16894145"}]},{"database":"GO","id":"GO:0055036","properties":[{"key":"GoTerm","value":"C:virion membrane"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0008076","properties":[{"key":"GoTerm","value":"C:voltage-gated potassium channel complex"},{"key":"GoEvidenceType","value":"IPI:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"16894145"}]},{"database":"GO","id":"GO:0042802","properties":[{"key":"GoTerm","value":"F:identical protein binding"},{"key":"GoEvidenceType","value":"IPI:IntAct"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"16894145"}]},{"database":"GO","id":"GO:0005216","properties":[{"key":"GoTerm","value":"F:monoatomic ion channel activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0141079","properties":[{"key":"GoTerm","value":"P:symbiont-mediated activation of host inflammasome-mediated signal transduction"},{"key":"GoEvidenceType","value":"EXP:SigSci"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31034780"}]},{"database":"GO","id":"GO:0052170","properties":[{"key":"GoTerm","value":"P:symbiont-mediated suppression of host innate immune response"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-KW"}]},{"database":"GO","id":"GO:0039502","properties":[{"key":"GoTerm","value":"P:symbiont-mediated suppression of host type I interferon-mediated signaling pathway"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-KW"}]},{"database":"GO","id":"GO:0055085","properties":[{"key":"GoTerm","value":"P:transmembrane transport"},{"key":"GoEvidenceType","value":"IDA:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16894145"}]},{"database":"CDD","id":"cd21648","properties":[{"key":"EntryName","value":"SARS-CoV-like_ORF3a"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR046446","properties":[{"key":"EntryName","value":"a/bCoV_VIROPORIN_3A-like_CD"}]},{"database":"InterPro","id":"IPR046445","properties":[{"key":"EntryName","value":"a/bCoV_VIROPORIN_3A-like_TM"}]},{"database":"InterPro","id":"IPR024407","properties":[{"key":"EntryName","value":"Protein_3a_bCoV"}]},{"database":"Pfam","id":"PF11289","properties":[{"key":"EntryName","value":"bCoV_viroporin"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51967","properties":[{"key":"EntryName","value":"COV_VIROPORIN_3A_CD"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51966","properties":[{"key":"EntryName","value":"COV_VIROPORIN_3A_TM"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MDLFMRFFTLGSITAQPVKIDNASPASTVHATATIPLQASLPFGWLVIGVAFLAVFQSATKIIALNKRWQLALYKGFQFICNLLLLFVTIYSHLLLVAAGMEAQFLYLYALIYFLQCINACRIIMRCWLCWKCKSKNPLLYDANYFVCWHTHNYDYCIPYNSVTDTIVVTEGDGISTPKLKEDYQIGGYSEDRHSGVKDYVVVHGYFTEVYYQLESTQITTDTGIENATFFIFNKLVKDPPNVQIHTIDGSSGVANPAMDPIYDEPTTTTSVPL","length":274,"molWeight":30903,"crc64":"E48C7D44A4DE34FE","md5":"3CDBD3EE56980F0C9131B9D05B57AC50"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"INTERACTION":4,"SUBCELLULAR LOCATION":1,"DOMAIN":1,"PTM":1},"countByFeatureType":{"Chain":1,"Topological domain":4,"Transmembrane":3,"Domain":2,"Site":1,"Glycosylation":4,"Natural variant":9,"Mutagenesis":12,"Helix":5,"Turn":1,"Beta strand":8},"uniParcId":"UPI000018DB73"}}