{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P47818","secondaryAccessions":["D6VYM0"],"uniProtkbId":"CCC1_YEAST","entryAudit":{"firstPublicDate":"1996-02-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1996-02-01","entryVersion":184,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)","commonName":"Baker's yeast","taxonId":559292,"lineage":["Eukaryota","Fungi","Dikarya","Ascomycota","Saccharomycotina","Saccharomycetes","Saccharomycetales","Saccharomycetaceae","Saccharomyces"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Protein CCC1"}},"alternativeNames":[{"fullName":{"value":"Cross-complementer of CSG1 protein 1"}}]},"genes":[{"geneName":{"value":"CCC1"},"orderedLocusNames":[{"value":"YLR220W"}],"orfNames":[{"value":"L8083.6"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11390404"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8668190"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8866476"}],"value":"Has a role in both calcium and manganese homeostasis. Involved in the transfer of iron and Mn(2+) from the cytosol to the vacuole for storage of these metals"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"Fe(2+)(in) = Fe(2+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:28486"},{"database":"ChEBI","id":"CHEBI:29033"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11390404"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:28487"},"evidences":[{"evidenceCode":"ECO:0000305"}]}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11390404"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14562095"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8866476"}],"value":"Golgi apparatus membrane","id":"SL-0134"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Vacuole membrane","id":"SL-0271"},"topology":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15652485"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18070921"}],"value":"Down-regulated under iron starvation by TIS11. Transcriptionally up-regulated by YAP5 in response to increased cytosolic iron"}],"commentType":"INDUCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8866476"}],"value":"Deletion causes an increase in metal sensitivity at 15 mM manganese, but does not affect invertase glycosylation. Deletion shows increased sensitivity to external iron, which is suppressed by MRS3 or MRS4 overexpression requiring oxygen but not respiration, and exacerbated by ectopic expression of the iron transporter FET4. Deletion also results in decreased vacuolar iron content and decreased iron stores, which affect cytosolic iron levels and cell growth. Deletion together with MRS3 and MRS4 restores cellular and mitochondrial iron homeostasis to near normal level, corrects the MRS3 and MRS4 double deletion phenotype (which shows increased resistance to cobalt but decreased resistance to copper and cadmium), and has near normal levels of aconitase activity. When overexpressed, maintains respiratory function in a YFH1 deletion mutant regardless of extracellular iron concentration, activates the iron-dependent transcription factor AFT1 resulting in an increase in iron uptake, cytosolic iron accumulation and a change in copper metabolism. Overexpression prevents excessive mitochondrial iron accumulation by limiting mitochondrial iron uptake and results in increased expression of the high affinity iron transport system composed of FET3 and FTR1. Overexpression also suppresses the rapamycin-resistant phenotype of PMR1 deletion mutant"}],"commentType":"DISRUPTION PHENOTYPE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14562106"}],"value":"Present with 2840 molecules/cell in log phase SD medium"}],"commentType":"MISCELLANEOUS"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the CCC1 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":322,"modifier":"EXACT"}},"description":"Protein CCC1","featureId":"PRO_0000089394"},{"type":"Topological domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":99,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":100,"modifier":"EXACT"},"end":{"value":120,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":121,"modifier":"EXACT"},"end":{"value":129,"modifier":"EXACT"}},"description":"Vacuolar","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":130,"modifier":"EXACT"},"end":{"value":150,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":151,"modifier":"EXACT"},"end":{"value":236,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":237,"modifier":"EXACT"},"end":{"value":257,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":258,"modifier":"EXACT"},"end":{"value":259,"modifier":"EXACT"}},"description":"Vacuolar","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":260,"modifier":"EXACT"},"end":{"value":280,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":281,"modifier":"EXACT"},"end":{"value":300,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":301,"modifier":"EXACT"},"end":{"value":321,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":322,"modifier":"EXACT"},"end":{"value":322,"modifier":"EXACT"}},"description":"Vacuolar","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Region","location":{"start":{"value":19,"modifier":"EXACT"},"end":{"value":86,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":26,"modifier":"EXACT"},"end":{"value":53,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":60,"modifier":"EXACT"},"end":{"value":70,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Modified residue","location":{"start":{"value":29,"modifier":"EXACT"},"end":{"value":29,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18407956"}]},{"type":"Modified residue","location":{"start":{"value":53,"modifier":"EXACT"},"end":{"value":53,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19779198"}]},{"type":"Modified residue","location":{"start":{"value":68,"modifier":"EXACT"},"end":{"value":68,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18407956"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19779198"}]},{"type":"Modified residue","location":{"start":{"value":71,"modifier":"EXACT"},"end":{"value":71,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18407956"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19779198"}]},{"type":"Modified residue","location":{"start":{"value":83,"modifier":"EXACT"},"end":{"value":83,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"17330950"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18407956"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19779198"}]}],"keywords":[{"id":"KW-0333","category":"Cellular component","name":"Golgi apparatus"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"id":"KW-0813","category":"Biological process","name":"Transport"},{"id":"KW-0926","category":"Cellular component","name":"Vacuole"}],"references":[{"referenceNumber":1,"citation":{"id":"7941738","citationType":"journal article","authors":["Fu D.","Beeler T.J.","Dunn T.M."],"citationCrossReferences":[{"database":"PubMed","id":"7941738"},{"database":"DOI","id":"10.1002/yea.320100411"}],"title":"Sequence, mapping and disruption of CCC1, a gene that cross-complements the Ca(2+)-sensitive phenotype of csg1 mutants.","publicationDate":"1994","journal":"Yeast","firstPage":"515","lastPage":"521","volume":"10"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"]},{"referenceNumber":2,"citation":{"id":"9169871","citationType":"journal article","authors":["Johnston M.","Hillier L.W.","Riles L.","Albermann K.","Andre B.","Ansorge W.","Benes V.","Brueckner M.","Delius H.","Dubois E.","Duesterhoeft A.","Entian K.-D.","Floeth M.","Goffeau A.","Hebling U.","Heumann K.","Heuss-Neitzel D.","Hilbert H.","Hilger F.","Kleine K.","Koetter P.","Louis E.J.","Messenguy F.","Mewes H.-W.","Miosga T.","Moestl D.","Mueller-Auer S.","Nentwich U.","Obermaier B.","Piravandi E.","Pohl T.M.","Portetelle D.","Purnelle B.","Rechmann S.","Rieger M.","Rinke M.","Rose M.","Scharfe M.","Scherens B.","Scholler P.","Schwager C.","Schwarz S.","Underwood A.P.","Urrestarazu L.A.","Vandenbol M.","Verhasselt P.","Vierendeels F.","Voet M.","Volckaert G.","Voss H.","Wambutt R.","Wedler E.","Wedler H.","Zimmermann F.K.","Zollner A.","Hani J.","Hoheisel J.D."],"citationCrossReferences":[{"database":"PubMed","id":"9169871"},{"database":"DOI","id":"10.1038/387s087"}],"title":"The nucleotide sequence of Saccharomyces cerevisiae chromosome XII.","publicationDate":"1997","journal":"Nature","firstPage":"87","lastPage":"90","volume":"387"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"ATCC 204508 / S288c","type":"STRAIN"}]},{"referenceNumber":3,"citation":{"id":"24374639","citationType":"journal article","authors":["Engel S.R.","Dietrich F.S.","Fisk D.G.","Binkley G.","Balakrishnan R.","Costanzo M.C.","Dwight S.S.","Hitz B.C.","Karra K.","Nash R.S.","Weng S.","Wong E.D.","Lloyd P.","Skrzypek M.S.","Miyasato S.R.","Simison M.","Cherry J.M."],"citationCrossReferences":[{"database":"PubMed","id":"24374639"},{"database":"DOI","id":"10.1534/g3.113.008995"}],"title":"The reference genome sequence of Saccharomyces cerevisiae: Then and now.","publicationDate":"2014","journal":"G3 (Bethesda)","firstPage":"389","lastPage":"398","volume":"4"},"referencePositions":["GENOME REANNOTATION"],"referenceComments":[{"value":"ATCC 204508 / S288c","type":"STRAIN"}]},{"referenceNumber":4,"citation":{"id":"17322287","citationType":"journal article","authors":["Hu Y.","Rolfs A.","Bhullar B.","Murthy T.V.S.","Zhu C.","Berger M.F.","Camargo A.A.","Kelley F.","McCarron S.","Jepson D.","Richardson A.","Raphael J.","Moreira D.","Taycher E.","Zuo D.","Mohr S.","Kane M.F.","Williamson J.","Simpson A.J.G.","Bulyk M.L.","Harlow E.","Marsischky G.","Kolodner R.D.","LaBaer J."],"citationCrossReferences":[{"database":"PubMed","id":"17322287"},{"database":"DOI","id":"10.1101/gr.6037607"}],"title":"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae.","publicationDate":"2007","journal":"Genome Res.","firstPage":"536","lastPage":"543","volume":"17"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"],"referenceComments":[{"value":"ATCC 204508 / S288c","type":"STRAIN"}]},{"referenceNumber":5,"citation":{"id":"8668190","citationType":"journal article","authors":["Pozos T.C.","Sekler I.","Cyert M.S."],"citationCrossReferences":[{"database":"PubMed","id":"8668190"},{"database":"DOI","id":"10.1128/mcb.16.7.3730"}],"title":"The product of HUM1, a novel yeast gene, is required for vacuolar Ca2+/H+ exchange and is related to mammalian Na+/Ca2+ exchangers.","publicationDate":"1996","journal":"Mol. Cell. Biol.","firstPage":"3730","lastPage":"3741","volume":"16"},"referencePositions":["FUNCTION"],"referenceComments":[{"value":"S288c / YPH1","type":"STRAIN"}]},{"referenceNumber":6,"citation":{"id":"8866476","citationType":"journal article","authors":["Lapinskas P.J.","Lin S.-J.","Culotta V.C."],"citationCrossReferences":[{"database":"PubMed","id":"8866476"},{"database":"DOI","id":"10.1111/j.1365-2958.1996.tb02561.x"}],"title":"The role of the Saccharomyces cerevisiae CCC1 gene in the homeostasis of manganese ions.","publicationDate":"1996","journal":"Mol. Microbiol.","firstPage":"519","lastPage":"528","volume":"21"},"referencePositions":["FUNCTION","SUBCELLULAR LOCATION","DISRUPTION PHENOTYPE"]},{"referenceNumber":7,"citation":{"id":"10713071","citationType":"journal article","authors":["Chen O.S.","Kaplan J."],"citationCrossReferences":[{"database":"PubMed","id":"10713071"},{"database":"DOI","id":"10.1074/jbc.275.11.7626"}],"title":"CCC1 suppresses mitochondrial damage in the yeast model of Friedreich's ataxia by limiting mitochondrial iron accumulation.","publicationDate":"2000","journal":"J. Biol. Chem.","firstPage":"7626","lastPage":"7632","volume":"275"},"referencePositions":["OVEREXPRESSION PHENOTYPE"]},{"referenceNumber":8,"citation":{"id":"11390404","citationType":"journal article","authors":["Li L.","Chen O.S.","McVey Ward D.","Kaplan J."],"citationCrossReferences":[{"database":"PubMed","id":"11390404"},{"database":"DOI","id":"10.1074/jbc.m103944200"}],"title":"CCC1 is a transporter that mediates vacuolar iron storage in yeast.","publicationDate":"2001","journal":"J. Biol. Chem.","firstPage":"29515","lastPage":"29519","volume":"276"},"referencePositions":["FUNCTION","TRANSPORTER ACTIVITY","SUBCELLULAR LOCATION","CHARACTERIZATION OF DELETION MUTANT"]},{"referenceNumber":9,"citation":{"id":"14562095","citationType":"journal article","authors":["Huh W.-K.","Falvo J.V.","Gerke L.C.","Carroll A.S.","Howson R.W.","Weissman J.S.","O'Shea E.K."],"citationCrossReferences":[{"database":"PubMed","id":"14562095"},{"database":"DOI","id":"10.1038/nature02026"}],"title":"Global analysis of protein localization in budding yeast.","publicationDate":"2003","journal":"Nature","firstPage":"686","lastPage":"691","volume":"425"},"referencePositions":["SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]"]},{"referenceNumber":10,"citation":{"id":"14562106","citationType":"journal article","authors":["Ghaemmaghami S.","Huh W.-K.","Bower K.","Howson R.W.","Belle A.","Dephoure N.","O'Shea E.K.","Weissman J.S."],"citationCrossReferences":[{"database":"PubMed","id":"14562106"},{"database":"DOI","id":"10.1038/nature02046"}],"title":"Global analysis of protein expression in yeast.","publicationDate":"2003","journal":"Nature","firstPage":"737","lastPage":"741","volume":"425"},"referencePositions":["LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS]"]},{"referenceNumber":11,"citation":{"id":"15161905","citationType":"journal article","authors":["Li L.","Kaplan J."],"citationCrossReferences":[{"database":"PubMed","id":"15161905"},{"database":"DOI","id":"10.1074/jbc.m403146200"}],"title":"A mitochondrial-vacuolar signaling pathway in yeast that affects iron and copper metabolism.","publicationDate":"2004","journal":"J. Biol. Chem.","firstPage":"33653","lastPage":"33661","volume":"279"},"referencePositions":["CHARACTERIZATION OF DELETION MUTANT"]},{"referenceNumber":12,"citation":{"id":"15652485","citationType":"journal article","authors":["Puig S.","Askeland E.","Thiele D.J."],"citationCrossReferences":[{"database":"PubMed","id":"15652485"},{"database":"DOI","id":"10.1016/j.cell.2004.11.032"}],"title":"Coordinated remodeling of cellular metabolism during iron deficiency through targeted mRNA degradation.","publicationDate":"2005","journal":"Cell","firstPage":"99","lastPage":"110","volume":"120"},"referencePositions":["INDUCTION"]},{"referenceNumber":13,"citation":{"id":"16847258","citationType":"journal article","authors":["Kim H.","Melen K.","Oesterberg M.","von Heijne G."],"citationCrossReferences":[{"database":"PubMed","id":"16847258"},{"database":"DOI","id":"10.1073/pnas.0604075103"}],"title":"A global topology map of the Saccharomyces cerevisiae membrane proteome.","publicationDate":"2006","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"11142","lastPage":"11147","volume":"103"},"referencePositions":["TOPOLOGY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"ATCC 208353 / W303-1A","type":"STRAIN"}]},{"referenceNumber":14,"citation":{"id":"17603109","citationType":"journal article","authors":["Devasahayam G.","Burke D.J.","Sturgill T.W."],"citationCrossReferences":[{"database":"PubMed","id":"17603109"},{"database":"DOI","id":"10.1534/genetics.107.073577"}],"title":"Golgi manganese transport is required for rapamycin signaling in Saccharomyces cerevisiae.","publicationDate":"2007","journal":"Genetics","firstPage":"231","lastPage":"238","volume":"177"},"referencePositions":["EFFECT OF OVEREXPRESSION"]},{"referenceNumber":15,"citation":{"id":"17330950","citationType":"journal article","authors":["Li X.","Gerber S.A.","Rudner A.D.","Beausoleil S.A.","Haas W.","Villen J.","Elias J.E.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"17330950"},{"database":"DOI","id":"10.1021/pr060559j"}],"title":"Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae.","publicationDate":"2007","journal":"J. Proteome Res.","firstPage":"1190","lastPage":"1197","volume":"6"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-83","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"ADR376","type":"STRAIN"}]},{"referenceNumber":16,"citation":{"id":"18070921","citationType":"journal article","authors":["Li L.","Bagley D.","Ward D.M.","Kaplan J."],"citationCrossReferences":[{"database":"PubMed","id":"18070921"},{"database":"DOI","id":"10.1128/mcb.01219-07"}],"title":"Yap5 is an iron-responsive transcriptional activator that regulates vacuolar iron storage in yeast.","publicationDate":"2008","journal":"Mol. Cell. Biol.","firstPage":"1326","lastPage":"1337","volume":"28"},"referencePositions":["INDUCTION"]},{"referenceNumber":17,"citation":{"id":"18407956","citationType":"journal article","authors":["Albuquerque C.P.","Smolka M.B.","Payne S.H.","Bafna V.","Eng J.","Zhou H."],"citationCrossReferences":[{"database":"PubMed","id":"18407956"},{"database":"DOI","id":"10.1074/mcp.m700468-mcp200"}],"title":"A multidimensional chromatography technology for in-depth phosphoproteome analysis.","publicationDate":"2008","journal":"Mol. Cell. Proteomics","firstPage":"1389","lastPage":"1396","volume":"7"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-29; SER-68; SER-71 AND SER-83","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":18,"citation":{"id":"19779198","citationType":"journal article","authors":["Holt L.J.","Tuch B.B.","Villen J.","Johnson A.D.","Gygi S.P.","Morgan D.O."],"citationCrossReferences":[{"database":"PubMed","id":"19779198"},{"database":"DOI","id":"10.1126/science.1172867"}],"title":"Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution.","publicationDate":"2009","journal":"Science","firstPage":"1682","lastPage":"1686","volume":"325"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-53; SER-68; SER-71 AND SER-83","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"L24112","properties":[{"key":"ProteinId","value":"AAA62622.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"U14913","properties":[{"key":"ProteinId","value":"AAB67452.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"U19027","properties":[{"key":"ProteinId","value":"AAB67409.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AY557952","properties":[{"key":"ProteinId","value":"AAS56278.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BK006945","properties":[{"key":"ProteinId","value":"DAA09536.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"S43453","properties":[{"key":"EntryName","value":"S43453"}]},{"database":"RefSeq","id":"NP_013321.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001182107.1"}]},{"database":"AlphaFoldDB","id":"P47818","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P47818","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"31487","properties":[{"key":"Interactions","value":"140"}]},{"database":"DIP","id":"DIP-782N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"P47818","properties":[{"key":"Number of interactors","value":"53"}]},{"database":"IntAct","id":"P47818","properties":[{"key":"Interactions","value":"1"}]},{"database":"MINT","id":"P47818","properties":[{"key":"Description","value":"-"}]},{"database":"STRING","id":"4932.YLR220W","properties":[{"key":"Description","value":"-"}]},{"database":"TCDB","id":"2.A.89.1.1","properties":[{"key":"FamilyName","value":"the vacuolar iron transporter (vit) family"}]},{"database":"iPTMnet","id":"P47818","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"4932-YLR220W","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"P47818","properties":[{"key":"Description","value":"-"}]},{"database":"EnsemblFungi","id":"YLR220W_mRNA","properties":[{"key":"ProteinId","value":"YLR220W"},{"key":"GeneId","value":"YLR220W"}]},{"database":"GeneID","id":"850917","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"sce:YLR220W","properties":[{"key":"Description","value":"-"}]},{"database":"AGR","id":"SGD:S000004210","properties":[{"key":"Description","value":"-"}]},{"database":"SGD","id":"S000004210","properties":[{"key":"GeneName","value":"CCC1"}]},{"database":"VEuPathDB","id":"FungiDB:YLR220W","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG4473","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"HOGENOM","id":"CLU_038957_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P47818","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"MNFHHTL","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"73465at2759","properties":[{"key":"Description","value":"-"}]},{"database":"BioCyc","id":"YEAST:G3O-32334-MONOMER","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"850917","properties":[{"key":"hits","value":"3 hits in 10 CRISPR screens"}]},{"database":"CD-CODE","id":"E03F929F","properties":[{"key":"EntryName","value":"Stress granule"}]},{"database":"PRO","id":"PR:P47818","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000002311","properties":[{"key":"Component","value":"Chromosome XII"}]},{"database":"RNAct","id":"P47818","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"GO","id":"GO:0000324","properties":[{"key":"GoTerm","value":"C:fungal-type vacuole"},{"key":"GoEvidenceType","value":"IDA:SGD"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"23708375"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"34203091"}]},{"database":"GO","id":"GO:0000329","properties":[{"key":"GoTerm","value":"C:fungal-type vacuole membrane"},{"key":"GoEvidenceType","value":"IDA:SGD"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11390404"}]},{"database":"GO","id":"GO:0005794","properties":[{"key":"GoTerm","value":"C:Golgi apparatus"},{"key":"GoEvidenceType","value":"IDA:SGD"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"8866476"}]},{"database":"GO","id":"GO:0000139","properties":[{"key":"GoTerm","value":"C:Golgi membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0015093","properties":[{"key":"GoTerm","value":"F:ferrous iron transmembrane transporter activity"},{"key":"GoEvidenceType","value":"IMP:SGD"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"11390404"},{"evidenceCode":"ECO:0000315","source":"PubMed","id":"34203091"}]},{"database":"GO","id":"GO:0005384","properties":[{"key":"GoTerm","value":"F:manganese ion transmembrane transporter activity"},{"key":"GoEvidenceType","value":"IMP:SGD"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"11390404"}]},{"database":"GO","id":"GO:1990461","properties":[{"key":"GoTerm","value":"P:detoxification of iron ion"},{"key":"GoEvidenceType","value":"IMP:SGD"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"34203091"}]},{"database":"GO","id":"GO:0006874","properties":[{"key":"GoTerm","value":"P:intracellular calcium ion homeostasis"},{"key":"GoEvidenceType","value":"IMP:SGD"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"7941738"}]},{"database":"GO","id":"GO:0006879","properties":[{"key":"GoTerm","value":"P:intracellular iron ion homeostasis"},{"key":"GoEvidenceType","value":"IMP:SGD"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"10713071"},{"evidenceCode":"ECO:0000315","source":"PubMed","id":"34203091"}]},{"database":"GO","id":"GO:0030026","properties":[{"key":"GoTerm","value":"P:intracellular manganese ion homeostasis"},{"key":"GoEvidenceType","value":"IMP:SGD"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"8866476"}]},{"database":"GO","id":"GO:0006826","properties":[{"key":"GoTerm","value":"P:iron ion transport"},{"key":"GoEvidenceType","value":"IMP:SGD"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"11390404"}]},{"database":"GO","id":"GO:0006828","properties":[{"key":"GoTerm","value":"P:manganese ion transport"},{"key":"GoEvidenceType","value":"IMP:SGD"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"11390404"}]},{"database":"CDD","id":"cd02435","properties":[{"key":"EntryName","value":"CCC1"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR008217","properties":[{"key":"EntryName","value":"Ccc1_fam"}]},{"database":"PANTHER","id":"PTHR31851","properties":[{"key":"EntryName","value":"FE(2+)/MN(2+) TRANSPORTER PCL1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01988","properties":[{"key":"EntryName","value":"VIT1"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSIVALKNAVVTLIQKAKGSGGTSELGGSESTPLLRGSNSNSSRHDNLSSSSSDIIYGRNSAQDLENSPMSVGKDNRNGDNGSDNEKANLGFFQSVDPRVISDLIIGLSDGLTVPFALTAGLSSLGDAKLVITGGFAELISGAISMGLGGYLGAKSESDYYHAEVKKEKRKFYDNSNLINREIEDILLEINPNFSDETIVSFIKDLQRTPELMVDFIIRYGRGLDEPAENRELISAVTIGGGYLLGGLVPLVPYFFVSDVGTGLIYSIIVMVVTLFWFGYVKTKLSMGSGSSTSKKVTEGVEMVVVGGVAAGAAWFFVKLLG","length":322,"molWeight":34250,"crc64":"374081A49F0C43D1","md5":"CAA8CB2D9F0592B9DF4922FE255607F2"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"SUBCELLULAR LOCATION":1,"INDUCTION":1,"DISRUPTION PHENOTYPE":1,"MISCELLANEOUS":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Topological domain":6,"Transmembrane":5,"Region":1,"Compositional bias":2,"Modified residue":5},"uniParcId":"UPI000012729E"}}