{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P51512","secondaryAccessions":["B2RAN7","Q14824","Q52H48"],"uniProtkbId":"MMP16_HUMAN","entryAudit":{"firstPublicDate":"1996-10-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1998-07-15","entryVersion":221,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Matrix metalloproteinase-16"},"shortNames":[{"value":"MMP-16"}],"ecNumbers":[{"value":"3.4.24.-"}]},"alternativeNames":[{"fullName":{"value":"MMP-X2"}},{"fullName":{"value":"Membrane-type matrix metalloproteinase 3"},"shortNames":[{"value":"MT-MMP 3"},{"value":"MTMMP3"}]},{"fullName":{"value":"Membrane-type-3 matrix metalloproteinase"},"shortNames":[{"value":"MT3-MMP"},{"value":"MT3MMP"}]}],"flag":"Precursor"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:7162"}],"value":"MMP16"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:7162"}],"value":"C8orf57"},{"value":"MMPX2"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11278606"}],"value":"Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. Isoform short cleaves fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells"}],"commentType":"FUNCTION"},{"commentType":"COFACTOR","cofactors":[{"name":"Zn(2+)","evidences":[{"evidenceCode":"ECO:0000250"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:29105"}}],"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Binds 2 zinc ions per subunit."}]}},{"commentType":"COFACTOR","cofactors":[{"name":"Ca(2+)","evidences":[{"evidenceCode":"ECO:0000250"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:29108"}}]},{"texts":[{"value":"TIMP-2 shows little inhibitory activity compared to TIMP-1. TIMP-1 seems to have less binding affinity than TIMP-2 for the short isoform"}],"commentType":"ACTIVITY REGULATION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11278606"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14741217"}],"value":"Interacts with CSPG4 through CSPG4 chondroitin sulfate glycosaminoglycan"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","molecule":"Isoform Long","note":{"texts":[{"value":"Localized at the cell surface of melanoma cells"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Single-pass type I membrane protein","id":"SL-9905"},"orientation":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Extracellular side","id":"SL-9911"}}]},{"commentType":"SUBCELLULAR LOCATION","molecule":"Isoform Short","note":{"texts":[{"value":"Localized at the cell surface of melanoma cells"}]},"subcellularLocations":[{"location":{"value":"Secreted, extracellular space, extracellular matrix","id":"SL-0111"}},{"location":{"value":"Cell surface","id":"SL-0310"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"Long"},"isoformIds":["P51512-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"Short"},"synonyms":[{"value":"SM3"}],"isoformIds":["P51512-2"],"sequenceIds":["VSP_005453","VSP_005454"],"isoformSequenceStatus":"Described"}]},{"texts":[{"value":"Expressed in heart, brain, placenta, ovary and small intestine. Isoform Short is found in the ovary"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"value":"Expressed in tissues undergoing reconstruction. Present in fetal tissues, especially in brain. Expression seems to decline with advanced development"}],"commentType":"DEVELOPMENTAL STAGE"},{"texts":[{"value":"The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"The precursor is cleaved by a furin endopeptidase"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the peptidase M10A family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":31,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Propeptide","location":{"start":{"value":32,"modifier":"EXACT"},"end":{"value":119,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250"}],"featureId":"PRO_0000028812"},{"type":"Chain","location":{"start":{"value":120,"modifier":"EXACT"},"end":{"value":607,"modifier":"EXACT"}},"description":"Matrix metalloproteinase-16","featureId":"PRO_0000028813"},{"type":"Topological domain","location":{"start":{"value":120,"modifier":"EXACT"},"end":{"value":564,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":565,"modifier":"EXACT"},"end":{"value":585,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":586,"modifier":"EXACT"},"end":{"value":607,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Repeat","location":{"start":{"value":340,"modifier":"EXACT"},"end":{"value":388,"modifier":"EXACT"}},"description":"Hemopexin 1"},{"type":"Repeat","location":{"start":{"value":389,"modifier":"EXACT"},"end":{"value":434,"modifier":"EXACT"}},"description":"Hemopexin 2"},{"type":"Repeat","location":{"start":{"value":436,"modifier":"EXACT"},"end":{"value":484,"modifier":"EXACT"}},"description":"Hemopexin 3"},{"type":"Repeat","location":{"start":{"value":485,"modifier":"EXACT"},"end":{"value":532,"modifier":"EXACT"}},"description":"Hemopexin 4"},{"type":"Region","location":{"start":{"value":281,"modifier":"EXACT"},"end":{"value":340,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Motif","location":{"start":{"value":99,"modifier":"EXACT"},"end":{"value":106,"modifier":"EXACT"}},"description":"Cysteine switch","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Compositional bias","location":{"start":{"value":294,"modifier":"EXACT"},"end":{"value":315,"modifier":"EXACT"}},"description":"Pro residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Active site","location":{"start":{"value":247,"modifier":"EXACT"},"end":{"value":247,"modifier":"EXACT"}},"description":""},{"type":"Binding site","location":{"start":{"value":101,"modifier":"EXACT"},"end":{"value":101,"modifier":"EXACT"}},"description":"in inhibited form","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000250"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"2","note":"catalytic"}},{"type":"Binding site","location":{"start":{"value":183,"modifier":"EXACT"},"end":{"value":183,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"1RM8"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"1"}},{"type":"Binding site","location":{"start":{"value":193,"modifier":"EXACT"},"end":{"value":193,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"1RM8"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"1","note":"structural"}},{"type":"Binding site","location":{"start":{"value":195,"modifier":"EXACT"},"end":{"value":195,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"1RM8"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"1","note":"structural"}},{"type":"Binding site","location":{"start":{"value":200,"modifier":"EXACT"},"end":{"value":200,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"1RM8"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"2"}},{"type":"Binding site","location":{"start":{"value":201,"modifier":"EXACT"},"end":{"value":201,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"1RM8"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"2"}},{"type":"Binding site","location":{"start":{"value":203,"modifier":"EXACT"},"end":{"value":203,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"1RM8"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"2"}},{"type":"Binding site","location":{"start":{"value":205,"modifier":"EXACT"},"end":{"value":205,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"1RM8"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"2"}},{"type":"Binding site","location":{"start":{"value":208,"modifier":"EXACT"},"end":{"value":208,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"1RM8"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"1","note":"structural"}},{"type":"Binding site","location":{"start":{"value":215,"modifier":"EXACT"},"end":{"value":215,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"1RM8"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"1"}},{"type":"Binding site","location":{"start":{"value":217,"modifier":"EXACT"},"end":{"value":217,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"1"}},{"type":"Binding site","location":{"start":{"value":219,"modifier":"EXACT"},"end":{"value":219,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"1RM8"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"1"}},{"type":"Binding site","location":{"start":{"value":221,"modifier":"EXACT"},"end":{"value":221,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"1RM8"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"1","note":"structural"}},{"type":"Binding site","location":{"start":{"value":223,"modifier":"EXACT"},"end":{"value":223,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"1RM8"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"2"}},{"type":"Binding site","location":{"start":{"value":226,"modifier":"EXACT"},"end":{"value":226,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"1RM8"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"2"}},{"type":"Binding site","location":{"start":{"value":246,"modifier":"EXACT"},"end":{"value":246,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"1RM8"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"2","note":"catalytic"}},{"type":"Binding site","location":{"start":{"value":250,"modifier":"EXACT"},"end":{"value":250,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"1RM8"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"2","note":"catalytic"}},{"type":"Binding site","location":{"start":{"value":256,"modifier":"EXACT"},"end":{"value":256,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"1RM8"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"2","note":"catalytic"}},{"type":"Glycosylation","location":{"start":{"value":83,"modifier":"EXACT"},"end":{"value":83,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Disulfide bond","location":{"start":{"value":343,"modifier":"EXACT"},"end":{"value":532,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Alternative sequence","location":{"start":{"value":408,"modifier":"EXACT"},"end":{"value":457,"modifier":"EXACT"}},"description":"in isoform Short","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"9396633"}],"featureId":"VSP_005453","alternativeSequence":{"originalSequence":"GNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGD","alternativeSequences":["VKGDTLSVIQDGWLYKYHWKWILEQRQSVPVLSRQTEKHKTYEELSSITY"]}},{"type":"Alternative sequence","location":{"start":{"value":458,"modifier":"EXACT"},"end":{"value":607,"modifier":"EXACT"}},"description":"in isoform Short","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"9396633"}],"featureId":"VSP_005454","alternativeSequence":{}},{"type":"Sequence conflict","location":{"start":{"value":521,"modifier":"EXACT"},"end":{"value":521,"modifier":"EXACT"}},"description":"in Ref. 1; BAA23742","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"Y","alternativeSequences":["H"]}},{"type":"Beta strand","location":{"start":{"value":128,"modifier":"EXACT"},"end":{"value":136,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1RM8"}]},{"type":"Turn","location":{"start":{"value":141,"modifier":"EXACT"},"end":{"value":143,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1RM8"}]},{"type":"Helix","location":{"start":{"value":145,"modifier":"EXACT"},"end":{"value":160,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1RM8"}]},{"type":"Beta strand","location":{"start":{"value":166,"modifier":"EXACT"},"end":{"value":169,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1RM8"}]},{"type":"Beta strand","location":{"start":{"value":177,"modifier":"EXACT"},"end":{"value":179,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1RM8"}]},{"type":"Beta strand","location":{"start":{"value":183,"modifier":"EXACT"},"end":{"value":191,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1RM8"}]},{"type":"Beta strand","location":{"start":{"value":194,"modifier":"EXACT"},"end":{"value":196,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1RM8"}]},{"type":"Beta strand","location":{"start":{"value":201,"modifier":"EXACT"},"end":{"value":204,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1RM8"}]},{"type":"Beta strand","location":{"start":{"value":207,"modifier":"EXACT"},"end":{"value":209,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1RM8"}]},{"type":"Turn","location":{"start":{"value":215,"modifier":"EXACT"},"end":{"value":218,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1RM8"}]},{"type":"Beta strand","location":{"start":{"value":220,"modifier":"EXACT"},"end":{"value":223,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1RM8"}]},{"type":"Beta strand","location":{"start":{"value":228,"modifier":"EXACT"},"end":{"value":231,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1RM8"}]},{"type":"Beta strand","location":{"start":{"value":234,"modifier":"EXACT"},"end":{"value":239,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1RM8"}]},{"type":"Helix","location":{"start":{"value":240,"modifier":"EXACT"},"end":{"value":252,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1RM8"}]},{"type":"Helix","location":{"start":{"value":254,"modifier":"EXACT"},"end":{"value":257,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1RM8"}]},{"type":"Beta strand","location":{"start":{"value":265,"modifier":"EXACT"},"end":{"value":267,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1RM8"}]},{"type":"Helix","location":{"start":{"value":280,"modifier":"EXACT"},"end":{"value":290,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1RM8"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0106","category":"Ligand","name":"Calcium"},{"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"id":"KW-0165","category":"PTM","name":"Cleavage on pair of basic residues"},{"id":"KW-0177","category":"Biological process","name":"Collagen degradation"},{"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"id":"KW-0272","category":"Cellular component","name":"Extracellular matrix"},{"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"id":"KW-0482","category":"Molecular function","name":"Metalloprotease"},{"id":"KW-0645","category":"Molecular function","name":"Protease"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0677","category":"Domain","name":"Repeat"},{"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"id":"KW-0732","category":"Domain","name":"Signal"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"id":"KW-0862","category":"Ligand","name":"Zinc"},{"id":"KW-0865","category":"PTM","name":"Zymogen"}],"references":[{"referenceNumber":1,"citation":{"id":"7559440","citationType":"journal article","authors":["Takino T.","Sato H.","Shinagawa A.","Seiki M."],"citationCrossReferences":[{"database":"PubMed","id":"7559440"},{"database":"DOI","id":"10.1074/jbc.270.39.23013"}],"title":"Identification of the second membrane-type matrix metalloproteinase (MT-MMP-2) gene from a human placenta cDNA library. MT-MMPs form a unique membrane-type subclass in the MMP family.","publicationDate":"1995","journal":"J. Biol. Chem.","firstPage":"23013","lastPage":"23020","volume":"270"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG)"],"referenceComments":[{"value":"Placenta","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"CI-A1VR5LV4RIQ72","citationType":"submission","authors":["Seiki M."],"publicationDate":"DEC-1997","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["SEQUENCE REVISION"]},{"referenceNumber":3,"citation":{"id":"9396633","citationType":"journal article","authors":["Matsumoto S.","Katoh M.","Saito S.","Watanabe T.","Masuho Y."],"citationCrossReferences":[{"database":"PubMed","id":"9396633"},{"database":"DOI","id":"10.1016/s0167-4781(97)00120-6"}],"title":"Identification of soluble type of membrane-type matrix metalloproteinase-3 formed by alternatively spliced mRNA.","publicationDate":"1997","journal":"Biochim. Biophys. Acta","firstPage":"159","lastPage":"170","volume":"1354"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LONG AND SHORT)"],"referenceComments":[{"value":"Ovary","type":"TISSUE"}]},{"referenceNumber":4,"citation":{"id":"9092507","citationType":"journal article","authors":["Shofuda K.","Yasumitsu H.","Nishihashi A.","Miki K.","Miyazaki K."],"citationCrossReferences":[{"database":"PubMed","id":"9092507"},{"database":"DOI","id":"10.1074/jbc.272.15.9749"}],"title":"Expression of three membrane-type matrix metalloproteinases (MT-MMPs) in rat vascular smooth muscle cells and characterization of MT3-MMPs with and without transmembrane domain.","publicationDate":"1997","journal":"J. Biol. Chem.","firstPage":"9749","lastPage":"9754","volume":"272"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG)"],"referenceComments":[{"value":"Fetal brain","type":"TISSUE"}]},{"referenceNumber":5,"citation":{"id":"CI-7CALJ9DN3DHUP","citationType":"submission","authoringGroup":["NIEHS SNPs program"],"publicationDate":"APR-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"]},{"referenceNumber":6,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG)"]},{"referenceNumber":7,"citation":{"id":"CI-5GBDQ6B103N1E","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"JUL-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":8,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG)"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":9,"citation":{"id":"11278606","citationType":"journal article","authors":["Iida J.","Pei D.","Kang T.","Simpson M.A.","Herlyn M.","Furcht L.T.","McCarthy J.B."],"citationCrossReferences":[{"database":"PubMed","id":"11278606"},{"database":"DOI","id":"10.1074/jbc.m010053200"}],"title":"Melanoma chondroitin sulfate proteoglycan regulates matrix metalloproteinase-dependent human melanoma invasion into type I collagen.","publicationDate":"2001","journal":"J. Biol. Chem.","firstPage":"18786","lastPage":"18794","volume":"276"},"referencePositions":["INTERACTION WITH CSPG4","SUBCELLULAR LOCATION","FUNCTION"]},{"referenceNumber":10,"citation":{"id":"14741217","citationType":"journal article","authors":["Lang R.","Braun M.","Sounni N.E.","Noel A.","Frankenne F.","Foidart J.M.","Bode W.","Maskos K."],"citationCrossReferences":[{"database":"PubMed","id":"14741217"},{"database":"DOI","id":"10.1016/j.jmb.2003.12.022"}],"title":"Crystal structure of the catalytic domain of MMP-16/MT3-MMP: characterization of MT-MMP specific features.","publicationDate":"2004","journal":"J. Mol. Biol.","firstPage":"213","lastPage":"225","volume":"336"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 124-292 IN COMPLEX WITH INHIBITOR; CALCIUM AND ZINC","ZINC-BINDING SITES","CALCIUM-BINDING SITES"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"1RM8"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AB009303","properties":[{"key":"ProteinId","value":"BAA23742.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"D83646","properties":[{"key":"ProteinId","value":"BAA12022.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"D83647","properties":[{"key":"ProteinId","value":"BAA12023.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"D85511","properties":[{"key":"ProteinId","value":"BAA22226.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"DQ003082","properties":[{"key":"ProteinId","value":"AAX84515.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AK314274","properties":[{"key":"ProteinId","value":"BAG36934.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"CH471060","properties":[{"key":"ProteinId","value":"EAW91651.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC069500","properties":[{"key":"ProteinId","value":"AAH69500.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC075004","properties":[{"key":"ProteinId","value":"AAH75004.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC075005","properties":[{"key":"ProteinId","value":"AAH75005.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS6246.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P51512-1"},{"database":"RefSeq","id":"NP_005932.2","properties":[{"key":"NucleotideSequenceId","value":"NM_005941.5"}],"isoformId":"P51512-1"},{"database":"PDB","id":"1RM8","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"A=124-292"}]},{"database":"PDBsum","id":"1RM8","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"P51512","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P51512","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"110468","properties":[{"key":"Interactions","value":"15"}]},{"database":"FunCoup","id":"P51512","properties":[{"key":"Number of interactors","value":"1137"}]},{"database":"IntAct","id":"P51512","properties":[{"key":"Interactions","value":"1"}]},{"database":"MINT","id":"P51512","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-MMP16","properties":[{"key":"Evidences","value":"2 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000286614","properties":[{"key":"Description","value":"-"}]},{"database":"BindingDB","id":"P51512","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL2200","properties":[{"key":"Description","value":"-"}]},{"database":"DrugBank","id":"DB03880","properties":[{"key":"GenericName","value":"Batimastat"}]},{"database":"DrugBank","id":"DB00786","properties":[{"key":"GenericName","value":"Marimastat"}]},{"database":"GuidetoPHARMACOLOGY","id":"1640","properties":[{"key":"Description","value":"-"}]},{"database":"MEROPS","id":"M10.016","properties":[{"key":"Description","value":"-"}]},{"database":"GlyCosmos","id":"P51512","properties":[{"key":"glycosylation","value":"1 site, No reported glycans"}]},{"database":"GlyGen","id":"P51512","properties":[{"key":"glycosylation","value":"1 site"}]},{"database":"iPTMnet","id":"P51512","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"P51512","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"P51512","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"MMP16","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"3041669","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"P51512","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"P51512","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000286614","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"P51512","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"56313","properties":[{"key":"Description","value":"-"}],"isoformId":"P51512-1"},{"database":"ProteomicsDB","id":"56314","properties":[{"key":"Description","value":"-"}],"isoformId":"P51512-2"},{"database":"Antibodypedia","id":"12678","properties":[{"key":"antibodies","value":"422 antibodies from 40 providers"}]},{"database":"DNASU","id":"4325","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000286614.11","properties":[{"key":"ProteinId","value":"ENSP00000286614.6"},{"key":"GeneId","value":"ENSG00000156103.16"}],"isoformId":"P51512-1"},{"database":"GeneID","id":"4325","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:4325","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000286614.11","properties":[{"key":"ProteinId","value":"ENSP00000286614.6"},{"key":"RefSeqNucleotideId","value":"NM_005941.5"},{"key":"RefSeqProteinId","value":"NP_005932.2"}]},{"database":"UCSC","id":"uc003yeb.5","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"P51512-1"},{"database":"AGR","id":"HGNC:7162","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA30874","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"4325","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"4325","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"MMP16","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:7162","properties":[{"key":"GeneName","value":"MMP16"}]},{"database":"HPA","id":"ENSG00000156103","properties":[{"key":"ExpressionPatterns","value":"Tissue enhanced (brain)"}]},{"database":"MIM","id":"602262","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000156103","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000156103","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG1565","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000157532","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_015489_8_1_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P51512","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"RKNDRPR","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"406838at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"P51512","properties":[{"key":"Number of GO annotations","value":"6 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"P51512","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"P51512","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-1592389","properties":[{"key":"PathwayName","value":"Activation of Matrix Metalloproteinases"}]},{"database":"Reactome","id":"R-HSA-9839383","properties":[{"key":"PathwayName","value":"TGFBR3 PTM regulation"}]},{"database":"SignaLink","id":"P51512","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"P51512","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000156103","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"4325","properties":[{"key":"hits","value":"14 hits in 1161 CRISPR screens"}]},{"database":"ChiTaRS","id":"MMP16","properties":[{"key":"OrganismName","value":"human"}]},{"database":"EvolutionaryTrace","id":"P51512","properties":[{"key":"Description","value":"-"}]},{"database":"GeneWiki","id":"MMP16","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"4325","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"P51512","properties":[{"key":"DevelopmentLevel","value":"Tchem"}]},{"database":"PRO","id":"PR:P51512","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 8"}]},{"database":"RNAct","id":"P51512","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000156103","properties":[{"key":"ExpressionPatterns","value":"Expressed in endothelial cell and 148 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"P51512","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0009986","properties":[{"key":"GoTerm","value":"C:cell surface"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0031012","properties":[{"key":"GoTerm","value":"C:extracellular matrix"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0005796","properties":[{"key":"GoTerm","value":"C:Golgi lumen"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IDA:ParkinsonsUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"7559440"}]},{"database":"GO","id":"GO:0008047","properties":[{"key":"GoTerm","value":"F:enzyme activator activity"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"7559440"}]},{"database":"GO","id":"GO:0070006","properties":[{"key":"GoTerm","value":"F:metalloaminopeptidase activity"},{"key":"GoEvidenceType","value":"IDA:ParkinsonsUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24970228"}]},{"database":"GO","id":"GO:0004222","properties":[{"key":"GoTerm","value":"F:metalloendopeptidase activity"},{"key":"GoEvidenceType","value":"IDA:ParkinsonsUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"27229514"}]},{"database":"GO","id":"GO:0008270","properties":[{"key":"GoTerm","value":"F:zinc ion binding"},{"key":"GoEvidenceType","value":"IDA:ParkinsonsUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"27229514"}]},{"database":"GO","id":"GO:0030574","properties":[{"key":"GoTerm","value":"P:collagen catabolic process"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0030198","properties":[{"key":"GoTerm","value":"P:extracellular matrix organization"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0016485","properties":[{"key":"GoTerm","value":"P:protein processing"},{"key":"GoEvidenceType","value":"IDA:ParkinsonsUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"27229514"}]},{"database":"GO","id":"GO:0006508","properties":[{"key":"GoTerm","value":"P:proteolysis"},{"key":"GoEvidenceType","value":"IDA:ParkinsonsUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24970228"}]},{"database":"GO","id":"GO:0001501","properties":[{"key":"GoTerm","value":"P:skeletal system development"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"CDD","id":"cd00094","properties":[{"key":"EntryName","value":"HX"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd04278","properties":[{"key":"EntryName","value":"ZnMc_MMP"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.390.10:FF:000005","properties":[{"key":"EntryName","value":"Matrix metallopeptidase 16"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.110.10.10:FF:000001","properties":[{"key":"EntryName","value":"Matrix metallopeptidase 24"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.390.10","properties":[{"key":"EntryName","value":"Collagenase (Catalytic Domain)"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.110.10.10","properties":[{"key":"EntryName","value":"Hemopexin-like domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000585","properties":[{"key":"EntryName","value":"Hemopexin-like_dom"}]},{"database":"InterPro","id":"IPR036375","properties":[{"key":"EntryName","value":"Hemopexin-like_dom_sf"}]},{"database":"InterPro","id":"IPR018487","properties":[{"key":"EntryName","value":"Hemopexin-like_repeat"}]},{"database":"InterPro","id":"IPR018486","properties":[{"key":"EntryName","value":"Hemopexin_CS"}]},{"database":"InterPro","id":"IPR033739","properties":[{"key":"EntryName","value":"M10A_MMP"}]},{"database":"InterPro","id":"IPR024079","properties":[{"key":"EntryName","value":"MetalloPept_cat_dom_sf"}]},{"database":"InterPro","id":"IPR001818","properties":[{"key":"EntryName","value":"Pept_M10_metallopeptidase"}]},{"database":"InterPro","id":"IPR021190","properties":[{"key":"EntryName","value":"Pept_M10A"}]},{"database":"InterPro","id":"IPR021805","properties":[{"key":"EntryName","value":"Pept_M10A_metallopeptidase_C"}]},{"database":"InterPro","id":"IPR021158","properties":[{"key":"EntryName","value":"Pept_M10A_Zn_BS"}]},{"database":"InterPro","id":"IPR006026","properties":[{"key":"EntryName","value":"Peptidase_Metallo"}]},{"database":"InterPro","id":"IPR002477","properties":[{"key":"EntryName","value":"Peptidoglycan-bd-like"}]},{"database":"InterPro","id":"IPR036365","properties":[{"key":"EntryName","value":"PGBD-like_sf"}]},{"database":"PANTHER","id":"PTHR10201","properties":[{"key":"EntryName","value":"MATRIX METALLOPROTEINASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10201:SF26","properties":[{"key":"EntryName","value":"MATRIX METALLOPROTEINASE-16"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF11857","properties":[{"key":"EntryName","value":"DUF3377"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00045","properties":[{"key":"EntryName","value":"Hemopexin"},{"key":"MatchStatus","value":"4"}]},{"database":"Pfam","id":"PF00413","properties":[{"key":"EntryName","value":"Peptidase_M10"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01471","properties":[{"key":"EntryName","value":"PG_binding_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PIRSF","id":"PIRSF001191","properties":[{"key":"EntryName","value":"Peptidase_M10A_matrix"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00138","properties":[{"key":"EntryName","value":"MATRIXIN"}]},{"database":"SMART","id":"SM00120","properties":[{"key":"EntryName","value":"HX"},{"key":"MatchStatus","value":"4"}]},{"database":"SMART","id":"SM00235","properties":[{"key":"EntryName","value":"ZnMc"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF50923","properties":[{"key":"EntryName","value":"Hemopexin-like domain"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF55486","properties":[{"key":"EntryName","value":"Metalloproteases ('zincins'), catalytic domain"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF47090","properties":[{"key":"EntryName","value":"PGBD-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00546","properties":[{"key":"EntryName","value":"CYSTEINE_SWITCH"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00024","properties":[{"key":"EntryName","value":"HEMOPEXIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51642","properties":[{"key":"EntryName","value":"HEMOPEXIN_2"},{"key":"MatchStatus","value":"4"}]},{"database":"PROSITE","id":"PS00142","properties":[{"key":"EntryName","value":"ZINC_PROTEASE"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRVKEGHSPPDDVDIVIKLDNTASTVKAIAIVIPCILALCLLVLVYTVFQFKRKGTPRHILYCKRSMQEWV","length":607,"molWeight":69521,"crc64":"30D6247D9CB21663","md5":"EF1FE8224209E849D03C6661BE7C56AA"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"COFACTOR":2,"ACTIVITY REGULATION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":2,"ALTERNATIVE PRODUCTS":2,"TISSUE SPECIFICITY":1,"DEVELOPMENTAL STAGE":1,"DOMAIN":1,"PTM":1,"SIMILARITY":1},"countByFeatureType":{"Signal":1,"Propeptide":1,"Chain":1,"Topological domain":2,"Transmembrane":1,"Repeat":4,"Region":1,"Motif":1,"Compositional bias":1,"Active site":1,"Binding site":18,"Glycosylation":1,"Disulfide bond":1,"Alternative sequence":2,"Sequence conflict":1,"Beta strand":11,"Turn":2,"Helix":4},"uniParcId":"UPI000003DC73"}}