{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P55343","uniProtkbId":"MRAZ_BACSU","entryAudit":{"firstPublicDate":"1996-10-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1996-10-01","entryVersion":140,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Bacillus subtilis (strain 168)","taxonId":224308,"lineage":["Bacteria","Bacillati","Bacillota","Bacilli","Caryophanales","Bacillaceae","Bacillus"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"value":"Transcriptional regulator MraZ"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_01008"}],"value":"mraZ"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"8636036"}],"value":"yllB"}],"orderedLocusNames":[{"value":"BSU15130"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_01008"}],"value":"Forms oligomers"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_01008"}],"value":"Cytoplasm, nucleoid","id":"SL-0187"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8636036"}],"value":"Transcribed at a constant level in all growth phases. Part of the mraZ-rsmH-ftsL-pbpB operon"}],"commentType":"INDUCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8636036"}],"value":"No visible phenotype"}],"commentType":"DISRUPTION PHENOTYPE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_01008"}],"value":"Belongs to the MraZ family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":143,"modifier":"EXACT"}},"description":"Transcriptional regulator MraZ","featureId":"PRO_0000108459"},{"type":"Domain","location":{"start":{"value":5,"modifier":"EXACT"},"end":{"value":47,"modifier":"EXACT"}},"description":"SpoVT-AbrB 1","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01076"}]},{"type":"Domain","location":{"start":{"value":76,"modifier":"EXACT"},"end":{"value":119,"modifier":"EXACT"}},"description":"SpoVT-AbrB 2","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01076"}]}],"keywords":[{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0677","category":"Domain","name":"Repeat"},{"id":"KW-0804","category":"Biological process","name":"Transcription"},{"id":"KW-0805","category":"Biological process","name":"Transcription regulation"}],"references":[{"referenceNumber":1,"citation":{"id":"8636036","citationType":"journal article","authors":["Daniel R.A.","Williams A.M.","Errington J."],"citationCrossReferences":[{"database":"PubMed","id":"8636036"},{"database":"DOI","id":"10.1128/jb.178.8.2343-2350.1996"}],"title":"A complex four-gene operon containing essential cell division gene pbpB in Bacillus subtilis.","publicationDate":"1996","journal":"J. Bacteriol.","firstPage":"2343","lastPage":"2350","volume":"178"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]","INDUCTION","DISRUPTION PHENOTYPE"],"referenceComments":[{"value":"168","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"9384377","citationType":"journal article","authors":["Kunst F.","Ogasawara N.","Moszer I.","Albertini A.M.","Alloni G.","Azevedo V.","Bertero M.G.","Bessieres P.","Bolotin A.","Borchert S.","Borriss R.","Boursier L.","Brans A.","Braun M.","Brignell S.C.","Bron S.","Brouillet S.","Bruschi C.V.","Caldwell B.","Capuano V.","Carter N.M.","Choi S.-K.","Codani J.-J.","Connerton I.F.","Cummings N.J.","Daniel R.A.","Denizot F.","Devine K.M.","Duesterhoeft A.","Ehrlich S.D.","Emmerson P.T.","Entian K.-D.","Errington J.","Fabret C.","Ferrari E.","Foulger D.","Fritz C.","Fujita M.","Fujita Y.","Fuma S.","Galizzi A.","Galleron N.","Ghim S.-Y.","Glaser P.","Goffeau A.","Golightly E.J.","Grandi G.","Guiseppi G.","Guy B.J.","Haga K.","Haiech J.","Harwood C.R.","Henaut A.","Hilbert H.","Holsappel S.","Hosono S.","Hullo M.-F.","Itaya M.","Jones L.-M.","Joris B.","Karamata D.","Kasahara Y.","Klaerr-Blanchard M.","Klein C.","Kobayashi Y.","Koetter P.","Koningstein G.","Krogh S.","Kumano M.","Kurita K.","Lapidus A.","Lardinois S.","Lauber J.","Lazarevic V.","Lee S.-M.","Levine A.","Liu H.","Masuda S.","Mauel C.","Medigue C.","Medina N.","Mellado R.P.","Mizuno M.","Moestl D.","Nakai S.","Noback M.","Noone D.","O'Reilly M.","Ogawa K.","Ogiwara A.","Oudega B.","Park S.-H.","Parro V.","Pohl T.M.","Portetelle D.","Porwollik S.","Prescott A.M.","Presecan E.","Pujic P.","Purnelle B.","Rapoport G.","Rey M.","Reynolds S.","Rieger M.","Rivolta C.","Rocha E.","Roche B.","Rose M.","Sadaie Y.","Sato T.","Scanlan E.","Schleich S.","Schroeter R.","Scoffone F.","Sekiguchi J.","Sekowska A.","Seror S.J.","Serror P.","Shin B.-S.","Soldo B.","Sorokin A.","Tacconi E.","Takagi T.","Takahashi H.","Takemaru K.","Takeuchi M.","Tamakoshi A.","Tanaka T.","Terpstra P.","Tognoni A.","Tosato V.","Uchiyama S.","Vandenbol M.","Vannier F.","Vassarotti A.","Viari A.","Wambutt R.","Wedler E.","Wedler H.","Weitzenegger T.","Winters P.","Wipat A.","Yamamoto H.","Yamane K.","Yasumoto K.","Yata K.","Yoshida K.","Yoshikawa H.-F.","Zumstein E.","Yoshikawa H.","Danchin A."],"citationCrossReferences":[{"database":"PubMed","id":"9384377"},{"database":"DOI","id":"10.1038/36786"}],"title":"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis.","publicationDate":"1997","journal":"Nature","firstPage":"249","lastPage":"256","volume":"390"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"168","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"Z68230","properties":[{"key":"ProteinId","value":"CAA92524.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL009126","properties":[{"key":"ProteinId","value":"CAB13386.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"H69875","properties":[{"key":"EntryName","value":"H69875"}]},{"database":"RefSeq","id":"NP_389396.1","properties":[{"key":"NucleotideSequenceId","value":"NC_000964.3"}]},{"database":"RefSeq","id":"WP_003221402.1","properties":[{"key":"NucleotideSequenceId","value":"NC_000964.3"}]},{"database":"AlphaFoldDB","id":"P55343","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P55343","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"P55343","properties":[{"key":"Number of interactors","value":"273"}]},{"database":"STRING","id":"224308.BSU15130","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"224308-BSU15130","properties":[{"key":"Description","value":"-"}]},{"database":"EnsemblBacteria","id":"CAB13386","properties":[{"key":"ProteinId","value":"CAB13386"},{"key":"GeneId","value":"BSU_15130"}]},{"database":"GeneID","id":"306027024","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"86873978","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"935932","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"bsu:BSU15130","properties":[{"key":"Description","value":"-"}]},{"database":"PATRIC","id":"fig|224308.179.peg.1649","properties":[{"key":"GeneDesignation","value":"-"}]},{"database":"eggNOG","id":"COG2001","properties":[{"key":"ToxonomicScope","value":"Bacteria"}]},{"database":"InParanoid","id":"P55343","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"9807753at2","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"P55343","properties":[{"key":"Description","value":"-"}]},{"database":"BioCyc","id":"BSUB:BSU15130-MONOMER","properties":[{"key":"Description","value":"-"}]},{"database":"PRO","id":"PR:P55343","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000001570","properties":[{"key":"Component","value":"Chromosome"}]},{"database":"AbasyAtlas","id":"P55343","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0009295","properties":[{"key":"GoTerm","value":"C:nucleoid"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0003700","properties":[{"key":"GoTerm","value":"F:DNA-binding transcription factor activity"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0000976","properties":[{"key":"GoTerm","value":"F:transcription cis-regulatory region binding"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:2000143","properties":[{"key":"GoTerm","value":"P:negative regulation of DNA-templated transcription initiation"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"CDD","id":"cd16321","properties":[{"key":"EntryName","value":"MraZ_C"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd16320","properties":[{"key":"EntryName","value":"MraZ_N"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.1550.20:FF:000002","properties":[{"key":"EntryName","value":"Transcriptional regulator MraZ"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.1550.20","properties":[{"key":"EntryName","value":"Transcriptional regulator MraZ domain"},{"key":"MatchStatus","value":"1"}]},{"database":"HAMAP","id":"MF_01008","properties":[{"key":"EntryName","value":"MraZ"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR003444","properties":[{"key":"EntryName","value":"MraZ"}]},{"database":"InterPro","id":"IPR035644","properties":[{"key":"EntryName","value":"MraZ_C"}]},{"database":"InterPro","id":"IPR020603","properties":[{"key":"EntryName","value":"MraZ_dom"}]},{"database":"InterPro","id":"IPR035642","properties":[{"key":"EntryName","value":"MraZ_N"}]},{"database":"InterPro","id":"IPR038619","properties":[{"key":"EntryName","value":"MraZ_sf"}]},{"database":"InterPro","id":"IPR007159","properties":[{"key":"EntryName","value":"SpoVT-AbrB_dom"}]},{"database":"InterPro","id":"IPR037914","properties":[{"key":"EntryName","value":"SpoVT-AbrB_sf"}]},{"database":"NCBIfam","id":"TIGR00242","properties":[{"key":"EntryName","value":"division/cell wall cluster transcriptional repressor MraZ"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR34701","properties":[{"key":"EntryName","value":"TRANSCRIPTIONAL REGULATOR MRAZ"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR34701:SF1","properties":[{"key":"EntryName","value":"TRANSCRIPTIONAL REGULATOR MRAZ"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02381","properties":[{"key":"EntryName","value":"MraZ"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF89447","properties":[{"key":"EntryName","value":"AbrB/MazE/MraZ-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51740","properties":[{"key":"EntryName","value":"SPOVT_ABRB"},{"key":"MatchStatus","value":"2"}]}],"sequence":{"value":"MFMGEYQHTIDAKGRMIVPAKFREGLGEQFVLTRGLDQCLFGYPMHEWKQIEEKLKALPLTKKDARAFTRFFFSGATECELDKQGRVNIASSLLNYAKLEKECVVIGVSNRIELWSKVIWEQYTEEQEDSFAEIAENMIGFDI","length":143,"molWeight":16568,"crc64":"410EC77302A7BF99","md5":"D564C450AB5166D7FD61BCE5D9B01557"},"extraAttributes":{"countByCommentType":{"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"INDUCTION":1,"DISRUPTION PHENOTYPE":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Domain":2},"uniParcId":"UPI0000060375"}}