P47989
type: Protein
reviewed: true
created: 1996-02-01
modified: 2026-01-28
version: 231
mnemonic: XDH_HUMAN
replaces: Q16681
replaces: Q16712
replaces: Q4PJ16
citation: http://purl.uniprot.org/citations/8224915
citation: SIP3E45D7188C8E035
citation: http://purl.uniprot.org/citations/8135849
citation: http://purl.uniprot.org/citations/7575623
citation: http://purl.uniprot.org/citations/8670112
citation: SIPCB7D9AB1E4CB4DB2
citation: http://purl.uniprot.org/citations/9153281
citation: http://purl.uniprot.org/citations/10844591
citation: http://purl.uniprot.org/citations/18780401
citation: http://purl.uniprot.org/citations/24275569
citation: http://purl.uniprot.org/citations/17301077
citation: SIP7257E036AC30FE0D
citation: http://purl.uniprot.org/citations/11379872
citation: http://purl.uniprot.org/citations/14551354
citation: http://purl.uniprot.org/citations/16959974
citation: http://purl.uniprot.org/citations/34356852
conflicting sequence: SIPB563A3A0924CF7F4
recommended name: SIP07818B4A69BDEEB3
domain: SIP98F4675818496BCF
domain: SIP82FFAEF6372F2E09
organism: http://purl.uniprot.org/taxonomy/9606
isolated from: http://purl.uniprot.org/tissues/564
isolated from: http://purl.uniprot.org/tissues/942
isolated from: http://purl.uniprot.org/tissues/636
annotation: SIP55921106F608AF69
annotation: SIPBBE93B1999D05DA1
annotation: SIP0EE0CCAEBA3E40AB
annotation: SIP074FF1476A51BA53
annotation: SIPC92F0433C476EC83
annotation: SIP53EA73E91B0CC272
annotation: SIP852442DC3DBC668F
annotation: SIPABE6D842A1EC4813
annotation: SIP65D5192C01AF24CD
annotation: SIPA7744E11D5173EBE
annotation: SIP1C01C6DB9BA94BFA
annotation: SIP976D79C90CFE5404
annotation: SIP41F6D1183EF361E0
annotation: SIP391EE1171C304B05
annotation: SIP443E59ABACEC7762
annotation: PRO_0000166084
annotation: SIPE94CDE0F05680CA3
annotation: SIP33993606D0093C33
annotation: SIP0A341A9B1D722780
annotation: SIP2137122996D9C4DB
annotation: SIP8D180073478159C4
annotation: SIP7A08E00B01A1F36B
annotation: SIPBEB2EB2621692695
annotation: SIP6838C7138FFE8CD8
annotation: SIPC40113AACB5686BF
annotation: SIP299B2BE809FE1CC3
annotation: SIPD39896068B39B096
annotation: SIP54A865DF10783B36
annotation: SIP45D100CEC130CB64
annotation: SIP8C7609E4B181597B
annotation: SIPE857AA7962602388
annotation: SIPDE12ACAD5BD5504B
annotation: SIP34F2D5685753E611
annotation: SIPC86908FDA9F9BFBC
annotation: SIPFA4010C411BD9DD5
annotation: SIPCB1E187C65D46AC9
annotation: SIP645D7B27977BBC4F
annotation: SIPA866ABA65A542D8F
annotation: SIPAB66ECF6A246CFA6
annotation: SIP0135273B78420059
annotation: SIP739DC700A0C78570
annotation: SIP925F8052E05A6555
annotation: SIP64C1FDF9C7F5BA6E
annotation: VAR_023976
annotation: VAR_045900
annotation: VAR_090557
annotation: VAR_023977

http://purl.uniprot.org/citations/8224915
type: Journal Citation
title: Cloning of the cDNA encoding human xanthine dehydrogenase (oxidase): structural analysis of the protein and chromosomal location of the gene.
author: Ichida K.
author: Amaya Y.
author: Noda K.
author: Minoshima S.
author: Hosoya T.
author: Sakai O.
author: Shimizu N.
author: Nishino T.
primary topic of: https://pubmed.ncbi.nlm.nih.gov/8224915
date: 1993
name: Gene
volume: 133
pages: 279-284

P47989-citation-8224915
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [MRNA]

Liver
type: Tissue

SIP3E45D7188C8E035
type: Submission Citation
author: Ichida K.
date: 2000-09
submitted to: EMBL/GenBank/DDBJ

P47989-citation-SIP3E45D7188C8E035
type: Citation Statement
scope: SEQUENCE REVISION TO 191; 231 AND 1150

http://purl.uniprot.org/citations/8135849
type: Journal Citation
title: Molecular cloning, tissue expression of human xanthine dehydrogenase.
author: Xu P.
author: Huecksteadt T.P.
author: Harrison R.
author: Hoidal J.R.
primary topic of: https://pubmed.ncbi.nlm.nih.gov/8135849
date: 1994
erratum: http://purl.uniprot.org/citations/7575623
name: Biochem. Biophys. Res. Commun.
volume: 199
pages: 998-1004

http://purl.uniprot.org/citations/7575623
type: Journal Citation
author: Xu P.
author: Huecksteadt T.P.
author: Harrison R.
author: Hoidal J.R.
primary topic of: https://pubmed.ncbi.nlm.nih.gov/7575623
date: 1995
name: Biochem. Biophys. Res. Commun.
volume: 215
pages: 429

P47989-citation-8135849
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [MRNA]
scope: VARIANT ARG-172

http://purl.uniprot.org/citations/8670112
type: Journal Citation
title: Cloning and expression in vitro of human xanthine dehydrogenase/oxidase.
author: Saksela M.
author: Raivio K.O.
primary topic of: https://pubmed.ncbi.nlm.nih.gov/8670112
date: 1996
name: Biochem. J.
volume: 315
pages: 235-239

P47989-citation-8670112
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [MRNA]
scope: CATALYTIC ACTIVITY

Small intestine
type: Tissue

SIPCB7D9AB1E4CB4DB2
type: Submission Citation
group: NIEHS SNPs program
date: 2005-06
submitted to: EMBL/GenBank/DDBJ

P47989-citation-SIPCB7D9AB1E4CB4DB2
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
scope: VARIANTS LYS-133; ARG-172; MET-235; MET-395; SER-555; ALA-584; GLN-607; ASN-617; ILE-623; VAL-646; VAL-703; MET-910; LEU-1091; THR-1109; CYS-1176 AND TRP-1296

http://purl.uniprot.org/citations/9153281
type: Journal Citation
title: Identification of two mutations in human xanthine dehydrogenase gene responsible for classical type I xanthinuria.
author: Ichida K.
author: Amaya Y.
author: Kamatani N.
author: Nishino T.
author: Hosoya T.
author: Sakai O.
primary topic of: https://pubmed.ncbi.nlm.nih.gov/9153281
date: 1997
name: J. Clin. Invest.
volume: 99
pages: 2391-2397

P47989-citation-9153281
type: Citation Statement
scope: INVOLVEMENT IN XAN1
scope: VARIANT ARG-1150

http://purl.uniprot.org/citations/10844591
type: Journal Citation
title: XDH gene mutation is the underlying cause of classical xanthinuria: a second report.
author: Levartovsky D.
author: Lagziel A.
author: Sperling O.
author: Liberman U.
author: Yaron M.
author: Hosoya T.
author: Ichida K.
author: Peretz H.
primary topic of: https://pubmed.ncbi.nlm.nih.gov/10844591
date: 2000
name: Kidney Int.
volume: 57
pages: 2215-2220

P47989-citation-10844591
type: Citation Statement
scope: INVOLVEMENT IN XAN1

http://purl.uniprot.org/citations/18780401
type: Journal Citation
title: Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry.
author: Picariello G.
author: Ferranti P.
author: Mamone G.
author: Roepstorff P.
author: Addeo F.
primary topic of: https://pubmed.ncbi.nlm.nih.gov/18780401
date: 2008
name: Proteomics
volume: 8
pages: 3833-3847

P47989-citation-18780401
type: Citation Statement
scope: IDENTIFICATION BY MASS SPECTROMETRY

Milk
type: Tissue

http://purl.uniprot.org/citations/24275569
type: Journal Citation
title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
author: Bian Y.
author: Song C.
author: Cheng K.
author: Dong M.
author: Wang F.
author: Huang J.
author: Sun D.
author: Wang L.
author: Ye M.
author: Zou H.
primary topic of: https://pubmed.ncbi.nlm.nih.gov/24275569
date: 2014
name: J. Proteomics
volume: 96
pages: 253-262

P47989-citation-24275569
type: Citation Statement
scope: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]

http://purl.uniprot.org/citations/17301077
type: Journal Citation
title: Human xanthine oxidase changes its substrate specificity to aldehyde oxidase type upon mutation of amino acid residues in the active site: roles of active site residues in binding and activation of purine substrate.
author: Yamaguchi Y.
author: Matsumura T.
author: Ichida K.
author: Okamoto K.
author: Nishino T.
primary topic of: https://pubmed.ncbi.nlm.nih.gov/17301077
date: 2007
name: J. Biochem.
volume: 141
pages: 513-524

P47989-citation-17301077
type: Citation Statement
scope: X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) OF MUTANT VAL-803 IN COMPLEX WITH FAD; 2FE-2S IRON-SULFUR CENTERS; SALICYLATE; MOLYBDOPTERIN AND CALCIUM IONS
scope: COFACTOR
scope: CATALYTIC ACTIVITY
scope: FUNCTION
scope: SUBUNIT

SIP7257E036AC30FE0D
type: Submission Citation
title: Human milk xanthine dehydrogenase is incompletely converted to the oxidase form in the absence of proteolysis. A structural explanation.
author: Pearson A.R.
author: Godber B.L.J.
author: Eisenthal R.
author: Taylor G.L.
author: Harrison R.
date: 2009-02
submitted to: PDB

P47989-citation-SIP7257E036AC30FE0D
type: Citation Statement
scope: X-RAY CRYSTALLOGRAPHY (3.59 ANGSTROMS) IN COMPLEX WITH FAD AND IRON-SULFUR CENTERS
scope: TISSUE SPECIFICITY
scope: ACTIVITY REGULATION
scope: DISULFIDE BONDS

http://purl.uniprot.org/citations/11379872
type: Journal Citation
title: Identification of a new point mutation in the human xanthine dehydrogenase gene responsible for a case of classical type I xanthinuria.
author: Sakamoto N.
author: Yamamoto T.
author: Moriwaki Y.
author: Teranishi T.
author: Toyoda M.
author: Onishi Y.
author: Kuroda S.
author: Sakaguchi K.
author: Fujisawa T.
author: Maeda M.
author: Hada T.
primary topic of: https://pubmed.ncbi.nlm.nih.gov/11379872
date: 2001
name: Hum. Genet.
volume: 108
pages: 279-283

P47989-citation-11379872
type: Citation Statement
scope: VARIANT XAN1 CYS-149

http://purl.uniprot.org/citations/14551354
type: Journal Citation
title: Mutational analysis of the xanthine dehydrogenase gene in a Turkish family with autosomal recessive classical xanthinuria.
author: Gok F.
author: Ichida K.
author: Topaloglu R.
primary topic of: https://pubmed.ncbi.nlm.nih.gov/14551354
date: 2003
name: Nephrol. Dial. Transplant.
volume: 18
pages: 2278-2283

P47989-citation-14551354
type: Citation Statement
scope: INVOLVEMENT IN XAN1

http://purl.uniprot.org/citations/16959974
type: Journal Citation
title: The consensus coding sequences of human breast and colorectal cancers.
author: Sjoeblom T.
author: Jones S.
author: Wood L.D.
author: Parsons D.W.
author: Lin J.
author: Barber T.D.
author: Mandelker D.
author: Leary R.J.
author: Ptak J.
author: Silliman N.
author: Szabo S.
author: Buckhaults P.
author: Farrell C.
author: Meeh P.
author: Markowitz S.D.
author: Willis J.
author: Dawson D.
author: Willson J.K.V.
author: Gazdar A.F.
author: Hartigan J.
author: Wu L.
author: Liu C.
author: Parmigiani G.
author: Park B.H.
author: Bachman K.E.
author: Papadopoulos N.
author: Vogelstein B.
author: Kinzler K.W.
author: Velculescu V.E.
primary topic of: https://pubmed.ncbi.nlm.nih.gov/16959974
date: 2006
name: Science
volume: 314
pages: 268-274

P47989-citation-16959974
type: Citation Statement
scope: VARIANTS [LARGE SCALE ANALYSIS] PHE-763 AND GLY-791

http://purl.uniprot.org/citations/34356852
type: Journal Citation
title: Classical Xanthinuria in Nine Israeli Families and Two Isolated Cases from Germany: Molecular, Biochemical and Population Genetics Aspects.
author: Peretz H.
author: Lagziel A.
author: Bittner F.
author: Kabha M.
author: Shtauber-Naamati M.
author: Zhuravel V.
author: Usher S.
author: Rump S.
author: Wollers S.
author: Bork B.
author: Mandel H.
author: Falik-Zaccai T.
author: Kalfon L.
author: Graessler J.
author: Zeharia A.
author: Heib N.
author: Shalev H.
author: Landau D.
author: Levartovsky D.
primary topic of: https://pubmed.ncbi.nlm.nih.gov/34356852
date: 2021
name: Biomedicines
volume: 9
pages: 788

P47989-citation-34356852
type: Citation Statement
scope: VARIANTS XAN1 PHE-150; 478-TRP--VAL-1333 DEL; 722-LYS--VAL-1333 DEL AND 825-ARG--VAL-1333 DEL

S66573
type: Resource
database: PIR
comment: XOHUDH

2CKJ
type: Structure Resource
database: PDB
method: X-Ray Crystallography
resolution: 3.59
chain sequence mapping: PDB 2CKJ tt2tt1333

PDB 2CKJ tt2tt1333
chain: A/B/C/D=2-1333

2E1Q
type: Structure Resource
database: PDB
method: X-Ray Crystallography
resolution: 2.60
chain sequence mapping: PDB 2E1Q tt1tt1333

PDB 2E1Q tt1tt1333
chain: A/B/C/D=1-1333

http://purl.uniprot.org/biogrid/113335
type: Resource
database: BioGRID
comment: 25

P47989
type: Resource
database: FunCoup
comment: 560

P47989
type: Resource
database: IntAct
comment: 10

DB03601
type: Resource
database: DrugBank
comment: 5-deoxyflavanone

DB00640
type: Resource
database: DrugBank
comment: Adenosine

DB00041
type: Resource
database: DrugBank
comment: Aldesleukin

DB00437
type: Resource
database: DrugBank
comment: Allopurinol

DB00993
type: Resource
database: DrugBank
comment: Azathioprine

DB16101
type: Resource
database: DrugBank
comment: Baicalein

DB00958
type: Resource
database: DrugBank
comment: Carboplatin

DB01136
type: Resource
database: DrugBank
comment: Carvedilol

DB00856
type: Resource
database: DrugBank
comment: Chlorphenesin

DB17283
type: Resource
database: DrugBank
comment: Chrysoeriol

DB00515
type: Resource
database: DrugBank
comment: Cisplatin

DB11672
type: Resource
database: DrugBank
comment: Curcumin

DB00746
type: Resource
database: DrugBank
comment: Deferoxamine

DB03328
type: Resource
database: DrugBank
comment: Dioxo(sulfanyl)molybdenum

DB00997
type: Resource
database: DrugBank
comment: Doxorubicin

DB03516
type: Resource
database: DrugBank
comment: Eniluracil

DB12466
type: Resource
database: DrugBank
comment: Favipiravir

DB04854
type: Resource
database: DrugBank
comment: Febuxostat

DB03147
type: Resource
database: DrugBank
comment: Flavin adenine dinucleotide

DB16628
type: Resource
database: DrugBank
comment: Fosdenopterin

DB04335
type: Resource
database: DrugBank
comment: Inosine

DB01020
type: Resource
database: DrugBank
comment: Isosorbide mononitrate

DB00583
type: Resource
database: DrugBank
comment: Levocarnitine

DB00170
type: Resource
database: DrugBank
comment: Menadione

DB01033
type: Resource
database: DrugBank
comment: Mercaptopurine

DB00157
type: Resource
database: DrugBank
comment: NADH

DB03841
type: Resource
database: DrugBank
comment: Niraxostat

DB00336
type: Resource
database: DrugBank
comment: Nitrofural

DB01250
type: Resource
database: DrugBank
comment: Olsalazine

DB05262
type: Resource
database: DrugBank
comment: Oxypurinol

DB06478
type: Resource
database: DrugBank
comment: Porfiromycin

DB01168
type: Resource
database: DrugBank
comment: Procarbazine

DB00339
type: Resource
database: DrugBank
comment: Pyrazinamide

DB00127
type: Resource
database: DrugBank
comment: Spermine

DB01685
type: Resource
database: DrugBank
comment: Topiroxostat

DB00831
type: Resource
database: DrugBank
comment: Trifluoperazine

http://purl.uniprot.org/antibodypedia/4018
type: Resource
database: Antibodypedia
comment: 280 antibodies from 36 providers

uc002rnv.2
type: Resource
database: UCSC
comment: human

http://purl.uniprot.org/hgnc/12805
type: Resource
database: HGNC
comment: XDH

ENSG00000158125
type: Resource
database: HPA
comment: Group enriched (breast, intestine, liver)

http://purl.uniprot.org/mim/278300
type: Resource
database: MIM
comment: phenotype

http://purl.uniprot.org/mim/607633
type: Resource
database: MIM
comment: gene

Orphanet_93601
type: Resource
database: Orphanet
comment: Xanthinuria type I

KOG0430
type: Resource
database: eggNOG
comment: Eukaryota

P47989
type: Resource
database: PAN-GO
comment: 3 GO annotations based on evolutionary models

http://purl.uniprot.org/brenda/1.17.1.4
type: Resource
database: BRENDA
comment: 2681

http://purl.uniprot.org/brenda/1.17.3.2
type: Resource
database: BRENDA
comment: 2681

R-HSA-74259
type: Resource
database: Reactome
comment: Purine catabolism

R-HSA-8851680
type: Resource
database: Reactome
comment: Butyrophilin (BTN) family interactions

R-HSA-9748787
type: Resource
database: Reactome
comment: Azathioprine ADME

http://purl.uniprot.org/biogrid-orcs/7498
type: Resource
database: BioGRID-ORCS
comment: 13 hits in 1155 CRISPR screens

XDH
type: Resource
database: ChiTaRS
comment: human

P47989
type: Resource
database: Pharos
comment: Tclin

P47989
type: Resource
database: RNAct
comment: protein

ENSG00000158125
type: Resource
database: Bgee
comment: Expressed in jejunal mucosa and 126 other cell types or tissues

3.10.20.30:FF:000015
type: Resource
database: FunFam
comment: Aldehyde oxidase 1
signature sequence match: FunFam 3.10.20.30:FF:000015 match 1

3.30.365.10:FF:000003
type: Resource
database: FunFam
comment: Aldehyde oxidase 1
signature sequence match: FunFam 3.30.365.10:FF:000003 match 1

3.30.365.10:FF:000001
type: Resource
database: FunFam
comment: Xanthine dehydrogenase oxidase
signature sequence match: FunFam 3.30.365.10:FF:000001 match 1

3.30.365.10:FF:000002
type: Resource
database: FunFam
comment: Xanthine dehydrogenase oxidase
signature sequence match: FunFam 3.30.365.10:FF:000002 match 1

3.30.365.10:FF:000004
type: Resource
database: FunFam
comment: Xanthine dehydrogenase oxidase
signature sequence match: FunFam 3.30.365.10:FF:000004 match 1

3.30.390.50:FF:000001
type: Resource
database: FunFam
comment: Xanthine dehydrogenase oxidase
signature sequence match: FunFam 3.30.390.50:FF:000001 match 1

3.30.43.10:FF:000001
type: Resource
database: FunFam
comment: Xanthine dehydrogenase/oxidase
signature sequence match: FunFam 3.30.43.10:FF:000001 match 1

3.30.465.10:FF:000004
type: Resource
database: FunFam
comment: Xanthine dehydrogenase/oxidase
signature sequence match: FunFam 3.30.465.10:FF:000004 match 1

3.90.1170.50:FF:000002
type: Resource
database: FunFam
comment: Xanthine dehydrogenase/oxidase
signature sequence match: FunFam 3.90.1170.50:FF:000002 match 1

1.10.150.120:FF:000002
type: Resource
database: FunFam
comment: xanthine dehydrogenase/oxidase
signature sequence match: FunFam 1.10.150.120:FF:000002 match 1

3.30.365.10:FF:000006
type: Resource
database: FunFam
comment: xanthine dehydrogenase/oxidase
signature sequence match: FunFam 3.30.365.10:FF:000006 match 1

http://purl.uniprot.org/gene3d/1.10.150.120
type: Resource
database: Gene3D
comment: [2Fe-2S]-binding domain
signature sequence match: Gene3D 1.10.150.120 match 1

http://purl.uniprot.org/gene3d/3.90.1170.50
type: Resource
database: Gene3D
comment: Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead
signature sequence match: Gene3D 3.90.1170.50 match 1

http://purl.uniprot.org/gene3d/3.30.365.10
type: Resource
database: Gene3D
comment: Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain
signature sequence match: Gene3D 3.30.365.10 match 1
signature sequence match: Gene3D 3.30.365.10 match 2
signature sequence match: Gene3D 3.30.365.10 match 3
signature sequence match: Gene3D 3.30.365.10 match 4
signature sequence match: Gene3D 3.30.365.10 match 5

http://purl.uniprot.org/gene3d/3.30.390.50
type: Resource
database: Gene3D
comment: CO dehydrogenase flavoprotein, C-terminal domain
signature sequence match: Gene3D 3.30.390.50 match 1

http://purl.uniprot.org/gene3d/3.30.43.10
type: Resource
database: Gene3D
comment: Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2
signature sequence match: Gene3D 3.30.43.10 match 1

IPR002888
type: Resource
database: InterPro
comment: 2Fe-2S-bd

IPR036884
type: Resource
database: InterPro
comment: 2Fe-2S-bd_dom_sf

IPR036010
type: Resource
database: InterPro
comment: 2Fe-2S_ferredoxin-like_sf

IPR001041
type: Resource
database: InterPro
comment: 2Fe-2S_ferredoxin-type

IPR006058
type: Resource
database: InterPro
comment: 2Fe2S_fd_BS

IPR000674
type: Resource
database: InterPro
comment: Ald_Oxase/Xan_DH_a/b

IPR036856
type: Resource
database: InterPro
comment: Ald_Oxase/Xan_DH_a/b_sf

IPR016208
type: Resource
database: InterPro
comment: Ald_Oxase/xanthine_DH-like

IPR008274
type: Resource
database: InterPro
comment: AldOxase/xan_DH_MoCoBD1

IPR046867
type: Resource
database: InterPro
comment: AldOxase/xan_DH_MoCoBD2

IPR037165
type: Resource
database: InterPro
comment: AldOxase/xan_DH_Mopterin-bd_sf

IPR012675
type: Resource
database: InterPro
comment: Beta-grasp_dom_sf

IPR005107
type: Resource
database: InterPro
comment: CO_DH_flav_C

IPR036683
type: Resource
database: InterPro
comment: CO_DH_flav_C_dom_sf

IPR016166
type: Resource
database: InterPro
comment: FAD-bd_PCMH

IPR036318
type: Resource
database: InterPro
comment: FAD-bd_PCMH-like_sf

IPR016167
type: Resource
database: InterPro
comment: FAD-bd_PCMH_sub1

IPR016169
type: Resource
database: InterPro
comment: FAD-bd_PCMH_sub2

IPR002346
type: Resource
database: InterPro
comment: Mopterin_DH_FAD-bd

IPR022407
type: Resource
database: InterPro
comment: OxRdtase_Mopterin_BS

IPR014307
type: Resource
database: InterPro
comment: Xanthine_DH_ssu

TIGR02963
type: Resource
database: NCBIfam
comment: xanthine_xdhA
signature sequence match: NCBIfam TIGR02963 match 1

PTHR45444
type: Resource
database: PANTHER
comment: XANTHINE DEHYDROGENASE
signature sequence match: PANTHER PTHR45444 match 1

PTHR45444:SF3
type: Resource
database: PANTHER
comment: XANTHINE DEHYDROGENASE
signature sequence match: PANTHER PTHR45444:SF3 match 1

PF01315
type: Resource
database: Pfam
comment: Ald_Xan_dh_C
signature sequence match: Pfam PF01315 match 1

PF03450
type: Resource
database: Pfam
comment: CO_deh_flav_C
signature sequence match: Pfam PF03450 match 1

PF00941
type: Resource
database: Pfam
comment: FAD_binding_5
signature sequence match: Pfam PF00941 match 1

PF00111
type: Resource
database: Pfam
comment: Fer2
signature sequence match: Pfam PF00111 match 1

PF01799
type: Resource
database: Pfam
comment: Fer2_2
signature sequence match: Pfam PF01799 match 1

PF02738
type: Resource
database: Pfam
comment: MoCoBD_1
signature sequence match: Pfam PF02738 match 1

PF20256
type: Resource
database: Pfam
comment: MoCoBD_2
signature sequence match: Pfam PF20256 match 1

PIRSF000127
type: Resource
database: PIRSF
comment: Xanthine_DH
signature sequence match: PIRSF PIRSF000127 match 1

SM01008
type: Resource
database: SMART
comment: Ald_Xan_dh_C
signature sequence match: SMART SM01008 match 1

SM01092
type: Resource
database: SMART
comment: CO_deh_flav_C
signature sequence match: SMART SM01092 match 1

SSF54292
type: Resource
database: SUPFAM
comment: 2Fe-2S ferredoxin-like
signature sequence match: SUPFAM SSF54292 match 1

SSF55447
type: Resource
database: SUPFAM
comment: CO dehydrogenase flavoprotein C-terminal domain-like
signature sequence match: SUPFAM SSF55447 match 1

SSF47741
type: Resource
database: SUPFAM
comment: CO dehydrogenase ISP C-domain like
signature sequence match: SUPFAM SSF47741 match 1

SSF54665
type: Resource
database: SUPFAM
comment: CO dehydrogenase molybdoprotein N-domain-like
signature sequence match: SUPFAM SSF54665 match 1

SSF56176
type: Resource
database: SUPFAM
comment: FAD-binding/transporter-associated domain-like
signature sequence match: SUPFAM SSF56176 match 1

SSF56003
type: Resource
database: SUPFAM
comment: Molybdenum cofactor-binding domain
signature sequence match: SUPFAM SSF56003 match 1

PS00197
type: Resource
database: PROSITE
comment: 2FE2S_FER_1
signature sequence match: PROSITE PS00197 match 1

PS51085
type: Resource
database: PROSITE
comment: 2FE2S_FER_2
signature sequence match: PROSITE PS51085 match 1

PS51387
type: Resource
database: PROSITE
comment: FAD_PCMH
signature sequence match: PROSITE PS51387 match 1

PS00559
type: Resource
database: PROSITE
comment: MOLYBDOPTERIN_EUK
signature sequence match: PROSITE PS00559 match 1

SIP07818B4A69BDEEB3
type: Structured Name
full name: Xanthine dehydrogenase/oxidase

SIP0A4ABE2ADDC885CF
type: Structured Name
full name: Xanthine dehydrogenase
short name: XD
ec name: 1.17.1.4

SIPC05CAC97D7F3B17B
type: Structured Name
full name: Xanthine oxidase
short name: XO
ec name: 1.17.3.2

SIP35E92B6416CA7204
type: Structured Name
full name: Xanthine oxidoreductase
short name: XOR

XDH
type: Gene
alternative label: XDHA

SIP55921106F608AF69
type: Function Annotation
comment: Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species. Has also low oxidase activity towards aldehydes (in vitro).

SIPC92F0433C476EC83
type: Cofactor Annotation
comment: Binds 2 [2Fe-2S] clusters.
cofactor: CHEBI_190135

SIP852442DC3DBC668F
type: Cofactor Annotation
comment: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.
cofactor: CHEBI_71302

SIPABE6D842A1EC4813
type: Activity Regulation Annotation
comment: Can be converted from the dehydrogenase form (D) to the oxidase form (O) irreversibly by proteolysis or reversibly through the oxidation of sulfhydryl groups.

SIP65D5192C01AF24CD
type: Subunit Annotation
comment: Homodimer. Interacts with BTN1A1 (By similarity).

SIP1C01C6DB9BA94BFA
type: Tissue Specificity Annotation
comment: Detected in milk (at protein level).

SIP976D79C90CFE5404
type: PTM Annotation
comment: Subject to partial proteolysis; this alters the enzyme from the dehydrogenase form (D) to the oxidase form (O).

SIP41F6D1183EF361E0
type: PTM Annotation
comment: Contains sulfhydryl groups that are easily oxidized (in vitro); this alters the enzyme from the dehydrogenase form (D) to the oxidase form (O).

SIP391EE1171C304B05
type: Disease Annotation
comment: The disease is caused by variants affecting the gene represented in this entry.
disease: http://purl.uniprot.org/diseases/1153

SIP443E59ABACEC7762
type: Similarity Annotation
comment: Belongs to the xanthine dehydrogenase family.

PRO_0000166084
type: Chain Annotation
comment: Xanthine dehydrogenase/oxidase
mass: 146424
range: 22575409924684078tt1tt1333

22575409924684078tt1
type: Position
type: ExactPosition
position: 1
reference: P47989-1

22575409924684078tt1333
type: Position
type: ExactPosition
position: 1333
reference: P47989-1

SIPE94CDE0F05680CA3
type: Domain Extent Annotation
comment: 2Fe-2S ferredoxin-type
range: 22575409924684078tt4tt91

22575409924684078tt4
type: Position
type: ExactPosition
position: 4
reference: P47989-1

22575409924684078tt91
type: Position
type: ExactPosition
position: 91
reference: P47989-1

SIP33993606D0093C33
type: Domain Extent Annotation
comment: FAD-binding PCMH-type
range: 22575409924684078tt229tt414

22575409924684078tt229
type: Position
type: ExactPosition
position: 229
reference: P47989-1

22575409924684078tt414
type: Position
type: ExactPosition
position: 414
reference: P47989-1

SIP0A341A9B1D722780
type: Active Site Annotation
comment: Proton acceptor
range: 22575409924684078tt1262tt1262

22575409924684078tt1262
type: Position
type: ExactPosition
position: 1262
reference: P47989-1

22575409924684078tt43
type: Position
type: ExactPosition
position: 43
reference: P47989-1

22575409924684078tt48
type: Position
type: ExactPosition
position: 48
reference: P47989-1

22575409924684078tt51
type: Position
type: ExactPosition
position: 51
reference: P47989-1

22575409924684078tt73
type: Position
type: ExactPosition
position: 73
reference: P47989-1

22575409924684078tt113
type: Position
type: ExactPosition
position: 113
reference: P47989-1

22575409924684078tt116
type: Position
type: ExactPosition
position: 116
reference: P47989-1

22575409924684078tt148
type: Position
type: ExactPosition
position: 148
reference: P47989-1

22575409924684078tt150
type: Position
type: ExactPosition
position: 150
reference: P47989-1

22575409924684078tt257
type: Position
type: ExactPosition
position: 257
reference: P47989-1

22575409924684078tt264
type: Position
type: ExactPosition
position: 264
reference: P47989-1

22575409924684078tt337
type: Position
type: ExactPosition
position: 337
reference: P47989-1

22575409924684078tt347
type: Position
type: ExactPosition
position: 347
reference: P47989-1

22575409924684078tt351
type: Position
type: ExactPosition
position: 351
reference: P47989-1

22575409924684078tt360
type: Position
type: ExactPosition
position: 360
reference: P47989-1

22575409924684078tt404
type: Position
type: ExactPosition
position: 404
reference: P47989-1

22575409924684078tt422
type: Position
type: ExactPosition
position: 422
reference: P47989-1

22575409924684078tt768
type: Position
type: ExactPosition
position: 768
reference: P47989-1

22575409924684078tt799
type: Position
type: ExactPosition
position: 799
reference: P47989-1

22575409924684078tt803
type: Position
type: ExactPosition
position: 803
reference: P47989-1

22575409924684078tt881
type: Position
type: ExactPosition
position: 881
reference: P47989-1

22575409924684078tt913
type: Position
type: ExactPosition
position: 913
reference: P47989-1

22575409924684078tt915
type: Position
type: ExactPosition
position: 915
reference: P47989-1

22575409924684078tt1011
type: Position
type: ExactPosition
position: 1011
reference: P47989-1

22575409924684078tt1080
type: Position
type: ExactPosition
position: 1080
reference: P47989-1

SIP925F8052E05A6555
type: Disulfide Bond Annotation
comment: In oxidase form
range: 22575409924684078tt509tt509
range: 22575409924684078tt1318tt1318

22575409924684078tt509
type: Position
type: ExactPosition
position: 509
reference: P47989-1

22575409924684078tt1318
type: Position
type: ExactPosition
position: 1318
reference: P47989-1

SIP64C1FDF9C7F5BA6E
type: Disulfide Bond Annotation
comment: In oxidase form
range: 22575409924684078tt536tt536
range: 22575409924684078tt993tt993

22575409924684078tt536
type: Position
type: ExactPosition
position: 536
reference: P47989-1

22575409924684078tt993
type: Position
type: ExactPosition
position: 993
reference: P47989-1

VAR_023976
type: Natural Variant Annotation
substitution: K
range: 22575409924684078tt133tt133

22575409924684078tt133
type: Position
type: ExactPosition
position: 133
reference: P47989-1

VAR_045900
type: Natural Variant Annotation
comment: In XAN1.
substitution: C
related: http://purl.uniprot.org/diseases/1153
range: 22575409924684078tt149tt149

22575409924684078tt149
type: Position
type: ExactPosition
position: 149
reference: P47989-1

VAR_090557
type: Natural Variant Annotation
comment: In XAN1.
substitution: F
related: http://purl.uniprot.org/diseases/1153
range: 22575409924684078tt150tt150

VAR_023977
type: Natural Variant Annotation
substitution: R
range: 22575409924684078tt172tt172

22575409924684078tt172
type: Position
type: ExactPosition
position: 172
reference: P47989-1

VAR_023978
type: Natural Variant Annotation
substitution: M
range: 22575409924684078tt235tt235

22575409924684078tt235
type: Position
type: ExactPosition
position: 235
reference: P47989-1

VAR_023979
type: Natural Variant Annotation
substitution: M
range: 22575409924684078tt395tt395

22575409924684078tt395
type: Position
type: ExactPosition
position: 395
reference: P47989-1

VAR_090558
type: Natural Variant Annotation
comment: In XAN1.
related: http://purl.uniprot.org/diseases/1153
range: 22575409924684078tt478tt1333

22575409924684078tt478
type: Position
type: ExactPosition
position: 478
reference: P47989-1

VAR_023980
type: Natural Variant Annotation
substitution: S
range: 22575409924684078tt555tt555

22575409924684078tt555
type: Position
type: ExactPosition
position: 555
reference: P47989-1

VAR_023981
type: Natural Variant Annotation
substitution: A
range: 22575409924684078tt584tt584

22575409924684078tt584
type: Position
type: ExactPosition
position: 584
reference: P47989-1

VAR_023982
type: Natural Variant Annotation
substitution: Q
range: 22575409924684078tt607tt607

22575409924684078tt607
type: Position
type: ExactPosition
position: 607
reference: P47989-1

VAR_023983
type: Natural Variant Annotation
substitution: N
range: 22575409924684078tt617tt617

22575409924684078tt617
type: Position
type: ExactPosition
position: 617
reference: P47989-1

VAR_023984
type: Natural Variant Annotation
substitution: I
range: 22575409924684078tt623tt623

22575409924684078tt623
type: Position
type: ExactPosition
position: 623
reference: P47989-1

VAR_023985
type: Natural Variant Annotation
substitution: V
range: 22575409924684078tt646tt646

22575409924684078tt646
type: Position
type: ExactPosition
position: 646
reference: P47989-1

VAR_023986
type: Natural Variant Annotation
substitution: V
range: 22575409924684078tt703tt703

22575409924684078tt703
type: Position
type: ExactPosition
position: 703
reference: P47989-1

VAR_090559
type: Natural Variant Annotation
comment: In XAN1.
related: http://purl.uniprot.org/diseases/1153
range: 22575409924684078tt722tt1333

22575409924684078tt722
type: Position
type: ExactPosition
position: 722
reference: P47989-1

VAR_035899
type: Natural Variant Annotation
comment: In a breast cancer sample; somatic mutation.
substitution: F
range: 22575409924684078tt763tt763

22575409924684078tt763
type: Position
type: ExactPosition
position: 763
reference: P47989-1

VAR_035900
type: Natural Variant Annotation
comment: In a breast cancer sample; somatic mutation.
substitution: G
range: 22575409924684078tt791tt791

22575409924684078tt791
type: Position
type: ExactPosition
position: 791
reference: P47989-1

VAR_090560
type: Natural Variant Annotation
comment: In XAN1.
related: http://purl.uniprot.org/diseases/1153
range: 22575409924684078tt825tt1333

22575409924684078tt825
type: Position
type: ExactPosition
position: 825
reference: P47989-1

VAR_023987
type: Natural Variant Annotation
substitution: M
range: 22575409924684078tt910tt910

22575409924684078tt910
type: Position
type: ExactPosition
position: 910
reference: P47989-1

VAR_023988
type: Natural Variant Annotation
substitution: L
range: 22575409924684078tt1091tt1091

22575409924684078tt1091
type: Position
type: ExactPosition
position: 1091
reference: P47989-1

VAR_023989
type: Natural Variant Annotation
substitution: T
range: 22575409924684078tt1109tt1109

22575409924684078tt1109
type: Position
type: ExactPosition
position: 1109
reference: P47989-1

VAR_045901
type: Natural Variant Annotation
substitution: R
range: 22575409924684078tt1150tt1150

22575409924684078tt1150
type: Position
type: ExactPosition
position: 1150
reference: P47989-1

VAR_023990
type: Natural Variant Annotation
substitution: C
range: 22575409924684078tt1176tt1176

22575409924684078tt1176
type: Position
type: ExactPosition
position: 1176
reference: P47989-1

VAR_023991
type: Natural Variant Annotation
substitution: W
range: 22575409924684078tt1296tt1296

22575409924684078tt1296
type: Position
type: ExactPosition
position: 1296
reference: P47989-1

SIPFC8E0D13276AD1AC
type: Mutagenesis Annotation
comment: Strongly decreased activity towards xanthine and hypoxanthine. Increased affinity and activity towards aromatic aldehydes.
substitution: V
range: 22575409924684078tt803tt803

SIPA58412FF0ADBBCE3
type: Mutagenesis Annotation
comment: Abolishes xanthine oxidase activity.
substitution: M
range: 22575409924684078tt881tt881

SIPCD0EED2F629A70D2
type: Sequence Conflict Annotation
conflicting sequence: SIPB563A3A0924CF7F4
substitution: E
range: 22575409924684078tt259tt259

22575409924684078tt259
type: Position
type: ExactPosition
position: 259
reference: P47989-1

SIP8B8360E6C9069AD2
type: Sequence Conflict Annotation
conflicting sequence: SIPB563A3A0924CF7F4
substitution: HV
range: 22575409924684078tt333tt334

22575409924684078tt333
type: Position
type: ExactPosition
position: 333
reference: P47989-1

22575409924684078tt334
type: Position
type: ExactPosition
position: 334
reference: P47989-1

SIP6617C5C88164B48B
type: Sequence Conflict Annotation
conflicting sequence: SIPB563A3A0924CF7F4
substitution: Q
range: 22575409924684078tt495tt495

22575409924684078tt495
type: Position
type: ExactPosition
position: 495
reference: P47989-1

SIP347E2CD1FC5ABBCF
type: Sequence Conflict Annotation
conflicting sequence: SIPB563A3A0924CF7F4
substitution: LLL
range: 22575409924684078tt515tt517

22575409924684078tt515
type: Position
type: ExactPosition
position: 515
reference: P47989-1

22575409924684078tt517
type: Position
type: ExactPosition
position: 517
reference: P47989-1

22575409924684078tt6
type: Position
type: ExactPosition
position: 6
reference: P47989-1

22575409924684078tt10
type: Position
type: ExactPosition
position: 10
reference: P47989-1

22575409924684078tt13
type: Position
type: ExactPosition
position: 13
reference: P47989-1

22575409924684078tt17
type: Position
type: ExactPosition
position: 17
reference: P47989-1

22575409924684078tt26
type: Position
type: ExactPosition
position: 26
reference: P47989-1

22575409924684078tt32
type: Position
type: ExactPosition
position: 32
reference: P47989-1

22575409924684078tt44
type: Position
type: ExactPosition
position: 44
reference: P47989-1

22575409924684078tt52
type: Position
type: ExactPosition
position: 52
reference: P47989-1

22575409924684078tt59
type: Position
type: ExactPosition
position: 59
reference: P47989-1

22575409924684078tt60
type: Position
type: ExactPosition
position: 60
reference: P47989-1

22575409924684078tt63
type: Position
type: ExactPosition
position: 63
reference: P47989-1

22575409924684078tt64
type: Position
type: ExactPosition
position: 64
reference: P47989-1

22575409924684078tt71
type: Position
type: ExactPosition
position: 71
reference: P47989-1

22575409924684078tt72
type: Position
type: ExactPosition
position: 72
reference: P47989-1

22575409924684078tt74
type: Position
type: ExactPosition
position: 74
reference: P47989-1

22575409924684078tt77
type: Position
type: ExactPosition
position: 77
reference: P47989-1

22575409924684078tt79
type: Position
type: ExactPosition
position: 79
reference: P47989-1

22575409924684078tt84
type: Position
type: ExactPosition
position: 84
reference: P47989-1

22575409924684078tt86
type: Position
type: ExactPosition
position: 86
reference: P47989-1

22575409924684078tt88
type: Position
type: ExactPosition
position: 88
reference: P47989-1

22575409924684078tt90
type: Position
type: ExactPosition
position: 90
reference: P47989-1

22575409924684078tt100
type: Position
type: ExactPosition
position: 100
reference: P47989-1

22575409924684078tt107
type: Position
type: ExactPosition
position: 107
reference: P47989-1

22575409924684078tt117
type: Position
type: ExactPosition
position: 117
reference: P47989-1

22575409924684078tt130
type: Position
type: ExactPosition
position: 130
reference: P47989-1

22575409924684078tt136
type: Position
type: ExactPosition
position: 136
reference: P47989-1

22575409924684078tt141
type: Position
type: ExactPosition
position: 141
reference: P47989-1

22575409924684078tt142
type: Position
type: ExactPosition
position: 142
reference: P47989-1

22575409924684078tt145
type: Position
type: ExactPosition
position: 145
reference: P47989-1

22575409924684078tt151
type: Position
type: ExactPosition
position: 151
reference: P47989-1

22575409924684078tt154
type: Position
type: ExactPosition
position: 154
reference: P47989-1

22575409924684078tt160
type: Position
type: ExactPosition
position: 160
reference: P47989-1

22575409924684078tt161
type: Position
type: ExactPosition
position: 161
reference: P47989-1

22575409924684078tt163
type: Position
type: ExactPosition
position: 163
reference: P47989-1

22575409924684078tt198
type: Position
type: ExactPosition
position: 198
reference: P47989-1

22575409924684078tt200
type: Position
type: ExactPosition
position: 200
reference: P47989-1

22575409924684078tt206
type: Position
type: ExactPosition
position: 206
reference: P47989-1

22575409924684078tt208
type: Position
type: ExactPosition
position: 208
reference: P47989-1

22575409924684078tt214
type: Position
type: ExactPosition
position: 214
reference: P47989-1

22575409924684078tt218
type: Position
type: ExactPosition
position: 218
reference: P47989-1

22575409924684078tt227
type: Position
type: ExactPosition
position: 227
reference: P47989-1

22575409924684078tt230
type: Position
type: ExactPosition
position: 230
reference: P47989-1

22575409924684078tt238
type: Position
type: ExactPosition
position: 238
reference: P47989-1

22575409924684078tt242
type: Position
type: ExactPosition
position: 242
reference: P47989-1

22575409924684078tt251
type: Position
type: ExactPosition
position: 251
reference: P47989-1

22575409924684078tt270
type: Position
type: ExactPosition
position: 270
reference: P47989-1

22575409924684078tt276
type: Position
type: ExactPosition
position: 276
reference: P47989-1

22575409924684078tt280
type: Position
type: ExactPosition
position: 280
reference: P47989-1

22575409924684078tt285
type: Position
type: ExactPosition
position: 285
reference: P47989-1

22575409924684078tt288
type: Position
type: ExactPosition
position: 288
reference: P47989-1

22575409924684078tt290
type: Position
type: ExactPosition
position: 290
reference: P47989-1

22575409924684078tt292
type: Position
type: ExactPosition
position: 292
reference: P47989-1

22575409924684078tt294
type: Position
type: ExactPosition
position: 294
reference: P47989-1

22575409924684078tt300
type: Position
type: ExactPosition
position: 300
reference: P47989-1

22575409924684078tt305
type: Position
type: ExactPosition
position: 305
reference: P47989-1

22575409924684078tt318
type: Position
type: ExactPosition
position: 318
reference: P47989-1

22575409924684078tt321
type: Position
type: ExactPosition
position: 321
reference: P47989-1

22575409924684078tt323
type: Position
type: ExactPosition
position: 323
reference: P47989-1

22575409924684078tt325
type: Position
type: ExactPosition
position: 325
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22575409924684078tt335
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position: 471
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reference: P47989-1

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reference: P47989-1

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position: 1013
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reference: P47989-1

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reference: P47989-1

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reference: P47989-1

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position: 1043
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position: 1055
reference: P47989-1

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position: 1059
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position: 1061
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position: 1069
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reference: P47989-1

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position: 1172
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position: 1182
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position: 1189
reference: P47989-1

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position: 1208
reference: P47989-1

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position: 1225
reference: P47989-1

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position: 1227
reference: P47989-1

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position: 1233
reference: P47989-1

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position: 1235
reference: P47989-1

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position: 1238
reference: P47989-1

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position: 1244
reference: P47989-1

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position: 1254
reference: P47989-1

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type: Position
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position: 1256
reference: P47989-1

22575409924684078tt1263
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position: 1263
reference: P47989-1

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type: Position
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position: 1268
reference: P47989-1

22575409924684078tt1269
type: Position
type: ExactPosition
position: 1269
reference: P47989-1

22575409924684078tt1286
type: Position
type: ExactPosition
position: 1286
reference: P47989-1

22575409924684078tt1303
type: Position
type: ExactPosition
position: 1303
reference: P47989-1

22575409924684078tt1309
type: Position
type: ExactPosition
position: 1309
reference: P47989-1

22575409924684078tt1315
type: Position
type: ExactPosition
position: 1315
reference: P47989-1

22575409924684078tt1317
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type: ExactPosition
position: 1317
reference: P47989-1

1
subclass of: CHEBI_190135

2
subclass of: CHEBI_190135

substrate

http://purl.uniprot.org/intact/2557331-12193965
type: Interaction
type: Non Self Interaction
xeno: false
experiments: 3
participant: EBI-2557331
participant: GRIP1

GRIP1
type: Participant

P47989-1
type: Simple Sequence
modified: 2007-01-23
version: 4
mass: 146424
value: MTADKLVFFVNGRKVVEKNADPETTLLAYLRRKLGLSGTKLGCGEGGCGACTVMLSKYDRLQNKIVHFSANACLAPICSLHHVAVTTVEGIGSTKTRLHPVQERIAKSHGSQCGFCTPGIVMSMYTLLRNQPEPTMEEIENAFQGNLCRCTGYRPILQGFRTFARDGGCCGGDGNNPNCCMNQKKDHSVSLSPSLFKPEEFTPLDPTQEPIFPPELLRLKDTPRKQLRFEGERVTWIQASTLKELLDLKAQHPDAKLVVGNTEIGIEMKFKNMLFPMIVCPAWIPELNSVEHGPDGISFGAACPLSIVEKTLVDAVAKLPAQKTEVFRGVLEQLRWFAGKQVKSVASVGGNIITASPISDLNPVFMASGAKLTLVSRGTRRTVQMDHTFFPGYRKTLLSPEEILLSIEIPYSREGEYFSAFKQASRREDDIAKVTSGMRVLFKPGTTEVQELALCYGGMANRTISALKTTQRQLSKLWKEELLQDVCAGLAEELHLPPDAPGGMVDFRCTLTLSFFFKFYLTVLQKLGQENLEDKCGKLDPTFASATLLFQKDPPADVQLFQEVPKGQSEEDMVGRPLPHLAADMQASGEAVYCDDIPRYENELSLRLVTSTRAHAKIKSIDTSEAKKVPGFVCFISADDVPGSNITGICNDETVFAKDKVTCVGHIIGAVVADTPEHTQRAAQGVKITYEELPAIITIEDAIKNNSFYGPELKIEKGDLKKGFSEADNVVSGEIYIGGQEHFYLETHCTIAVPKGEAGEMELFVSTQNTMKTQSFVAKMLGVPANRIVVRVKRMGGGFGGKETRSTVVSTAVALAAYKTGRPVRCMLDRDEDMLITGGRHPFLARYKVGFMKTGTVVALEVDHFSNVGNTQDLSQSIMERALFHMDNCYKIPNIRGTGRLCKTNLPSNTAFRGFGGPQGMLIAECWMSEVAVTCGMPAEEVRRKNLYKEGDLTHFNQKLEGFTLPRCWEECLASSQYHARKSEVDKFNKENCWKKRGLCIIPTKFGISFTVPFLNQAGALLHVYTDGSVLLTHGGTEMGQGLHTKMVQVASRALKIPTSKIYISETSTNTVPNTSPTAASVSADLNGQAVYAACQTILKRLEPYKKKNPSGSWEDWVTAAYMDTVSLSATGFYRTPNLGYSFETNSGNPFHYFSYGVACSEVEIDCLTGDHKNLRTDIVMDVGSSLNPAIDIGQVEGAFVQGLGLFTLEELHYSPEGSLHTRGPSTYKIPAFGSIPIEFRVSLLRDCPNKKAIYASKAVGEPPLFLAASIFFAIKDAIRAARAQHTGNNVKELFRLDSPATPEKIRNACVDKFTTLCVTGVPENCKPWSVRV

…
creator: MGI
manual: true
evidence: ECO_0000314

…
creator: UniProtKB
manual: true
evidence: ECO_0007005

…
creator: UniProtKB
manual: true
evidence: ECO_0000314

…
creator: UniProtKB
manual: true
evidence: ECO_0000353

…
manual: true
evidence: ECO_0000250

…
manual: true
evidence: ECO_0000255
source: PRU00465

…
manual: true
evidence: ECO_0000255
source: PRU00718

…
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/10844591

…
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/11379872

…
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/14551354

…
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/16959974

…
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/17301077

…
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/34356852

…
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/8135849

…
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/8670112

…
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/9153281

…
manual: true
evidence: ECO_0000269
source: SIP7257E036AC30FE0D

…
manual: true
evidence: ECO_0000269
source: SIPCB7D9AB1E4CB4DB2

…
manual: true
evidence: ECO_0000305