{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P47580","uniProtkbId":"Y338_MYCGE","entryAudit":{"firstPublicDate":"1996-02-01","lastAnnotationUpdateDate":"2026-06-10","lastSequenceUpdateDate":"2018-01-31","entryVersion":115,"sequenceVersion":2},"annotationScore":2.0,"organism":{"scientificName":"Mycoplasmoides genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37)","commonName":"Mycoplasma genitalium","taxonId":243273,"lineage":["Bacteria","Bacillati","Mycoplasmatota","Mycoplasmoidales","Mycoplasmoidaceae","Mycoplasmoides"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"value":"Uncharacterized lipoprotein MG338"}},"flag":"Precursor"},"genes":[{"orderedLocusNames":[{"value":"MG338"}]}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00303"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00303"}],"value":"Lipid-anchor","id":"SL-9901"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16407165"}],"value":"Probably essential, it was not disrupted in a global transposon mutagenesis study"}],"commentType":"DISRUPTION PHENOTYPE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the MG307/MG309/MG338 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":26,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00303"}]},{"type":"Chain","location":{"start":{"value":27,"modifier":"EXACT"},"end":{"value":1270,"modifier":"EXACT"}},"description":"Uncharacterized lipoprotein MG338","featureId":"PRO_0000014036"},{"type":"Region","location":{"start":{"value":942,"modifier":"EXACT"},"end":{"value":967,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Coiled coil","location":{"start":{"value":92,"modifier":"EXACT"},"end":{"value":123,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Coiled coil","location":{"start":{"value":175,"modifier":"EXACT"},"end":{"value":204,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Compositional bias","location":{"start":{"value":943,"modifier":"EXACT"},"end":{"value":957,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":958,"modifier":"EXACT"},"end":{"value":967,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Lipidation","location":{"start":{"value":27,"modifier":"EXACT"},"end":{"value":27,"modifier":"EXACT"}},"description":"N-palmitoyl cysteine","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00303"}]},{"type":"Lipidation","location":{"start":{"value":27,"modifier":"EXACT"},"end":{"value":27,"modifier":"EXACT"}},"description":"S-diacylglycerol cysteine","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00303"}]}],"keywords":[{"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"id":"KW-0449","category":"PTM","name":"Lipoprotein"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0564","category":"PTM","name":"Palmitate"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"7569993","citationType":"journal article","authors":["Fraser C.M.","Gocayne J.D.","White O.","Adams M.D.","Clayton R.A.","Fleischmann R.D.","Bult C.J.","Kerlavage A.R.","Sutton G.G.","Kelley J.M.","Fritchman J.L.","Weidman J.F.","Small K.V.","Sandusky M.","Fuhrmann J.L.","Nguyen D.T.","Utterback T.R.","Saudek D.M.","Phillips C.A.","Merrick J.M.","Tomb J.-F.","Dougherty B.A.","Bott K.F.","Hu P.-C.","Lucier T.S.","Peterson S.N.","Smith H.O.","Hutchison C.A. III","Venter J.C."],"citationCrossReferences":[{"database":"PubMed","id":"7569993"},{"database":"DOI","id":"10.1126/science.270.5235.397"}],"title":"The minimal gene complement of Mycoplasma genitalium.","publicationDate":"1995","journal":"Science","firstPage":"397","lastPage":"403","volume":"270"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"ATCC 33530 / DSM 19775 / NCTC 10195 / G37","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"8253680","citationType":"journal article","authors":["Peterson S.N.","Hu P.-C.","Bott K.F.","Hutchison C.A. III"],"citationCrossReferences":[{"database":"PubMed","id":"8253680"},{"database":"DOI","id":"10.1128/jb.175.24.7918-7930.1993"}],"title":"A survey of the Mycoplasma genitalium genome by using random sequencing.","publicationDate":"1993","journal":"J. Bacteriol.","firstPage":"7918","lastPage":"7930","volume":"175"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1022-1113"],"referenceComments":[{"value":"ATCC 33530 / DSM 19775 / NCTC 10195 / G37","type":"STRAIN"}]},{"referenceNumber":3,"citation":{"id":"16407165","citationType":"journal article","authors":["Glass J.I.","Assad-Garcia N.","Alperovich N.","Yooseph S.","Lewis M.R.","Maruf M.","Hutchison C.A. III","Smith H.O.","Venter J.C."],"citationCrossReferences":[{"database":"PubMed","id":"16407165"},{"database":"DOI","id":"10.1073/pnas.0510013103"}],"title":"Essential genes of a minimal bacterium.","publicationDate":"2006","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"425","lastPage":"430","volume":"103"},"referencePositions":["SEQUENCE REVISION","DISRUPTION PHENOTYPE"],"referenceComments":[{"value":"ATCC 33530 / DSM 19775 / NCTC 10195 / G37","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"L43967","properties":[{"key":"ProteinId","value":"AAC71563.2"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"U01809","properties":[{"key":"ProteinId","value":"AAD12341.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"D64237","properties":[{"key":"EntryName","value":"D64237"}]},{"database":"RefSeq","id":"WP_009885969.1","properties":[{"key":"NucleotideSequenceId","value":"NC_000908.2"}]},{"database":"AlphaFoldDB","id":"P47580","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P47580","properties":[{"key":"Description","value":"-"}]},{"database":"STRING","id":"243273.MG_338","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"99647231","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"mge:MG_338","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG5031Z7V","properties":[{"key":"ToxonomicScope","value":"Bacteria"}]},{"database":"HOGENOM","id":"CLU_007912_0_0_14","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P47580","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"394364at2","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000807","properties":[{"key":"Component","value":"Chromosome"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"InterPro","id":"IPR022186","properties":[{"key":"EntryName","value":"DUF3713"}]},{"database":"Pfam","id":"PF12506","properties":[{"key":"EntryName","value":"DUF3713"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51257","properties":[{"key":"EntryName","value":"PROKAR_LIPOPROTEIN"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MAHRFKRWSLIALAFSGVGATAIITACSTINTANLFPTLNRSQKLIGFSDQNIINPDVVLKSALNDGSGVDSILRVSFGSALQKWYQANADRNISNRLKIFEENVEDEHDNLIDEKKRADRVKWPIEVQKEYDQFGGNQESWKKLKLYDRLITDFQSLIFNNISANVSLVNSSDTSVATTKENIEKTENKLKFINSNLNDVNGDFFTNLQAYLFSQWLIEENPFLLNQASFNYQSPIAGLGSIYDENAIGASNLNLSYNFPAFQDPSESGGQTNSAKLFEEFDKQLQTANSSGSSQSSAATNTRNDLLDFENKYSASKVLISKNNILSVLKTVNLSAAVIDQYHYLLNNKTELTTTTTTTTTTGGTSSNLNPLDKFIKSSSATTVMMKSAMTKSQEVTSDNNGFNVKSEFLKINPSLSSSGSDNSSNTQSFWKQVQALNNSSQTATIFDAVRMESNSSQAQVVTSNLLVSLSSKTTQKQQQKPVYVRGDDAIYAFHIDGGNYFLENSSPNKRNFEKQAEVLLMRFLQGQTNNFSKDNVSFSVDLFGSNSEFRSWANRNTTLKLYTALTTMLENGTSNNNGQKDVCDLAKKLLKNNTNLSETIKKQQDFNNSLSQIKSSYESYIKAANKLNNFRTDLANIEKLEQAIVDRANNYIKLQKEAKESSIGWGQPLPYKRANDGSYPSLAKFFNNNSDQSSAQTLTLKTTAAAITSDNEPTREKNNQTLKTLTTEVENKAKELVEKWKATTYSSSQYSEIITLKSSQLNDLDLDLILSLLTDSGIRTGTVANIFKNWYFKNTNSFTNNFDTSNKELKGEFSDFNDLVKQALYIRSWQNLTSKERFGYYKDLGSVNSTSTMLQMQNKAAQSHTSSSVNQTLLDLAKKAFEKELEDPNQDAEYKYMRFLQALMWLVKNGAQNYKNLLQQAIPIGTRAFVSWTVGYDKNPSATVSQKTKSSTSSANENPFNRFLQNPNYTQGSEINWFNDKQTPIQPDSLLESENTYRFTDEPFNNSVALSNKSQGSSDKKYFYGFNGLTINSNQSISTASAGLTQQLFNNYGQLITATDKAGALSQYKDKFTLWSLINKTSSDAELNAFGELLHRSVNVDTNNLSRFNSRGEPLISFDNKKKFLLNVVDRLDDLYFHKFEGYVGLSKAANTDGSNTEGYKTVQTVPLTNDSSIQTLSYVIQITNDDVNKISSNWKNNKANSLGLKKEIFMSLLIEQALDEGTQELAFLDLIRENQKQHQREHQQILVGDKRLYDILGQTLAINAKNF","length":1270,"molWeight":142391,"crc64":"8818DD046F763444","md5":"3187F3D36CBC8602F5355EFFEA8987CB"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"DISRUPTION PHENOTYPE":1,"SIMILARITY":1},"countByFeatureType":{"Signal":1,"Chain":1,"Region":1,"Coiled coil":2,"Compositional bias":2,"Lipidation":2},"uniParcId":"UPI000067DA66"}}