{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P51858","secondaryAccessions":["B3KU21","D3DVC9","Q5SZ07","Q5SZ08","Q5SZ09"],"uniProtkbId":"HDGF_HUMAN","entryAudit":{"firstPublicDate":"1996-10-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1996-10-01","entryVersion":212,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Hepatoma-derived growth factor"},"shortNames":[{"value":"HDGF"}]},"alternativeNames":[{"fullName":{"value":"High mobility group protein 1-like 2"},"shortNames":[{"value":"HMG-1L2"}]}]},"genes":[{"geneName":{"value":"HDGF"},"synonyms":[{"value":"HMG1L2"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11751870"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15491618"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17974029"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26845719"}],"value":"Acts as a transcriptional repressor (PubMed:17974029). Has mitogenic activity for fibroblasts (PubMed:11751870, PubMed:26845719). Heparin-binding protein (PubMed:15491618)"}],"commentType":"FUNCTION","molecule":"Isoform 1"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26845719"}],"value":"Does not have mitogenic activity for fibroblasts (PubMed:26845719). Does not bind heparin (PubMed:26845719)"}],"commentType":"FUNCTION","molecule":"Isoform 2"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26845719"}],"value":"Has mitogenic activity for fibroblasts (PubMed:26845719). Heparin-binding protein (PubMed:26845719)"}],"commentType":"FUNCTION","molecule":"Isoform 3"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17270212"}],"value":"Monomer, and domain-swapped homodimer (PubMed:17270212)"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26845719"}],"value":"Interacts with nuclear proteins NCL and YBX1/YB1 (PubMed:26845719)"}],"commentType":"SUBUNIT","molecule":"Isoform 1"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26845719"}],"value":"Interacts with cytoskeletal proteins such as actin, dynein, tubulin and vimentin (PubMed:26845719)"}],"commentType":"SUBUNIT","molecule":"Isoform 2"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26845719"}],"value":"Interacts with cytoskeletal proteins such as dynein and tubulin but does not interact with actin or vimentin (PubMed:26845719)"}],"commentType":"SUBUNIT","molecule":"Isoform 3"},{"commentType":"SUBCELLULAR LOCATION","molecule":"Isoform 1","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27926477"}],"value":"Secreted by exosomes and is located inside the exosome (PubMed:27926477). May also be secreted as free protein via an as yet unknown pathway (PubMed:27926477)"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11751870"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26845719"}],"value":"Nucleus","id":"SL-0191"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11751870"}],"value":"Cytoplasm","id":"SL-0086"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27926477"}],"value":"Secreted, extracellular exosome","id":"SL-0466"}}]},{"commentType":"SUBCELLULAR LOCATION","molecule":"Isoform 2","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27926477"}],"value":"Secreted by exosomes and is located on the outer exosome surface"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26845719"}],"value":"Nucleus","id":"SL-0191"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26845719"}],"value":"Cytoplasm","id":"SL-0086"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27926477"}],"value":"Secreted, extracellular exosome","id":"SL-0466"}}]},{"commentType":"SUBCELLULAR LOCATION","molecule":"Isoform 3","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27926477"}],"value":"Secreted by exosomes and is located on the outer exosome surface"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26845719"}],"value":"Nucleus","id":"SL-0191"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26845719"}],"value":"Cytoplasm","id":"SL-0086"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27926477"}],"value":"Secreted, extracellular exosome","id":"SL-0466"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"26845719"}],"value":"HDFG-A"}],"isoformIds":["P51858-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"26845719"}],"value":"HDGF-C"}],"isoformIds":["P51858-2"],"sequenceIds":["VSP_045620"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"26845719"}],"value":"HDGF-B"}],"isoformIds":["P51858-3"],"sequenceIds":["VSP_047328"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7929202"}],"value":"Ubiquitous"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15491618"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17270212"}],"value":"The PWWP domain harbors the heparin-binding sites and is responsible for DNA-binding, while the C-terminal region is essentially unstructured"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P51859"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26845719"}],"value":"The N-terminal region does not contain a typical signal sequence but is required for secretion (By similarity). It also determines exosomal location (PubMed:26845719)"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18331345"}],"value":"Sumoylated with SUMO1. Sumoylation prevents binding to chromatin"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P51859"}],"value":"Phosphorylation at Ser-165 is likely to be required for secretion"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the HDGF family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":240,"modifier":"EXACT"}},"description":"Hepatoma-derived growth factor","featureId":"PRO_0000191700"},{"type":"Domain","location":{"start":{"value":12,"modifier":"EXACT"},"end":{"value":69,"modifier":"EXACT"}},"description":"PWWP","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00162"}]},{"type":"Region","location":{"start":{"value":69,"modifier":"EXACT"},"end":{"value":240,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Motif","location":{"start":{"value":75,"modifier":"EXACT"},"end":{"value":80,"modifier":"EXACT"}},"description":"Nuclear localization signal","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11751870"}]},{"type":"Motif","location":{"start":{"value":155,"modifier":"EXACT"},"end":{"value":170,"modifier":"EXACT"}},"description":"Bipartite nuclear localization signal"},{"type":"Compositional bias","location":{"start":{"value":91,"modifier":"EXACT"},"end":{"value":106,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":110,"modifier":"EXACT"},"end":{"value":121,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":135,"modifier":"EXACT"},"end":{"value":173,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":180,"modifier":"EXACT"},"end":{"value":197,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":212,"modifier":"EXACT"},"end":{"value":225,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":226,"modifier":"EXACT"},"end":{"value":240,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Binding site","location":{"start":{"value":19,"modifier":"EXACT"},"end":{"value":19,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:28304"}],"evidences":[{"evidenceCode":"ECO:0000305"}],"ligand":{"name":"heparin","id":"ChEBI:CHEBI:28304"}},{"type":"Binding site","location":{"start":{"value":21,"modifier":"EXACT"},"end":{"value":21,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:28304"}],"evidences":[{"evidenceCode":"ECO:0000305"}],"ligand":{"name":"heparin","id":"ChEBI:CHEBI:28304"}},{"type":"Binding site","location":{"start":{"value":72,"modifier":"EXACT"},"end":{"value":72,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:28304"}],"evidences":[{"evidenceCode":"ECO:0000305"}],"ligand":{"name":"heparin","id":"ChEBI:CHEBI:28304"}},{"type":"Binding site","location":{"start":{"value":75,"modifier":"EXACT"},"end":{"value":75,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:28304"}],"evidences":[{"evidenceCode":"ECO:0000305"}],"ligand":{"name":"heparin","id":"ChEBI:CHEBI:28304"}},{"type":"Binding site","location":{"start":{"value":79,"modifier":"EXACT"},"end":{"value":79,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:28304"}],"evidences":[{"evidenceCode":"ECO:0000305"}],"ligand":{"name":"heparin","id":"ChEBI:CHEBI:28304"}},{"type":"Binding site","location":{"start":{"value":80,"modifier":"EXACT"},"end":{"value":80,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:28304"}],"evidences":[{"evidenceCode":"ECO:0000305"}],"ligand":{"name":"heparin","id":"ChEBI:CHEBI:28304"}},{"type":"Modified residue","location":{"start":{"value":44,"modifier":"EXACT"},"end":{"value":44,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19608861"}]},{"type":"Modified residue","location":{"start":{"value":132,"modifier":"EXACT"},"end":{"value":132,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"16807684"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"17081983"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"17487921"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18088087"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18318008"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19367720"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19690332"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]},{"type":"Modified residue","location":{"start":{"value":133,"modifier":"EXACT"},"end":{"value":133,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"16807684"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"17081983"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"17487921"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18088087"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18318008"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19367720"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]},{"type":"Modified residue","location":{"start":{"value":165,"modifier":"EXACT"},"end":{"value":165,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"15302935"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"16964243"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"17081983"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18318008"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18691976"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19367720"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19369195"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19690332"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]},{"type":"Modified residue","location":{"start":{"value":184,"modifier":"EXACT"},"end":{"value":184,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":199,"modifier":"EXACT"},"end":{"value":199,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8VHK7"}]},{"type":"Modified residue","location":{"start":{"value":200,"modifier":"EXACT"},"end":{"value":200,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"16964243"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]},{"type":"Modified residue","location":{"start":{"value":202,"modifier":"EXACT"},"end":{"value":202,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]},{"type":"Modified residue","location":{"start":{"value":206,"modifier":"EXACT"},"end":{"value":206,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"}]},{"type":"Modified residue","location":{"start":{"value":239,"modifier":"EXACT"},"end":{"value":239,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Disulfide bond","location":{"start":{"value":12,"modifier":"EXACT"},"end":{"value":108,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P51859"}]},{"type":"Cross-link","location":{"start":{"value":80,"modifier":"EXACT"},"end":{"value":80,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternate"},{"type":"Cross-link","location":{"start":{"value":80,"modifier":"EXACT"},"end":{"value":80,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"25218447"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"25772364"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":29,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"}],"featureId":"VSP_045620","alternativeSequence":{"originalSequence":"MSRSNRQKEYKCGDLVFAKMKGYPHWPAR","alternativeSequences":["MEQRAGGNRVQTSTLNCAGAAV"]}},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":29,"modifier":"EXACT"}},"description":"in isoform 3","evidences":[{"evidenceCode":"ECO:0000305"}],"featureId":"VSP_047328","alternativeSequence":{"originalSequence":"MSRSNRQKEYKCGDLVFAKMKGYPHWPAR","alternativeSequences":["MHPEGGQFVPQLLGHLLATKLKRFLLSKGGRRAQIPDVSRATPHT"]}},{"type":"Natural variant","location":{"start":{"value":201,"modifier":"EXACT"},"end":{"value":201,"modifier":"EXACT"}},"description":"in dbSNP:rs4399146","featureCrossReferences":[{"database":"dbSNP","id":"rs4399146"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14702039"}],"featureId":"VAR_061209","alternativeSequence":{"originalSequence":"P","alternativeSequences":["L"]}},{"type":"Mutagenesis","location":{"start":{"value":165,"modifier":"EXACT"},"end":{"value":165,"modifier":"EXACT"}},"description":"Abolishes secretion and alters location of the protein from inside the exosome to the exosomal surface.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27926477"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["A"]}},{"type":"Sequence conflict","location":{"start":{"value":206,"modifier":"EXACT"},"end":{"value":206,"modifier":"EXACT"}},"description":"in Ref. 2; BAG53283","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["P"]}},{"type":"Beta strand","location":{"start":{"value":7,"modifier":"EXACT"},"end":{"value":9,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1RI0"}]},{"type":"Beta strand","location":{"start":{"value":15,"modifier":"EXACT"},"end":{"value":20,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1RI0"}]},{"type":"Beta strand","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":31,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1RI0"}]},{"type":"Beta strand","location":{"start":{"value":35,"modifier":"EXACT"},"end":{"value":38,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1RI0"}]},{"type":"Beta strand","location":{"start":{"value":45,"modifier":"EXACT"},"end":{"value":49,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1RI0"}]},{"type":"Turn","location":{"start":{"value":50,"modifier":"EXACT"},"end":{"value":53,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1RI0"}]},{"type":"Beta strand","location":{"start":{"value":54,"modifier":"EXACT"},"end":{"value":58,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1RI0"}]},{"type":"Helix","location":{"start":{"value":60,"modifier":"EXACT"},"end":{"value":62,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2NLU"}]},{"type":"Helix","location":{"start":{"value":66,"modifier":"EXACT"},"end":{"value":72,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1RI0"}]},{"type":"Helix","location":{"start":{"value":80,"modifier":"EXACT"},"end":{"value":90,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1RI0"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0007","category":"PTM","name":"Acetylation"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0903","category":"Technical term","name":"Direct protein sequencing"},{"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"id":"KW-0339","category":"Molecular function","name":"Growth factor"},{"id":"KW-0358","category":"Molecular function","name":"Heparin-binding"},{"id":"KW-1017","category":"PTM","name":"Isopeptide bond"},{"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0678","category":"Molecular function","name":"Repressor"},{"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"id":"KW-0804","category":"Biological process","name":"Transcription"},{"id":"KW-0805","category":"Biological process","name":"Transcription regulation"},{"id":"KW-0832","category":"PTM","name":"Ubl conjugation"}],"references":[{"referenceNumber":1,"citation":{"id":"7929202","citationType":"journal article","authors":["Nakamura H.","Izumoto Y.","Kambe H.","Kuroda T.","Mori T.","Kawamura K.","Yamamoto H.","Kishimoto T."],"citationCrossReferences":[{"database":"PubMed","id":"7929202"},{"database":"DOI","id":"10.1016/s0021-9258(17)31509-0"}],"title":"Molecular cloning of complementary DNA for a novel human hepatoma-derived growth factor. Its homology with high mobility group-1 protein.","publicationDate":"1994","journal":"J. Biol. Chem.","firstPage":"25143","lastPage":"25149","volume":"269"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)","PROTEIN SEQUENCE OF 4-24","TISSUE SPECIFICITY"],"referenceComments":[{"value":"Hepatoma","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)","VARIANT LEU-201"]},{"referenceNumber":3,"citation":{"id":"16710414","citationType":"journal article","authors":["Gregory S.G.","Barlow K.F.","McLay K.E.","Kaul R.","Swarbreck D.","Dunham A.","Scott C.E.","Howe K.L.","Woodfine K.","Spencer C.C.A.","Jones M.C.","Gillson C.","Searle S.","Zhou Y.","Kokocinski F.","McDonald L.","Evans R.","Phillips K.","Atkinson A.","Cooper R.","Jones C.","Hall R.E.","Andrews T.D.","Lloyd C.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Anderson F.","Andrew R.W.","Ashwell R.I.S.","Aubin K.","Babbage A.K.","Bagguley C.L.","Bailey J.","Beasley H.","Bethel G.","Bird C.P.","Bray-Allen S.","Brown J.Y.","Brown A.J.","Buckley D.","Burton J.","Bye J.","Carder C.","Chapman J.C.","Clark S.Y.","Clarke G.","Clee C.","Cobley V.","Collier R.E.","Corby N.","Coville G.J.","Davies J.","Deadman R.","Dunn M.","Earthrowl M.","Ellington A.G.","Errington H.","Frankish A.","Frankland J.","French L.","Garner P.","Garnett J.","Gay L.","Ghori M.R.J.","Gibson R.","Gilby L.M.","Gillett W.","Glithero R.J.","Grafham D.V.","Griffiths C.","Griffiths-Jones S.","Grocock R.","Hammond S.","Harrison E.S.I.","Hart E.","Haugen E.","Heath P.D.","Holmes S.","Holt K.","Howden P.J.","Hunt A.R.","Hunt S.E.","Hunter G.","Isherwood J.","James R.","Johnson C.","Johnson D.","Joy A.","Kay M.","Kershaw J.K.","Kibukawa M.","Kimberley A.M.","King A.","Knights A.J.","Lad H.","Laird G.","Lawlor S.","Leongamornlert D.A.","Lloyd D.M.","Loveland J.","Lovell J.","Lush M.J.","Lyne R.","Martin S.","Mashreghi-Mohammadi M.","Matthews L.","Matthews N.S.W.","McLaren S.","Milne S.","Mistry S.","Moore M.J.F.","Nickerson T.","O'Dell C.N.","Oliver K.","Palmeiri A.","Palmer S.A.","Parker A.","Patel D.","Pearce A.V.","Peck A.I.","Pelan S.","Phelps K.","Phillimore B.J.","Plumb R.","Rajan J.","Raymond C.","Rouse G.","Saenphimmachak C.","Sehra H.K.","Sheridan E.","Shownkeen R.","Sims S.","Skuce C.D.","Smith M.","Steward C.","Subramanian S.","Sycamore N.","Tracey A.","Tromans A.","Van Helmond Z.","Wall M.","Wallis J.M.","White S.","Whitehead S.L.","Wilkinson J.E.","Willey D.L.","Williams H.","Wilming L.","Wray P.W.","Wu Z.","Coulson A.","Vaudin M.","Sulston J.E.","Durbin R.M.","Hubbard T.","Wooster R.","Dunham I.","Carter N.P.","McVean G.","Ross M.T.","Harrow J.","Olson M.V.","Beck S.","Rogers J.","Bentley D.R."],"citationCrossReferences":[{"database":"PubMed","id":"16710414"},{"database":"DOI","id":"10.1038/nature04727"}],"title":"The DNA sequence and biological annotation of human chromosome 1.","publicationDate":"2006","journal":"Nature","firstPage":"315","lastPage":"321","volume":"441"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":4,"citation":{"id":"CI-5GBD0VIIJ7C63","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"SEP-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":5,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":6,"citation":{"id":"11751870","citationType":"journal article","authors":["Kishima Y.","Yamamoto H.","Izumoto Y.","Yoshida K.","Enomoto H.","Yamamoto M.","Kuroda T.","Ito H.","Yoshizaki K.","Nakamura H."],"citationCrossReferences":[{"database":"PubMed","id":"11751870"},{"database":"DOI","id":"10.1074/jbc.m111122200"}],"title":"Hepatoma-derived growth factor stimulates cell growth after translocation to the nucleus by nuclear localization signals.","publicationDate":"2002","journal":"J. Biol. Chem.","firstPage":"10315","lastPage":"10322","volume":"277"},"referencePositions":["SUBCELLULAR LOCATION (ISOFORM 1)","NUCLEAR LOCALIZATION SIGNAL"]},{"referenceNumber":7,"citation":{"id":"15302935","citationType":"journal article","authors":["Beausoleil S.A.","Jedrychowski M.","Schwartz D.","Elias J.E.","Villen J.","Li J.","Cohn M.A.","Cantley L.C.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"15302935"},{"database":"DOI","id":"10.1073/pnas.0404720101"}],"title":"Large-scale characterization of HeLa cell nuclear phosphoproteins.","publicationDate":"2004","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"12130","lastPage":"12135","volume":"101"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-165","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":8,"citation":{"id":"17081983","citationType":"journal article","authors":["Olsen J.V.","Blagoev B.","Gnad F.","Macek B.","Kumar C.","Mortensen P.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"17081983"},{"database":"DOI","id":"10.1016/j.cell.2006.09.026"}],"title":"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.","publicationDate":"2006","journal":"Cell","firstPage":"635","lastPage":"648","volume":"127"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-132; SER-133 AND SER-165","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":9,"citation":{"id":"16964243","citationType":"journal article","authors":["Beausoleil S.A.","Villen J.","Gerber S.A.","Rush J.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"16964243"},{"database":"DOI","id":"10.1038/nbt1240"}],"title":"A probability-based approach for high-throughput protein phosphorylation analysis and site localization.","publicationDate":"2006","journal":"Nat. Biotechnol.","firstPage":"1285","lastPage":"1292","volume":"24"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-165 AND THR-200","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":10,"citation":{"id":"16807684","citationType":"journal article","authors":["Beranova-Giorgianni S.","Zhao Y.","Desiderio D.M.","Giorgianni F."],"citationCrossReferences":[{"database":"PubMed","id":"16807684"},{"database":"DOI","id":"10.1007/s11102-006-8916-x"}],"title":"Phosphoproteomic analysis of the human pituitary.","publicationDate":"2006","journal":"Pituitary","firstPage":"109","lastPage":"120","volume":"9"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-132 AND SER-133","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Pituitary","type":"TISSUE"}]},{"referenceNumber":11,"citation":{"id":"17974029","citationType":"journal article","authors":["Yang J.","Everett A.D."],"citationCrossReferences":[{"database":"PubMed","id":"17974029"},{"database":"DOI","id":"10.1186/1471-2199-8-101"}],"title":"Hepatoma-derived growth factor binds DNA through the N-terminal PWWP domain.","publicationDate":"2007","journal":"BMC Mol. Biol.","firstPage":"101","lastPage":"101","volume":"8"},"referencePositions":["FUNCTION","SUBCELLULAR LOCATION","DNA-BINDING"]},{"referenceNumber":12,"citation":{"id":"17487921","citationType":"journal article","authors":["Giorgianni F.","Zhao Y.","Desiderio D.M.","Beranova-Giorgianni S."],"citationCrossReferences":[{"database":"PubMed","id":"17487921"},{"database":"DOI","id":"10.1002/elps.200600782"}],"title":"Toward a global characterization of the phosphoproteome in prostate cancer cells: identification of phosphoproteins in the LNCaP cell line.","publicationDate":"2007","journal":"Electrophoresis","firstPage":"2027","lastPage":"2034","volume":"28"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-132 AND SER-133","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Prostate cancer","type":"TISSUE"}]},{"referenceNumber":13,"citation":{"id":"18331345","citationType":"journal article","authors":["Thakar K.","Niedenthal R.","Okaz E.","Franken S.","Jakobs A.","Gupta S.","Kelm S.","Dietz F."],"citationCrossReferences":[{"database":"PubMed","id":"18331345"},{"database":"DOI","id":"10.1111/j.1742-4658.2008.06303.x"}],"title":"SUMOylation of the hepatoma-derived growth factor negatively influences its binding to chromatin.","publicationDate":"2008","journal":"FEBS J.","firstPage":"1411","lastPage":"1426","volume":"275"},"referencePositions":["SUMOYLATION AT LYS-80"]},{"referenceNumber":14,"citation":{"id":"19367720","citationType":"journal article","authors":["Carrascal M.","Ovelleiro D.","Casas V.","Gay M.","Abian J."],"citationCrossReferences":[{"database":"PubMed","id":"19367720"},{"database":"DOI","id":"10.1021/pr800500r"}],"title":"Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.","publicationDate":"2008","journal":"J. Proteome Res.","firstPage":"5167","lastPage":"5176","volume":"7"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-132; SER-133 AND SER-165","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"T-cell","type":"TISSUE"}]},{"referenceNumber":15,"citation":{"id":"18088087","citationType":"journal article","authors":["Zahedi R.P.","Lewandrowski U.","Wiesner J.","Wortelkamp S.","Moebius J.","Schuetz C.","Walter U.","Gambaryan S.","Sickmann A."],"citationCrossReferences":[{"database":"PubMed","id":"18088087"},{"database":"DOI","id":"10.1021/pr0704130"}],"title":"Phosphoproteome of resting human platelets.","publicationDate":"2008","journal":"J. Proteome Res.","firstPage":"526","lastPage":"534","volume":"7"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-132 AND SER-133","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Platelet","type":"TISSUE"}]},{"referenceNumber":16,"citation":{"id":"18691976","citationType":"journal article","authors":["Daub H.","Olsen J.V.","Bairlein M.","Gnad F.","Oppermann F.S.","Korner R.","Greff Z.","Keri G.","Stemmann O.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"18691976"},{"database":"DOI","id":"10.1016/j.molcel.2008.07.007"}],"title":"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.","publicationDate":"2008","journal":"Mol. Cell","firstPage":"438","lastPage":"448","volume":"31"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-165","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":17,"citation":{"id":"18669648","citationType":"journal article","authors":["Dephoure N.","Zhou C.","Villen J.","Beausoleil S.A.","Bakalarski C.E.","Elledge S.J.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"18669648"},{"database":"DOI","id":"10.1073/pnas.0805139105"}],"title":"A quantitative atlas of mitotic phosphorylation.","publicationDate":"2008","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"10762","lastPage":"10767","volume":"105"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-200; SER-206 AND SER-239","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":18,"citation":{"id":"18318008","citationType":"journal article","authors":["Han G.","Ye M.","Zhou H.","Jiang X.","Feng S.","Jiang X.","Tian R.","Wan D.","Zou H.","Gu J."],"citationCrossReferences":[{"database":"PubMed","id":"18318008"},{"database":"DOI","id":"10.1002/pmic.200700884"}],"title":"Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.","publicationDate":"2008","journal":"Proteomics","firstPage":"1346","lastPage":"1361","volume":"8"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-132; SER-133 AND SER-165","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":19,"citation":{"id":"19413330","citationType":"journal article","authors":["Gauci S.","Helbig A.O.","Slijper M.","Krijgsveld J.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"19413330"},{"database":"DOI","id":"10.1021/ac9004309"}],"title":"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.","publicationDate":"2009","journal":"Anal. Chem.","firstPage":"4493","lastPage":"4501","volume":"81"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":20,"citation":{"id":"19369195","citationType":"journal article","authors":["Oppermann F.S.","Gnad F.","Olsen J.V.","Hornberger R.","Greff Z.","Keri G.","Mann M.","Daub H."],"citationCrossReferences":[{"database":"PubMed","id":"19369195"},{"database":"DOI","id":"10.1074/mcp.m800588-mcp200"}],"title":"Large-scale proteomics analysis of the human kinome.","publicationDate":"2009","journal":"Mol. Cell. Proteomics","firstPage":"1751","lastPage":"1764","volume":"8"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-165","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":21,"citation":{"id":"19690332","citationType":"journal article","authors":["Mayya V.","Lundgren D.H.","Hwang S.-I.","Rezaul K.","Wu L.","Eng J.K.","Rodionov V.","Han D.K."],"citationCrossReferences":[{"database":"PubMed","id":"19690332"},{"database":"DOI","id":"10.1126/scisignal.2000007"}],"title":"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.","publicationDate":"2009","journal":"Sci. Signal.","firstPage":"RA46","lastPage":"RA46","volume":"2"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-132 AND SER-165","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Leukemic T-cell","type":"TISSUE"}]},{"referenceNumber":22,"citation":{"id":"19608861","citationType":"journal article","authors":["Choudhary C.","Kumar C.","Gnad F.","Nielsen M.L.","Rehman M.","Walther T.C.","Olsen J.V.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"19608861"},{"database":"DOI","id":"10.1126/science.1175371"}],"title":"Lysine acetylation targets protein complexes and co-regulates major cellular functions.","publicationDate":"2009","journal":"Science","firstPage":"834","lastPage":"840","volume":"325"},"referencePositions":["ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-44","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":23,"citation":{"id":"20068231","citationType":"journal article","authors":["Olsen J.V.","Vermeulen M.","Santamaria A.","Kumar C.","Miller M.L.","Jensen L.J.","Gnad F.","Cox J.","Jensen T.S.","Nigg E.A.","Brunak S.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"20068231"},{"database":"DOI","id":"10.1126/scisignal.2000475"}],"title":"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.","publicationDate":"2010","journal":"Sci. Signal.","firstPage":"RA3","lastPage":"RA3","volume":"3"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-133; SER-165; THR-200 AND SER-239","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":24,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Buerckstuemmer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":25,"citation":{"id":"21406692","citationType":"journal article","authors":["Rigbolt K.T.","Prokhorova T.A.","Akimov V.","Henningsen J.","Johansen P.T.","Kratchmarova I.","Kassem M.","Mann M.","Olsen J.V.","Blagoev B."],"citationCrossReferences":[{"database":"PubMed","id":"21406692"},{"database":"DOI","id":"10.1126/scisignal.2001570"}],"title":"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.","publicationDate":"2011","journal":"Sci. Signal.","firstPage":"RS3","lastPage":"RS3","volume":"4"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-165","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":26,"citation":{"id":"23186163","citationType":"journal article","authors":["Zhou H.","Di Palma S.","Preisinger C.","Peng M.","Polat A.N.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"23186163"},{"database":"DOI","id":"10.1021/pr300630k"}],"title":"Toward a comprehensive characterization of a human cancer cell phosphoproteome.","publicationDate":"2013","journal":"J. Proteome Res.","firstPage":"260","lastPage":"271","volume":"12"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-132; SER-133; SER-165; THR-184 AND SER-239","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"},{"value":"Erythroleukemia","type":"TISSUE"}]},{"referenceNumber":27,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-132; SER-133; SER-165; THR-200 AND SER-202","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":28,"citation":{"id":"25218447","citationType":"journal article","authors":["Hendriks I.A.","D'Souza R.C.","Yang B.","Verlaan-de Vries M.","Mann M.","Vertegaal A.C."],"citationCrossReferences":[{"database":"PubMed","id":"25218447"},{"database":"DOI","id":"10.1038/nsmb.2890"}],"title":"Uncovering global SUMOylation signaling networks in a site-specific manner.","publicationDate":"2014","journal":"Nat. Struct. Mol. Biol.","firstPage":"927","lastPage":"936","volume":"21"},"referencePositions":["SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-80","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":29,"citation":{"id":"25114211","citationType":"journal article","authors":["Impens F.","Radoshevich L.","Cossart P.","Ribet D."],"citationCrossReferences":[{"database":"PubMed","id":"25114211"},{"database":"DOI","id":"10.1073/pnas.1413825111"}],"title":"Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.","publicationDate":"2014","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"12432","lastPage":"12437","volume":"111"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":30,"citation":{"id":"25772364","citationType":"journal article","authors":["Hendriks I.A.","Treffers L.W.","Verlaan-de Vries M.","Olsen J.V.","Vertegaal A.C."],"citationCrossReferences":[{"database":"PubMed","id":"25772364"},{"database":"DOI","id":"10.1016/j.celrep.2015.02.033"}],"title":"SUMO-2 orchestrates chromatin modifiers in response to DNA damage.","publicationDate":"2015","journal":"Cell Rep.","firstPage":"1778","lastPage":"1791","volume":"10"},"referencePositions":["SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-80","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":31,"citation":{"id":"26845719","citationType":"journal article","authors":["Nuesse J.","Mirastschijski U.","Waespy M.","Oetjen J.","Brandes N.","Rebello O.","Paroni F.","Kelm S.","Dietz F."],"citationCrossReferences":[{"database":"PubMed","id":"26845719"},{"database":"DOI","id":"10.1515/hsz-2015-0273"}],"title":"Two new isoforms of the human hepatoma-derived growth factor interact with components of the cytoskeleton.","publicationDate":"2016","journal":"Biol. Chem.","firstPage":"417","lastPage":"436","volume":"397"},"referencePositions":["ALTERNATIVE SPLICING","FUNCTION","INTERACTION WITH ACTIN; DYNEIN; TUBULIN; VIMENTIN; NCL AND YBX1","SUBCELLULAR LOCATION","DOMAIN"]},{"referenceNumber":32,"citation":{"id":"27926477","citationType":"journal article","authors":["Nuesse J.","Blumrich E.M.","Mirastschijski U.","Kappelmann L.","Kelm S.","Dietz F."],"citationCrossReferences":[{"database":"PubMed","id":"27926477"},{"database":"DOI","id":"10.1515/hsz-2016-0315"}],"title":"Intra- or extra-exosomal secretion of HDGF isoforms: the extraordinary function of the HDGF-A N-terminal peptide.","publicationDate":"2017","journal":"Biol. Chem.","firstPage":"793","lastPage":"811","volume":"398"},"referencePositions":["SUBCELLULAR LOCATION","MUTAGENESIS OF SER-165"]},{"referenceNumber":33,"citation":{"id":"28112733","citationType":"journal article","authors":["Hendriks I.A.","Lyon D.","Young C.","Jensen L.J.","Vertegaal A.C.","Nielsen M.L."],"citationCrossReferences":[{"database":"PubMed","id":"28112733"},{"database":"DOI","id":"10.1038/nsmb.3366"}],"title":"Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.","publicationDate":"2017","journal":"Nat. Struct. Mol. Biol.","firstPage":"325","lastPage":"336","volume":"24"},"referencePositions":["SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-80","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":34,"citation":{"id":"17270212","citationType":"journal article","authors":["Sue S.C.","Lee W.T.","Tien S.C.","Lee S.C.","Yu J.G.","Wu W.J.","Wu W.G.","Huang T.-H."],"citationCrossReferences":[{"database":"PubMed","id":"17270212"},{"database":"DOI","id":"10.1016/j.jmb.2007.01.010"}],"title":"PWWP module of human hepatoma-derived growth factor forms a domain-swapped dimer with much higher affinity for heparin.","publicationDate":"2007","journal":"J. Mol. Biol.","firstPage":"456","lastPage":"472","volume":"367"},"referencePositions":["STRUCTURE BY NMR OF 1-100","SUBUNIT","DOMAIN"]},{"referenceNumber":35,"citation":{"id":"15491618","citationType":"journal article","authors":["Sue S.C.","Chen J.Y.","Lee S.C.","Wu W.G.","Huang T.-H."],"citationCrossReferences":[{"database":"PubMed","id":"15491618"},{"database":"DOI","id":"10.1016/j.jmb.2004.09.014"}],"title":"Solution structure and heparin interaction of human hepatoma-derived growth factor.","publicationDate":"2004","journal":"J. Mol. Biol.","firstPage":"1365","lastPage":"1377","volume":"343"},"referencePositions":["STRUCTURE BY NMR OF 1-100","FUNCTION","HEPARIN-BINDING SITES","DOMAIN"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"D16431","properties":[{"key":"ProteinId","value":"BAA03903.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK096411","properties":[{"key":"ProteinId","value":"BAG53283.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AL590666","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471121","properties":[{"key":"ProteinId","value":"EAW52910.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471121","properties":[{"key":"ProteinId","value":"EAW52911.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471121","properties":[{"key":"ProteinId","value":"EAW52912.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC018991","properties":[{"key":"ProteinId","value":"AAH18991.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS1156.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P51858-1"},{"database":"CCDS","id":"CCDS44247.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P51858-3"},{"database":"CCDS","id":"CCDS44248.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P51858-2"},{"database":"PIR","id":"A55055","properties":[{"key":"EntryName","value":"A55055"}]},{"database":"RefSeq","id":"NP_001119522.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001126050.2"}],"isoformId":"P51858-3"},{"database":"RefSeq","id":"NP_001119523.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001126051.1"}],"isoformId":"P51858-2"},{"database":"RefSeq","id":"NP_001306115.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001319186.2"}]},{"database":"RefSeq","id":"NP_001306116.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001319187.2"}]},{"database":"RefSeq","id":"NP_001306117.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001319188.2"}]},{"database":"RefSeq","id":"NP_004485.1","properties":[{"key":"NucleotideSequenceId","value":"NM_004494.3"}],"isoformId":"P51858-1"},{"database":"PDB","id":"1RI0","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=1-100"}]},{"database":"PDB","id":"2NLU","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A/B=1-100"}]},{"database":"PDBsum","id":"1RI0","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2NLU","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"P51858","properties":[{"key":"Description","value":"-"}]},{"database":"BMRB","id":"P51858","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P51858","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"109318","properties":[{"key":"Interactions","value":"337"}]},{"database":"CORUM","id":"P51858","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"P51858","properties":[{"key":"Number of interactors","value":"894"}]},{"database":"IntAct","id":"P51858","properties":[{"key":"Interactions","value":"141"}]},{"database":"MINT","id":"P51858","properties":[{"key":"Description","value":"-"}]},{"database":"STRING","id":"9606.ENSP00000357189","properties":[{"key":"Description","value":"-"}]},{"database":"BindingDB","id":"P51858","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL5724677","properties":[{"key":"Description","value":"-"}]},{"database":"DrugBank","id":"DB09130","properties":[{"key":"GenericName","value":"Copper"}]},{"database":"GlyGen","id":"P51858","properties":[{"key":"glycosylation","value":"1 site, 1 O-linked glycan (1 site)"}]},{"database":"iPTMnet","id":"P51858","properties":[{"key":"Description","value":"-"}]},{"database":"MetOSite","id":"P51858","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"P51858","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"P51858","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"HDGF","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"1708157","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"P51858","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"P51858","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000357189","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"P51858","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"56439","properties":[{"key":"Description","value":"-"}],"isoformId":"P51858-1"},{"database":"ProteomicsDB","id":"64044","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"64045","properties":[{"key":"Description","value":"-"}]},{"database":"Pumba","id":"P51858","properties":[{"key":"Description","value":"-"}]},{"database":"TopDownProteomics","id":"P51858-1","properties":[{"key":"Description","value":"-"}],"isoformId":"P51858-1"},{"database":"TopDownProteomics","id":"P51858-2","properties":[{"key":"Description","value":"-"}],"isoformId":"P51858-2"},{"database":"Antibodypedia","id":"34226","properties":[{"key":"antibodies","value":"397 antibodies from 41 providers"}]},{"database":"DNASU","id":"3068","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000357325.10","properties":[{"key":"ProteinId","value":"ENSP00000349878.5"},{"key":"GeneId","value":"ENSG00000143321.19"}],"isoformId":"P51858-1"},{"database":"Ensembl","id":"ENST00000368206.5","properties":[{"key":"ProteinId","value":"ENSP00000357189.5"},{"key":"GeneId","value":"ENSG00000143321.19"}],"isoformId":"P51858-3"},{"database":"Ensembl","id":"ENST00000368209.9","properties":[{"key":"ProteinId","value":"ENSP00000357192.5"},{"key":"GeneId","value":"ENSG00000143321.19"}],"isoformId":"P51858-2"},{"database":"GeneID","id":"3068","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:3068","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000357325.10","properties":[{"key":"ProteinId","value":"ENSP00000349878.5"},{"key":"RefSeqNucleotideId","value":"NM_004494.3"},{"key":"RefSeqProteinId","value":"NP_004485.1"}]},{"database":"UCSC","id":"uc001fpy.5","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"P51858-1"},{"database":"AGR","id":"HGNC:4856","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA29234","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"3068","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"3068","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"HDGF","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:4856","properties":[{"key":"GeneName","value":"HDGF"}]},{"database":"HPA","id":"ENSG00000143321","properties":[{"key":"ExpressionPatterns","value":"Low tissue specificity"}]},{"database":"MIM","id":"600339","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000143321","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000143321","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG1904","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000157485","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_090867_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P51858","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"KWTRGEF","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"62853at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"P51858","properties":[{"key":"Number of GO annotations","value":"2 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"P51858","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"P51858","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-381038","properties":[{"key":"PathwayName","value":"XBP1(S) activates chaperone genes"}]},{"database":"SignaLink","id":"P51858","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000143321","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"3068","properties":[{"key":"hits","value":"19 hits in 1170 CRISPR screens"}]},{"database":"ChiTaRS","id":"HDGF","properties":[{"key":"OrganismName","value":"human"}]},{"database":"EvolutionaryTrace","id":"P51858","properties":[{"key":"Description","value":"-"}]},{"database":"GeneWiki","id":"Hepatoma-derived_growth_factor","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"3068","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"P51858","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:P51858","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 1"}]},{"database":"RNAct","id":"P51858","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000143321","properties":[{"key":"ExpressionPatterns","value":"Expressed in endometrium epithelium and 204 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"P51858","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11751870"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26845719"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"HDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"20551380"},{"evidenceCode":"ECO:0007005","source":"PubMed","id":"27068509"},{"evidenceCode":"ECO:0007005","source":"PubMed","id":"27559042"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11751870"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26845719"}]},{"database":"GO","id":"GO:0017053","properties":[{"key":"GoTerm","value":"C:transcription repressor complex"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19162039"}]},{"database":"GO","id":"GO:0003779","properties":[{"key":"GoTerm","value":"F:actin binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}]},{"database":"GO","id":"GO:0001227","properties":[{"key":"GoTerm","value":"F:DNA-binding transcription repressor activity, RNA polymerase II-specific"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0008201","properties":[{"key":"GoTerm","value":"F:heparin binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"7929202"}]},{"database":"GO","id":"GO:0003723","properties":[{"key":"GoTerm","value":"F:RNA binding"},{"key":"GoEvidenceType","value":"HDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"22658674"}]},{"database":"GO","id":"GO:0000978","properties":[{"key":"GoTerm","value":"F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0003714","properties":[{"key":"GoTerm","value":"F:transcription corepressor activity"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19162039"}]},{"database":"GO","id":"GO:0001222","properties":[{"key":"GoTerm","value":"F:transcription corepressor binding"},{"key":"GoEvidenceType","value":"IPI:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"19162039"}]},{"database":"GO","id":"GO:0015631","properties":[{"key":"GoTerm","value":"F:tubulin binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}]},{"database":"GO","id":"GO:0006338","properties":[{"key":"GoTerm","value":"P:chromatin remodeling"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0000122","properties":[{"key":"GoTerm","value":"P:negative regulation of transcription by RNA polymerase II"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19162039"}]},{"database":"GO","id":"GO:0051781","properties":[{"key":"GoTerm","value":"P:positive regulation of cell division"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}]},{"database":"GO","id":"GO:0045944","properties":[{"key":"GoTerm","value":"P:positive regulation of transcription by RNA polymerase II"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0034504","properties":[{"key":"GoTerm","value":"P:protein localization to nucleus"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0007165","properties":[{"key":"GoTerm","value":"P:signal transduction"},{"key":"GoEvidenceType","value":"NAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"7929202"}]},{"database":"FunFam","id":"2.30.30.140:FF:000017","properties":[{"key":"EntryName","value":"hepatoma-derived growth factor isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.30.30.140","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"IDEAL","id":"IID00454","properties":[{"key":"Description","value":"-"}]},{"database":"InterPro","id":"IPR000313","properties":[{"key":"EntryName","value":"PWWP_dom"}]},{"database":"PANTHER","id":"PTHR12550:SF41","properties":[{"key":"EntryName","value":"HEPATOMA-DERIVED GROWTH FACTOR"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR12550","properties":[{"key":"EntryName","value":"HEPATOMA-DERIVED GROWTH FACTOR-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00855","properties":[{"key":"EntryName","value":"PWWP"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00293","properties":[{"key":"EntryName","value":"PWWP"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF63748","properties":[{"key":"EntryName","value":"Tudor/PWWP/MBT"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50812","properties":[{"key":"EntryName","value":"PWWP"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSRSNRQKEYKCGDLVFAKMKGYPHWPARIDEMPEAAVKSTANKYQVFFFGTHETAFLGPKDLFPYEESKEKFGKPNKRKGFSEGLWEIENNPTVKASGYQSSQKKSCVEEPEPEPEAAEGDGDKKGNAEGSSDEEGKLVIDEPAKEKNEKGALKRRAGDLLEDSPKRPKEAENPEGEEKEAATLEVERPLPMEVEKNSTPSEPGSGRGPPQEEEEEEDEEEEATKEDAEAPGIRDHESL","length":240,"molWeight":26788,"crc64":"DD60D9203BDD4B34","md5":"231E021BFAB75D30C287F931E8711D4E"},"extraAttributes":{"countByCommentType":{"FUNCTION":3,"SUBUNIT":4,"SUBCELLULAR LOCATION":3,"ALTERNATIVE PRODUCTS":3,"TISSUE SPECIFICITY":1,"DOMAIN":2,"PTM":2,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Domain":1,"Region":1,"Motif":2,"Compositional bias":6,"Binding site":6,"Modified residue":10,"Disulfide bond":1,"Cross-link":2,"Alternative sequence":2,"Natural variant":1,"Mutagenesis":1,"Sequence conflict":1,"Beta strand":6,"Turn":1,"Helix":3},"uniParcId":"UPI0000044935"}}