{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P51825","secondaryAccessions":["B4DTU1","E9PBM3"],"uniProtkbId":"AFF1_HUMAN","entryAudit":{"firstPublicDate":"1996-10-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1996-10-01","entryVersion":198,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"AF4/FMR2 family member 1"}},"alternativeNames":[{"fullName":{"value":"ALL1-fused gene from chromosome 4 protein"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"1423625"}],"value":"Protein AF-4"}]},{"fullName":{"value":"Protein FEL"}},{"fullName":{"value":"Proto-oncogene AF4"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:7135"}],"value":"AFF1"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:7135"}],"value":"AF4"},{"value":"FEL"},{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:7135"}],"value":"MLLT2"},{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:7135"}],"value":"PBM1"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"41062835"}],"value":"Plays an essential role in the activation of transcription elongation from RNA polymerase II promoters, after transcriptional pausing in response to DNA damage. Upon DNA damage, AFF1-mediated transcriptional recovery requires AFF1 poly-ADP-ribosylation by PARP1"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22195968"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23260655"}],"value":"Component of the super elongation complex (SEC), at least composed of EAF1, EAF2, CDK9, MLLT3/AF9, AFF (AFF1 or AFF4), the P-TEFb complex and ELL (ELL, ELL2 or ELL3)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P51825","intActId":"EBI-2610180"},"interactantTwo":{"uniProtKBAccession":"P42568","geneName":"MLLT3","intActId":"EBI-716132"},"numberOfExperiments":7,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P51825","intActId":"EBI-2610180"},"interactantTwo":{"uniProtKBAccession":"P04608","geneName":"tat","intActId":"EBI-6164389"},"numberOfExperiments":3,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"P51825-3","intActId":"EBI-24213872"},"interactantTwo":{"uniProtKBAccession":"P53367","geneName":"ARFIP1","intActId":"EBI-2808808"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"41062835"}],"value":"Associates with chromatin and is recruited to DNA damage sites in a PARP1-dependent manner"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"41062835"}],"value":"Nucleus","id":"SL-0191"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["P51825-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["P51825-2"],"sequenceIds":["VSP_046095","VSP_046096"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"isoformIds":["P51825-3"],"sequenceIds":["VSP_046096"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"41062835"}],"value":"Ubiquitinated by SIAH1"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"41062835"}],"value":"Poly-ADP-ribosylated by PARP1 on serine residues between aminoacids 601-900 in response to DNA damage; poly-ADP-ribosylation by PARP1 enhances AFF1 stability after DNA damage by preventing SIAH1-mediated ubiquitination and degradation"}],"commentType":"PTM"},{"commentType":"DISEASE","note":{"texts":[{"value":"A chromosomal aberration involving AFF1 is associated with acute leukemias. Translocation t(4;11)(q21;q23) with KMT2A/MLL1. The result is a rogue activator protein"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the AF4 family"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Frameshift","sequence":"AAA36642.1","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"WEB RESOURCE","resourceName":"Atlas of Genetics and Cytogenetics in Oncology and Haematology","resourceUrl":"https://atlasgeneticsoncology.org/gene/3/AF4","ftp":false}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1210,"modifier":"EXACT"}},"description":"AF4/FMR2 family member 1","featureId":"PRO_0000215910"},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":45,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":73,"modifier":"EXACT"},"end":{"value":314,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":366,"modifier":"EXACT"},"end":{"value":957,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":601,"modifier":"EXACT"},"end":{"value":900,"modifier":"EXACT"}},"description":"Required for recruitment to DNA damage sites. Required for interaction with PARP1 and poly-ADP-ribosylation","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"41062835"}]},{"type":"Region","location":{"start":{"value":1098,"modifier":"EXACT"},"end":{"value":1119,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":9,"modifier":"EXACT"},"end":{"value":35,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":78,"modifier":"EXACT"},"end":{"value":87,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":215,"modifier":"EXACT"},"end":{"value":238,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":245,"modifier":"EXACT"},"end":{"value":259,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":267,"modifier":"EXACT"},"end":{"value":279,"modifier":"EXACT"}},"description":"Pro residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":394,"modifier":"EXACT"},"end":{"value":419,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":423,"modifier":"EXACT"},"end":{"value":439,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":442,"modifier":"EXACT"},"end":{"value":453,"modifier":"EXACT"}},"description":"Pro residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":454,"modifier":"EXACT"},"end":{"value":472,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":473,"modifier":"EXACT"},"end":{"value":497,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":536,"modifier":"EXACT"},"end":{"value":546,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":586,"modifier":"EXACT"},"end":{"value":602,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":688,"modifier":"EXACT"},"end":{"value":699,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":707,"modifier":"EXACT"},"end":{"value":724,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":732,"modifier":"EXACT"},"end":{"value":747,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":816,"modifier":"EXACT"},"end":{"value":834,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":871,"modifier":"EXACT"},"end":{"value":880,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":906,"modifier":"EXACT"},"end":{"value":932,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1110,"modifier":"EXACT"},"end":{"value":1119,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Modified residue","location":{"start":{"value":199,"modifier":"EXACT"},"end":{"value":199,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"O88573"}]},{"type":"Modified residue","location":{"start":{"value":206,"modifier":"EXACT"},"end":{"value":206,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18691976"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19369195"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19690332"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"}]},{"type":"Modified residue","location":{"start":{"value":212,"modifier":"EXACT"},"end":{"value":212,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18691976"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19369195"}]},{"type":"Modified residue","location":{"start":{"value":220,"modifier":"EXACT"},"end":{"value":220,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"}]},{"type":"Modified residue","location":{"start":{"value":588,"modifier":"EXACT"},"end":{"value":588,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19369195"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":612,"modifier":"EXACT"},"end":{"value":612,"modifier":"EXACT"}},"description":"ADP-ribosylserine; by PARP1","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"41062835"}]},{"type":"Modified residue","location":{"start":{"value":634,"modifier":"EXACT"},"end":{"value":634,"modifier":"EXACT"}},"description":"ADP-ribosylserine; by PARP1","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"41062835"}]},{"type":"Modified residue","location":{"start":{"value":639,"modifier":"EXACT"},"end":{"value":639,"modifier":"EXACT"}},"description":"ADP-ribosylserine; by PARP1","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"41062835"}]},{"type":"Modified residue","location":{"start":{"value":674,"modifier":"EXACT"},"end":{"value":674,"modifier":"EXACT"}},"description":"ADP-ribosylserine; by PARP1","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"41062835"}]},{"type":"Modified residue","location":{"start":{"value":675,"modifier":"EXACT"},"end":{"value":675,"modifier":"EXACT"}},"description":"ADP-ribosylserine; by PARP1","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"41062835"}]},{"type":"Modified residue","location":{"start":{"value":681,"modifier":"EXACT"},"end":{"value":681,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19608861"}]},{"type":"Modified residue","location":{"start":{"value":697,"modifier":"EXACT"},"end":{"value":697,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18691976"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"}]},{"type":"Modified residue","location":{"start":{"value":715,"modifier":"EXACT"},"end":{"value":715,"modifier":"EXACT"}},"description":"ADP-ribosylserine; by PARP1","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"41062835"}]},{"type":"Modified residue","location":{"start":{"value":750,"modifier":"EXACT"},"end":{"value":750,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19369195"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19690332"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":755,"modifier":"EXACT"},"end":{"value":755,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"}]},{"type":"Modified residue","location":{"start":{"value":781,"modifier":"EXACT"},"end":{"value":781,"modifier":"EXACT"}},"description":"ADP-ribosylserine; by PARP1","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"41062835"}]},{"type":"Modified residue","location":{"start":{"value":808,"modifier":"EXACT"},"end":{"value":808,"modifier":"EXACT"}},"description":"ADP-ribosylserine; by PARP1","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"41062835"}]},{"type":"Modified residue","location":{"start":{"value":837,"modifier":"EXACT"},"end":{"value":837,"modifier":"EXACT"}},"description":"ADP-ribosylserine; by PARP1","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"41062835"}]},{"type":"Modified residue","location":{"start":{"value":838,"modifier":"EXACT"},"end":{"value":838,"modifier":"EXACT"}},"description":"ADP-ribosylserine; by PARP1","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"41062835"}]},{"type":"Modified residue","location":{"start":{"value":839,"modifier":"EXACT"},"end":{"value":839,"modifier":"EXACT"}},"description":"ADP-ribosylserine; by PARP1","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"41062835"}]},{"type":"Modified residue","location":{"start":{"value":857,"modifier":"EXACT"},"end":{"value":857,"modifier":"EXACT"}},"description":"ADP-ribosylserine; by PARP1","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"41062835"}]},{"type":"Modified residue","location":{"start":{"value":859,"modifier":"EXACT"},"end":{"value":859,"modifier":"EXACT"}},"description":"ADP-ribosylserine; by PARP1","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"41062835"}]},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":5,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"}],"featureId":"VSP_046095","alternativeSequence":{"originalSequence":"MAAQS","alternativeSequences":["MAFTERVNSSGN"]}},{"type":"Alternative sequence","location":{"start":{"value":1096,"modifier":"EXACT"},"end":{"value":1096,"modifier":"EXACT"}},"description":"in isoform 2 and isoform 3","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"8443374"}],"featureId":"VSP_046096","alternativeSequence":{"originalSequence":"A","alternativeSequences":["AR"]}},{"type":"Natural variant","location":{"start":{"value":209,"modifier":"EXACT"},"end":{"value":209,"modifier":"EXACT"}},"description":"in dbSNP:rs3733378","featureCrossReferences":[{"database":"dbSNP","id":"rs3733378"}],"featureId":"VAR_020370","alternativeSequence":{"originalSequence":"P","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":1204,"modifier":"EXACT"},"end":{"value":1204,"modifier":"EXACT"}},"description":"in a breast cancer sample; somatic mutation","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16959974"}],"featureId":"VAR_036130","alternativeSequence":{"originalSequence":"Q","alternativeSequences":["K"]}},{"type":"Sequence conflict","location":{"start":{"value":46,"modifier":"EXACT"},"end":{"value":46,"modifier":"EXACT"}},"description":"in Ref. 2; AAA36642","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["R"]}},{"type":"Sequence conflict","location":{"start":{"value":624,"modifier":"EXACT"},"end":{"value":624,"modifier":"EXACT"}},"description":"in Ref. 2; AAA36642","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["G"]}},{"type":"Sequence conflict","location":{"start":{"value":762,"modifier":"EXACT"},"end":{"value":762,"modifier":"EXACT"}},"description":"in Ref. 3; BAG62103","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"M","alternativeSequences":["V"]}},{"type":"Sequence conflict","location":{"start":{"value":820,"modifier":"EXACT"},"end":{"value":820,"modifier":"EXACT"}},"description":"in Ref. 3; BAG62103","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["G"]}},{"type":"Sequence conflict","location":{"start":{"value":899,"modifier":"EXACT"},"end":{"value":905,"modifier":"EXACT"}},"description":"in Ref. 2; AAA36642","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"SASSTKS","alternativeSequences":["VPAVPRV"]}},{"type":"Sequence conflict","location":{"start":{"value":928,"modifier":"EXACT"},"end":{"value":929,"modifier":"EXACT"}},"description":"in Ref. 2; AAA36642","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"EH","alternativeSequences":["AD"]}},{"type":"Sequence conflict","location":{"start":{"value":999,"modifier":"EXACT"},"end":{"value":999,"modifier":"EXACT"}},"description":"in Ref. 2; AAA36642","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"I","alternativeSequences":["N"]}},{"type":"Sequence conflict","location":{"start":{"value":1140,"modifier":"EXACT"},"end":{"value":1140,"modifier":"EXACT"}},"description":"in Ref. 2; AAA36642","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"N","alternativeSequences":["I"]}},{"type":"Turn","location":{"start":{"value":768,"modifier":"EXACT"},"end":{"value":770,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2LM0"}]},{"type":"Helix","location":{"start":{"value":774,"modifier":"EXACT"},"end":{"value":777,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2LM0"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0007","category":"PTM","name":"Acetylation"},{"id":"KW-0013","category":"PTM","name":"ADP-ribosylation"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0160","category":"Coding sequence diversity","name":"Chromosomal rearrangement"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-0656","category":"Disease","name":"Proto-oncogene"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0804","category":"Biological process","name":"Transcription"},{"id":"KW-0805","category":"Biological process","name":"Transcription regulation"},{"id":"KW-0832","category":"PTM","name":"Ubl conjugation"}],"references":[{"referenceNumber":1,"citation":{"id":"8506309","citationType":"journal article","authors":["Nakamura T.","Alder H.","Gu Y.","Prasad R.","Canaani O.","Kamada N.","Gale R.P.","Lange B.","Crist W.M.","Nowell P.C.","Croce C.M.","Canaani E."],"citationCrossReferences":[{"database":"PubMed","id":"8506309"},{"database":"DOI","id":"10.1073/pnas.90.10.4631"}],"title":"Genes on chromosomes 4, 9, and 19 involved in 11q23 abnormalities in acute leukemia share sequence homology and/or common motifs.","publicationDate":"1993","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"4631","lastPage":"4635","volume":"90"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)"]},{"referenceNumber":2,"citation":{"id":"8443374","citationType":"journal article","authors":["Morrissey J.","Tkachuk D.C.","Milatovich A.","Francke U.","Link M.","Cleary M.L."],"citationCrossReferences":[{"database":"PubMed","id":"8443374"},{"database":"DOI","id":"10.1182/blood.v81.5.1124.1124"}],"title":"A serine/proline-rich protein is fused to HRX in t(4;11) acute leukemias.","publicationDate":"1993","journal":"Blood","firstPage":"1124","lastPage":"1131","volume":"81"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3)","CHROMOSOMAL TRANSLOCATION WITH KMT2A"]},{"referenceNumber":3,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)"],"referenceComments":[{"value":"Placenta","type":"TISSUE"}]},{"referenceNumber":4,"citation":{"id":"15815621","citationType":"journal article","authors":["Hillier L.W.","Graves T.A.","Fulton R.S.","Fulton L.A.","Pepin K.H.","Minx P.","Wagner-McPherson C.","Layman D.","Wylie K.","Sekhon M.","Becker M.C.","Fewell G.A.","Delehaunty K.D.","Miner T.L.","Nash W.E.","Kremitzki C.","Oddy L.","Du H.","Sun H.","Bradshaw-Cordum H.","Ali J.","Carter J.","Cordes M.","Harris A.","Isak A.","van Brunt A.","Nguyen C.","Du F.","Courtney L.","Kalicki J.","Ozersky P.","Abbott S.","Armstrong J.","Belter E.A.","Caruso L.","Cedroni M.","Cotton M.","Davidson T.","Desai A.","Elliott G.","Erb T.","Fronick C.","Gaige T.","Haakenson W.","Haglund K.","Holmes A.","Harkins R.","Kim K.","Kruchowski S.S.","Strong C.M.","Grewal N.","Goyea E.","Hou S.","Levy A.","Martinka S.","Mead K.","McLellan M.D.","Meyer R.","Randall-Maher J.","Tomlinson C.","Dauphin-Kohlberg S.","Kozlowicz-Reilly A.","Shah N.","Swearengen-Shahid S.","Snider J.","Strong J.T.","Thompson J.","Yoakum M.","Leonard S.","Pearman C.","Trani L.","Radionenko M.","Waligorski J.E.","Wang C.","Rock S.M.","Tin-Wollam A.-M.","Maupin R.","Latreille P.","Wendl M.C.","Yang S.-P.","Pohl C.","Wallis J.W.","Spieth J.","Bieri T.A.","Berkowicz N.","Nelson J.O.","Osborne J.","Ding L.","Meyer R.","Sabo A.","Shotland Y.","Sinha P.","Wohldmann P.E.","Cook L.L.","Hickenbotham M.T.","Eldred J.","Williams D.","Jones T.A.","She X.","Ciccarelli F.D.","Izaurralde E.","Taylor J.","Schmutz J.","Myers R.M.","Cox D.R.","Huang X.","McPherson J.D.","Mardis E.R.","Clifton S.W.","Warren W.C.","Chinwalla A.T.","Eddy S.R.","Marra M.A.","Ovcharenko I.","Furey T.S.","Miller W.","Eichler E.E.","Bork P.","Suyama M.","Torrents D.","Waterston R.H.","Wilson R.K."],"citationCrossReferences":[{"database":"PubMed","id":"15815621"},{"database":"DOI","id":"10.1038/nature03466"}],"title":"Generation and annotation of the DNA sequences of human chromosomes 2 and 4.","publicationDate":"2005","journal":"Nature","firstPage":"724","lastPage":"731","volume":"434"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":5,"citation":{"id":"1423625","citationType":"journal article","authors":["Gu Y.","Nakamura T.","Alder H.","Prasad R.","Canaani O.","Cimino G.","Croce C.M.","Canaani E."],"citationCrossReferences":[{"database":"PubMed","id":"1423625"},{"database":"DOI","id":"10.1016/0092-8674(92)90603-a"}],"title":"The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene.","publicationDate":"1992","journal":"Cell","firstPage":"701","lastPage":"708","volume":"71"},"referencePositions":["CHROMOSOMAL TRANSLOCATION WITH KMT2A"]},{"referenceNumber":6,"citation":{"id":"18691976","citationType":"journal article","authors":["Daub H.","Olsen J.V.","Bairlein M.","Gnad F.","Oppermann F.S.","Korner R.","Greff Z.","Keri G.","Stemmann O.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"18691976"},{"database":"DOI","id":"10.1016/j.molcel.2008.07.007"}],"title":"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.","publicationDate":"2008","journal":"Mol. Cell","firstPage":"438","lastPage":"448","volume":"31"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-206; SER-212 AND THR-697","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":7,"citation":{"id":"18669648","citationType":"journal article","authors":["Dephoure N.","Zhou C.","Villen J.","Beausoleil S.A.","Bakalarski C.E.","Elledge S.J.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"18669648"},{"database":"DOI","id":"10.1073/pnas.0805139105"}],"title":"A quantitative atlas of mitotic phosphorylation.","publicationDate":"2008","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"10762","lastPage":"10767","volume":"105"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-206; SER-212; THR-220; SER-750 AND THR-755","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":8,"citation":{"id":"19369195","citationType":"journal article","authors":["Oppermann F.S.","Gnad F.","Olsen J.V.","Hornberger R.","Greff Z.","Keri G.","Mann M.","Daub H."],"citationCrossReferences":[{"database":"PubMed","id":"19369195"},{"database":"DOI","id":"10.1074/mcp.m800588-mcp200"}],"title":"Large-scale proteomics analysis of the human kinome.","publicationDate":"2009","journal":"Mol. Cell. Proteomics","firstPage":"1751","lastPage":"1764","volume":"8"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-206; SER-212; SER-588 AND SER-750","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":9,"citation":{"id":"19690332","citationType":"journal article","authors":["Mayya V.","Lundgren D.H.","Hwang S.-I.","Rezaul K.","Wu L.","Eng J.K.","Rodionov V.","Han D.K."],"citationCrossReferences":[{"database":"PubMed","id":"19690332"},{"database":"DOI","id":"10.1126/scisignal.2000007"}],"title":"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.","publicationDate":"2009","journal":"Sci. Signal.","firstPage":"RA46","lastPage":"RA46","volume":"2"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-206 AND SER-750","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Leukemic T-cell","type":"TISSUE"}]},{"referenceNumber":10,"citation":{"id":"19608861","citationType":"journal article","authors":["Choudhary C.","Kumar C.","Gnad F.","Nielsen M.L.","Rehman M.","Walther T.C.","Olsen J.V.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"19608861"},{"database":"DOI","id":"10.1126/science.1175371"}],"title":"Lysine acetylation targets protein complexes and co-regulates major cellular functions.","publicationDate":"2009","journal":"Science","firstPage":"834","lastPage":"840","volume":"325"},"referencePositions":["ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-681","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":11,"citation":{"id":"20068231","citationType":"journal article","authors":["Olsen J.V.","Vermeulen M.","Santamaria A.","Kumar C.","Miller M.L.","Jensen L.J.","Gnad F.","Cox J.","Jensen T.S.","Nigg E.A.","Brunak S.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"20068231"},{"database":"DOI","id":"10.1126/scisignal.2000475"}],"title":"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.","publicationDate":"2010","journal":"Sci. Signal.","firstPage":"RA3","lastPage":"RA3","volume":"3"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-206","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":12,"citation":{"id":"22195968","citationType":"journal article","authors":["Smith E.R.","Lin C.","Garrett A.S.","Thornton J.","Mohaghegh N.","Hu D.","Jackson J.","Saraf A.","Swanson S.K.","Seidel C.","Florens L.","Washburn M.P.","Eissenberg J.C.","Shilatifard A."],"citationCrossReferences":[{"database":"PubMed","id":"22195968"},{"database":"DOI","id":"10.1016/j.molcel.2011.12.008"}],"title":"The little elongation complex regulates small nuclear RNA transcription.","publicationDate":"2011","journal":"Mol. Cell","firstPage":"954","lastPage":"965","volume":"44"},"referencePositions":["IDENTIFICATION IN THE SEC COMPLEX"]},{"referenceNumber":13,"citation":{"id":"21406692","citationType":"journal article","authors":["Rigbolt K.T.","Prokhorova T.A.","Akimov V.","Henningsen J.","Johansen P.T.","Kratchmarova I.","Kassem M.","Mann M.","Olsen J.V.","Blagoev B."],"citationCrossReferences":[{"database":"PubMed","id":"21406692"},{"database":"DOI","id":"10.1126/scisignal.2001570"}],"title":"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.","publicationDate":"2011","journal":"Sci. Signal.","firstPage":"RS3","lastPage":"RS3","volume":"4"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-697","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":14,"citation":{"id":"22895430","citationType":"journal article","authors":["Luo Z.","Lin C.","Shilatifard A."],"citationCrossReferences":[{"database":"PubMed","id":"22895430"},{"database":"DOI","id":"10.1038/nrm3417"}],"title":"The super elongation complex (SEC) family in transcriptional control.","publicationDate":"2012","journal":"Nat. Rev. Mol. Cell Biol.","firstPage":"543","lastPage":"547","volume":"13"},"referencePositions":["REVIEW ON THE SUPER ELONGATION COMPLEX"]},{"referenceNumber":15,"citation":{"id":"23186163","citationType":"journal article","authors":["Zhou H.","Di Palma S.","Preisinger C.","Peng M.","Polat A.N.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"23186163"},{"database":"DOI","id":"10.1021/pr300630k"}],"title":"Toward a comprehensive characterization of a human cancer cell phosphoproteome.","publicationDate":"2013","journal":"J. Proteome Res.","firstPage":"260","lastPage":"271","volume":"12"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-588 AND SER-750","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"},{"value":"Erythroleukemia","type":"TISSUE"}]},{"referenceNumber":16,"citation":{"id":"41062835","citationType":"journal article","authors":["Zhu F.","Fu H.","Zhu W.","Li C.","Yang M.","Feng Z.","Shao Y.","Li Z.","Guo Y.","Huang M.","Zhang Y.","He Y.","Lu Y.","Wu Z.","Zhou Q.","Jiao H.","Huang J.","Zhang L.","Xue Y.","Lu H."],"citationCrossReferences":[{"database":"PubMed","id":"41062835"},{"database":"DOI","id":"10.1038/s41589-025-02045-5"}],"title":"Stabilization of AFF1 by PARylation ensures transcriptional restart after DNA damage.","publicationDate":"2025","journal":"Nat. Chem. Biol.","firstPage":"0","lastPage":"0","volume":"0"},"referencePositions":["FUNCTION","ADP-RIBOSYLATION AT SER-612; SER-634; SER-639; SER-674; SER-675; SER-715; SER-781; SER-808; SER-837; SER-838; SER-839; SER-857 AND SER-859","UBIQUITINATION BY SIAH1","SUBCELLULAR LOCATION","MASS SPECTROMETRY"]},{"referenceNumber":17,"citation":{"id":"23260655","citationType":"journal article","authors":["Leach B.I.","Kuntimaddi A.","Schmidt C.R.","Cierpicki T.","Johnson S.A.","Bushweller J.H."],"citationCrossReferences":[{"database":"PubMed","id":"23260655"},{"database":"DOI","id":"10.1016/j.str.2012.11.011"}],"title":"Leukemia fusion target AF9 is an intrinsically disordered transcriptional regulator that recruits multiple partners via coupled folding and binding.","publicationDate":"2013","journal":"Structure","firstPage":"176","lastPage":"183","volume":"21"},"referencePositions":["STRUCTURE BY NMR OF 738-779 IN COMPLEX WITH MLLT3"]},{"referenceNumber":18,"citation":{"id":"16959974","citationType":"journal article","authors":["Sjoeblom T.","Jones S.","Wood L.D.","Parsons D.W.","Lin J.","Barber T.D.","Mandelker D.","Leary R.J.","Ptak J.","Silliman N.","Szabo S.","Buckhaults P.","Farrell C.","Meeh P.","Markowitz S.D.","Willis J.","Dawson D.","Willson J.K.V.","Gazdar A.F.","Hartigan J.","Wu L.","Liu C.","Parmigiani G.","Park B.H.","Bachman K.E.","Papadopoulos N.","Vogelstein B.","Kinzler K.W.","Velculescu V.E."],"citationCrossReferences":[{"database":"PubMed","id":"16959974"},{"database":"DOI","id":"10.1126/science.1133427"}],"title":"The consensus coding sequences of human breast and colorectal cancers.","publicationDate":"2006","journal":"Science","firstPage":"268","lastPage":"274","volume":"314"},"referencePositions":["VARIANT [LARGE SCALE ANALYSIS] LYS-1204"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"L13773","properties":[{"key":"ProteinId","value":"AAA58360.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"L25050","properties":[{"key":"ProteinId","value":"AAA36642.1"},{"key":"Status","value":"ALT_FRAME"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK300364","properties":[{"key":"ProteinId","value":"BAG62103.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AC092658","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC093779","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC093827","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"CCDS","id":"CCDS3616.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P51825-1"},{"database":"CCDS","id":"CCDS54775.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P51825-2"},{"database":"CCDS","id":"CCDS93557.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P51825-3"},{"database":"PIR","id":"A58198","properties":[{"key":"EntryName","value":"A58198"}]},{"database":"PIR","id":"I39410","properties":[{"key":"EntryName","value":"I39410"}]},{"database":"RefSeq","id":"NP_001160165.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001166693.3"}],"isoformId":"P51825-2"},{"database":"RefSeq","id":"NP_001300888.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001313959.2"}],"isoformId":"P51825-3"},{"database":"RefSeq","id":"NP_001300889.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001313960.2"}]},{"database":"RefSeq","id":"NP_005926.1","properties":[{"key":"NucleotideSequenceId","value":"NM_005935.4"}],"isoformId":"P51825-1"},{"database":"RefSeq","id":"XP_005263064.1","properties":[{"key":"NucleotideSequenceId","value":"XM_005263007.4"}],"isoformId":"P51825-2"},{"database":"RefSeq","id":"XP_011530275.1","properties":[{"key":"NucleotideSequenceId","value":"XM_011531973.4"}],"isoformId":"P51825-2"},{"database":"RefSeq","id":"XP_054206027.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054350052.1"}],"isoformId":"P51825-2"},{"database":"RefSeq","id":"XP_054206028.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054350053.1"}],"isoformId":"P51825-2"},{"database":"PDB","id":"2LM0","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=738-779"}]},{"database":"PDBsum","id":"2LM0","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"P51825","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P51825","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"110445","properties":[{"key":"Interactions","value":"72"}]},{"database":"CORUM","id":"P51825","properties":[{"key":"Description","value":"-"}]},{"database":"DIP","id":"DIP-56407N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"P51825","properties":[{"key":"Number of interactors","value":"1168"}]},{"database":"IntAct","id":"P51825","properties":[{"key":"Interactions","value":"37"}]},{"database":"MINT","id":"P51825","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-AFF1","properties":[{"key":"Evidences","value":"2 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000378578","properties":[{"key":"Description","value":"-"}]},{"database":"BindingDB","id":"P51825","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL5724736","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"P51825","properties":[{"key":"glycosylation","value":"1 site"}]},{"database":"iPTMnet","id":"P51825","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"P51825","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"AFF1","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"1703194","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"P51825","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"P51825","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000378578","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"P51825","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"19254","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"56427","properties":[{"key":"Description","value":"-"}],"isoformId":"P51825-1"},{"database":"Pumba","id":"P51825","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"25387","properties":[{"key":"antibodies","value":"267 antibodies from 33 providers"}]},{"database":"DNASU","id":"4299","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000307808.10","properties":[{"key":"ProteinId","value":"ENSP00000305689.6"},{"key":"GeneId","value":"ENSG00000172493.24"}],"isoformId":"P51825-1"},{"database":"Ensembl","id":"ENST00000395146.9","properties":[{"key":"ProteinId","value":"ENSP00000378578.4"},{"key":"GeneId","value":"ENSG00000172493.24"}],"isoformId":"P51825-2"},{"database":"Ensembl","id":"ENST00000544085.6","properties":[{"key":"ProteinId","value":"ENSP00000440843.3"},{"key":"GeneId","value":"ENSG00000172493.24"}],"isoformId":"P51825-3"},{"database":"Ensembl","id":"ENST00000935002.1","properties":[{"key":"ProteinId","value":"ENSP00000605061.1"},{"key":"GeneId","value":"ENSG00000172493.24"}],"isoformId":"P51825-2"},{"database":"Ensembl","id":"ENST00000935003.1","properties":[{"key":"ProteinId","value":"ENSP00000605062.1"},{"key":"GeneId","value":"ENSG00000172493.24"}],"isoformId":"P51825-2"},{"database":"GeneID","id":"4299","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:4299","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000395146.9","properties":[{"key":"ProteinId","value":"ENSP00000378578.4"},{"key":"RefSeqNucleotideId","value":"NM_001166693.3"},{"key":"RefSeqProteinId","value":"NP_001160165.1"}],"isoformId":"P51825-2"},{"database":"UCSC","id":"uc003hqj.5","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"P51825-1"},{"database":"AGR","id":"HGNC:7135","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA30851","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"4299","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"4299","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"AFF1","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:7135","properties":[{"key":"GeneName","value":"AFF1"}]},{"database":"HPA","id":"ENSG00000172493","properties":[{"key":"ExpressionPatterns","value":"Low tissue specificity"}]},{"database":"MalaCards","id":"AFF1","properties":[{"key":"Description","value":"-"}]},{"database":"MIM","id":"159557","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000172493","properties":[{"key":"Description","value":"-"}]},{"database":"Orphanet","id":"589595","properties":[{"key":"Disease","value":"Mixed phenotype acute leukemia with t(v;11q23.3)"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000172493","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502QVDA","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00950000182974","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_006484_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P51825","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"KFTMSLK","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"6382204at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"P51825","properties":[{"key":"Number of GO annotations","value":"5 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"P51825","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"P51825","properties":[{"key":"Description","value":"-"}]},{"database":"SignaLink","id":"P51825","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"P51825","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000172493","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"4299","properties":[{"key":"hits","value":"21 hits in 1166 CRISPR screens"}]},{"database":"ChiTaRS","id":"AFF1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GeneWiki","id":"AFF1","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"4299","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"P51825","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:P51825","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 4"}]},{"database":"RNAct","id":"P51825","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000172493","properties":[{"key":"ExpressionPatterns","value":"Expressed in choroid plexus epithelium and 215 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"P51825","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0000785","properties":[{"key":"GoTerm","value":"C:chromatin"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"41062835"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"41062835"}]},{"database":"GO","id":"GO:0090734","properties":[{"key":"GoTerm","value":"C:site of DNA damage"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"41062835"}]},{"database":"GO","id":"GO:0032783","properties":[{"key":"GoTerm","value":"C:super elongation complex"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0008023","properties":[{"key":"GoTerm","value":"C:transcription elongation factor complex"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"22195968"}]},{"database":"GO","id":"GO:0003712","properties":[{"key":"GoTerm","value":"F:transcription coregulator activity"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0006354","properties":[{"key":"GoTerm","value":"P:DNA-templated transcription elongation"},{"key":"GoEvidenceType","value":"EXP:GO_Central"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22547686"}]},{"database":"GO","id":"GO:0050877","properties":[{"key":"GoTerm","value":"P:nervous system process"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0032968","properties":[{"key":"GoTerm","value":"P:positive regulation of transcription elongation by RNA polymerase II"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"41062835"}]},{"database":"GO","id":"GO:0006355","properties":[{"key":"GoTerm","value":"P:regulation of DNA-templated transcription"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"DisProt","id":"DP02349","properties":[{"key":"Description","value":"-"}]},{"database":"Gene3D","id":"6.10.250.2670","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"IDEAL","id":"IID00554","properties":[{"key":"Description","value":"-"}]},{"database":"InterPro","id":"IPR007797","properties":[{"key":"EntryName","value":"AF4/FMR2"}]},{"database":"InterPro","id":"IPR043640","properties":[{"key":"EntryName","value":"AF4/FMR2_CHD"}]},{"database":"InterPro","id":"IPR043639","properties":[{"key":"EntryName","value":"AF4_int"}]},{"database":"PANTHER","id":"PTHR10528","properties":[{"key":"EntryName","value":"AF4/FMR2 FAMILY MEMBER"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10528:SF6","properties":[{"key":"EntryName","value":"AF4_FMR2 FAMILY MEMBER 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF05110","properties":[{"key":"EntryName","value":"AF-4"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF18875","properties":[{"key":"EntryName","value":"AF4_int"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF18876","properties":[{"key":"EntryName","value":"AFF4_CHD"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MAAQSSLYNDDRNLLRIREKERRNQEAHQEKEAFPEKIPLFGEPYKTAKGDELSSRIQNMLGNYEEVKEFLSTKSHTHRLDASENRLGKPKYPLIPDKGSSIPSSSFHTSVHHQSIHTPASGPLSVGNISHNPKMAQPRTEPMPSLHAKSCGPPDSQHLTQDRLGQEGFGSSHHKKGDRRADGDHCASVTDSAPERELSPLISLPSPVPPLSPIHSNQQTLPRTQGSSKVHGSSNNSKGYCPAKSPKDLAVKVHDKETPQDSLVAPAQPPSQTFPPPSLPSKSVAMQQKPTAYVRPMDGQDQAPSESPELKPLPEDYRQQTFEKTDLKVPAKAKLTKLKMPSQSVEQTYSNEVHCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSSVTQNQKQYDTSSKTHSNSQQGTSSMLEDDLQLSDSEDSDSEQTPEKPPSSSAPPSAPQSLPEPVASAHSSSAESESTSDSDSSSDSESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNWLTKVSQPAAPPEGPRSTEPPRRHPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEPPQRQTVGTKQPKKPVKASARAGSRTSLQGEREPGLLPYGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTPEHFALVPLTESQGPPHSGSGSRTSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQSLMVKITLDLLSRIPQPPGKGSRQRKAEDKQPPAGKKHSSEKRSSDSSSKLAKKRKGEAERDCDNKKIRLEKEIKSQSSSSSSSHKESSKTKPSRPSSQSSKKEMLPPPPVSSSSQKPAKPALKRSRREADTCGQDPPKSASSTKSNHKDSSIPKQRRVEGKGSRSSSEHKGSSGDTANPFPVPSLPNGNSKPGKPQVKFDKQQADLHMREAKKMKQKAELMTDRVGKAFKYLEAVLSFIECGIATESESQSSKSAYSVYSETVDLIKFIMSLKSFSDATAPTQEKIFAVLCMRCQSILNMAMFRCKKDIAIKYSRTLNKHFESSSKVAQAPSPCIASTGTPSPLSPMPSPASSVGSQSSAGSVGSSGVAATISTPVTIQNMTSSYVTITSHVLTAFDLWEQAEALTRKNKEFFARLSTNVCTLALNSSLVDLVHYTRQGFQQLQELTKTP","length":1210,"molWeight":131422,"crc64":"F0E334DF8FC2FF04","md5":"94EB873C19CA04FFB4DD298F6CE8B9B0"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"INTERACTION":3,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":3,"PTM":2,"DISEASE":1,"SIMILARITY":1,"SEQUENCE CAUTION":1,"WEB RESOURCE":1},"countByFeatureType":{"Chain":1,"Region":5,"Compositional bias":19,"Modified residue":22,"Alternative sequence":2,"Natural variant":2,"Sequence conflict":8,"Turn":1,"Helix":1},"uniParcId":"UPI0000125658"}}