{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P48426","secondaryAccessions":["B0YJ66","B4DGX2","D3DRV1","P53807","Q5VUX3"],"uniProtkbId":"PI42A_HUMAN","entryAudit":{"firstPublicDate":"1996-02-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2001-08-14","entryVersion":204,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9367159"}],"value":"2.7.1.149"}]},"alternativeNames":[{"fullName":{"value":"1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha"}},{"fullName":{"value":"Diphosphoinositide kinase 2-alpha"}},{"fullName":{"value":"PIP5KIII"}},{"fullName":{"value":"Phosphatidylinositol 5-Phosphate 4-Kinase"},"shortNames":[{"value":"PI5P4Kalpha"}]},{"fullName":{"value":"Phosphatidylinositol 5-phosphate 4-kinase type II alpha"},"shortNames":[{"value":"PI(5)P 4-kinase type II alpha"},{"value":"PIP4KII-alpha"}]},{"fullName":{"value":"PtdIns(4)P-5-kinase B isoform"}},{"fullName":{"value":"PtdIns(4)P-5-kinase C isoform"}},{"fullName":{"value":"PtdIns(5)P-4-kinase isoform 2-alpha"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:8997"}],"value":"PIP4K2A"},"synonyms":[{"value":"PI5P4KA"},{"value":"PIP5K2"},{"value":"PIP5K2A"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"O70172"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9R0I8"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18364242"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23326584"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26774281"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29353240"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31091439"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9367159"}],"value":"Catalyzes the phosphorylation of phosphatidylinositol 5-phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) (PubMed:23326584, PubMed:9367159). Has both ATP- and GTP-dependent kinase activities (PubMed:26774281). May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2 (PubMed:18364242). May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation (By similarity). Required for lysosome-peroxisome membrane contacts and intracellular cholesterol transport through modulating peroxisomal PtdIns(4,5)P2 level (PubMed:29353240). In collaboration with PIP4K2B, has a role in mediating autophagy in times of nutrient stress (By similarity). Required for autophagosome-lysosome fusion and the regulation of cellular lipid metabolism (PubMed:31091439). May be involved in thrombopoiesis, and the terminal maturation of megakaryocytes and regulation of their size (By similarity). Negatively regulates insulin signaling through a catalytic-independent mechanism (PubMed:31091439). PIP4Ks interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3 (PubMed:31091439)"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:12280"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:57795"},{"database":"ChEBI","id":"CHEBI:58456"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"2.7.1.149","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9367159"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:12281"},"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"9367159"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:55992"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:83423"},{"database":"ChEBI","id":"CHEBI:84968"},{"database":"ChEBI","id":"CHEBI:456216"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23326584"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26774281"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:55993"},"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"26774281"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + GTP = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + GDP + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:55964"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:37565"},{"database":"ChEBI","id":"CHEBI:58189"},{"database":"ChEBI","id":"CHEBI:83423"},{"database":"ChEBI","id":"CHEBI:84968"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26774281"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:55965"},"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"26774281"}]}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9R0I8"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23326584"}],"value":"In rod outer segments, activated by light. 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