{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P46937","secondaryAccessions":["B4DTY1","B7ZA01","E3WEB5","E3WEB6","E9PRV2","F5H202","K0KQ18","K0KYZ8","K0L195","K0L1G3","Q7Z574","Q8IUY9"],"uniProtkbId":"YAP1_HUMAN","entryAudit":{"firstPublicDate":"1995-11-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2010-04-20","entryVersion":234,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Transcriptional coactivator YAP1"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"7782338"}],"value":"Yes-associated protein 1"}]},"alternativeNames":[{"fullName":{"value":"Protein yorkie homolog"}},{"fullName":{"value":"Yes-associated protein YAP65 homolog"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:16262"}],"value":"YAP1"},"synonyms":[{"value":"YAP65"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P46938"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16772533"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17974916"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18158288"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18280240"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18579750"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21364637"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25778702"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25849865"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26598551"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30447097"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32369015"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34404733"}],"value":"Transcriptional regulator with dual roles as a coactivator and corepressor. Critical downstream regulatory target in the Hippo signaling pathway, crucial for organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:17974916, PubMed:18280240, PubMed:18579750, PubMed:21364637, PubMed:30447097). The Hippo signaling pathway core involves a kinase cascade featuring STK3/MST2 and STK4/MST1, along with its regulatory partner SAV1, which phosphorylates and activates LATS1/2 in complex with their regulatory protein, MOB1. This activation leads to the phosphorylation and inactivation of the YAP1 oncoprotein and WWTR1/TAZ (PubMed:18158288). Phosphorylation of YAP1 by LATS1/2 prevents its nuclear translocation, thereby regulating the expression of its target genes (PubMed:18158288, PubMed:26598551, PubMed:34404733). The transcriptional regulation of gene expression requires TEAD transcription factors and modulates cell growth, anchorage-independent growth, and induction of epithelial-mesenchymal transition (EMT) (PubMed:18579750). Plays a key role in tissue tension and 3D tissue shape by regulating the cortical actomyosin network, acting via ARHGAP18, a Rho GTPase activating protein that suppresses F-actin polymerization (PubMed:25778702). It also suppresses ciliogenesis by acting as a transcriptional corepressor of TEAD4 target genes AURKA and PLK1 (PubMed:25849865). In conjunction with WWTR1, regulates TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). Synergizes with WBP2 to enhance PGR activity (PubMed:16772533). Promotes keratinocyte proliferation (PubMed:32369015)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12807903"}],"value":"Activates the C-terminal fragment (CTF) of ERBB4 (isoform 3)"}],"commentType":"FUNCTION","molecule":"Isoform 2"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12807903"}],"value":"Activates the C-terminal fragment (CTF) of ERBB4 (isoform 3)"}],"commentType":"FUNCTION","molecule":"Isoform 3"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P46938"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12807903"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17502622"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17535448"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17974916"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18158288"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18280240"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18579750"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20123905"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20123908"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21205866"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21685363"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22525271"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23873930"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26598551"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31835537"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9202023"}],"value":"Part of a complex when phosphorylated that contains DSG3, PKP1, YAP1 and YWHAG; the complex is required for localization of DSG3 and YAP1 to the cell membrane in keratinocytes (PubMed:31835537). Binds to the SH3 domain of the YES kinase. Binds to WBP1 and WBP2 (PubMed:9202023). Binds, in vitro, through the WW1 domain, to neural isoforms of ENAH that contain the PPSY motif (By similarity). The phosphorylated form interacts with YWHAB (PubMed:17974916). Interacts (via WW domains) with LATS1 (via PPxY motif 2) (PubMed:18158288). Interacts with LATS2 (PubMed:18158288). Interacts with TEAD1, TEAD2, TEAD3 and TEAD4 (PubMed:18579750, PubMed:20123905, PubMed:20123908). Interacts with TP73 (PubMed:18280240). Interacts with RUNX1 (PubMed:18280240). Interacts with HCK (PubMed:17535448). Interacts (via WW domains) with PTPN14 (via PPxY motif 2); this interaction leads to the cytoplasmic sequestration of YAP1 and inhibits its transcriptional coactivator activity (PubMed:22525271). Interacts (when phosphorylated at Ser-127) with SMAD2, SMAD3 and WWTR1 (By similarity). Interacts with PRRG2 (via cytoplasmic domain) (PubMed:17502622). Interacts (via WW domains) with PRRG4 (via cytoplasmic domain) (PubMed:23873930). Interacts (phosphorylated) with CLDN18; the interaction sequesters YAP1 away from the nucleus and thereby restricts transcription of YAP1 target genes (By similarity). Interacts with SMAD1 (PubMed:21685363). Interacts with AMOTL2, the interaction is required for ubiquitination of AMOTL2 and localization of YAP1 to tight junctions (PubMed:21205866, PubMed:26598551). Interacts with AMOT isoform 1; the interaction facilitates translocation of YAP1 to the cytoplasm and tight junctions (PubMed:21205866). Interacts with SFN; the interaction promotes sequestration of YAP1 in the cytoplasm (By similarity). Interacts with YWHAG (By similarity)"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12807903"}],"value":"Interacts (via WW domain 1) with isoform 3 of ERBB4 (via PPxY motif 2)"}],"commentType":"SUBUNIT","molecule":"Isoform 3"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12807903"}],"value":"Interacts (via WW domain 1) with isoform 3 of ERBB4 (via PPxY motif 2)"}],"commentType":"SUBUNIT","molecule":"Isoform 2"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P46937","intActId":"EBI-1044059"},"interactantTwo":{"uniProtKBAccession":"Q02410","geneName":"APBA1","intActId":"EBI-368690"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P46937","intActId":"EBI-1044059"},"interactantTwo":{"uniProtKBAccession":"Q99767","geneName":"APBA2","intActId":"EBI-81711"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P46937","intActId":"EBI-1044059"},"interactantTwo":{"uniProtKBAccession":"O15169","geneName":"AXIN1","intActId":"EBI-710484"},"numberOfExperiments":11,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P46937","intActId":"EBI-1044059"},"interactantTwo":{"uniProtKBAccession":"Q9Y297","geneName":"BTRC","intActId":"EBI-307461"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P46937","intActId":"EBI-1044059"},"interactantTwo":{"uniProtKBAccession":"P35222","geneName":"CTNNB1","intActId":"EBI-491549"},"numberOfExperiments":15,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P46937","intActId":"EBI-1044059"},"interactantTwo":{"uniProtKBAccession":"Q92841","geneName":"DDX17","intActId":"EBI-746012"},"numberOfExperiments":7,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P46937","intActId":"EBI-1044059"},"interactantTwo":{"uniProtKBAccession":"Q12959","geneName":"DLG1","intActId":"EBI-357481"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P46937","intActId":"EBI-1044059"},"interactantTwo":{"uniProtKBAccession":"Q15700","geneName":"DLG2","intActId":"EBI-80426"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P46937","intActId":"EBI-1044059"},"interactantTwo":{"uniProtKBAccession":"Q92796","geneName":"DLG3","intActId":"EBI-80440"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P46937","intActId":"EBI-1044059"},"interactantTwo":{"uniProtKBAccession":"P78352","geneName":"DLG4","intActId":"EBI-80389"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P46937","intActId":"EBI-1044059"},"interactantTwo":{"uniProtKBAccession":"Q15303","geneName":"ERBB4","intActId":"EBI-80371"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P46937","intActId":"EBI-1044059"},"interactantTwo":{"uniProtKBAccession":"Q68DX3","geneName":"FRMPD2","intActId":"EBI-53993476"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P46937","intActId":"EBI-1044059"},"interactantTwo":{"uniProtKBAccession":"A4D2P6","geneName":"GRID2IP","intActId":"EBI-15893226"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P46937","intActId":"EBI-1044059"},"interactantTwo":{"uniProtKBAccession":"Q9Y3R0","geneName":"GRIP1","intActId":"EBI-5349621"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P46937","intActId":"EBI-1044059"},"interactantTwo":{"uniProtKBAccession":"Q9C0E4","geneName":"GRIP2","intActId":"EBI-949557"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P46937","intActId":"EBI-1044059"},"interactantTwo":{"uniProtKBAccession":"Q14005","geneName":"IL16","intActId":"EBI-2831580"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P46937","intActId":"EBI-1044059"},"interactantTwo":{"uniProtKBAccession":"O95835","geneName":"LATS1","intActId":"EBI-444209"},"numberOfExperiments":10,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P46937","intActId":"EBI-1044059"},"interactantTwo":{"uniProtKBAccession":"Q9NUP9","geneName":"LIN7C","intActId":"EBI-1171517"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P46937","intActId":"EBI-1044059"},"interactantTwo":{"uniProtKBAccession":"Q8TBB1","geneName":"LNX1","intActId":"EBI-739832"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P46937","intActId":"EBI-1044059"},"interactantTwo":{"uniProtKBAccession":"Q8N448","geneName":"LNX2","intActId":"EBI-2340947"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P46937","intActId":"EBI-1044059"},"interactantTwo":{"uniProtKBAccession":"Q86UL8","geneName":"MAGI2","intActId":"EBI-311035"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P46937","intActId":"EBI-1044059"},"interactantTwo":{"uniProtKBAccession":"Q02750","geneName":"MAP2K1","intActId":"EBI-492564"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P46937","intActId":"EBI-1044059"},"interactantTwo":{"uniProtKBAccession":"O75970","geneName":"MPDZ","intActId":"EBI-821405"},"numberOfExperiments":8,"organismDiffer":false},{"in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LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A0A8C0NGY6"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P46938"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18158288"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20048001"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21205866"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22525271"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25849865"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29695716"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31835537"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34404733"}],"value":"Both phosphorylation and cell density can regulate its subcellular localization (PubMed:18158288, PubMed:20048001). Phosphorylation sequesters it in the cytoplasm by inhibiting its translocation into the nucleus (PubMed:18158288, PubMed:20048001, PubMed:34404733). At low density, predominantly nuclear and is translocated to the cytoplasm at high density (PubMed:18158288, PubMed:20048001, PubMed:25849865). PTPN14 induces translocation from the nucleus to the cytoplasm (PubMed:22525271). In the nucleus, phosphorylation by PRP4K induces nuclear exclusion (PubMed:29695716). Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm at the blastocyst and epiblast stages (By similarity). Localizes to the cytoplasm and tight junctions following interaction with AMOT isoform 1 (PubMed:21205866). Localizes to tight junctions following interaction with AMOTL2 (By similarity). Translocates to the nucleus in the presence of SNAIL1 (By similarity). Found at the cell membrane in keratinocytes in response to mechanical strain (PubMed:31835537)"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18158288"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18280240"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20048001"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21205866"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22525271"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25849865"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26598551"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29400695"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29695716"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31835537"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34404733"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"41511042"}],"value":"Cytoplasm","id":"SL-0086"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17974916"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18158288"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18280240"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20048001"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21145499"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21205866"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22525271"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25849865"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26598551"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28169360"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29400695"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29695716"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30447097"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31835537"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34404733"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38512451"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"41511042"}],"value":"Nucleus","id":"SL-0191"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A0A8C0NGY6"}],"value":"Cell junction, tight junction","id":"SL-0265"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31835537"}],"value":"Cell membrane","id":"SL-0039"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"synonyms":[{"value":"YAP1-2gamma"},{"value":"YAP2L"}],"isoformIds":["P46937-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"synonyms":[{"value":"YAP1-2alpha"},{"value":"YAP2"}],"isoformIds":["P46937-2"],"sequenceIds":["VSP_039054"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"synonyms":[{"value":"YAP1-1beta"}],"isoformIds":["P46937-3"],"sequenceIds":["VSP_039053","VSP_039055"],"isoformSequenceStatus":"Described"},{"name":{"value":"4"},"isoformIds":["P46937-4"],"sequenceIds":["VSP_045190"],"isoformSequenceStatus":"Described"},{"name":{"value":"5"},"synonyms":[{"value":"YAP1-1alpha"}],"isoformIds":["P46937-5"],"sequenceIds":["VSP_039053","VSP_039054"],"isoformSequenceStatus":"Described"},{"name":{"value":"6"},"synonyms":[{"value":"YAP1-1gamma"}],"isoformIds":["P46937-6"],"sequenceIds":["VSP_039053"],"isoformSequenceStatus":"Described"},{"name":{"value":"7"},"synonyms":[{"value":"YAP1-1delta"}],"isoformIds":["P46937-7"],"sequenceIds":["VSP_039053","VSP_053483"],"isoformSequenceStatus":"Described"},{"name":{"value":"8"},"synonyms":[{"value":"YAP1-2beta"}],"isoformIds":["P46937-8"],"sequenceIds":["VSP_039055"],"isoformSequenceStatus":"Described"},{"name":{"value":"9"},"synonyms":[{"value":"YAP1-2delta"}],"isoformIds":["P46937-9"],"sequenceIds":["VSP_053483"],"isoformSequenceStatus":"Described"}],"note":{"texts":[{"value":"Isoforms of the YAP1-1 form contain only one WW domain."}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16461361"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17974916"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7782338"}],"value":"Increased expression seen in some liver and prostate cancers. Isoforms lacking the transactivation domain found in striatal neurons of patients with Huntington disease (at protein level)"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31835537"}],"value":"Induced in the hours following cyclic mechanical strain in keratinocytes"}],"commentType":"INDUCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20123905"}],"value":"The first coiled-coil region mediates most of the interaction with TEAD transcription factors"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18158288"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18280240"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20048001"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21364637"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29695716"}],"value":"Phosphorylated by LATS1 and LATS2; leading to cytoplasmic translocation and inactivation (PubMed:18158288, PubMed:20048001). Phosphorylated by ABL1; leading to YAP1 stabilization, enhanced interaction with TP73 and recruitment onto proapoptotic genes; in response to DNA damage (PubMed:18280240). Phosphorylation at Ser-400 and Ser-403 by CK1 is triggered by previous phosphorylation at Ser-397 by LATS proteins and leads to YAP1 ubiquitination by SCF(beta-TRCP) E3 ubiquitin ligase and subsequent degradation (PubMed:20048001). Phosphorylated at Thr-119, Ser-138, Thr-154, Ser-367 and Thr-412 by MAPK8/JNK1 and MAPK9/JNK2, which is required for the regulation of apoptosis by YAP1 (PubMed:21364637). Phosphorylated in the nucleus by PRP4K; phosphorylation leads to nuclear exclusion (PubMed:29695716)"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38512451"}],"value":"Lactylation by AARS1 promotes nuclear localization and stabilization of YAP1, leading to increased Hippo signaling pathway (PubMed:38512451). 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