{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P49816","uniProtkbId":"TSC2_RAT","entryAudit":{"firstPublicDate":"1996-10-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1996-10-01","entryVersion":198,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Rattus norvegicus","commonName":"Rat","taxonId":10116,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Glires","Rodentia","Myomorpha","Muroidea","Muridae","Murinae","Rattus"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"9045618"}],"value":"Tuberin"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"8519695"}],"value":"Tuberous sclerosis 2 protein homolog"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"8519695"},{"evidenceCode":"ECO:0000312","source":"RGD","id":"3908"}],"value":"Tsc2"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P49815"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12172553"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16707451"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9045618"}],"value":"Catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553). Within the TSC-TBC complex, TSC2 acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (By similarity). In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling (By similarity). The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 (By similarity). Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling (PubMed:16707451). Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 (PubMed:9045618)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P49815"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9045618"}],"value":"Component of the TSC-TBC complex (also named Rhebulator complex), composed of 2 molecules of TSC1, 2 molecules of TSC2 and 1 molecule of TBC1D7 (By similarity). Probably forms a complex composed of chaperones HSP90 and HSP70, co-chaperones STIP1/HOP, CDC37, PPP5C, PTGES3/p23, TSC1 and client protein TSC2 (By similarity). Probably forms a complex composed of chaperones HSP90 and HSP70, co-chaperones CDC37, PPP5C, TSC1 and client protein TSC2, CDK4, AKT, RAF1 and NR3C1; this complex does not contain co-chaperones STIP1/HOP and PTGES3/p23 (By similarity). Forms a complex containing HSP90AA1, TSC1 and TSC2; TSC1 is required to recruit TCS2 to the complex thereby stabilizing TSC2 (By similarity). Interacts with TSC1 and HERC1; the interaction with TSC1 stabilizes TSC2 and prevents the interaction with HERC1 (By similarity). May also interact with the adapter molecule RABEP1 (PubMed:9045618). The final complex may contain TSC2 and RABEP1 linked to RAB5 (PubMed:9045618). Interacts with HSPA1 and HSPA8 (By similarity). Interacts with NAA10 (via C-terminal domain) (By similarity). Interacts with RRAGA (polyubiquitinated) (By similarity). Interacts with WDR45B (By similarity). Interacts with RPAP3 and URI1 (By similarity). Interacts with YWHAG (By similarity). Interacts with RHEB (By similarity)"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P49815"}],"value":"Recruited to lysosomal membranes in a RHEB-dependent process in absence of nutrients (By similarity). In response to insulin signaling and phosphorylation by PKB/AKT1, the complex dissociates from lysosomal membranes and relocalizes to the cytosol (By similarity)"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P49815"}],"value":"Lysosome membrane","id":"SL-0157"},"topology":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P49815"}],"value":"Peripheral membrane protein","id":"SL-9903"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P49815"}],"value":"Cytoplasm, cytosol","id":"SL-0091"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["P49816-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["P49816-2"],"sequenceIds":["VSP_004481"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"isoformIds":["P49816-3"],"sequenceIds":["VSP_004482"],"isoformSequenceStatus":"Described"},{"name":{"value":"4"},"isoformIds":["P49816-4"],"sequenceIds":["VSP_004481","VSP_004482"],"isoformSequenceStatus":"Described"}],"note":{"texts":[{"value":"Additional isoforms seem to exist."}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8519695"}],"value":"CNS, uterus, heart, skeletal muscle, kidney and spleen"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P49815"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12172553"}],"value":"Phosphorylation at Ser-939 and Thr-1466 by PKB/AKT1 in response to insulin signaling and growth factor stimulation inhibits the ability of the TSC-TBC complex to suppress mTORC1 signaling: phosphorylation promotes dissociation of the TSC-TBC complex from lysosomal membranes, leading to activation of mTORC1 by RHEB (PubMed:12172553). Phosphorylation at Ser-1388, Ser-1420 or Ser-1422 does not affect interaction with TSC1 (By similarity). Phosphorylation by AMPK activates it and leads to negative regulation of the mTORC1 complex (By similarity). Phosphorylated at Ser-1800 by RPS6KA1; phosphorylation inhibits TSC2 ability to suppress mTORC1 signaling (By similarity). Phosphorylated by DAPK1 (By similarity)"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P49815"}],"value":"Ubiquitinated by the DCX(FBXW5) E3 ubiquitin-protein ligase complex, leading to its subsequent degradation. Ubiquitinated by MYCBP2 independently of its phosphorylation status leading to subsequent degradation; association with TSC1 protects from ubiquitination"}],"commentType":"PTM"},{"commentType":"DISEASE","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8519695"}],"value":"A germline insertion in Tsc2 is the cause of the Eker rat model of inherited cancer susceptibility. Gives rise to a spectrum of epithelial and nonepithelial neoplasms"}]}}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1809,"modifier":"EXACT"}},"description":"Tuberin","featureId":"PRO_0000065656"},{"type":"Domain","location":{"start":{"value":1533,"modifier":"EXACT"},"end":{"value":1760,"modifier":"EXACT"}},"description":"Rap-GAP","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00165"}]},{"type":"Region","location":{"start":{"value":1078,"modifier":"EXACT"},"end":{"value":1136,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1330,"modifier":"EXACT"},"end":{"value":1359,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1373,"modifier":"EXACT"},"end":{"value":1392,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1405,"modifier":"EXACT"},"end":{"value":1492,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1764,"modifier":"EXACT"},"end":{"value":1793,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1078,"modifier":"EXACT"},"end":{"value":1097,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1376,"modifier":"EXACT"},"end":{"value":1392,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1405,"modifier":"EXACT"},"end":{"value":1418,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1449,"modifier":"EXACT"},"end":{"value":1464,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Modified residue","location":{"start":{"value":540,"modifier":"EXACT"},"end":{"value":540,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P49815"}]},{"type":"Modified residue","location":{"start":{"value":664,"modifier":"EXACT"},"end":{"value":664,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P49815"}]},{"type":"Modified residue","location":{"start":{"value":927,"modifier":"EXACT"},"end":{"value":927,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P49815"}]},{"type":"Modified residue","location":{"start":{"value":939,"modifier":"EXACT"},"end":{"value":939,"modifier":"EXACT"}},"description":"Phosphoserine; by PKB/AKT1","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12172553"}]},{"type":"Modified residue","location":{"start":{"value":981,"modifier":"EXACT"},"end":{"value":981,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P49815"}]},{"type":"Modified residue","location":{"start":{"value":1130,"modifier":"EXACT"},"end":{"value":1130,"modifier":"EXACT"}},"description":"Phosphoserine; by PKB/AKT1","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12172553"}]},{"type":"Modified residue","location":{"start":{"value":1132,"modifier":"EXACT"},"end":{"value":1132,"modifier":"EXACT"}},"description":"Phosphoserine; by PKB/AKT1","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12172553"}]},{"type":"Modified residue","location":{"start":{"value":1155,"modifier":"EXACT"},"end":{"value":1155,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P49815"}]},{"type":"Modified residue","location":{"start":{"value":1271,"modifier":"EXACT"},"end":{"value":1271,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P49815"}]},{"type":"Modified residue","location":{"start":{"value":1340,"modifier":"EXACT"},"end":{"value":1340,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P49815"}]},{"type":"Modified residue","location":{"start":{"value":1341,"modifier":"EXACT"},"end":{"value":1341,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P49815"}]},{"type":"Modified residue","location":{"start":{"value":1349,"modifier":"EXACT"},"end":{"value":1349,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P49815"}]},{"type":"Modified residue","location":{"start":{"value":1366,"modifier":"EXACT"},"end":{"value":1366,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P49815"}]},{"type":"Modified residue","location":{"start":{"value":1389,"modifier":"EXACT"},"end":{"value":1389,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"22673903"}]},{"type":"Modified residue","location":{"start":{"value":1413,"modifier":"EXACT"},"end":{"value":1413,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"22673903"}]},{"type":"Modified residue","location":{"start":{"value":1420,"modifier":"EXACT"},"end":{"value":1420,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P49815"}]},{"type":"Modified residue","location":{"start":{"value":1422,"modifier":"EXACT"},"end":{"value":1422,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12172553"}]},{"type":"Modified residue","location":{"start":{"value":1456,"modifier":"EXACT"},"end":{"value":1456,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P49815"}]},{"type":"Modified residue","location":{"start":{"value":1466,"modifier":"EXACT"},"end":{"value":1466,"modifier":"EXACT"}},"description":"Phosphothreonine; by PKB/AKT1","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12172553"}]},{"type":"Modified residue","location":{"start":{"value":1766,"modifier":"EXACT"},"end":{"value":1766,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q61037"}]},{"type":"Modified residue","location":{"start":{"value":1800,"modifier":"EXACT"},"end":{"value":1800,"modifier":"EXACT"}},"description":"Phosphoserine; by RPS6KA1","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P49815"}]},{"type":"Modified residue","location":{"start":{"value":1801,"modifier":"EXACT"},"end":{"value":1801,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P49815"}]},{"type":"Alternative sequence","location":{"start":{"value":947,"modifier":"EXACT"},"end":{"value":989,"modifier":"EXACT"}},"description":"in isoform 2 and isoform 4","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"8519695"}],"featureId":"VSP_004481","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":1272,"modifier":"EXACT"},"end":{"value":1294,"modifier":"EXACT"}},"description":"in isoform 3 and isoform 4","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"8519695"}],"featureId":"VSP_004482","alternativeSequence":{}},{"type":"Mutagenesis","location":{"start":{"value":314,"modifier":"EXACT"},"end":{"value":314,"modifier":"EXACT"}},"description":"In chemically induced renal carcinoma.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10029074"}],"alternativeSequence":{"originalSequence":"N","alternativeSequences":["S"]}},{"type":"Mutagenesis","location":{"start":{"value":713,"modifier":"EXACT"},"end":{"value":713,"modifier":"EXACT"}},"description":"In chemically induced renal carcinoma.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10029074"}],"alternativeSequence":{"originalSequence":"L","alternativeSequences":["R"]}},{"type":"Mutagenesis","location":{"start":{"value":939,"modifier":"EXACT"},"end":{"value":939,"modifier":"EXACT"}},"description":"Decreased phosphorylation by PKB/AKT1; when associated with A-1130--1132-A and A-1422.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12172553"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":939,"modifier":"EXACT"},"end":{"value":939,"modifier":"EXACT"}},"description":"Mimics phosphorylation, leading to inhibit the ability of TSC2 to suppress mTORC1 signaling; when associated with D-1130--1132-E.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12172553"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["D"]}},{"type":"Mutagenesis","location":{"start":{"value":1130,"modifier":"EXACT"},"end":{"value":1132,"modifier":"EXACT"}},"description":"Decreased phosphorylation by PKB/AKT1; when associated with A-939 and A-1422.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12172553"}],"alternativeSequence":{"originalSequence":"SMS","alternativeSequences":["AMA"]}},{"type":"Mutagenesis","location":{"start":{"value":1130,"modifier":"EXACT"},"end":{"value":1132,"modifier":"EXACT"}},"description":"Mimics phosphorylation, leading to inhibit the ability of TSC2 to suppress mTORC1 signaling; when associated with D-939.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12172553"}],"alternativeSequence":{"originalSequence":"SMS","alternativeSequences":["DME"]}},{"type":"Mutagenesis","location":{"start":{"value":1422,"modifier":"EXACT"},"end":{"value":1422,"modifier":"EXACT"}},"description":"Decreased phosphorylation by PKB/AKT1; when associated with A-939 and A-1130--1132-A.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12172553"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["A"]}},{"type":"Sequence conflict","location":{"start":{"value":932,"modifier":"EXACT"},"end":{"value":932,"modifier":"EXACT"}},"description":"in Ref. 2; BAA08914","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["S"]}},{"type":"Sequence conflict","location":{"start":{"value":1514,"modifier":"EXACT"},"end":{"value":1514,"modifier":"EXACT"}},"description":"in Ref. 2; BAA08914","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"C","alternativeSequences":["F"]}},{"type":"Sequence conflict","location":{"start":{"value":1730,"modifier":"EXACT"},"end":{"value":1730,"modifier":"EXACT"}},"description":"in Ref. 2; BAA08914","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["S"]}}],"keywords":[{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0343","category":"Molecular function","name":"GTPase activation"},{"id":"KW-0458","category":"Cellular component","name":"Lysosome"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0043","category":"Disease","name":"Tumor suppressor"},{"id":"KW-0832","category":"PTM","name":"Ubl conjugation"}],"references":[{"referenceNumber":1,"citation":{"id":"8519695","citationType":"journal article","authors":["Xiao G.-H.","Jin F.","Yeung R.S."],"citationCrossReferences":[{"database":"PubMed","id":"8519695"}],"title":"Identification of tuberous sclerosis 2 messenger RNA splice variants that are conserved and differentially expressed in rat and human tissues.","publicationDate":"1995","journal":"Cell Growth Differ.","firstPage":"1185","lastPage":"1191","volume":"6"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4)","TISSUE SPECIFICITY","DISEASE"],"referenceComments":[{"value":"Wistar","type":"STRAIN"},{"value":"Kidney","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"7651821","citationType":"journal article","authors":["Kobayashi T.","Nishizawa M.","Hirayama Y.","Kobayashi E.","Hino O."],"citationCrossReferences":[{"database":"PubMed","id":"7651821"},{"database":"DOI","id":"10.1093/nar/23.14.2608"}],"title":"cDNA structure, alternative splicing and exon-intron organization of the predisposing tuberous sclerosis (Tsc2) gene of the Eker rat model.","publicationDate":"1995","journal":"Nucleic Acids Res.","firstPage":"2608","lastPage":"2613","volume":"23"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)"],"referenceComments":[{"value":"Long Evans","type":"STRAIN"},{"value":"Brain","type":"TISSUE"},{"value":"Kidney","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"9045618","citationType":"journal article","authors":["Xiao G.-H.","Shoarinejad F.","Jin F.","Golemis E.A.","Yeung R.S."],"citationCrossReferences":[{"database":"PubMed","id":"9045618"},{"database":"DOI","id":"10.1074/jbc.272.10.6097"}],"title":"The tuberous sclerosis 2 gene product, tuberin, functions as a Rab5 GTPase activating protein (GAP) in modulating endocytosis.","publicationDate":"1997","journal":"J. Biol. Chem.","firstPage":"6097","lastPage":"6100","volume":"272"},"referencePositions":["FUNCTION","INTERACTION WITH RABEP1"]},{"referenceNumber":4,"citation":{"id":"10029074","citationType":"journal article","authors":["Satake N.","Kobayashi T.","Kobayashi E.","Izumi K.","Hino O."],"citationCrossReferences":[{"database":"PubMed","id":"10029074"}],"title":"Isolation and characterization of a rat homologue of the human tuberous sclerosis 1 gene (Tsc1) and analysis of its mutations in rat renal carcinomas.","publicationDate":"1999","journal":"Cancer Res.","firstPage":"849","lastPage":"855","volume":"59"},"referencePositions":["MUTAGENESIS OF ASN-314 AND LEU-713"]},{"referenceNumber":5,"citation":{"id":"12172553","citationType":"journal article","authors":["Inoki K.","Li Y.","Zhu T.","Wu J.","Guan K.L."],"citationCrossReferences":[{"database":"PubMed","id":"12172553"},{"database":"DOI","id":"10.1038/ncb839"}],"title":"TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling.","publicationDate":"2002","journal":"Nat. Cell Biol.","firstPage":"648","lastPage":"657","volume":"4"},"referencePositions":["FUNCTION","PHOSPHORYLATION AT SER-939; SER-1130; SER-1132; SER-1422 AND THR-1466","MUTAGENESIS OF SER-939; 1130-SER--SER-1132 AND SER-1422"]},{"referenceNumber":6,"citation":{"id":"16707451","citationType":"journal article","authors":["Jiang X.","Yeung R.S."],"citationCrossReferences":[{"database":"PubMed","id":"16707451"},{"database":"DOI","id":"10.1158/0008-5472.can-05-4510"}],"title":"Regulation of microtubule-dependent protein transport by the TSC2/mammalian target of rapamycin pathway.","publicationDate":"2006","journal":"Cancer Res.","firstPage":"5258","lastPage":"5269","volume":"66"},"referencePositions":["FUNCTION"]},{"referenceNumber":7,"citation":{"id":"22673903","citationType":"journal article","authors":["Lundby A.","Secher A.","Lage K.","Nordsborg N.B.","Dmytriyev A.","Lundby C.","Olsen J.V."],"citationCrossReferences":[{"database":"PubMed","id":"22673903"},{"database":"DOI","id":"10.1038/ncomms1871"}],"title":"Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.","publicationDate":"2012","journal":"Nat. Commun.","firstPage":"876","lastPage":"876","volume":"3"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1389 AND SER-1413","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"U24150","properties":[{"key":"ProteinId","value":"AAC52289.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"D50413","properties":[{"key":"ProteinId","value":"BAA08914.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"PIR","id":"S57329","properties":[{"key":"EntryName","value":"S57329"}]},{"database":"RefSeq","id":"NP_036812.3","properties":[{"key":"NucleotideSequenceId","value":"NM_012680.4"}]},{"database":"RefSeq","id":"XP_006245971.2","properties":[{"key":"NucleotideSequenceId","value":"XM_006245909.5"}]},{"database":"AlphaFoldDB","id":"P49816","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P49816","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"246972","properties":[{"key":"Interactions","value":"9"}]},{"database":"FunCoup","id":"P49816","properties":[{"key":"Number of interactors","value":"2225"}]},{"database":"IntAct","id":"P49816","properties":[{"key":"Interactions","value":"4"}]},{"database":"MINT","id":"P49816","properties":[{"key":"Description","value":"-"}]},{"database":"STRING","id":"10116.ENSRNOP00000016221","properties":[{"key":"Description","value":"-"}]},{"database":"iPTMnet","id":"P49816","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"P49816","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"10116-ENSRNOP00000016221","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"24855","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"rno:24855","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"RGD:3908","properties":[{"key":"OrganismName","value":"rat"}],"isoformId":"P49816-1"},{"database":"AGR","id":"RGD:3908","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"7249","properties":[{"key":"Description","value":"-"}]},{"database":"RGD","id":"3908","properties":[{"key":"GeneName","value":"Tsc2"}]},{"database":"eggNOG","id":"KOG3687","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"InParanoid","id":"P49816","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"48921at9989","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"P49816","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-RNO-1632852","properties":[{"key":"PathwayName","value":"Macroautophagy"}]},{"database":"Reactome","id":"R-RNO-165181","properties":[{"key":"PathwayName","value":"Inhibition of TSC complex formation by AKT (PKB)"}]},{"database":"Reactome","id":"R-RNO-198323","properties":[{"key":"PathwayName","value":"AKT phosphorylates targets in the cytosol"}]},{"database":"Reactome","id":"R-RNO-380972","properties":[{"key":"PathwayName","value":"Energy dependent regulation of mTOR by LKB1-AMPK"}]},{"database":"Reactome","id":"R-RNO-5628897","properties":[{"key":"PathwayName","value":"TP53 Regulates Metabolic Genes"}]},{"database":"Reactome","id":"R-RNO-8854214","properties":[{"key":"PathwayName","value":"TBC/RABGAPs"}]},{"database":"PRO","id":"PR:P49816","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000002494","properties":[{"key":"Component","value":"Unplaced"}]},{"database":"GO","id":"GO:0005901","properties":[{"key":"GoTerm","value":"C:caveola"},{"key":"GoEvidenceType","value":"IDA:RGD"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15093748"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"ISO:RGD"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0030425","properties":[{"key":"GoTerm","value":"C:dendrite"},{"key":"GoEvidenceType","value":"IDA:RGD"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15525761"}]},{"database":"GO","id":"GO:0098978","properties":[{"key":"GoTerm","value":"C:glutamatergic synapse"},{"key":"GoEvidenceType","value":"IDA:SynGO"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24889507"}]},{"database":"GO","id":"GO:0005794","properties":[{"key":"GoTerm","value":"C:Golgi apparatus"},{"key":"GoEvidenceType","value":"ISO:RGD"}]},{"database":"GO","id":"GO:0030426","properties":[{"key":"GoTerm","value":"C:growth cone"},{"key":"GoEvidenceType","value":"IDA:RGD"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"14559897"}]},{"database":"GO","id":"GO:0005765","properties":[{"key":"GoTerm","value":"C:lysosomal membrane"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0005764","properties":[{"key":"GoTerm","value":"C:lysosome"},{"key":"GoEvidenceType","value":"ISO:RGD"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"ISO:RGD"}]},{"database":"GO","id":"GO:0043025","properties":[{"key":"GoTerm","value":"C:neuronal cell body"},{"key":"GoEvidenceType","value":"IDA:RGD"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15525761"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"ISO:RGD"}]},{"database":"GO","id":"GO:0048471","properties":[{"key":"GoTerm","value":"C:perinuclear region of cytoplasm"},{"key":"GoEvidenceType","value":"IDA:RGD"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"14559897"}]},{"database":"GO","id":"GO:0014069","properties":[{"key":"GoTerm","value":"C:postsynaptic density"},{"key":"GoEvidenceType","value":"ISO:RGD"}]},{"database":"GO","id":"GO:0045202","properties":[{"key":"GoTerm","value":"C:synapse"},{"key":"GoEvidenceType","value":"ISO:RGD"}]},{"database":"GO","id":"GO:0033596","properties":[{"key":"GoTerm","value":"C:TSC1-TSC2 complex"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0071889","properties":[{"key":"GoTerm","value":"F:14-3-3 protein binding"},{"key":"GoEvidenceType","value":"ISO:RGD"}]},{"database":"GO","id":"GO:0005096","properties":[{"key":"GoTerm","value":"F:GTPase activator activity"},{"key":"GoEvidenceType","value":"IDA:RGD"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12869586"}]},{"database":"GO","id":"GO:0051879","properties":[{"key":"GoTerm","value":"F:Hsp90 protein binding"},{"key":"GoEvidenceType","value":"ISO:RGD"}]},{"database":"GO","id":"GO:0019902","properties":[{"key":"GoTerm","value":"F:phosphatase binding"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0042803","properties":[{"key":"GoTerm","value":"F:protein homodimerization activity"},{"key":"GoEvidenceType","value":"ISO:RGD"}]},{"database":"GO","id":"GO:0044877","properties":[{"key":"GoTerm","value":"F:protein-containing complex binding"},{"key":"GoEvidenceType","value":"IPI:RGD"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"15093748"}]},{"database":"GO","id":"GO:0031267","properties":[{"key":"GoTerm","value":"F:small GTPase binding"},{"key":"GoEvidenceType","value":"ISO:RGD"}]},{"database":"GO","id":"GO:0043276","properties":[{"key":"GoTerm","value":"P:anoikis"},{"key":"GoEvidenceType","value":"ISO:RGD"}]},{"database":"GO","id":"GO:0030030","properties":[{"key":"GoTerm","value":"P:cell projection organization"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"16286931"}]},{"database":"GO","id":"GO:0032869","properties":[{"key":"GoTerm","value":"P:cellular response to insulin stimulus"},{"key":"GoEvidenceType","value":"ISO:RGD"}]},{"database":"GO","id":"GO:0009267","properties":[{"key":"GoTerm","value":"P:cellular response to starvation"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0097709","properties":[{"key":"GoTerm","value":"P:connective tissue replacement"},{"key":"GoEvidenceType","value":"ISO:RGD"}]},{"database":"GO","id":"GO:0098708","properties":[{"key":"GoTerm","value":"P:D-glucose import across plasma membrane"},{"key":"GoEvidenceType","value":"ISO:RGD"}]},{"database":"GO","id":"GO:0030010","properties":[{"key":"GoTerm","value":"P:establishment of cell polarity"},{"key":"GoEvidenceType","value":"IMP:RGD"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"20530489"}]},{"database":"GO","id":"GO:0098976","properties":[{"key":"GoTerm","value":"P:excitatory chemical synaptic transmission"},{"key":"GoEvidenceType","value":"ISO:RGD"}]},{"database":"GO","id":"GO:0007507","properties":[{"key":"GoTerm","value":"P:heart development"},{"key":"GoEvidenceType","value":"ISO:RGD"}]},{"database":"GO","id":"GO:0098977","properties":[{"key":"GoTerm","value":"P:inhibitory chemical synaptic transmission"},{"key":"GoEvidenceType","value":"ISO:RGD"}]},{"database":"GO","id":"GO:0008104","properties":[{"key":"GoTerm","value":"P:intracellular protein localization"},{"key":"GoEvidenceType","value":"ISO:RGD"}]},{"database":"GO","id":"GO:0001822","properties":[{"key":"GoTerm","value":"P:kidney development"},{"key":"GoEvidenceType","value":"ISO:RGD"}]},{"database":"GO","id":"GO:0036446","properties":[{"key":"GoTerm","value":"P:myofibroblast differentiation"},{"key":"GoEvidenceType","value":"ISO:RGD"}]},{"database":"GO","id":"GO:0050771","properties":[{"key":"GoTerm","value":"P:negative regulation of axonogenesis"},{"key":"GoEvidenceType","value":"IMP:RGD"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"18794346"}]},{"database":"GO","id":"GO:0008285","properties":[{"key":"GoTerm","value":"P:negative regulation of cell population proliferation"},{"key":"GoEvidenceType","value":"IMP:RGD"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"17376623"}]},{"database":"GO","id":"GO:0045792","properties":[{"key":"GoTerm","value":"P:negative regulation of cell size"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"16286931"}]},{"database":"GO","id":"GO:0050680","properties":[{"key":"GoTerm","value":"P:negative regulation of epithelial cell proliferation"},{"key":"GoEvidenceType","value":"IDA:RGD"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"14612383"}]},{"database":"GO","id":"GO:0010719","properties":[{"key":"GoTerm","value":"P:negative regulation of epithelial to mesenchymal transition"},{"key":"GoEvidenceType","value":"IMP:RGD"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"20813961"}]},{"database":"GO","id":"GO:0048147","properties":[{"key":"GoTerm","value":"P:negative regulation of fibroblast proliferation"},{"key":"GoEvidenceType","value":"IDA:RGD"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18056446"}]},{"database":"GO","id":"GO:0016242","properties":[{"key":"GoTerm","value":"P:negative regulation of macroautophagy"},{"key":"GoEvidenceType","value":"IMP:RGD"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"24599401"}]},{"database":"GO","id":"GO:0043407","properties":[{"key":"GoTerm","value":"P:negative regulation of MAP kinase activity"},{"key":"GoEvidenceType","value":"IMP:RGD"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"14612383"}]},{"database":"GO","id":"GO:0051898","properties":[{"key":"GoTerm","value":"P:negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"},{"key":"GoEvidenceType","value":"ISO:RGD"}]},{"database":"GO","id":"GO:0048550","properties":[{"key":"GoTerm","value":"P:negative regulation of pinocytosis"},{"key":"GoEvidenceType","value":"IMP:RGD"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"9045618"}]},{"database":"GO","id":"GO:0006469","properties":[{"key":"GoTerm","value":"P:negative regulation of protein kinase activity"},{"key":"GoEvidenceType","value":"ISO:RGD"}]},{"database":"GO","id":"GO:0001933","properties":[{"key":"GoTerm","value":"P:negative regulation of protein phosphorylation"},{"key":"GoEvidenceType","value":"IMP:RGD"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"18056446"}]},{"database":"GO","id":"GO:0032007","properties":[{"key":"GoTerm","value":"P:negative regulation of TOR signaling"},{"key":"GoEvidenceType","value":"IDA:RGD"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12869586"}]},{"database":"GO","id":"GO:1904262","properties":[{"key":"GoTerm","value":"P:negative regulation of TORC1 signaling"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:1905563","properties":[{"key":"GoTerm","value":"P:negative regulation of vascular endothelial cell proliferation"},{"key":"GoEvidenceType","value":"IMP:RGD"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"11553313"}]},{"database":"GO","id":"GO:0030178","properties":[{"key":"GoTerm","value":"P:negative regulation of Wnt signaling pathway"},{"key":"GoEvidenceType","value":"IDA:RGD"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12511557"}]},{"database":"GO","id":"GO:0001843","properties":[{"key":"GoTerm","value":"P:neural tube closure"},{"key":"GoEvidenceType","value":"ISO:RGD"}]},{"database":"GO","id":"GO:0050918","properties":[{"key":"GoTerm","value":"P:positive chemotaxis"},{"key":"GoEvidenceType","value":"ISO:RGD"}]},{"database":"GO","id":"GO:0010508","properties":[{"key":"GoTerm","value":"P:positive regulation of autophagy"},{"key":"GoEvidenceType","value":"ISO:RGD"}]},{"database":"GO","id":"GO:0045785","properties":[{"key":"GoTerm","value":"P:positive regulation of cell adhesion"},{"key":"GoEvidenceType","value":"IMP:RGD"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"20813961"}]},{"database":"GO","id":"GO:0060999","properties":[{"key":"GoTerm","value":"P:positive regulation of dendritic spine development"},{"key":"GoEvidenceType","value":"IMP:RGD"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"16595860"}]},{"database":"GO","id":"GO:0010763","properties":[{"key":"GoTerm","value":"P:positive regulation of fibroblast migration"},{"key":"GoEvidenceType","value":"IMP:RGD"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"20530489"}]},{"database":"GO","id":"GO:0046628","properties":[{"key":"GoTerm","value":"P:positive regulation of insulin receptor signaling pathway"},{"key":"GoEvidenceType","value":"ISO:RGD"}]},{"database":"GO","id":"GO:0016239","properties":[{"key":"GoTerm","value":"P:positive regulation of macroautophagy"},{"key":"GoEvidenceType","value":"ISO:RGD"}]},{"database":"GO","id":"GO:0010976","properties":[{"key":"GoTerm","value":"P:positive regulation of neuron projection development"},{"key":"GoEvidenceType","value":"IMP:RGD"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"17376623"}]},{"database":"GO","id":"GO:0045944","properties":[{"key":"GoTerm","value":"P:positive regulation of transcription by RNA polymerase II"},{"key":"GoEvidenceType","value":"ISO:RGD"}]},{"database":"GO","id":"GO:0006606","properties":[{"key":"GoTerm","value":"P:protein import into nucleus"},{"key":"GoEvidenceType","value":"ISO:RGD"}]},{"database":"GO","id":"GO:0034394","properties":[{"key":"GoTerm","value":"P:protein localization to cell surface"},{"key":"GoEvidenceType","value":"IMP:RGD"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"20813961"}]},{"database":"GO","id":"GO:0044861","properties":[{"key":"GoTerm","value":"P:protein transport into plasma membrane raft"},{"key":"GoEvidenceType","value":"ISO:RGD"}]},{"database":"GO","id":"GO:0072014","properties":[{"key":"GoTerm","value":"P:proximal tubule development"},{"key":"GoEvidenceType","value":"ISO:RGD"}]},{"database":"GO","id":"GO:0051726","properties":[{"key":"GoTerm","value":"P:regulation of cell cycle"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0030100","properties":[{"key":"GoTerm","value":"P:regulation of endocytosis"},{"key":"GoEvidenceType","value":"ISO:RGD"}]},{"database":"GO","id":"GO:0046626","properties":[{"key":"GoTerm","value":"P:regulation of insulin receptor signaling pathway"},{"key":"GoEvidenceType","value":"ISO:RGD"}]},{"database":"GO","id":"GO:0099175","properties":[{"key":"GoTerm","value":"P:regulation of postsynapse organization"},{"key":"GoEvidenceType","value":"IDA:SynGO"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24889507"}]},{"database":"GO","id":"GO:0051056","properties":[{"key":"GoTerm","value":"P:regulation of small GTPase mediated signal transduction"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0001666","properties":[{"key":"GoTerm","value":"P:response to hypoxia"},{"key":"GoEvidenceType","value":"ISO:RGD"}]},{"database":"GO","id":"GO:0007264","properties":[{"key":"GoTerm","value":"P:small GTPase-mediated signal transduction"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0035176","properties":[{"key":"GoTerm","value":"P:social behavior"},{"key":"GoEvidenceType","value":"IMP:RGD"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"20927644"}]},{"database":"GO","id":"GO:0048771","properties":[{"key":"GoTerm","value":"P:tissue remodeling"},{"key":"GoEvidenceType","value":"ISO:RGD"}]},{"database":"FunFam","id":"3.40.50.11210:FF:000004","properties":[{"key":"EntryName","value":"Tuberin isoform X3"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.25.10.10","properties":[{"key":"EntryName","value":"Leucine-rich Repeat Variant"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.11210","properties":[{"key":"EntryName","value":"Rap/Ran-GAP"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR011989","properties":[{"key":"EntryName","value":"ARM-like"}]},{"database":"InterPro","id":"IPR016024","properties":[{"key":"EntryName","value":"ARM-type_fold"}]},{"database":"InterPro","id":"IPR035974","properties":[{"key":"EntryName","value":"Rap/Ran-GAP_sf"}]},{"database":"InterPro","id":"IPR000331","properties":[{"key":"EntryName","value":"Rap/Ran_GAP_dom"}]},{"database":"InterPro","id":"IPR003913","properties":[{"key":"EntryName","value":"Tuberin"}]},{"database":"InterPro","id":"IPR018515","properties":[{"key":"EntryName","value":"Tuberin-type_domain"}]},{"database":"InterPro","id":"IPR027107","properties":[{"key":"EntryName","value":"Tuberin/Ral-act_asu"}]},{"database":"InterPro","id":"IPR024584","properties":[{"key":"EntryName","value":"Tuberin_N"}]},{"database":"PANTHER","id":"PTHR10063","properties":[{"key":"EntryName","value":"TUBERIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10063:SF0","properties":[{"key":"EntryName","value":"TUBERIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF11864","properties":[{"key":"EntryName","value":"DUF3384"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02145","properties":[{"key":"EntryName","value":"Rap_GAP"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF03542","properties":[{"key":"EntryName","value":"Tuberin"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01431","properties":[{"key":"EntryName","value":"TUBERIN"}]},{"database":"SUPFAM","id":"SSF48371","properties":[{"key":"EntryName","value":"ARM repeat"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF111347","properties":[{"key":"EntryName","value":"Rap/Ran-GAP"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50085","properties":[{"key":"EntryName","value":"RAPGAP"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MAKPTSKDSGLKEKFKILLGLGTSRPNPRCAEGKQTEFIITAEILRELSGECGLNNRIRMIGQICDVAKTKKLEEHAVEALWKAVSDLLQPERPPEARHAVLALLKAIVQGQGDRLGVLRALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELAEFVLQWMDVGLSSEFLLVLVNLVKFNSCYLDEYIAPMVHMICLLCIRTVSSVDIEVSLQVLDAVVCYNCLPAESLPLFIITLCRTVNVKELCEPCWKLMRNLLGTHLGHSAIYNMCRIMENRSYMEDAPLLRGAVFFVGMALWGAHRLYSLKNSPTSVLPSFYEAMTCPNEVVSYEIVLSITRLIKKYRKELQAVTWDILLDIIERLLQQLQNLDSPELRTIVHDLLTTVEELCDQNEFHGSQERYYELVESYADQRPESSLLNLITYRAQSIHPAKDGWIQNLQLLMERFFRNECRSAVRIKVLDVLSFVLLINRQFYEEELINSVVISQLSHIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVMARSLSPPLELEERDLAVYSASLEDVKTAVLGLLVILQTKLYTLPASHATRVYETLISHIQLHYKHGYSLPIASSIRLQAFDFLLLLRADSLHRLGLPNKDGVVRFSPYCLCDCAELDRASEKKASGPLSPPTGPPSPVPTGPAVRLGHLPYSLLFRVLLQCLKQETDWKVLKLVLSKLPESLRYKVLIFTSPCSVDQLSSALCSMLSAPKTLERLRGTPEGFSRTDLHLAVVPVLTALISYHNYLDKTRQREMVYCLEQGLIYRCASQCVVALAICSVEMPDIIIKALPVLVVKLTHISATASMAIPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRCRLPFRKDFVPYITKGLRSNVLLSFDDTPEKDKFRARSTSLNERPKSLRIARAPKQGLNNSPPVKEFKESCAAEAFRCRSISVSEHVVRSRIQTSLTSASLGSADENSMAQADDNLKNLHLELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVGNKLVTVTTSVGTGTRSLLGLDSGDLQGGSASSSDPGTHVRQTKEAPAKLESQAGQQVSRGARDRVRSMSGGHGLRVGVLDTSAPYTPGGPASLGAQAAPAARPEKPCAGAQLPAAEKANLAAYVPLLTQGWAEILVRRPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKEHRDTALYKSLSVPAAGTAKPPTLPRSNTVASFSSLYQPSCQGQLHRSVSWADSAVVLEEGSPGEAHVPVEPPELEDFEAALGTDRHCQRPDAYSRSSSASSQEEKSHLEELAAGGIPIERAISSEGARPTVDLSFQPSQPLSKSSSSPELQTLQDILGDLGDKTDIGRLSPEAKVRSQSGILDGEAATWSAPGEESRITVPPEGPLPSSSPRSPSGLRPRGYTISDSAPSRRGKRVERDNFKSRTAASSAEKVPGINPSFVFLQLYHSPFCGDESNKPILLPNESFERSVQLLDQIPSYDTHKIAVLYVGEGQSSSELAILSNEHGSYRYTEFLTGLGRLIELKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGNDFVSIIYNDSGEDFKLGTIKGQFNFVHVIITPLDYKCNLLTLQCRKDMEGLVDTSVAKIVSDRNLSFVARQMALHANMASQVHHRRSNPTDIYPSKWIARLRHIKRLRQRIREEVHYSNPSLPLMHPPAHTKVPAQAPTEATPTYETGQRKRLISSVDDFTEFV","length":1809,"molWeight":201278,"crc64":"6190BEFB45272664","md5":"B973F1FF65C09ED7B669C1A854860D7D"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":4,"TISSUE SPECIFICITY":1,"PTM":2,"DISEASE":1},"countByFeatureType":{"Chain":1,"Domain":1,"Region":5,"Compositional bias":4,"Modified residue":22,"Alternative sequence":2,"Mutagenesis":7,"Sequence conflict":3},"uniParcId":"UPI0000137741"}}