{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P53121","secondaryAccessions":["D6VU10"],"uniProtkbId":"FLC3_YEAST","entryAudit":{"firstPublicDate":"1996-10-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1996-10-01","entryVersion":166,"sequenceVersion":1},"annotationScore":4.0,"organism":{"scientificName":"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)","commonName":"Baker's yeast","taxonId":559292,"lineage":["Eukaryota","Fungi","Dikarya","Ascomycota","Saccharomycotina","Saccharomycetes","Saccharomycetales","Saccharomycetaceae","Saccharomyces"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Putative flavin carrier protein 3"}},"alternativeNames":[{"fullName":{"value":"FAD transporter 3"}},{"fullName":{"value":"TRP-like ion channel FLC3"}}],"flag":"Precursor"},"genes":[{"geneName":{"value":"FLC3"},"orderedLocusNames":[{"value":"YGL139W"}],"orfNames":[{"value":"G2812"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"May be responsible for the transport of FAD into the endoplasmic reticulum lumen, where it is required for oxidative protein folding"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16717099"}],"value":"Endoplasmic reticulum membrane","id":"SL-0097"},"topology":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16717099"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the transient receptor potential (TRP) ion channel family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":28,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Chain","location":{"start":{"value":29,"modifier":"EXACT"},"end":{"value":802,"modifier":"EXACT"}},"description":"Putative flavin carrier protein 3","featureId":"PRO_0000202738"},{"type":"Topological domain","location":{"start":{"value":29,"modifier":"EXACT"},"end":{"value":169,"modifier":"EXACT"}},"description":"Lumenal","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":170,"modifier":"EXACT"},"end":{"value":190,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":191,"modifier":"EXACT"},"end":{"value":200,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":201,"modifier":"EXACT"},"end":{"value":221,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":222,"modifier":"EXACT"},"end":{"value":229,"modifier":"EXACT"}},"description":"Lumenal","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":230,"modifier":"EXACT"},"end":{"value":250,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":251,"modifier":"EXACT"},"end":{"value":255,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":256,"modifier":"EXACT"},"end":{"value":278,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":279,"modifier":"EXACT"},"end":{"value":323,"modifier":"EXACT"}},"description":"Lumenal","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":324,"modifier":"EXACT"},"end":{"value":344,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":345,"modifier":"EXACT"},"end":{"value":377,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":378,"modifier":"EXACT"},"end":{"value":398,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":399,"modifier":"EXACT"},"end":{"value":405,"modifier":"EXACT"}},"description":"Lumenal","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":406,"modifier":"EXACT"},"end":{"value":426,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":427,"modifier":"EXACT"},"end":{"value":467,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":468,"modifier":"EXACT"},"end":{"value":488,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":489,"modifier":"EXACT"},"end":{"value":495,"modifier":"EXACT"}},"description":"Lumenal","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":496,"modifier":"EXACT"},"end":{"value":516,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":517,"modifier":"EXACT"},"end":{"value":525,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":526,"modifier":"EXACT"},"end":{"value":546,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":547,"modifier":"EXACT"},"end":{"value":557,"modifier":"EXACT"}},"description":"Lumenal","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":558,"modifier":"EXACT"},"end":{"value":578,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":579,"modifier":"EXACT"},"end":{"value":802,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Region","location":{"start":{"value":629,"modifier":"EXACT"},"end":{"value":802,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":653,"modifier":"EXACT"},"end":{"value":663,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":697,"modifier":"EXACT"},"end":{"value":717,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":761,"modifier":"EXACT"},"end":{"value":788,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Modified residue","location":{"start":{"value":616,"modifier":"EXACT"},"end":{"value":616,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18407956"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19779198"}]},{"type":"Modified residue","location":{"start":{"value":635,"modifier":"EXACT"},"end":{"value":635,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19779198"}]},{"type":"Modified residue","location":{"start":{"value":779,"modifier":"EXACT"},"end":{"value":779,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18407956"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19779198"}]},{"type":"Modified residue","location":{"start":{"value":782,"modifier":"EXACT"},"end":{"value":782,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18407956"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19779198"}]},{"type":"Glycosylation","location":{"start":{"value":149,"modifier":"EXACT"},"end":{"value":149,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":321,"modifier":"EXACT"},"end":{"value":321,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":547,"modifier":"EXACT"},"end":{"value":547,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""}],"keywords":[{"id":"KW-0256","category":"Cellular component","name":"Endoplasmic reticulum"},{"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0732","category":"Domain","name":"Signal"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"9169869","citationType":"journal article","authors":["Tettelin H.","Agostoni-Carbone M.L.","Albermann K.","Albers M.","Arroyo J.","Backes U.","Barreiros T.","Bertani I.","Bjourson A.J.","Brueckner M.","Bruschi C.V.","Carignani G.","Castagnoli L.","Cerdan E.","Clemente M.L.","Coblenz A.","Coglievina M.","Coissac E.","Defoor E.","Del Bino S.","Delius H.","Delneri D.","de Wergifosse P.","Dujon B.","Durand P.","Entian K.-D.","Eraso P.","Escribano V.","Fabiani L.","Fartmann B.","Feroli F.","Feuermann M.","Frontali L.","Garcia-Gonzalez M.","Garcia-Saez M.I.","Goffeau A.","Guerreiro P.","Hani J.","Hansen M.","Hebling U.","Hernandez K.","Heumann K.","Hilger F.","Hofmann B.","Indge K.J.","James C.M.","Klima R.","Koetter P.","Kramer B.","Kramer W.","Lauquin G.","Leuther H.","Louis E.J.","Maillier E.","Marconi A.","Martegani E.","Mazon M.J.","Mazzoni C.","McReynolds A.D.K.","Melchioretto P.","Mewes H.-W.","Minenkova O.","Mueller-Auer S.","Nawrocki A.","Netter P.","Neu R.","Nombela C.","Oliver S.G.","Panzeri L.","Paoluzi S.","Plevani P.","Portetelle D.","Portillo F.","Potier S.","Purnelle B.","Rieger M.","Riles L.","Rinaldi T.","Robben J.","Rodrigues-Pousada C.","Rodriguez-Belmonte E.","Rodriguez-Torres A.M.","Rose M.","Ruzzi M.","Saliola M.","Sanchez-Perez M.","Schaefer B.","Schaefer M.","Scharfe M.","Schmidheini T.","Schreer A.","Skala J.","Souciet J.-L.","Steensma H.Y.","Talla E.","Thierry A.","Vandenbol M.","van der Aart Q.J.M.","Van Dyck L.","Vanoni M.","Verhasselt P.","Voet M.","Volckaert G.","Wambutt R.","Watson M.D.","Weber N.","Wedler E.","Wedler H.","Wipfli P.","Wolf K.","Wright L.F.","Zaccaria P.","Zimmermann M.","Zollner A.","Kleine K."],"citationCrossReferences":[{"database":"PubMed","id":"9169869"},{"database":"DOI","id":"10.1038/387s081"}],"title":"The nucleotide sequence of Saccharomyces cerevisiae chromosome VII.","publicationDate":"1997","journal":"Nature","firstPage":"81","lastPage":"84","volume":"387"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"ATCC 204508 / S288c","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"24374639","citationType":"journal article","authors":["Engel S.R.","Dietrich F.S.","Fisk D.G.","Binkley G.","Balakrishnan R.","Costanzo M.C.","Dwight S.S.","Hitz B.C.","Karra K.","Nash R.S.","Weng S.","Wong E.D.","Lloyd P.","Skrzypek M.S.","Miyasato S.R.","Simison M.","Cherry J.M."],"citationCrossReferences":[{"database":"PubMed","id":"24374639"},{"database":"DOI","id":"10.1534/g3.113.008995"}],"title":"The reference genome sequence of Saccharomyces cerevisiae: Then and now.","publicationDate":"2014","journal":"G3 (Bethesda)","firstPage":"389","lastPage":"398","volume":"4"},"referencePositions":["GENOME REANNOTATION"],"referenceComments":[{"value":"ATCC 204508 / S288c","type":"STRAIN"}]},{"referenceNumber":3,"citation":{"id":"9046099","citationType":"journal article","authors":["Voet M.","Defoor E.","Verhasselt P.","Riles L.","Robben J.","Volckaert G."],"citationCrossReferences":[{"database":"PubMed","id":"9046099"},{"database":"DOI","id":"10.1002/(sici)1097-0061(199702)13:2<177::aid-yea62>3.0.co;2-2"}],"title":"The sequence of a nearly unclonable 22.8 kb segment on the left arm chromosome VII from Saccharomyces cerevisiae reveals ARO2, RPL9A, TIP1, MRF1 genes and six new open reading frames.","publicationDate":"1997","journal":"Yeast","firstPage":"177","lastPage":"182","volume":"13"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-749"],"referenceComments":[{"value":"ATCC 96604 / S288c / FY1679","type":"STRAIN"}]},{"referenceNumber":4,"citation":{"id":"8840506","citationType":"journal article","authors":["Escribano V.","Eraso P.","Portillo F.","Mazon M.J."],"citationCrossReferences":[{"database":"PubMed","id":"8840506"},{"database":"DOI","id":"10.1002/(sici)1097-0061(199607)12:9%3c887::aid-yea971%3e3.0.co;2-d"}],"title":"Sequence analysis of a 14.6 kb DNA fragment of Saccharomyces cerevisiae chromosome VII reveals SEC27, SSM1b, a putative S-adenosylmethionine-dependent enzyme and six new open reading frames.","publicationDate":"1996","journal":"Yeast","firstPage":"887","lastPage":"892","volume":"12"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 616-802"],"referenceComments":[{"value":"ATCC 96604 / S288c / FY1679","type":"STRAIN"}]},{"referenceNumber":5,"citation":{"id":"16717099","citationType":"journal article","authors":["Protchenko O.","Rodriguez-Suarez R.","Androphy R.","Bussey H.","Philpott C.C."],"citationCrossReferences":[{"database":"PubMed","id":"16717099"},{"database":"DOI","id":"10.1074/jbc.m512812200"}],"title":"A screen for genes of heme uptake identifies the FLC family required for import of FAD into the endoplasmic reticulum.","publicationDate":"2006","journal":"J. Biol. Chem.","firstPage":"21445","lastPage":"21457","volume":"281"},"referencePositions":["SUBCELLULAR LOCATION"]},{"referenceNumber":6,"citation":{"id":"16847258","citationType":"journal article","authors":["Kim H.","Melen K.","Oesterberg M.","von Heijne G."],"citationCrossReferences":[{"database":"PubMed","id":"16847258"},{"database":"DOI","id":"10.1073/pnas.0604075103"}],"title":"A global topology map of the Saccharomyces cerevisiae membrane proteome.","publicationDate":"2006","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"11142","lastPage":"11147","volume":"103"},"referencePositions":["TOPOLOGY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"ATCC 208353 / W303-1A","type":"STRAIN"}]},{"referenceNumber":7,"citation":{"id":"17330950","citationType":"journal article","authors":["Li X.","Gerber S.A.","Rudner A.D.","Beausoleil S.A.","Haas W.","Villen J.","Elias J.E.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"17330950"},{"database":"DOI","id":"10.1021/pr060559j"}],"title":"Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae.","publicationDate":"2007","journal":"J. Proteome Res.","firstPage":"1190","lastPage":"1197","volume":"6"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"ADR376","type":"STRAIN"}]},{"referenceNumber":8,"citation":{"id":"18407956","citationType":"journal article","authors":["Albuquerque C.P.","Smolka M.B.","Payne S.H.","Bafna V.","Eng J.","Zhou H."],"citationCrossReferences":[{"database":"PubMed","id":"18407956"},{"database":"DOI","id":"10.1074/mcp.m700468-mcp200"}],"title":"A multidimensional chromatography technology for in-depth phosphoproteome analysis.","publicationDate":"2008","journal":"Mol. Cell. Proteomics","firstPage":"1389","lastPage":"1396","volume":"7"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-616; SER-779 AND SER-782","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":9,"citation":{"id":"19779198","citationType":"journal article","authors":["Holt L.J.","Tuch B.B.","Villen J.","Johnson A.D.","Gygi S.P.","Morgan D.O."],"citationCrossReferences":[{"database":"PubMed","id":"19779198"},{"database":"DOI","id":"10.1126/science.1172867"}],"title":"Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution.","publicationDate":"2009","journal":"Science","firstPage":"1682","lastPage":"1686","volume":"325"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-616; SER-635; SER-779 AND SER-782","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"X99960","properties":[{"key":"ProteinId","value":"CAA68223.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"Z72661","properties":[{"key":"ProteinId","value":"CAA96851.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"Z72660","properties":[{"key":"ProteinId","value":"CAA96850.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"X92670","properties":[{"key":"ProteinId","value":"CAA63357.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BK006941","properties":[{"key":"ProteinId","value":"DAA07971.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"S64153","properties":[{"key":"EntryName","value":"S64153"}]},{"database":"RefSeq","id":"NP_011376.3","properties":[{"key":"NucleotideSequenceId","value":"NM_001181004.3"}]},{"database":"AlphaFoldDB","id":"P53121","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"33113","properties":[{"key":"Interactions","value":"48"}]},{"database":"DIP","id":"DIP-5496N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"P53121","properties":[{"key":"Number of interactors","value":"27"}]},{"database":"STRING","id":"4932.YGL139W","properties":[{"key":"Description","value":"-"}]},{"database":"GlyCosmos","id":"P53121","properties":[{"key":"glycosylation","value":"3 sites, No reported glycans"}]},{"database":"GlyGen","id":"P53121","properties":[{"key":"glycosylation","value":"4 sites"}]},{"database":"iPTMnet","id":"P53121","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"4932-YGL139W","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"P53121","properties":[{"key":"Description","value":"-"}]},{"database":"EnsemblFungi","id":"YGL139W_mRNA","properties":[{"key":"ProteinId","value":"YGL139W"},{"key":"GeneId","value":"YGL139W"}]},{"database":"GeneID","id":"852738","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"sce:YGL139W","properties":[{"key":"Description","value":"-"}]},{"database":"AGR","id":"SGD:S000003107","properties":[{"key":"Description","value":"-"}]},{"database":"SGD","id":"S000003107","properties":[{"key":"GeneName","value":"FLC3"}]},{"database":"VEuPathDB","id":"FungiDB:YGL139W","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502QSVZ","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"HOGENOM","id":"CLU_010226_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P53121","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"SIMGWVF","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"5212126at2759","properties":[{"key":"Description","value":"-"}]},{"database":"BioCyc","id":"YEAST:G3O-30634-MONOMER","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"852738","properties":[{"key":"hits","value":"0 hits in 10 CRISPR screens"}]},{"database":"PRO","id":"PR:P53121","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000002311","properties":[{"key":"Component","value":"Chromosome VII"}]},{"database":"RNAct","id":"P53121","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"GO","id":"GO:0005783","properties":[{"key":"GoTerm","value":"C:endoplasmic reticulum"},{"key":"GoEvidenceType","value":"IDA:SGD"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16717099"}]},{"database":"GO","id":"GO:0005789","properties":[{"key":"GoTerm","value":"C:endoplasmic reticulum membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0005739","properties":[{"key":"GoTerm","value":"C:mitochondrion"},{"key":"GoEvidenceType","value":"HDA:SGD"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"14576278"},{"evidenceCode":"ECO:0007005","source":"PubMed","id":"16823961"}]},{"database":"GO","id":"GO:0015230","properties":[{"key":"GoTerm","value":"F:FAD transmembrane transporter activity"},{"key":"GoEvidenceType","value":"ISS:SGD"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"PubMed","id":"16717099"}]},{"database":"GO","id":"GO:0015883","properties":[{"key":"GoTerm","value":"P:FAD transport"},{"key":"GoEvidenceType","value":"ISS:SGD"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"PubMed","id":"16717099"}]},{"database":"GO","id":"GO:0009272","properties":[{"key":"GoTerm","value":"P:fungal-type cell wall biogenesis"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0030148","properties":[{"key":"GoTerm","value":"P:sphingolipid biosynthetic process"},{"key":"GoEvidenceType","value":"IGI:SGD"}],"evidences":[{"evidenceCode":"ECO:0000316","source":"PubMed","id":"27462707"}]},{"database":"GO","id":"GO:0055085","properties":[{"key":"GoTerm","value":"P:transmembrane transport"},{"key":"GoEvidenceType","value":"ISS:SGD"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"PubMed","id":"16717099"}]},{"database":"InterPro","id":"IPR010308","properties":[{"key":"EntryName","value":"TRP_C"}]},{"database":"InterPro","id":"IPR040241","properties":[{"key":"EntryName","value":"TRP_Flc/Pkd2-like"}]},{"database":"InterPro","id":"IPR032800","properties":[{"key":"EntryName","value":"TRP_N"}]},{"database":"PANTHER","id":"PTHR31145:SF4","properties":[{"key":"EntryName","value":"FLAVIN CARRIER PROTEIN 1-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR31145","properties":[{"key":"EntryName","value":"INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_7G01610)"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF06011","properties":[{"key":"EntryName","value":"TRP"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF14558","properties":[{"key":"EntryName","value":"TRP_N"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM01320","properties":[{"key":"EntryName","value":"TRP_N"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MRFLQVYKSSALIGLIILLASKVNLAEAKRKLVATSLVTCMENSQLSANSFDVVFNPDDRSLHYDLDMSTQIDSYIFADIDVYAYGFKIITKNVDLCSINWKQFCPVHPGNIQIDSIEYISSEYVNEIPGIAYQVPDIDAYARVKITNNVSEYLACIQIYFSNGKTVSQIGVKWATAVVAGIGLLLSAILSTFGNSTAASHISANTMSLFLYFQSVVVVAMQHVHRVPPIAAAWAENLVWSMGLIRISFMQRIFRWYVQSTGGTPSLYLTSTSMSVLAQRSWQYLMELPLIKRATNVLYGNANTLIFRGIKRLGYKMGIENTSIVCTGFTFFVLCGYVLAGFIIVFKCCVELATRLGWIQKARFWEFRKQWRMILKGALLRYIYIGFVQLTILSFWEFTERDSPAVIVIACLFILLSCGLMLWAAWRTVFFARRSVALYNNPAALLYGDEYVLHKYGFFYTMFNANHYWWNIVLLSYIFVKSLLVGFAQASGQTQVLFMFILDLFYFVAIIYYKPYLDRPTNIMNILIATVTVVNSFLFMFFSDLFNQSYKVAAIMGWIFFIMNAAFSFILLMMILAFAGMMLFSKNPDLRFKPAKDDRTSFQRNTMKPEGTVNRSVANELLALGNVAKDHDDNSDYESNDTGVNDELKQAQDETTPTTVTSSDDNKPTFSEKILSKFSRPKNENASTDALRVEAPKQQTFPHNLTNLSRENLSTLGSKPYPGHTRSQSDAHNGLINSFEEEDTSSNTDPFHDSTEGDLLDTSSSDGGFRSQNYVRDDSINSLGNNKQPLRKPPGFFDEGFM","length":802,"molWeight":90761,"crc64":"7BA13714AD912295","md5":"F6710047BC70C28095AC77F1B20BED01"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Signal":1,"Chain":1,"Topological domain":12,"Transmembrane":11,"Region":1,"Compositional bias":3,"Modified residue":4,"Glycosylation":3},"uniParcId":"UPI000013B100"}}