{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P48558","secondaryAccessions":["D6W0P0","Q6B2Q1"],"uniProtkbId":"BXI1_YEAST","entryAudit":{"firstPublicDate":"1996-02-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1996-02-01","entryVersion":156,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)","commonName":"Baker's yeast","taxonId":559292,"lineage":["Eukaryota","Fungi","Dikarya","Ascomycota","Saccharomycotina","Saccharomycetes","Saccharomycetales","Saccharomycetaceae","Saccharomyces"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Bax inhibitor 1"}},"alternativeNames":[{"fullName":{"value":"BH3 domain-containing protein BXI1"}}]},"genes":[{"geneName":{"value":"BXI1"},"synonyms":[{"value":"YBH3"}],"orderedLocusNames":[{"value":"YNL305C"}],"orfNames":[{"value":"N0405"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21673659"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21673967"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21926971"}],"value":"Links the unfolded protein response and programmed cell death and mediates mitochondrial-dependent apoptosis (PubMed:21673659, PubMed:21673967). Induces cell death and disruption of the mitochondrial transmembrane potential via the mitochondrial phosphate carrier MIR1 (PubMed:21673659). Dispensible for starvation-induced autophagy (PubMed:21926971)"}],"commentType":"FUNCTION"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P48558","intActId":"EBI-28349"},"interactantTwo":{"uniProtKBAccession":"Q08234","geneName":"YOL075C","intActId":"EBI-29278"},"numberOfExperiments":2,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21673659"}],"value":"Translocated from predominantly vacuolar sites in healthy cells to mitochondria upon apoptosis induction"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21673967"}],"value":"Endoplasmic reticulum membrane","id":"SL-0097"},"topology":{"evidences":[{"evidenceCode":"ECO:0000255"}],"value":"Multi-pass membrane protein","id":"SL-9909"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14562095"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21673659"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21673967"}],"value":"Vacuole membrane","id":"SL-0271"},"topology":{"evidences":[{"evidenceCode":"ECO:0000255"}],"value":"Multi-pass membrane protein","id":"SL-9909"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21673659"}],"value":"Mitochondrion membrane","id":"SL-0171"},"topology":{"evidences":[{"evidenceCode":"ECO:0000255"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21926971"}],"value":"No effect on autophagy during nitrogen starvation"}],"commentType":"DISRUPTION PHENOTYPE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the BI1 family. LFG subfamily"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":297,"modifier":"EXACT"}},"description":"Bax inhibitor 1","featureId":"PRO_0000203369"},{"type":"Topological domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":53,"modifier":"EXACT"}},"description":"Lumenal","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":54,"modifier":"EXACT"},"end":{"value":74,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":75,"modifier":"EXACT"},"end":{"value":85,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":86,"modifier":"EXACT"},"end":{"value":106,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":107,"modifier":"EXACT"},"end":{"value":146,"modifier":"EXACT"}},"description":"Lumenal","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":147,"modifier":"EXACT"},"end":{"value":167,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":168,"modifier":"EXACT"},"end":{"value":171,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":172,"modifier":"EXACT"},"end":{"value":192,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":193,"modifier":"EXACT"},"end":{"value":208,"modifier":"EXACT"}},"description":"Lumenal","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":209,"modifier":"EXACT"},"end":{"value":229,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":230,"modifier":"EXACT"},"end":{"value":239,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":240,"modifier":"EXACT"},"end":{"value":260,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":261,"modifier":"EXACT"},"end":{"value":270,"modifier":"EXACT"}},"description":"Lumenal","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":271,"modifier":"EXACT"},"end":{"value":291,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":292,"modifier":"EXACT"},"end":{"value":297,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Sequence conflict","location":{"start":{"value":84,"modifier":"EXACT"},"end":{"value":84,"modifier":"EXACT"}},"description":"in Ref. 4; AAT92698","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["A"]}}],"keywords":[{"id":"KW-0053","category":"Biological process","name":"Apoptosis"},{"id":"KW-0256","category":"Cellular component","name":"Endoplasmic reticulum"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"id":"KW-0926","category":"Cellular component","name":"Vacuole"}],"references":[{"referenceNumber":1,"citation":{"id":"8553702","citationType":"journal article","authors":["Maurer K.C.T.","Urbanus J.H.M.","Planta R.J."],"citationCrossReferences":[{"database":"PubMed","id":"8553702"},{"database":"DOI","id":"10.1002/yea.320111311"}],"title":"Sequence analysis of a 30 kb DNA segment from yeast chromosome XIV carrying a ribosomal protein gene cluster, the genes encoding a plasma membrane protein and a subunit of replication factor C, and a novel putative serine/threonine protein kinase gene.","publicationDate":"1995","journal":"Yeast","firstPage":"1303","lastPage":"1310","volume":"11"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"],"referenceComments":[{"value":"ATCC 96604 / S288c / FY1679","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"9169873","citationType":"journal article","authors":["Philippsen P.","Kleine K.","Poehlmann R.","Duesterhoeft A.","Hamberg K.","Hegemann J.H.","Obermaier B.","Urrestarazu L.A.","Aert R.","Albermann K.","Altmann R.","Andre B.","Baladron V.","Ballesta J.P.G.","Becam A.-M.","Beinhauer J.D.","Boskovic J.","Buitrago M.J.","Bussereau F.","Coster F.","Crouzet M.","D'Angelo M.","Dal Pero F.","De Antoni A.","del Rey F.","Doignon F.","Domdey H.","Dubois E.","Fiedler T.A.","Fleig U.","Floeth M.","Fritz C.","Gaillardin C.","Garcia-Cantalejo J.M.","Glansdorff N.","Goffeau A.","Gueldener U.","Herbert C.J.","Heumann K.","Heuss-Neitzel D.","Hilbert H.","Hinni K.","Iraqui Houssaini I.","Jacquet M.","Jimenez A.","Jonniaux J.-L.","Karpfinger-Hartl L.","Lanfranchi G.","Lepingle A.","Levesque H.","Lyck R.","Maftahi M.","Mallet L.","Maurer C.T.C.","Messenguy F.","Mewes H.-W.","Moestl D.","Nasr F.","Nicaud J.-M.","Niedenthal R.K.","Pandolfo D.","Pierard A.","Piravandi E.","Planta R.J.","Pohl T.M.","Purnelle B.","Rebischung C.","Remacha M.A.","Revuelta J.L.","Rinke M.","Saiz J.E.","Sartorello F.","Scherens B.","Sen-Gupta M.","Soler-Mira A.","Urbanus J.H.M.","Valle G.","Van Dyck L.","Verhasselt P.","Vierendeels F.","Vissers S.","Voet M.","Volckaert G.","Wach A.","Wambutt R.","Wedler H.","Zollner A.","Hani J."],"citationCrossReferences":[{"database":"PubMed","id":"9169873"},{"database":"DOI","id":"10.1038/387s093"}],"title":"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications.","publicationDate":"1997","journal":"Nature","firstPage":"93","lastPage":"98","volume":"387"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"ATCC 204508 / S288c","type":"STRAIN"}]},{"referenceNumber":3,"citation":{"id":"24374639","citationType":"journal article","authors":["Engel S.R.","Dietrich F.S.","Fisk D.G.","Binkley G.","Balakrishnan R.","Costanzo M.C.","Dwight S.S.","Hitz B.C.","Karra K.","Nash R.S.","Weng S.","Wong E.D.","Lloyd P.","Skrzypek M.S.","Miyasato S.R.","Simison M.","Cherry J.M."],"citationCrossReferences":[{"database":"PubMed","id":"24374639"},{"database":"DOI","id":"10.1534/g3.113.008995"}],"title":"The reference genome sequence of Saccharomyces cerevisiae: Then and now.","publicationDate":"2014","journal":"G3 (Bethesda)","firstPage":"389","lastPage":"398","volume":"4"},"referencePositions":["GENOME REANNOTATION"],"referenceComments":[{"value":"ATCC 204508 / S288c","type":"STRAIN"}]},{"referenceNumber":4,"citation":{"id":"17322287","citationType":"journal article","authors":["Hu Y.","Rolfs A.","Bhullar B.","Murthy T.V.S.","Zhu C.","Berger M.F.","Camargo A.A.","Kelley F.","McCarron S.","Jepson D.","Richardson A.","Raphael J.","Moreira D.","Taycher E.","Zuo D.","Mohr S.","Kane M.F.","Williamson J.","Simpson A.J.G.","Bulyk M.L.","Harlow E.","Marsischky G.","Kolodner R.D.","LaBaer J."],"citationCrossReferences":[{"database":"PubMed","id":"17322287"},{"database":"DOI","id":"10.1101/gr.6037607"}],"title":"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae.","publicationDate":"2007","journal":"Genome Res.","firstPage":"536","lastPage":"543","volume":"17"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"],"referenceComments":[{"value":"ATCC 204508 / S288c","type":"STRAIN"}]},{"referenceNumber":5,"citation":{"id":"14562095","citationType":"journal article","authors":["Huh W.-K.","Falvo J.V.","Gerke L.C.","Carroll A.S.","Howson R.W.","Weissman J.S.","O'Shea E.K."],"citationCrossReferences":[{"database":"PubMed","id":"14562095"},{"database":"DOI","id":"10.1038/nature02026"}],"title":"Global analysis of protein localization in budding yeast.","publicationDate":"2003","journal":"Nature","firstPage":"686","lastPage":"691","volume":"425"},"referencePositions":["SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]"]},{"referenceNumber":6,"citation":{"id":"16847258","citationType":"journal article","authors":["Kim H.","Melen K.","Oesterberg M.","von Heijne G."],"citationCrossReferences":[{"database":"PubMed","id":"16847258"},{"database":"DOI","id":"10.1073/pnas.0604075103"}],"title":"A global topology map of the Saccharomyces cerevisiae membrane proteome.","publicationDate":"2006","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"11142","lastPage":"11147","volume":"103"},"referencePositions":["TOPOLOGY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"ATCC 208353 / W303-1A","type":"STRAIN"}]},{"referenceNumber":7,"citation":{"id":"21673659","citationType":"journal article","authors":["Buttner S.","Ruli D.","Vogtle F.N.","Galluzzi L.","Moitzi B.","Eisenberg T.","Kepp O.","Habernig L.","Carmona-Gutierrez D.","Rockenfeller P.","Laun P.","Breitenbach M.","Khoury C.","Frohlich K.U.","Rechberger G.","Meisinger C.","Kroemer G.","Madeo F."],"citationCrossReferences":[{"database":"PubMed","id":"21673659"},{"database":"DOI","id":"10.1038/emboj.2011.197"}],"title":"A yeast BH3-only protein mediates the mitochondrial pathway of apoptosis.","publicationDate":"2011","journal":"EMBO J.","firstPage":"2779","lastPage":"2792","volume":"30"},"referencePositions":["FUNCTION","SUBCELLULAR LOCATION"]},{"referenceNumber":8,"citation":{"id":"21926971","citationType":"journal article","authors":["Castillo K.","Rojas-Rivera D.","Lisbona F.","Caballero B.","Nassif M.","Court F.A.","Schuck S.","Ibar C.","Walter P.","Sierralta J.","Glavic A.","Hetz C."],"citationCrossReferences":[{"database":"PubMed","id":"21926971"},{"database":"DOI","id":"10.1038/emboj.2011.318"}],"title":"BAX inhibitor-1 regulates autophagy by controlling the IRE1alpha branch of the unfolded protein response.","publicationDate":"2011","journal":"EMBO J.","firstPage":"4465","lastPage":"4478","volume":"30"},"referencePositions":["FUNCTION","DISRUPTION PHENOTYPE"]},{"referenceNumber":9,"citation":{"id":"21673967","citationType":"journal article","authors":["Cebulski J.","Malouin J.","Pinches N.","Cascio V.","Austriaco N."],"citationCrossReferences":[{"database":"PubMed","id":"21673967"},{"database":"DOI","id":"10.1371/journal.pone.0020882"}],"title":"Yeast Bax inhibitor, Bxi1p, is an ER-localized protein that links the unfolded protein response and programmed cell death in Saccharomyces cerevisiae.","publicationDate":"2011","journal":"PLoS ONE","firstPage":"E20882","lastPage":"E20882","volume":"6"},"referencePositions":["FUNCTION","SUBCELLULAR LOCATION"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"U23084","properties":[{"key":"ProteinId","value":"AAC49093.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"Z71581","properties":[{"key":"ProteinId","value":"CAA96233.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AY692679","properties":[{"key":"ProteinId","value":"AAT92698.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BK006947","properties":[{"key":"ProteinId","value":"DAA10256.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"S63281","properties":[{"key":"EntryName","value":"S63281"}]},{"database":"RefSeq","id":"NP_014094.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001183143.1"}]},{"database":"AlphaFoldDB","id":"P48558","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"35534","properties":[{"key":"Interactions","value":"43"}]},{"database":"DIP","id":"DIP-7944N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"P48558","properties":[{"key":"Number of interactors","value":"760"}]},{"database":"IntAct","id":"P48558","properties":[{"key":"Interactions","value":"16"}]},{"database":"MINT","id":"P48558","properties":[{"key":"Description","value":"-"}]},{"database":"STRING","id":"4932.YNL305C","properties":[{"key":"Description","value":"-"}]},{"database":"TCDB","id":"1.A.14.3.5","properties":[{"key":"FamilyName","value":"the calcium transporter a (cata) family (formerly the testis-enhanced gene transfer (tegt) family)"}]},{"database":"iPTMnet","id":"P48558","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"4932-YNL305C","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"P48558","properties":[{"key":"Description","value":"-"}]},{"database":"EnsemblFungi","id":"YNL305C_mRNA","properties":[{"key":"ProteinId","value":"YNL305C"},{"key":"GeneId","value":"YNL305C"}]},{"database":"GeneID","id":"855411","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"sce:YNL305C","properties":[{"key":"Description","value":"-"}]},{"database":"AGR","id":"SGD:S000005249","properties":[{"key":"Description","value":"-"}]},{"database":"SGD","id":"S000005249","properties":[{"key":"GeneName","value":"BXI1"}]},{"database":"VEuPathDB","id":"FungiDB:YNL305C","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG2322","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"HOGENOM","id":"CLU_058671_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P48558","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"FGVMSLY","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"7933078at2759","properties":[{"key":"Description","value":"-"}]},{"database":"BioCyc","id":"YEAST:G3O-33292-MONOMER","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"855411","properties":[{"key":"hits","value":"10 hits in 10 CRISPR screens"}]},{"database":"PRO","id":"PR:P48558","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000002311","properties":[{"key":"Component","value":"Chromosome XIV"}]},{"database":"RNAct","id":"P48558","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"GO","id":"GO:0005783","properties":[{"key":"GoTerm","value":"C:endoplasmic reticulum"},{"key":"GoEvidenceType","value":"IDA:SGD"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"21673967"}]},{"database":"GO","id":"GO:0005789","properties":[{"key":"GoTerm","value":"C:endoplasmic reticulum membrane"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21673967"}]},{"database":"GO","id":"GO:0000324","properties":[{"key":"GoTerm","value":"C:fungal-type vacuole"},{"key":"GoEvidenceType","value":"IDA:SGD"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"21673659"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"21673967"}]},{"database":"GO","id":"GO:0031966","properties":[{"key":"GoTerm","value":"C:mitochondrial membrane"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21673659"}]},{"database":"GO","id":"GO:0005739","properties":[{"key":"GoTerm","value":"C:mitochondrion"},{"key":"GoEvidenceType","value":"IDA:SGD"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"21673659"}]},{"database":"GO","id":"GO:0005774","properties":[{"key":"GoTerm","value":"C:vacuolar membrane"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14562095"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21673659"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21673967"}]},{"database":"GO","id":"GO:0005262","properties":[{"key":"GoTerm","value":"F:calcium channel activity"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0006915","properties":[{"key":"GoTerm","value":"P:apoptotic process"},{"key":"GoEvidenceType","value":"IMP:SGD"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"21673659"},{"evidenceCode":"ECO:0000315","source":"PubMed","id":"21673967"}]},{"database":"GO","id":"GO:0019722","properties":[{"key":"GoTerm","value":"P:calcium-mediated signaling"},{"key":"GoEvidenceType","value":"IMP:SGD"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"21673967"}]},{"database":"GO","id":"GO:0030968","properties":[{"key":"GoTerm","value":"P:endoplasmic reticulum unfolded protein response"},{"key":"GoEvidenceType","value":"IMP:SGD"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"21673967"}]},{"database":"GO","id":"GO:0000423","properties":[{"key":"GoTerm","value":"P:mitophagy"},{"key":"GoEvidenceType","value":"IDA:SGD"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"38465853"}]},{"database":"CDD","id":"cd10429","properties":[{"key":"EntryName","value":"GAAP_like"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR006214","properties":[{"key":"EntryName","value":"Bax_inhibitor_1-related"}]},{"database":"PANTHER","id":"PTHR23291","properties":[{"key":"EntryName","value":"BAX INHIBITOR-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR23291:SF50","properties":[{"key":"EntryName","value":"PROTEIN LIFEGUARD 4"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01027","properties":[{"key":"EntryName","value":"Bax1-I"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSGPPPPYEEQSSHLYGQPASSQDGNAFIPEDFKYSTVVISCEPIIRQRFMHKVYSLLSCQLLASLSFCYWASVSTSLQNFIMSHIALFYICMVVSLVSCIWLAVSPRPEDYEASVPEPLLTGSSEEPAQEQRRLPWYVLSSYKQKLTLLSIFTLSEAYCLSLVTLAYDKDTVLSALLITTIVVVGVSLTALSERFENVLNSATSIYYWLNWGLWIMIGMGLTALLFGWNTHSSKFNLLYGWLGAILFTAYLFIDTQLIFRKVYPDEEVRCAMMLYLDIVNLFLSILRILANSNDDN","length":297,"molWeight":33645,"crc64":"330784DA17152BB0","md5":"0DF305D05FE220028A9CF61779278503"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"INTERACTION":1,"SUBCELLULAR LOCATION":1,"DISRUPTION PHENOTYPE":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Topological domain":8,"Transmembrane":7,"Sequence conflict":1},"uniParcId":"UPI000013BA84"}}