{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P46379","secondaryAccessions":["A2ADJ7","A3KQ42","A3KQ44","A6NGY6","A6PWF7","B0UX84","B4DZ12","B4E3V4","E7EMZ4","F8VXY4","O95874","Q5HYL9","Q5SQ35","Q5SQ36","Q5SQ37","Q5SQ41","Q5SRP8","Q5SRP9","Q5STC1","Q5STX1","Q5STX3","Q96SA6","Q9BCN4"],"uniProtkbId":"BAG6_HUMAN","entryAudit":{"firstPublicDate":"1995-11-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2005-09-27","entryVersion":224,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Large proline-rich protein BAG6"}},"alternativeNames":[{"fullName":{"value":"BAG family molecular chaperone regulator 6"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:13919"}],"value":"BCL2-associated athanogene 6"},"shortNames":[{"value":"BAG-6"}]},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"2156268"}],"value":"HLA-B-associated transcript 3"}},{"fullName":{"value":"Protein G3"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"17403783"}],"value":"Protein Scythe"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:13919"}],"value":"BAG6"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"2156268"}],"value":"BAT3"},{"value":"G3"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9Z1R2"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20516149"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20676083"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21636303"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21743475"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23129660"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24981174"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25179605"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26565908"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26692333"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27193484"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28104892"}],"value":"ATP-independent molecular chaperone preventing the aggregation of misfolded and hydrophobic patches-containing proteins (PubMed:21636303). Functions as part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, which maintains these client proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation (PubMed:20516149, PubMed:21636303, PubMed:21743475, PubMed:28104892). The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum (PubMed:20516149, PubMed:20676083, PubMed:25535373, PubMed:28104892). Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated by RNF126, an E3 ubiquitin-protein ligase associated with BAG6 and are sorted to the proteasome (PubMed:24981174, PubMed:27193484, PubMed:28104892). SGTA which prevents the recruitment of RNF126 to BAG6 may negatively regulate the ubiquitination and the proteasomal degradation of client proteins (PubMed:23129660, PubMed:25179605, PubMed:27193484). Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum (PubMed:21743475). The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome (PubMed:21636303). BAG6 is also required for selective ubiquitin-mediated degradation of defective nascent chain polypeptides by the proteasome. In this context, it may participate in the production of antigenic peptides and play a role in antigen presentation in immune response (By similarity). BAG6 is also involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. BAG6 may ensure the proper degradation of these proteins and thereby protects the endoplasmic reticulum from protein overload upon stress (PubMed:26565908). By inhibiting the polyubiquitination and subsequent proteasomal degradation of HSPA2 it may also play a role in the assembly of the synaptonemal complex during spermatogenesis (By similarity). Also positively regulates apoptosis by interacting with and stabilizing the proapoptotic factor AIFM1 (By similarity). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17403783"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18765639"}],"value":"Involved in DNA damage-induced apoptosis: following DNA damage, accumulates in the nucleus and forms a complex with p300/EP300, enhancing p300/EP300-mediated p53/TP53 acetylation leading to increase p53/TP53 transcriptional activity (PubMed:17403783). When nuclear, may also act as a component of some chromatin regulator complex that regulates histone 3 'Lys-4' dimethylation (H3K4me2) (PubMed:18765639)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18055229"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18852879"}],"value":"Released extracellularly via exosomes, it is a ligand of the natural killer/NK cells receptor NCR3 and stimulates NK cells cytotoxicity. It may thereby trigger NK cells cytotoxicity against neighboring tumor cells and immature myeloid dendritic cells (DC)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14960581"}],"value":"Mediates ricin-induced apoptosis"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9Z1R2"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14960581"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17403783"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18765639"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20676083"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21636303"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23129660"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24160817"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24424410"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24981174"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25179605"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25713138"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26337389"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27113755"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27193484"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29042515"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34887561"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"40105103"}],"value":"Component of the BAG6/BAT3 complex, also named BAT3 complex, at least composed of BAG6, UBL4A and GET4/TRC35 (PubMed:20676083, PubMed:34887561). Interacts with GET4; the interaction is direct and localizes BAG6 in the cytosol (PubMed:21636303, PubMed:29042515). Interacts with UBL4A; the interaction is direct and required for UBL4A protein stability (PubMed:25713138). Interacts with AIFM1 (By similarity). Interacts with HSPA2 (By similarity). Interacts with CTCFL (PubMed:18765639). Interacts with p300/EP300 (PubMed:17403783). Interacts (via ubiquitin-like domain) with RNF126; required for BAG6-dependent ubiquitination of proteins mislocalized to the cytosol (PubMed:24981174, PubMed:27193484). Interacts (via ubiquitin-like domain) with SGTA; SGTA competes with RNF126 by binding the same region of BAG6, thereby promoting deubiquitination of BAG6-target proteins and rescuing them from degradation (PubMed:23129660, PubMed:24424410, PubMed:25179605, PubMed:27193484). Interacts with ricin A chain (PubMed:14960581). Interacts with VCP and AMFR; both form the VCP/p97-AMFR/gp78 complex (PubMed:21636303). Interacts with SYVN1 (PubMed:21636303). Interacts with USP13; the interaction is direct and may mediate UBL4A deubiquitination (PubMed:24424410). Interacts with ZFAND2B (PubMed:24160817, PubMed:26337389). Interacts with KPNA2 (PubMed:29042515). Interacts with UBQLN4 (PubMed:27113755). Interacts with MUL1/MAPL (PubMed:40105103)"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20547746"}],"value":"(Microbial infection) Interacts with L.pneumophila Lpg2160 and LegU1 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