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TAF6 homodimer connects TFIID modules, forming a rigid core (PubMed:33795473)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11583621"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18628956"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20096117"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29358700"}],"value":"Transcriptional regulator which acts primarily as a positive regulator of transcription (PubMed:20096117, PubMed:29358700). Recruited to the promoters of a number of genes including GADD45A and CDKN1A/p21, leading to transcriptional up-regulation and subsequent induction of apoptosis (PubMed:11583621). Also up-regulates expression of other genes including GCNA/ACRC, HES1 and IFFO1 (PubMed:18628956). In contrast, down-regulates transcription of MDM2 (PubMed:11583621). Acts as a transcriptional coactivator to enhance transcription of TP53/p53-responsive genes such as DUSP1 (PubMed:20096117). Can also activate transcription and apoptosis independently of TP53 (PubMed:18628956). Drives apoptosis via the intrinsic apoptotic pathway by up-regulating apoptosis effectors such as BCL2L11/BIM and PMAIP1/NOXA (PubMed:29358700)"}],"commentType":"FUNCTION","molecule":"Isoform 4"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12601814"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15601843"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15960975"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33795473"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7667268"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8262073"}],"value":"Component of the TFIID basal transcription factor complex, composed of TATA-box-binding protein TBP, and a number of TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473, PubMed:8262073). Interacts directly with TBP, TAF1/TAFII250, TAF9/TAFII31 and TAF12/TAFII20 (PubMed:7667268). The TAF6/TAFII70-TAF9/TAFII31 heterodimer forms an octamer complex with the TAF4B/TFII105-TAF12/TFIID20 heterodimer (PubMed:15601843). Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BACC1, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10 (PubMed:15960975). Also interacts with the GTFs, TFIIEalpha/GTF2E1 and TFIIFalpha/GTF2F1 (PubMed:7667268). Component of the TBP-free TAFII-histone acetylase complex (TFTC-HAT) (PubMed:12601814)"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20096117"}],"value":"Interacts with TP53/p53"}],"commentType":"SUBUNIT","molecule":"Isoform 1"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11583621"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20096117"}],"value":"Not part of the TBP-free TAFII-histone acetylase complex (TFTC-HAT) (PubMed:11583621). Part of a TFIID-like complex which lacks TAF9 (PubMed:11583621). 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