{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P50851","secondaryAccessions":["Q4W5J4","Q4W5L6","Q8NFQ0","Q9H2U3","Q9H2U4"],"uniProtkbId":"LRBA_HUMAN","entryAudit":{"firstPublicDate":"1996-10-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2009-09-22","entryVersion":222,"sequenceVersion":4},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Lipopolysaccharide-responsive and beige-like anchor protein"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"11254716"}],"value":"Beige-like protein"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"1505956"}],"value":"CDC4-like protein"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15554694"},{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:1742"}],"value":"LRBA"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"1505956"}],"value":"BGL"},{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"1505956"}],"value":"CDC4L"},{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"11254716"}],"value":"LBA"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9ESE1"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33773106"}],"value":"Involved in coupling signal transduction and vesicle trafficking to enable polarized secretion and/or membrane deposition of immune effector molecules (By similarity). Involved in phagophore growth during mitophagy by regulating ATG9A trafficking to mitochondria (PubMed:33773106)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31263572"}],"value":"Interacts with TOM1 and TOLLIP"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P50851","intActId":"EBI-1052167"},"interactantTwo":{"uniProtKBAccession":"P16410","geneName":"CTLA4","intActId":"EBI-1030991"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9ESE1"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000255"}],"value":"Single-pass membrane protein","id":"SL-9904"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9ESE1"}],"value":"Endoplasmic reticulum membrane","id":"SL-0097"},"topology":{"evidences":[{"evidenceCode":"ECO:0000255"}],"value":"Single-pass membrane protein","id":"SL-9904"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31263572"}],"value":"Golgi apparatus, trans-Golgi network membrane","id":"SL-0267"},"topology":{"evidences":[{"evidenceCode":"ECO:0000255"}],"value":"Single-pass membrane protein","id":"SL-9904"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9ESE1"}],"value":"Lysosome membrane","id":"SL-0157"},"topology":{"evidences":[{"evidenceCode":"ECO:0000255"}],"value":"Single-pass membrane protein","id":"SL-9904"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["P50851-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["P50851-2"],"sequenceIds":["VSP_038225","VSP_038226"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12160729"}],"value":"Ubiquitous"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"value":"By bacterial lipopolysaccharides (LPS)"}],"commentType":"INDUCTION"},{"commentType":"DISEASE","disease":{"diseaseId":"Immunodeficiency, common variable, 8, with autoimmunity","diseaseAccession":"DI-03490","acronym":"CVID8","description":"An autosomal recessive immunologic disorder associated with defective B-cell differentiation and decreased or absent antibody production. Affected individuals have early-childhood onset of recurrent infections, particularly respiratory infections, and also develop variable autoimmune disorders, including idiopathic thrombocytopenic purpura, autoimmune hemolytic anemia, and inflammatory bowel disease.","diseaseCrossReference":{"database":"MIM","id":"614700"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22608502"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"1505956"}],"value":"Was originally said to be similar to yeast CDC4, but that similarity is very limited"}],"commentType":"CAUTION"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Frameshift","sequence":"AAB09603.1","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Initiator methionine","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"Removed","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19413330"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"}]},{"type":"Chain","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":2863,"modifier":"EXACT"}},"description":"Lipopolysaccharide-responsive and beige-like anchor protein","featureId":"PRO_0000051068"},{"type":"Transmembrane","location":{"start":{"value":1531,"modifier":"EXACT"},"end":{"value":1548,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Repeat","location":{"start":{"value":1301,"modifier":"EXACT"},"end":{"value":1343,"modifier":"EXACT"}},"description":"WD 1"},{"type":"Domain","location":{"start":{"value":2073,"modifier":"EXACT"},"end":{"value":2181,"modifier":"EXACT"}},"description":"BEACH-type PH","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01119"}]},{"type":"Domain","location":{"start":{"value":2200,"modifier":"EXACT"},"end":{"value":2489,"modifier":"EXACT"}},"description":"BEACH","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00026"}]},{"type":"Repeat","location":{"start":{"value":2591,"modifier":"EXACT"},"end":{"value":2633,"modifier":"EXACT"}},"description":"WD 2"},{"type":"Repeat","location":{"start":{"value":2636,"modifier":"EXACT"},"end":{"value":2679,"modifier":"EXACT"}},"description":"WD 3"},{"type":"Repeat","location":{"start":{"value":2695,"modifier":"EXACT"},"end":{"value":2735,"modifier":"EXACT"}},"description":"WD 4"},{"type":"Repeat","location":{"start":{"value":2777,"modifier":"EXACT"},"end":{"value":2816,"modifier":"EXACT"}},"description":"WD 5"},{"type":"Repeat","location":{"start":{"value":2819,"modifier":"EXACT"},"end":{"value":2858,"modifier":"EXACT"}},"description":"WD 6"},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":35,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":969,"modifier":"EXACT"},"end":{"value":1005,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1018,"modifier":"EXACT"},"end":{"value":1039,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1161,"modifier":"EXACT"},"end":{"value":1193,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1586,"modifier":"EXACT"},"end":{"value":1668,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1759,"modifier":"EXACT"},"end":{"value":1789,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Coiled coil","location":{"start":{"value":1006,"modifier":"EXACT"},"end":{"value":1053,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Compositional bias","location":{"start":{"value":985,"modifier":"EXACT"},"end":{"value":1005,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1024,"modifier":"EXACT"},"end":{"value":1034,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1161,"modifier":"EXACT"},"end":{"value":1176,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1177,"modifier":"EXACT"},"end":{"value":1193,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1586,"modifier":"EXACT"},"end":{"value":1599,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1650,"modifier":"EXACT"},"end":{"value":1664,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1769,"modifier":"EXACT"},"end":{"value":1789,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Modified residue","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":2,"modifier":"EXACT"}},"description":"N-acetylalanine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19413330"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"}]},{"type":"Modified residue","location":{"start":{"value":10,"modifier":"EXACT"},"end":{"value":10,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":979,"modifier":"EXACT"},"end":{"value":979,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"}]},{"type":"Modified residue","location":{"start":{"value":1003,"modifier":"EXACT"},"end":{"value":1003,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9ESE1"}]},{"type":"Modified residue","location":{"start":{"value":1100,"modifier":"EXACT"},"end":{"value":1100,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"}]},{"type":"Modified residue","location":{"start":{"value":1135,"modifier":"EXACT"},"end":{"value":1135,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":1139,"modifier":"EXACT"},"end":{"value":1139,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"}]},{"type":"Modified residue","location":{"start":{"value":1233,"modifier":"EXACT"},"end":{"value":1233,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9ESE1"}]},{"type":"Modified residue","location":{"start":{"value":1247,"modifier":"EXACT"},"end":{"value":1247,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":1261,"modifier":"EXACT"},"end":{"value":1261,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]},{"type":"Modified residue","location":{"start":{"value":1488,"modifier":"EXACT"},"end":{"value":1488,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":1498,"modifier":"EXACT"},"end":{"value":1498,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":1605,"modifier":"EXACT"},"end":{"value":1605,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]},{"type":"Modified residue","location":{"start":{"value":1767,"modifier":"EXACT"},"end":{"value":1767,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9ESE1"}]},{"type":"Modified residue","location":{"start":{"value":1770,"modifier":"EXACT"},"end":{"value":1770,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9ESE1"}]},{"type":"Modified residue","location":{"start":{"value":2064,"modifier":"EXACT"},"end":{"value":2064,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":2496,"modifier":"EXACT"},"end":{"value":2496,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Alternative sequence","location":{"start":{"value":2016,"modifier":"EXACT"},"end":{"value":2026,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"12160729"}],"featureId":"VSP_038225","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":2684,"modifier":"EXACT"},"end":{"value":2684,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"12160729"}],"featureId":"VSP_038226","alternativeSequence":{}},{"type":"Natural variant","location":{"start":{"value":1090,"modifier":"EXACT"},"end":{"value":1090,"modifier":"EXACT"}},"description":"in dbSNP:rs1782360","featureCrossReferences":[{"database":"dbSNP","id":"rs1782360"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12160729"}],"featureId":"VAR_057605","alternativeSequence":{"originalSequence":"A","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":1230,"modifier":"EXACT"},"end":{"value":1230,"modifier":"EXACT"}},"description":"in dbSNP:rs34708681","featureCrossReferences":[{"database":"dbSNP","id":"rs34708681"}],"featureId":"VAR_057606","alternativeSequence":{"originalSequence":"G","alternativeSequences":["D"]}},{"type":"Natural variant","location":{"start":{"value":1677,"modifier":"EXACT"},"end":{"value":1677,"modifier":"EXACT"}},"description":"in dbSNP:rs17027133","featureCrossReferences":[{"database":"dbSNP","id":"rs17027133"}],"featureId":"VAR_057607","alternativeSequence":{"originalSequence":"N","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":1997,"modifier":"EXACT"},"end":{"value":1997,"modifier":"EXACT"}},"description":"in dbSNP:rs35879351","featureCrossReferences":[{"database":"dbSNP","id":"rs35879351"}],"featureId":"VAR_057608","alternativeSequence":{"originalSequence":"R","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":2038,"modifier":"EXACT"},"end":{"value":2038,"modifier":"EXACT"}},"description":"in a breast cancer sample; somatic mutation","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16959974"}],"featureId":"VAR_035883","alternativeSequence":{"originalSequence":"Q","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":2274,"modifier":"EXACT"},"end":{"value":2274,"modifier":"EXACT"}},"description":"in a breast cancer sample; somatic mutation","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16959974"}],"featureId":"VAR_035884","alternativeSequence":{"originalSequence":"G","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":2657,"modifier":"EXACT"},"end":{"value":2657,"modifier":"EXACT"}},"description":"in CVID8; dbSNP:rs199469663","featureCrossReferences":[{"database":"dbSNP","id":"rs199469663"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22608502"}],"featureId":"VAR_068690","alternativeSequence":{"originalSequence":"I","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":2701,"modifier":"EXACT"},"end":{"value":2701,"modifier":"EXACT"}},"description":"in a breast cancer sample; somatic mutation","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16959974"}],"featureId":"VAR_035885","alternativeSequence":{"originalSequence":"T","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":2704,"modifier":"EXACT"},"end":{"value":2704,"modifier":"EXACT"}},"description":"in dbSNP:rs3749574","featureCrossReferences":[{"database":"dbSNP","id":"rs3749574"}],"featureId":"VAR_057609","alternativeSequence":{"originalSequence":"A","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":2713,"modifier":"EXACT"},"end":{"value":2713,"modifier":"EXACT"}},"description":"in dbSNP:rs34662958","featureCrossReferences":[{"database":"dbSNP","id":"rs34662958"}],"featureId":"VAR_057610","alternativeSequence":{"originalSequence":"L","alternativeSequences":["F"]}},{"type":"Natural variant","location":{"start":{"value":2809,"modifier":"EXACT"},"end":{"value":2809,"modifier":"EXACT"}},"description":"in dbSNP:rs2290846","featureCrossReferences":[{"database":"dbSNP","id":"rs2290846"}],"featureId":"VAR_022028","alternativeSequence":{"originalSequence":"S","alternativeSequences":["L"]}},{"type":"Sequence conflict","location":{"start":{"value":377,"modifier":"EXACT"},"end":{"value":377,"modifier":"EXACT"}},"description":"in Ref. 2; AAM53530","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"F","alternativeSequences":["L"]}},{"type":"Sequence conflict","location":{"start":{"value":750,"modifier":"EXACT"},"end":{"value":751,"modifier":"EXACT"}},"description":"in Ref. 1; AAG48558","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"LA","alternativeSequences":["RP"]}},{"type":"Sequence conflict","location":{"start":{"value":2179,"modifier":"EXACT"},"end":{"value":2179,"modifier":"EXACT"}},"description":"in Ref. 1; AAG48558 and 3; AAB09603","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"Y","alternativeSequences":["F"]}},{"type":"Beta strand","location":{"start":{"value":2079,"modifier":"EXACT"},"end":{"value":2087,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1T77"}]},{"type":"Beta strand","location":{"start":{"value":2092,"modifier":"EXACT"},"end":{"value":2099,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1T77"}]},{"type":"Beta strand","location":{"start":{"value":2101,"modifier":"EXACT"},"end":{"value":2108,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1T77"}]},{"type":"Helix","location":{"start":{"value":2113,"modifier":"EXACT"},"end":{"value":2117,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1T77"}]},{"type":"Helix","location":{"start":{"value":2120,"modifier":"EXACT"},"end":{"value":2125,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1T77"}]},{"type":"Beta strand","location":{"start":{"value":2132,"modifier":"EXACT"},"end":{"value":2134,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1T77"}]},{"type":"Helix","location":{"start":{"value":2135,"modifier":"EXACT"},"end":{"value":2137,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1T77"}]},{"type":"Beta strand","location":{"start":{"value":2138,"modifier":"EXACT"},"end":{"value":2146,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1T77"}]},{"type":"Beta strand","location":{"start":{"value":2149,"modifier":"EXACT"},"end":{"value":2157,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1T77"}]},{"type":"Beta strand","location":{"start":{"value":2162,"modifier":"EXACT"},"end":{"value":2166,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1T77"}]},{"type":"Helix","location":{"start":{"value":2170,"modifier":"EXACT"},"end":{"value":2179,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1T77"}]},{"type":"Turn","location":{"start":{"value":2195,"modifier":"EXACT"},"end":{"value":2199,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1T77"}]},{"type":"Helix","location":{"start":{"value":2202,"modifier":"EXACT"},"end":{"value":2208,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1T77"}]},{"type":"Helix","location":{"start":{"value":2211,"modifier":"EXACT"},"end":{"value":2216,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1T77"}]},{"type":"Helix","location":{"start":{"value":2222,"modifier":"EXACT"},"end":{"value":2233,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1T77"}]},{"type":"Helix","location":{"start":{"value":2240,"modifier":"EXACT"},"end":{"value":2242,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1T77"}]},{"type":"Beta strand","location":{"start":{"value":2254,"modifier":"EXACT"},"end":{"value":2257,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1T77"}]},{"type":"Helix","location":{"start":{"value":2263,"modifier":"EXACT"},"end":{"value":2265,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1T77"}]},{"type":"Helix","location":{"start":{"value":2273,"modifier":"EXACT"},"end":{"value":2276,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1T77"}]},{"type":"Helix","location":{"start":{"value":2278,"modifier":"EXACT"},"end":{"value":2290,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1T77"}]},{"type":"Beta strand","location":{"start":{"value":2294,"modifier":"EXACT"},"end":{"value":2296,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1T77"}]},{"type":"Beta strand","location":{"start":{"value":2300,"modifier":"EXACT"},"end":{"value":2303,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1T77"}]},{"type":"Helix","location":{"start":{"value":2308,"modifier":"EXACT"},"end":{"value":2315,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1T77"}]},{"type":"Helix","location":{"start":{"value":2321,"modifier":"EXACT"},"end":{"value":2329,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1T77"}]},{"type":"Turn","location":{"start":{"value":2336,"modifier":"EXACT"},"end":{"value":2338,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1T77"}]},{"type":"Helix","location":{"start":{"value":2343,"modifier":"EXACT"},"end":{"value":2352,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1T77"}]},{"type":"Helix","location":{"start":{"value":2362,"modifier":"EXACT"},"end":{"value":2365,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1T77"}]},{"type":"Helix","location":{"start":{"value":2368,"modifier":"EXACT"},"end":{"value":2371,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1T77"}]},{"type":"Helix","location":{"start":{"value":2400,"modifier":"EXACT"},"end":{"value":2412,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1T77"}]},{"type":"Helix","location":{"start":{"value":2414,"modifier":"EXACT"},"end":{"value":2417,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1T77"}]},{"type":"Helix","location":{"start":{"value":2420,"modifier":"EXACT"},"end":{"value":2427,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1T77"}]},{"type":"Helix","location":{"start":{"value":2434,"modifier":"EXACT"},"end":{"value":2440,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1T77"}]},{"type":"Helix","location":{"start":{"value":2446,"modifier":"EXACT"},"end":{"value":2448,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1T77"}]},{"type":"Helix","location":{"start":{"value":2455,"modifier":"EXACT"},"end":{"value":2457,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1T77"}]},{"type":"Helix","location":{"start":{"value":2461,"modifier":"EXACT"},"end":{"value":2474,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1T77"}]},{"type":"Helix","location":{"start":{"value":2477,"modifier":"EXACT"},"end":{"value":2480,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1T77"}]},{"type":"Helix","location":{"start":{"value":2485,"modifier":"EXACT"},"end":{"value":2488,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1T77"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0007","category":"PTM","name":"Acetylation"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"id":"KW-0225","category":"Disease","name":"Disease variant"},{"id":"KW-0256","category":"Cellular component","name":"Endoplasmic reticulum"},{"id":"KW-0333","category":"Cellular component","name":"Golgi apparatus"},{"id":"KW-0458","category":"Cellular component","name":"Lysosome"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0677","category":"Domain","name":"Repeat"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"id":"KW-0853","category":"Domain","name":"WD repeat"}],"references":[{"referenceNumber":1,"citation":{"id":"11254716","citationType":"journal article","authors":["Wang J.-W.","Howson J.","Haller E.","Kerr W.G."],"citationCrossReferences":[{"database":"PubMed","id":"11254716"},{"database":"DOI","id":"10.4049/jimmunol.166.7.4586"}],"title":"Identification of a novel lipopolysaccharide-inducible gene with key features of both A kinase anchor proteins and chs1/beige proteins.","publicationDate":"2001","journal":"J. Immunol.","firstPage":"4586","lastPage":"4595","volume":"166"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)"]},{"referenceNumber":2,"citation":{"id":"12160729","citationType":"journal article","authors":["Dyomin V.G.","Chaganti S.R.","Dyomina K.","Palanisamy N.","Murty V.V.V.S.","Dalla-Favera R.","Chaganti R.S.K."],"citationCrossReferences":[{"database":"PubMed","id":"12160729"},{"database":"DOI","id":"10.1006/geno.2002.6822"}],"title":"BCL8 is a novel, evolutionarily conserved human gene family encoding proteins with presumptive protein kinase A anchoring function.","publicationDate":"2002","journal":"Genomics","firstPage":"158","lastPage":"165","volume":"80"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)","TISSUE SPECIFICITY","VARIANT GLY-1090"]},{"referenceNumber":3,"citation":{"id":"15815621","citationType":"journal article","authors":["Hillier L.W.","Graves T.A.","Fulton R.S.","Fulton L.A.","Pepin K.H.","Minx P.","Wagner-McPherson C.","Layman D.","Wylie K.","Sekhon M.","Becker M.C.","Fewell G.A.","Delehaunty K.D.","Miner T.L.","Nash W.E.","Kremitzki C.","Oddy L.","Du H.","Sun H.","Bradshaw-Cordum H.","Ali J.","Carter J.","Cordes M.","Harris A.","Isak A.","van Brunt A.","Nguyen C.","Du F.","Courtney L.","Kalicki J.","Ozersky P.","Abbott S.","Armstrong J.","Belter E.A.","Caruso L.","Cedroni M.","Cotton M.","Davidson T.","Desai A.","Elliott G.","Erb T.","Fronick C.","Gaige T.","Haakenson W.","Haglund K.","Holmes A.","Harkins R.","Kim K.","Kruchowski S.S.","Strong C.M.","Grewal N.","Goyea E.","Hou S.","Levy A.","Martinka S.","Mead K.","McLellan M.D.","Meyer R.","Randall-Maher J.","Tomlinson C.","Dauphin-Kohlberg S.","Kozlowicz-Reilly A.","Shah N.","Swearengen-Shahid S.","Snider J.","Strong J.T.","Thompson J.","Yoakum M.","Leonard S.","Pearman C.","Trani L.","Radionenko M.","Waligorski J.E.","Wang C.","Rock S.M.","Tin-Wollam A.-M.","Maupin R.","Latreille P.","Wendl M.C.","Yang S.-P.","Pohl C.","Wallis J.W.","Spieth J.","Bieri T.A.","Berkowicz N.","Nelson J.O.","Osborne J.","Ding L.","Meyer R.","Sabo A.","Shotland Y.","Sinha P.","Wohldmann P.E.","Cook L.L.","Hickenbotham M.T.","Eldred J.","Williams D.","Jones T.A.","She X.","Ciccarelli F.D.","Izaurralde E.","Taylor J.","Schmutz J.","Myers R.M.","Cox D.R.","Huang X.","McPherson J.D.","Mardis E.R.","Clifton S.W.","Warren W.C.","Chinwalla A.T.","Eddy S.R.","Marra M.A.","Ovcharenko I.","Furey T.S.","Miller W.","Eichler E.E.","Bork P.","Suyama M.","Torrents D.","Waterston R.H.","Wilson R.K."],"citationCrossReferences":[{"database":"PubMed","id":"15815621"},{"database":"DOI","id":"10.1038/nature03466"}],"title":"Generation and annotation of the DNA sequences of human chromosomes 2 and 4.","publicationDate":"2005","journal":"Nature","firstPage":"724","lastPage":"731","volume":"434"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":4,"citation":{"id":"CI-KADEL49M05MU","citationType":"submission","authors":["Mager D.L."],"publicationDate":"DEC-1994","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] OF 775-2863 (ISOFORM 1)"]},{"referenceNumber":5,"citation":{"id":"1505956","citationType":"journal article","authors":["Feuchter A.E.","Freeman J.D.","Mager D.L."],"citationCrossReferences":[{"database":"PubMed","id":"1505956"},{"database":"DOI","id":"10.1016/0888-7543(92)90041-p"}],"title":"Strategy for detecting cellular transcripts promoted by human endogenous long terminal repeats: identification of a novel gene (CDC4L) with homology to yeast CDC4.","publicationDate":"1992","journal":"Genomics","firstPage":"1237","lastPage":"1246","volume":"13"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] OF 2179-2863 (ISOFORM 1)"]},{"referenceNumber":6,"citation":{"id":"17081983","citationType":"journal article","authors":["Olsen J.V.","Blagoev B.","Gnad F.","Macek B.","Kumar C.","Mortensen P.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"17081983"},{"database":"DOI","id":"10.1016/j.cell.2006.09.026"}],"title":"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.","publicationDate":"2006","journal":"Cell","firstPage":"635","lastPage":"648","volume":"127"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":7,"citation":{"id":"17525332","citationType":"journal article","authors":["Matsuoka S.","Ballif B.A.","Smogorzewska A.","McDonald E.R. III","Hurov K.E.","Luo J.","Bakalarski C.E.","Zhao Z.","Solimini N.","Lerenthal Y.","Shiloh Y.","Gygi S.P.","Elledge S.J."],"citationCrossReferences":[{"database":"PubMed","id":"17525332"},{"database":"DOI","id":"10.1126/science.1140321"}],"title":"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.","publicationDate":"2007","journal":"Science","firstPage":"1160","lastPage":"1166","volume":"316"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Embryonic kidney","type":"TISSUE"}]},{"referenceNumber":8,"citation":{"id":"18669648","citationType":"journal article","authors":["Dephoure N.","Zhou C.","Villen J.","Beausoleil S.A.","Bakalarski C.E.","Elledge S.J.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"18669648"},{"database":"DOI","id":"10.1073/pnas.0805139105"}],"title":"A quantitative atlas of mitotic phosphorylation.","publicationDate":"2008","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"10762","lastPage":"10767","volume":"105"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-979","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":9,"citation":{"id":"19413330","citationType":"journal article","authors":["Gauci S.","Helbig A.O.","Slijper M.","Krijgsveld J.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"19413330"},{"database":"DOI","id":"10.1021/ac9004309"}],"title":"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.","publicationDate":"2009","journal":"Anal. Chem.","firstPage":"4493","lastPage":"4501","volume":"81"},"referencePositions":["ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2","CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":10,"citation":{"id":"19690332","citationType":"journal article","authors":["Mayya V.","Lundgren D.H.","Hwang S.-I.","Rezaul K.","Wu L.","Eng J.K.","Rodionov V.","Han D.K."],"citationCrossReferences":[{"database":"PubMed","id":"19690332"},{"database":"DOI","id":"10.1126/scisignal.2000007"}],"title":"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.","publicationDate":"2009","journal":"Sci. Signal.","firstPage":"RA46","lastPage":"RA46","volume":"2"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Leukemic T-cell","type":"TISSUE"}]},{"referenceNumber":11,"citation":{"id":"20068231","citationType":"journal article","authors":["Olsen J.V.","Vermeulen M.","Santamaria A.","Kumar C.","Miller M.L.","Jensen L.J.","Gnad F.","Cox J.","Jensen T.S.","Nigg E.A.","Brunak S.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"20068231"},{"database":"DOI","id":"10.1126/scisignal.2000475"}],"title":"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.","publicationDate":"2010","journal":"Sci. Signal.","firstPage":"RA3","lastPage":"RA3","volume":"3"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1488","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":12,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Buerckstuemmer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":13,"citation":{"id":"21406692","citationType":"journal article","authors":["Rigbolt K.T.","Prokhorova T.A.","Akimov V.","Henningsen J.","Johansen P.T.","Kratchmarova I.","Kassem M.","Mann M.","Olsen J.V.","Blagoev B."],"citationCrossReferences":[{"database":"PubMed","id":"21406692"},{"database":"DOI","id":"10.1126/scisignal.2001570"}],"title":"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.","publicationDate":"2011","journal":"Sci. Signal.","firstPage":"RS3","lastPage":"RS3","volume":"4"},"referencePositions":["ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2","PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10; SER-1100 AND SER-1139","CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":14,"citation":{"id":"22814378","citationType":"journal article","authors":["Van Damme P.","Lasa M.","Polevoda B.","Gazquez C.","Elosegui-Artola A.","Kim D.S.","De Juan-Pardo E.","Demeyer K.","Hole K.","Larrea E.","Timmerman E.","Prieto J.","Arnesen T.","Sherman F.","Gevaert K.","Aldabe R."],"citationCrossReferences":[{"database":"PubMed","id":"22814378"},{"database":"DOI","id":"10.1073/pnas.1210303109"}],"title":"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.","publicationDate":"2012","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"12449","lastPage":"12454","volume":"109"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":15,"citation":{"id":"23186163","citationType":"journal article","authors":["Zhou H.","Di Palma S.","Preisinger C.","Peng M.","Polat A.N.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"23186163"},{"database":"DOI","id":"10.1021/pr300630k"}],"title":"Toward a comprehensive characterization of a human cancer cell phosphoproteome.","publicationDate":"2013","journal":"J. Proteome Res.","firstPage":"260","lastPage":"271","volume":"12"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10; SER-1135; SER-1247; SER-1261; SER-1488; SER-1498; SER-2064 AND SER-2496","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"},{"value":"Erythroleukemia","type":"TISSUE"}]},{"referenceNumber":16,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1261 AND SER-1605","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":17,"citation":{"id":"31263572","citationType":"journal article","authors":["Keskitalo S.","Haapaniemi E.M.","Glumoff V.","Liu X.","Lehtinen V.","Fogarty C.","Rajala H.","Chiang S.C.","Mustjoki S.","Kovanen P.","Lohi J.","Bryceson Y.T.","Seppaenen M.","Kere J.","Heiskanen K.","Varjosalo M."],"citationCrossReferences":[{"database":"PubMed","id":"31263572"},{"database":"DOI","id":"10.1038/s41525-019-0088-5"}],"title":"Dominant TOM1 mutation associated with combined immunodeficiency and autoimmune disease.","publicationDate":"2019","journal":"NPJ Genom. Med.","firstPage":"14","lastPage":"14","volume":"4"},"referencePositions":["INTERACTION WITH TOM1 AND TOLLIP","SUBCELLULAR LOCATION"]},{"referenceNumber":18,"citation":{"id":"33773106","citationType":"journal article","authors":["Nguyen T.N.","Padman B.S.","Zellner S.","Khuu G.","Uoselis L.","Lam W.K.","Skulsuppaisarn M.","Lindblom R.S.J.","Watts E.M.","Behrends C.","Lazarou M."],"citationCrossReferences":[{"database":"PubMed","id":"33773106"},{"database":"DOI","id":"10.1016/j.molcel.2021.03.001"}],"title":"ATG4 family proteins drive phagophore growth independently of the LC3/GABARAP lipidation system.","publicationDate":"2021","journal":"Mol. Cell","firstPage":"2013","lastPage":"2030","volume":"81"},"referencePositions":["FUNCTION"]},{"referenceNumber":19,"citation":{"id":"15554694","citationType":"journal article","authors":["Gebauer D.","Li J.","Jogl G.","Shen Y.","Myszka D.G.","Tong L."],"citationCrossReferences":[{"database":"PubMed","id":"15554694"},{"database":"DOI","id":"10.1021/bi049498y"}],"title":"Crystal structure of the PH-BEACH domains of human LRBA/BGL.","publicationDate":"2004","journal":"Biochemistry","firstPage":"14873","lastPage":"14880","volume":"43"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 2076-2489"]},{"referenceNumber":20,"citation":{"id":"16959974","citationType":"journal article","authors":["Sjoeblom T.","Jones S.","Wood L.D.","Parsons D.W.","Lin J.","Barber T.D.","Mandelker D.","Leary R.J.","Ptak J.","Silliman N.","Szabo S.","Buckhaults P.","Farrell C.","Meeh P.","Markowitz S.D.","Willis J.","Dawson D.","Willson J.K.V.","Gazdar A.F.","Hartigan J.","Wu L.","Liu C.","Parmigiani G.","Park B.H.","Bachman K.E.","Papadopoulos N.","Vogelstein B.","Kinzler K.W.","Velculescu V.E."],"citationCrossReferences":[{"database":"PubMed","id":"16959974"},{"database":"DOI","id":"10.1126/science.1133427"}],"title":"The consensus coding sequences of human breast and colorectal cancers.","publicationDate":"2006","journal":"Science","firstPage":"268","lastPage":"274","volume":"314"},"referencePositions":["VARIANTS [LARGE SCALE ANALYSIS] HIS-2038; ARG-2274 AND LYS-2701"]},{"referenceNumber":21,"citation":{"id":"22608502","citationType":"journal article","authors":["Lopez-Herrera G.","Tampella G.","Pan-Hammarstrom Q.","Herholz P.","Trujillo-Vargas C.M.","Phadwal K.","Simon A.K.","Moutschen M.","Etzioni A.","Mory A.","Srugo I.","Melamed D.","Hultenby K.","Liu C.","Baronio M.","Vitali M.","Philippet P.","Dideberg V.","Aghamohammadi A.","Rezaei N.","Enright V.","Du L.","Salzer U.","Eibel H.","Pfeifer D.","Veelken H.","Stauss H.","Lougaris V.","Plebani A.","Gertz E.M.","Schaffer A.A.","Hammarstrom L.","Grimbacher B."],"citationCrossReferences":[{"database":"PubMed","id":"22608502"},{"database":"DOI","id":"10.1016/j.ajhg.2012.04.015"}],"title":"Deleterious mutations in LRBA are associated with a syndrome of immune deficiency and autoimmunity.","publicationDate":"2012","journal":"Am. J. Hum. Genet.","firstPage":"986","lastPage":"1001","volume":"90"},"referencePositions":["VARIANT CVID8 SER-2657"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AF216648","properties":[{"key":"ProteinId","value":"AAG48558.2"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF217149","properties":[{"key":"ProteinId","value":"AAG48559.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF467287","properties":[{"key":"ProteinId","value":"AAM53530.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AC092544","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC092612","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC093748","properties":[{"key":"ProteinId","value":"AAY40984.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC097373","properties":[{"key":"ProteinId","value":"AAY40973.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC104796","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC110813","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M83822","properties":[{"key":"ProteinId","value":"AAB09603.1"},{"key":"Status","value":"ALT_FRAME"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS3773.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P50851-1"},{"database":"CCDS","id":"CCDS58928.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P50851-2"},{"database":"RefSeq","id":"NP_001186211.2","properties":[{"key":"NucleotideSequenceId","value":"NM_001199282.3"}],"isoformId":"P50851-2"},{"database":"RefSeq","id":"NP_006717.2","properties":[{"key":"NucleotideSequenceId","value":"NM_006726.5"}],"isoformId":"P50851-1"},{"database":"RefSeq","id":"XP_011530736.1","properties":[{"key":"NucleotideSequenceId","value":"XM_011532434.3"}],"isoformId":"P50851-1"},{"database":"PDB","id":"1T77","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.40 A"},{"key":"Chains","value":"A/B/C/D=2076-2489"}]},{"database":"PDBsum","id":"1T77","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P50851","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"107423","properties":[{"key":"Interactions","value":"201"}]},{"database":"DIP","id":"DIP-50531N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"P50851","properties":[{"key":"Number of interactors","value":"2160"}]},{"database":"IntAct","id":"P50851","properties":[{"key":"Interactions","value":"102"}]},{"database":"MINT","id":"P50851","properties":[{"key":"Description","value":"-"}]},{"database":"STRING","id":"9606.ENSP00000349629","properties":[{"key":"Description","value":"-"}]},{"database":"BindingDB","id":"P50851","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL6066253","properties":[{"key":"Description","value":"-"}]},{"database":"GlyCosmos","id":"P50851","properties":[{"key":"glycosylation","value":"2 sites, 1 glycan"}]},{"database":"GlyGen","id":"P50851","properties":[{"key":"glycosylation","value":"8 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (4 sites)"}]},{"database":"iPTMnet","id":"P50851","properties":[{"key":"Description","value":"-"}]},{"database":"MetOSite","id":"P50851","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"P50851","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"P50851","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"LRBA","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"259016388","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"P50851","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"P50851","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000349629","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"P50851","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"56265","properties":[{"key":"Description","value":"-"}],"isoformId":"P50851-1"},{"database":"ProteomicsDB","id":"56266","properties":[{"key":"Description","value":"-"}],"isoformId":"P50851-2"},{"database":"Pumba","id":"P50851","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"16513","properties":[{"key":"antibodies","value":"71 antibodies from 20 providers"}]},{"database":"DNASU","id":"987","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000357115.9","properties":[{"key":"ProteinId","value":"ENSP00000349629.3"},{"key":"GeneId","value":"ENSG00000198589.16"}],"isoformId":"P50851-1"},{"database":"Ensembl","id":"ENST00000510413.5","properties":[{"key":"ProteinId","value":"ENSP00000421552.1"},{"key":"GeneId","value":"ENSG00000198589.16"}],"isoformId":"P50851-2"},{"database":"Ensembl","id":"ENST00000911751.1","properties":[{"key":"ProteinId","value":"ENSP00000581810.1"},{"key":"GeneId","value":"ENSG00000198589.16"}],"isoformId":"P50851-1"},{"database":"GeneID","id":"987","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:987","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"uc003ilu.5","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"P50851-1"},{"database":"AGR","id":"HGNC:1742","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA30444","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"987","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"987","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"LRBA","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:1742","properties":[{"key":"GeneName","value":"LRBA"}]},{"database":"HPA","id":"ENSG00000198589","properties":[{"key":"ExpressionPatterns","value":"Low tissue specificity"}]},{"database":"MalaCards","id":"LRBA","properties":[{"key":"Description","value":"-"}]},{"database":"MIM","id":"606453","properties":[{"key":"Type","value":"gene"}]},{"database":"MIM","id":"614700","properties":[{"key":"Type","value":"phenotype"}]},{"database":"OpenTargets","id":"ENSG00000198589","properties":[{"key":"Description","value":"-"}]},{"database":"Orphanet","id":"445018","properties":[{"key":"Disease","value":"Syndromic autoimmune enteropathy due to LRBA deficiency"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000198589","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG1787","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000154778","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_000218_2_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P50851","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"26681at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"P50851","properties":[{"key":"Number of GO annotations","value":"5 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"P50851","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"P50851","properties":[{"key":"Description","value":"-"}]},{"database":"SignaLink","id":"P50851","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"P50851","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000198589","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"987","properties":[{"key":"hits","value":"14 hits in 1154 CRISPR screens"}]},{"database":"ChiTaRS","id":"LRBA","properties":[{"key":"OrganismName","value":"human"}]},{"database":"EvolutionaryTrace","id":"P50851","properties":[{"key":"Description","value":"-"}]},{"database":"GeneWiki","id":"LRBA","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"987","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"P50851","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:P50851","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 4"}]},{"database":"RNAct","id":"P50851","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000198589","properties":[{"key":"ExpressionPatterns","value":"Expressed in upper leg skin and 190 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"P50851","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0005789","properties":[{"key":"GoTerm","value":"C:endoplasmic reticulum membrane"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0005794","properties":[{"key":"GoTerm","value":"C:Golgi apparatus"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0005765","properties":[{"key":"GoTerm","value":"C:lysosomal membrane"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"HDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"19946888"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0019901","properties":[{"key":"GoTerm","value":"F:protein kinase binding"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0000423","properties":[{"key":"GoTerm","value":"P:mitophagy"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"33773106"}]},{"database":"GO","id":"GO:0034497","properties":[{"key":"GoTerm","value":"P:protein localization to phagophore assembly site"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"33773106"}]},{"database":"CDD","id":"cd06071","properties":[{"key":"EntryName","value":"Beach"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd01201","properties":[{"key":"EntryName","value":"PH_BEACH"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.130.10.10:FF:000886","properties":[{"key":"EntryName","value":"lipopolysaccharide-responsive and beige-like anchor protein isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.25.10.10:FF:000168","properties":[{"key":"EntryName","value":"LPS responsive beige-like anchor protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.1540.10:FF:000001","properties":[{"key":"EntryName","value":"neurobeachin isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.30.29.30:FF:000059","properties":[{"key":"EntryName","value":"neurobeachin isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.120.200:FF:000010","properties":[{"key":"EntryName","value":"neurobeachin isoform X2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.120.200","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.1540.10","properties":[{"key":"EntryName","value":"BEACH domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.25.10.10","properties":[{"key":"EntryName","value":"Leucine-rich Repeat Variant"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.30.29.30","properties":[{"key":"EntryName","value":"Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.130.10.10","properties":[{"key":"EntryName","value":"YVTN repeat-like/Quinoprotein amine dehydrogenase"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR011989","properties":[{"key":"EntryName","value":"ARM-like"}]},{"database":"InterPro","id":"IPR016024","properties":[{"key":"EntryName","value":"ARM-type_fold"}]},{"database":"InterPro","id":"IPR000409","properties":[{"key":"EntryName","value":"BEACH_dom"}]},{"database":"InterPro","id":"IPR036372","properties":[{"key":"EntryName","value":"BEACH_dom_sf"}]},{"database":"InterPro","id":"IPR050865","properties":[{"key":"EntryName","value":"BEACH_Domain"}]},{"database":"InterPro","id":"IPR013320","properties":[{"key":"EntryName","value":"ConA-like_dom_sf"}]},{"database":"InterPro","id":"IPR046851","properties":[{"key":"EntryName","value":"NBCH_WD40"}]},{"database":"InterPro","id":"IPR010508","properties":[{"key":"EntryName","value":"NBEA-like_DUF1088"}]},{"database":"InterPro","id":"IPR031570","properties":[{"key":"EntryName","value":"NBEA/BDCP_DUF4704"}]},{"database":"InterPro","id":"IPR046852","properties":[{"key":"EntryName","value":"Neurobeachin_a-sol"}]},{"database":"InterPro","id":"IPR023362","properties":[{"key":"EntryName","value":"PH-BEACH_dom"}]},{"database":"InterPro","id":"IPR011993","properties":[{"key":"EntryName","value":"PH-like_dom_sf"}]},{"database":"InterPro","id":"IPR015943","properties":[{"key":"EntryName","value":"WD40/YVTN_repeat-like_dom_sf"}]},{"database":"InterPro","id":"IPR036322","properties":[{"key":"EntryName","value":"WD40_repeat_dom_sf"}]},{"database":"InterPro","id":"IPR001680","properties":[{"key":"EntryName","value":"WD40_rpt"}]},{"database":"PANTHER","id":"PTHR13743","properties":[{"key":"EntryName","value":"BEIGE/BEACH-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR13743:SF64","properties":[{"key":"EntryName","value":"LIPOPOLYSACCHARIDE-RESPONSIVE AND BEIGE-LIKE ANCHOR PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02138","properties":[{"key":"EntryName","value":"Beach"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF06469","properties":[{"key":"EntryName","value":"DUF1088"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF15787","properties":[{"key":"EntryName","value":"DUF4704"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF13385","properties":[{"key":"EntryName","value":"Laminin_G_3"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF20426","properties":[{"key":"EntryName","value":"NBCH_WD40"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF20425","properties":[{"key":"EntryName","value":"Neurobeachin"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF14844","properties":[{"key":"EntryName","value":"PH_BEACH"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM01026","properties":[{"key":"EntryName","value":"Beach"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00320","properties":[{"key":"EntryName","value":"WD40"},{"key":"MatchStatus","value":"5"}]},{"database":"SUPFAM","id":"SSF48371","properties":[{"key":"EntryName","value":"ARM repeat"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF81837","properties":[{"key":"EntryName","value":"BEACH domain"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF49899","properties":[{"key":"EntryName","value":"Concanavalin A-like lectins/glucanases"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF50729","properties":[{"key":"EntryName","value":"PH domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF50978","properties":[{"key":"EntryName","value":"WD40 repeat-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50197","properties":[{"key":"EntryName","value":"BEACH"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51783","properties":[{"key":"EntryName","value":"PH_BEACH"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MASEDNRVPSPPPTGDDGGGGGREETPTEGGALSLKPGLPIRGIRMKFAVLTGLVEVGEVSNRDIVETVFNLLVGGQFDLEMNFIIQEGESINCMVDLLEKCDITCQAEVWSMFTAILKKSIRNLQVCTEVGLVEKVLGKIEKVDNMIADLLVDMLGVLASYNLTVRELKLFFSKLQGDKGRWPPHAGKLLSVLKHMPQKYGPDAFFNFPGKSAAAIALPPIAKWPYQNGFTFHTWLRMDPVNNINVDKDKPYLYCFRTSKGLGYSAHFVGGCLIVTSIKSKGKGFQHCVKFDFKPQKWYMVTIVHIYNRWKNSELRCYVNGELASYGEITWFVNTSDTFDKCFLGSSETADANRVFCGQMTAVYLFSEALNAAQIFAIYQLGLGYKGTFKFKAESDLFLAEHHKLLLYDGKLSSAIAFTYNPRATDAQLCLESSPKDNPSIFVHSPHALMLQDVKAVLTHSIQSAMHSIGGVQVLFPLFAQLDYRQYLSDEIDLTICSTLLAFIMELLKNSIAMQEQMLACKGFLVIGYSLEKSSKSHVSRAVLELCLAFSKYLSNLQNGMPLLKQLCDHVLLNPAIWIHTPAKVQLMLYTYLSTEFIGTVNIYNTIRRVGTVLLIMHTLKYYYWAVNPQDRSGITPKGLDGPRPNQKEMLSLRAFLLMFIKQLVMKDSGVKEDELQAILNYLLTMHEDDNLMDVLQLLVALMSEHPNSMIPAFDQRNGLRVIYKLLASKSEGIRVQALKAMGYFLKHLAPKRKAEVMLGHGLFSLLAERLMLQTNLITMTTYNVLFEILIEQIGTQVIHKQHPDPDSSVKIQNPQILKVIATLLRNSPQCPESMEVRRAFLSDMIKLFNNSRENRRSLLQCSVWQEWMLSLCYFNPKNSDEQKITEMVYAIFRILLYHAVKYEWGGWRVWVDTLSITHSKVTFEIHKENLANIFREQQGKVDEEIGLCSSTSVQAASGIRRDINVSVGSQQPDTKDSPVCPHFTTNGNENSSIEKTSSLESASNIELQTTNTSYEEMKAEQENQELPDEGTLEETLTNETRNADDLEVSSDIIEAVAISSNSFITTGKDSMTVSEVTASISSPSEEDASEMPEFLDKSIVEEEEDDDYVELKVEGSPTEEANLPTELQDNSLSPAASEAGEKLDMFGNDDKLIFQEGKPVTEKQTDTETQDSKDSGIQTMTASGSSAMSPETTVSQIAVESDLGQMLEEGKKATNLTRETKLINDCHGSVSEASSEQKIAKLDVSNVATDTERLELKASPNVEAPQPHRHVLEISRQHEQPGQGIAPDAVNGQRRDSRSTVFRIPEFNWSQMHQRLLTDLLFSIETDIQMWRSHSTKTVMDFVNSSDNVIFVHNTIHLISQVMDNMVMACGGILPLLSAATSATHELENIEPTQGLSIEASVTFLQRLISLVDVLIFASSLGFTEIEAEKSMSSGGILRQCLRLVCAVAVRNCLECQQHSQLKTRGDKALKPMHSLIPLGKSAAKSPVDIVTGGISPVRDLDRLLQDMDINRLRAVVFRDIEDSKQAQFLALAVVYFISVLMVSKYRDILEPQNERHSQSCTETGSENENVSLSEITPAAFSTLTTASVEESESTSSARRRDSGIGEETATGLGSHVEVTPHTAPPGVSAGPDAISEVLSTLSLEVNKSPETKNDRGNDLDTKATPSVSVSKNVNVKDILRSLVNIPADGVTVDPALLPPACLGALGDLSVEQPVQFRSFDRSVIVAAKKSAVSPSTFNTSIPTNAVSVVSSVDSAQASDMGGESPGSRSSNAKLPSVPTVDSVSQDPVSNMSITERLEHALEKAAPLLREIFVDFAPFLSRTLLGSHGQELLIEGTSLVCMKSSSSVVELVMLLCSQEWQNSIQKNAGLAFIELVNEGRLLSQTMKDHLVRVANEAEFILSRQRAEDIHRHAEFESLCAQYSADKREDEKMCDHLIRAAKYRDHVTATQLIQKIINILTDKHGAWGNSAVSRPLEFWRLDYWEDDLRRRRRFVRNPLGSTHPEATLKTAVEHVCIFKLRENSKATDEDILAKGKQSIRSQALGNQNSENEILLEGDDDTLSSVDEKDLENLAGPVSLSTPAQLVAPSVVVKGTLSVTSSELYFEVDEEDPNFKKIDPKILAYTEGLHGKWLFTEIRSIFSRRYLLQNTALEIFMANRVAVMFNFPDPATVKKVVNYLPRVGVGTSFGLPQTRRISLASPRQLFKASNMTQRWQHREISNFEYLMFLNTIAGRSYNDLNQYPVFPWVITNYESEELDLTLPTNFRDLSKPIGALNPKRAAFFAERYESWEDDQVPKFHYGTHYSTASFVLAWLLRIEPFTTYFLNLQGGKFDHADRTFSSISRAWRNSQRDTSDIKELIPEFYYLPEMFVNFNNYNLGVMDDGTVVSDVELPPWAKTSEEFVHINRLALESEFVSCQLHQWIDLIFGYKQQGPEAVRALNVFYYLTYEGAVNLNSITDPVLREAVEAQIRSFGQTPSQLLIEPHPPRGSAMQVSPLMFTDKAQQDVIMVLKFPSNSPVTHVAANTQPGLATPAVITVTANRLFAVNKWHNLPAHQGAVQDQPYQLPVEIDPLIASNTGMHRRQITDLLDQSIQVHSQCFVITSDNRYILVCGFWDKSFRVYSTDTGRLIQVVFGHWDVVTCLARSESYIGGNCYILSGSRDATLLLWYWNGKCSGIGDNPGSETAAPRAILTGHDYEVTCAAVCAELGLVLSGSQEGPCLIHSMNGDLLRTLEGPENCLKPKLIQASREGHCVIFYENGLFCTFSVNGKLQATMETDDNIRAIQLSRDGQYLLTGGDRGVVVVRQVSDLKQLFAYPGCDAGIRAMALSYDQRCIISGMASGSIVLFYNDFNRWHHEYQTRY","length":2863,"molWeight":319108,"crc64":"58CD1F4314F685EE","md5":"80E1494CC808D51207F280EE4BB96139"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"INTERACTION":1,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":2,"TISSUE SPECIFICITY":1,"INDUCTION":1,"DISEASE":1,"CAUTION":1,"SEQUENCE CAUTION":1},"countByFeatureType":{"Initiator methionine":1,"Chain":1,"Transmembrane":1,"Repeat":6,"Domain":2,"Region":6,"Coiled coil":1,"Compositional bias":7,"Modified residue":17,"Alternative sequence":2,"Natural variant":11,"Sequence conflict":3,"Beta strand":10,"Helix":25,"Turn":2},"uniParcId":"UPI000013E35C"}}