{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P56508","secondaryAccessions":["D6VTE7"],"uniProtkbId":"SNA2_YEAST","entryAudit":{"firstPublicDate":"1998-07-15","lastAnnotationUpdateDate":"2026-01-28","lastSequenceUpdateDate":"1998-07-15","entryVersion":154,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)","commonName":"Baker's yeast","taxonId":559292,"lineage":["Eukaryota","Fungi","Dikarya","Ascomycota","Saccharomycotina","Saccharomycetes","Saccharomycetales","Saccharomycetaceae","Saccharomyces"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Protein SNA2"}}},"genes":[{"geneName":{"value":"SNA2"},"orderedLocusNames":[{"value":"YDR525W-A"}],"orfNames":[{"value":"YDR525BW"}]}],"comments":[{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"value":"Localized to punctate structures and lipid particles in the cytoplasm"}]},"subcellularLocations":[{"location":{"value":"Membrane","id":"SL-0162"},"topology":{"value":"Multi-pass membrane protein","id":"SL-9909"}},{"location":{"value":"Lipid droplet","id":"SL-0154"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14562106"}],"value":"Present with 20400 molecules/cell in log phase SD medium"}],"commentType":"MISCELLANEOUS"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the PMP3 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":79,"modifier":"EXACT"}},"description":"Protein SNA2","featureId":"PRO_0000193989"},{"type":"Topological domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":6,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":7,"modifier":"EXACT"},"end":{"value":27,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":28,"modifier":"EXACT"},"end":{"value":32,"modifier":"EXACT"}},"description":"Vesicular","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":33,"modifier":"EXACT"},"end":{"value":53,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":54,"modifier":"EXACT"},"end":{"value":79,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Modified residue","location":{"start":{"value":71,"modifier":"EXACT"},"end":{"value":71,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19779198"}]},{"type":"Modified residue","location":{"start":{"value":77,"modifier":"EXACT"},"end":{"value":77,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18407956"}]}],"keywords":[{"id":"KW-0551","category":"Cellular component","name":"Lipid droplet"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"9169867","citationType":"journal article","authors":["Jacq C.","Alt-Moerbe J.","Andre B.","Arnold W.","Bahr A.","Ballesta J.P.G.","Bargues M.","Baron L.","Becker A.","Biteau N.","Bloecker H.","Blugeon C.","Boskovic J.","Brandt P.","Brueckner M.","Buitrago M.J.","Coster F.","Delaveau T.","del Rey F.","Dujon B.","Eide L.G.","Garcia-Cantalejo J.M.","Goffeau A.","Gomez-Peris A.","Granotier C.","Hanemann V.","Hankeln T.","Hoheisel J.D.","Jaeger W.","Jimenez A.","Jonniaux J.-L.","Kraemer C.","Kuester H.","Laamanen P.","Legros Y.","Louis E.J.","Moeller-Rieker S.","Monnet A.","Moro M.","Mueller-Auer S.","Nussbaumer B.","Paricio N.","Paulin L.","Perea J.","Perez-Alonso M.","Perez-Ortin J.E.","Pohl T.M.","Prydz H.","Purnelle B.","Rasmussen S.W.","Remacha M.A.","Revuelta J.L.","Rieger M.","Salom D.","Saluz H.P.","Saiz J.E.","Saren A.-M.","Schaefer M.","Scharfe M.","Schmidt E.R.","Schneider C.","Scholler P.","Schwarz S.","Soler-Mira A.","Urrestarazu L.A.","Verhasselt P.","Vissers S.","Voet M.","Volckaert G.","Wagner G.","Wambutt R.","Wedler E.","Wedler H.","Woelfl S.","Harris D.E.","Bowman S.","Brown D.","Churcher C.M.","Connor R.","Dedman K.","Gentles S.","Hamlin N.","Hunt S.","Jones L.","McDonald S.","Murphy L.D.","Niblett D.","Odell C.","Oliver K.","Rajandream M.A.","Richards C.","Shore L.","Walsh S.V.","Barrell B.G.","Dietrich F.S.","Mulligan J.T.","Allen E.","Araujo R.","Aviles E.","Berno A.","Carpenter J.","Chen E.","Cherry J.M.","Chung E.","Duncan M.","Hunicke-Smith S.","Hyman R.W.","Komp C.","Lashkari D.","Lew H.","Lin D.","Mosedale D.","Nakahara K.","Namath A.","Oefner P.","Oh C.","Petel F.X.","Roberts D.","Schramm S.","Schroeder M.","Shogren T.","Shroff N.","Winant A.","Yelton M.A.","Botstein D.","Davis R.W.","Johnston M.","Andrews S.","Brinkman R.","Cooper J.","Ding H.","Du Z.","Favello A.","Fulton L.","Gattung S.","Greco T.","Hallsworth K.","Hawkins J.","Hillier L.W.","Jier M.","Johnson D.","Johnston L.","Kirsten J.","Kucaba T.","Langston Y.","Latreille P.","Le T.","Mardis E.","Menezes S.","Miller N.","Nhan M.","Pauley A.","Peluso D.","Rifkin L.","Riles L.","Taich A.","Trevaskis E.","Vignati D.","Wilcox L.","Wohldman P.","Vaudin M.","Wilson R.","Waterston R.","Albermann K.","Hani J.","Heumann K.","Kleine K.","Mewes H.-W.","Zollner A.","Zaccaria P."],"citationCrossReferences":[{"database":"PubMed","id":"9169867"},{"database":"DOI","id":"10.1038/387s075"}],"title":"The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.","publicationDate":"1997","journal":"Nature","firstPage":"75","lastPage":"78","volume":"387"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"ATCC 204508 / S288c","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"24374639","citationType":"journal article","authors":["Engel S.R.","Dietrich F.S.","Fisk D.G.","Binkley G.","Balakrishnan R.","Costanzo M.C.","Dwight S.S.","Hitz B.C.","Karra K.","Nash R.S.","Weng S.","Wong E.D.","Lloyd P.","Skrzypek M.S.","Miyasato S.R.","Simison M.","Cherry J.M."],"citationCrossReferences":[{"database":"PubMed","id":"24374639"},{"database":"DOI","id":"10.1534/g3.113.008995"}],"title":"The reference genome sequence of Saccharomyces cerevisiae: Then and now.","publicationDate":"2014","journal":"G3 (Bethesda)","firstPage":"389","lastPage":"398","volume":"4"},"referencePositions":["GENOME REANNOTATION"],"referenceComments":[{"value":"ATCC 204508 / S288c","type":"STRAIN"}]},{"referenceNumber":3,"citation":{"id":"17322287","citationType":"journal article","authors":["Hu Y.","Rolfs A.","Bhullar B.","Murthy T.V.S.","Zhu C.","Berger M.F.","Camargo A.A.","Kelley F.","McCarron S.","Jepson D.","Richardson A.","Raphael J.","Moreira D.","Taycher E.","Zuo D.","Mohr S.","Kane M.F.","Williamson J.","Simpson A.J.G.","Bulyk M.L.","Harlow E.","Marsischky G.","Kolodner R.D.","LaBaer J."],"citationCrossReferences":[{"database":"PubMed","id":"17322287"},{"database":"DOI","id":"10.1101/gr.6037607"}],"title":"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae.","publicationDate":"2007","journal":"Genome Res.","firstPage":"536","lastPage":"543","volume":"17"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"],"referenceComments":[{"value":"ATCC 204508 / S288c","type":"STRAIN"}]},{"referenceNumber":4,"citation":{"id":"9588799","citationType":"journal article","authors":["Rudd K.E.","Humphery-Smith I.","Wasinger V.C.","Bairoch A."],"citationCrossReferences":[{"database":"PubMed","id":"9588799"},{"database":"DOI","id":"10.1002/elps.1150190413"}],"title":"Low molecular weight proteins: a challenge for post-genomic research.","publicationDate":"1998","journal":"Electrophoresis","firstPage":"536","lastPage":"544","volume":"19"},"referencePositions":["IDENTIFICATION"]},{"referenceNumber":5,"citation":{"id":"11566881","citationType":"journal article","authors":["Reggiori F.","Pelham H.R.B."],"citationCrossReferences":[{"database":"PubMed","id":"11566881"},{"database":"DOI","id":"10.1093/emboj/20.18.5176"}],"title":"Sorting of proteins into multivesicular bodies: ubiquitin-dependent and -independent targeting.","publicationDate":"2001","journal":"EMBO J.","firstPage":"5176","lastPage":"5186","volume":"20"},"referencePositions":["SUBCELLULAR LOCATION"]},{"referenceNumber":6,"citation":{"id":"12524434","citationType":"journal article","authors":["Kim H.","Melen K.","von Heijne G."],"citationCrossReferences":[{"database":"PubMed","id":"12524434"},{"database":"DOI","id":"10.1074/jbc.m300163200"}],"title":"Topology models for 37 Saccharomyces cerevisiae membrane proteins based on C-terminal reporter fusions and predictions.","publicationDate":"2003","journal":"J. Biol. Chem.","firstPage":"10208","lastPage":"10213","volume":"278"},"referencePositions":["TOPOLOGY"]},{"referenceNumber":7,"citation":{"id":"14562095","citationType":"journal article","authors":["Huh W.-K.","Falvo J.V.","Gerke L.C.","Carroll A.S.","Howson R.W.","Weissman J.S.","O'Shea E.K."],"citationCrossReferences":[{"database":"PubMed","id":"14562095"},{"database":"DOI","id":"10.1038/nature02026"}],"title":"Global analysis of protein localization in budding yeast.","publicationDate":"2003","journal":"Nature","firstPage":"686","lastPage":"691","volume":"425"},"referencePositions":["SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]"]},{"referenceNumber":8,"citation":{"id":"14562106","citationType":"journal article","authors":["Ghaemmaghami S.","Huh W.-K.","Bower K.","Howson R.W.","Belle A.","Dephoure N.","O'Shea E.K.","Weissman J.S."],"citationCrossReferences":[{"database":"PubMed","id":"14562106"},{"database":"DOI","id":"10.1038/nature02046"}],"title":"Global analysis of protein expression in yeast.","publicationDate":"2003","journal":"Nature","firstPage":"737","lastPage":"741","volume":"425"},"referencePositions":["LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS]"]},{"referenceNumber":9,"citation":{"id":"16847258","citationType":"journal article","authors":["Kim H.","Melen K.","Oesterberg M.","von Heijne G."],"citationCrossReferences":[{"database":"PubMed","id":"16847258"},{"database":"DOI","id":"10.1073/pnas.0604075103"}],"title":"A global topology map of the Saccharomyces cerevisiae membrane proteome.","publicationDate":"2006","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"11142","lastPage":"11147","volume":"103"},"referencePositions":["TOPOLOGY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"ATCC 208353 / W303-1A","type":"STRAIN"}]},{"referenceNumber":10,"citation":{"id":"18407956","citationType":"journal article","authors":["Albuquerque C.P.","Smolka M.B.","Payne S.H.","Bafna V.","Eng J.","Zhou H."],"citationCrossReferences":[{"database":"PubMed","id":"18407956"},{"database":"DOI","id":"10.1074/mcp.m700468-mcp200"}],"title":"A multidimensional chromatography technology for in-depth phosphoproteome analysis.","publicationDate":"2008","journal":"Mol. Cell. Proteomics","firstPage":"1389","lastPage":"1396","volume":"7"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-77","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":11,"citation":{"id":"19779198","citationType":"journal article","authors":["Holt L.J.","Tuch B.B.","Villen J.","Johnson A.D.","Gygi S.P.","Morgan D.O."],"citationCrossReferences":[{"database":"PubMed","id":"19779198"},{"database":"DOI","id":"10.1126/science.1172867"}],"title":"Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution.","publicationDate":"2009","journal":"Science","firstPage":"1682","lastPage":"1686","volume":"325"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-71","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"U33057","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AY558561","properties":[{"key":"ProteinId","value":"AAS56887.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BK006938","properties":[{"key":"ProteinId","value":"DAA12357.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"S78716","properties":[{"key":"EntryName","value":"S78716"}]},{"database":"RefSeq","id":"NP_010814.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001184329.1"}]},{"database":"AlphaFoldDB","id":"P56508","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P56508","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"32575","properties":[{"key":"Interactions","value":"50"}]},{"database":"FunCoup","id":"P56508","properties":[{"key":"Number of interactors","value":"905"}]},{"database":"IntAct","id":"P56508","properties":[{"key":"Interactions","value":"10"}]},{"database":"STRING","id":"4932.YDR525W-A","properties":[{"key":"Description","value":"-"}]},{"database":"TCDB","id":"9.B.12.3.3","properties":[{"key":"FamilyName","value":"the sensitivity to sodium or salt stress-induced hydrophobic peptide (sna) family"}]},{"database":"iPTMnet","id":"P56508","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"4932-YDR525W-A","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"P56508","properties":[{"key":"Description","value":"-"}]},{"database":"TopDownProteomics","id":"P56508","properties":[{"key":"Description","value":"-"}]},{"database":"EnsemblFungi","id":"YDR525W-A_mRNA","properties":[{"key":"ProteinId","value":"YDR525W-A"},{"key":"GeneId","value":"YDR525W-A"}]},{"database":"GeneID","id":"852138","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"sce:YDR525W-A","properties":[{"key":"Description","value":"-"}]},{"database":"AGR","id":"SGD:S000007236","properties":[{"key":"Description","value":"-"}]},{"database":"SGD","id":"S000007236","properties":[{"key":"GeneName","value":"SNA2"}]},{"database":"VEuPathDB","id":"FungiDB:YDR525W-A","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG1773","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"HOGENOM","id":"CLU_107649_5_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P56508","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"HALWVIS","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"2802411at2759","properties":[{"key":"Description","value":"-"}]},{"database":"BioCyc","id":"YEAST:G3O-30089-MONOMER","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"852138","properties":[{"key":"hits","value":"5 hits in 10 CRISPR screens"}]},{"database":"PRO","id":"PR:P56508","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000002311","properties":[{"key":"Component","value":"Chromosome IV"}]},{"database":"RNAct","id":"P56508","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"HDA:SGD"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"14562095"}]},{"database":"GO","id":"GO:0000329","properties":[{"key":"GoTerm","value":"C:fungal-type vacuole membrane"},{"key":"GoEvidenceType","value":"IDA:SGD"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20406419"}]},{"database":"GO","id":"GO:0005811","properties":[{"key":"GoTerm","value":"C:lipid droplet"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"InterPro","id":"IPR000612","properties":[{"key":"EntryName","value":"PMP3"}]},{"database":"PANTHER","id":"PTHR21659","properties":[{"key":"EntryName","value":"HYDROPHOBIC PROTEIN RCI2 LOW TEMPERATURE AND SALT RESPONSIVE PROTEIN LTI6 -RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR21659:SF112","properties":[{"key":"EntryName","value":"PROTEIN SNA2-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01679","properties":[{"key":"EntryName","value":"Pmp3"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS01309","properties":[{"key":"EntryName","value":"UPF0057"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MHARDWFLVFIAIFIPPLAVWLKRGFFTKDLLINFLLFLLGFFPGLIHALYVISCHPYEENEARYSHLSSSDDNYGSLA","length":79,"molWeight":9180,"crc64":"BD6B749BE28F467B","md5":"7CD4A7D2F806E6253E913934E392C370"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"MISCELLANEOUS":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Topological domain":3,"Transmembrane":2,"Modified residue":2},"uniParcId":"UPI000013A872"}}