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In brain, detected in the olfactory bulb, neocortex and cerebellum (PubMed:18775783). Elevated in mitral cells and minimally expressed in bulb interneurons (PubMed:18775783). In the cortex, restricted to the upper portion of layer 5 (PubMed:18775783). In the cerebellum, excluded from Purkinje cells but expressed in granule cells (PubMed:18775783)"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18775783"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8268909"}],"value":"Levels increase during embryonic development, drop at postnatal day 0 and increase again during postnatal development, reaching a mmaxium at postnatal day 21 before dropping slightly at postnatal day 60 (PubMed:18775783). In 13 dpc embryos, expressed at high levels in the trachea, liver, esophagus, lung and velo-pharyngeal region (PubMed:8268909). Also detected in the central nervous system (PubMed:8268909)"}],"commentType":"DEVELOPMENTAL STAGE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the Tango2 family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6ICL3"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18775783"}],"value":"Previous published data showed conflicting results on the intracellular location of TANGO2. Has been reported to be located in the Golgi apparatus (By similarity). However, another study was unable to detect Golgi localization (By similarity). Has been reported to be located in the mitochondrion by several recent studies in mouse and human (PubMed:18775783). 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