{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P45468","secondaryAccessions":["Q2M959"],"uniProtkbId":"YRAQ_ECOLI","entryAudit":{"firstPublicDate":"1995-11-01","lastAnnotationUpdateDate":"2026-01-28","lastSequenceUpdateDate":"1995-11-01","entryVersion":136,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Escherichia coli (strain K12)","taxonId":83333,"lineage":["Bacteria","Pseudomonadati","Pseudomonadota","Gammaproteobacteria","Enterobacterales","Enterobacteriaceae","Escherichia"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"value":"UPF0718 protein YraQ"}}},"genes":[{"geneName":{"value":"yraQ"},"orderedLocusNames":[{"value":"b3151"},{"value":"JW3120"}]}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the UPF0718 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":346,"modifier":"EXACT"}},"description":"UPF0718 protein YraQ","featureId":"PRO_0000169454"},{"type":"Transmembrane","location":{"start":{"value":12,"modifier":"EXACT"},"end":{"value":32,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":71,"modifier":"EXACT"},"end":{"value":91,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":113,"modifier":"EXACT"},"end":{"value":133,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":146,"modifier":"EXACT"},"end":{"value":166,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":167,"modifier":"EXACT"},"end":{"value":187,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":223,"modifier":"EXACT"},"end":{"value":243,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":260,"modifier":"EXACT"},"end":{"value":280,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":296,"modifier":"EXACT"},"end":{"value":316,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":326,"modifier":"EXACT"},"end":{"value":346,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}],"keywords":[{"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"9278503","citationType":"journal article","authors":["Blattner F.R.","Plunkett G. III","Bloch C.A.","Perna N.T.","Burland V.","Riley M.","Collado-Vides J.","Glasner J.D.","Rode C.K.","Mayhew G.F.","Gregor J.","Davis N.W.","Kirkpatrick H.A.","Goeden M.A.","Rose D.J.","Mau B.","Shao Y."],"citationCrossReferences":[{"database":"PubMed","id":"9278503"},{"database":"DOI","id":"10.1126/science.277.5331.1453"}],"title":"The complete genome sequence of Escherichia coli K-12.","publicationDate":"1997","journal":"Science","firstPage":"1453","lastPage":"1462","volume":"277"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"K12 / MG1655 / ATCC 47076","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"16738553","citationType":"journal article","authors":["Hayashi K.","Morooka N.","Yamamoto Y.","Fujita K.","Isono K.","Choi S.","Ohtsubo E.","Baba T.","Wanner B.L.","Mori H.","Horiuchi T."],"citationCrossReferences":[{"database":"PubMed","id":"16738553"},{"database":"DOI","id":"10.1038/msb4100049"}],"title":"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.","publicationDate":"2006","journal":"Mol. Syst. Biol.","firstPage":"E1","lastPage":"E5","volume":"2"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"K12 / W3110 / ATCC 27325 / DSM 5911","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"U18997","properties":[{"key":"ProteinId","value":"AAA57954.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"U00096","properties":[{"key":"ProteinId","value":"AAC76185.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AP009048","properties":[{"key":"ProteinId","value":"BAE77197.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"C65105","properties":[{"key":"EntryName","value":"C65105"}]},{"database":"RefSeq","id":"NP_417620.1","properties":[{"key":"NucleotideSequenceId","value":"NC_000913.3"}]},{"database":"RefSeq","id":"WP_000147574.1","properties":[{"key":"NucleotideSequenceId","value":"NZ_CP009789.1"}]},{"database":"AlphaFoldDB","id":"P45468","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"4259268","properties":[{"key":"Interactions","value":"11"}]},{"database":"DIP","id":"DIP-12901N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"P45468","properties":[{"key":"Number of interactors","value":"222"}]},{"database":"IntAct","id":"P45468","properties":[{"key":"Interactions","value":"1"}]},{"database":"STRING","id":"511145.b3151","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"P45468","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"511145-b3151","properties":[{"key":"Description","value":"-"}]},{"database":"EnsemblBacteria","id":"AAC76185","properties":[{"key":"ProteinId","value":"AAC76185"},{"key":"GeneId","value":"b3151"}]},{"database":"GeneID","id":"947668","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"ecj:JW3120","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"eco:b3151","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"ecoc:C3026_17165","properties":[{"key":"Description","value":"-"}]},{"database":"PATRIC","id":"fig|1411691.4.peg.3579","properties":[{"key":"GeneDesignation","value":"-"}]},{"database":"EchoBASE","id":"EB2635","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"COG0701","properties":[{"key":"ToxonomicScope","value":"Bacteria"}]},{"database":"HOGENOM","id":"CLU_063039_0_0_6","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P45468","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"VPMYADI","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"8771795at2","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"P45468","properties":[{"key":"Description","value":"-"}]},{"database":"BioCyc","id":"EcoCyc:G7645-MONOMER","properties":[{"key":"Description","value":"-"}]},{"database":"PRO","id":"PR:P45468","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000625","properties":[{"key":"Component","value":"Chromosome"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IDA:EcoCyc"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15919996"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17309111"}]},{"database":"InterPro","id":"IPR005524","properties":[{"key":"EntryName","value":"DUF318"}]},{"database":"PANTHER","id":"PTHR43299","properties":[{"key":"EntryName","value":"UPF0718 PROTEIN YRAQ"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR43299:SF1","properties":[{"key":"EntryName","value":"UPF0718 PROTEIN YRAQ"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF03773","properties":[{"key":"EntryName","value":"ArsP_1"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MTGQSSSQAATPIQWWKPALFFLVVIAGLWYVKWEPYYGKAFTAAETHSIGKSILAQADANPWQAALDYAMIYFLAVWKAAVLGVILGSLIQVLIPRDWLLRTLGQSRFRGTLLGTLFSLPGMMCTCCAAPVAAGMRRQQVSMGGALAFWMGNPVLNPATLVFMGFVLGWGFAAIRLVAGLVMVLLIATLVQKWVRETPQTQAPVEIDIPEAQGGFFSRWGRALWTLFWSTIPVYILAVLVLGAARVWLFPHADGAVDNSLMWVVAMAVAGCLFVIPTAAEIPIVQTMMLAGMGTAPALALLMTLPAVSLPSLIMLRKAFPAKALWLTGAMVAVSGVIVGGLALLF","length":346,"molWeight":37257,"crc64":"E101740DDB0CAD1B","md5":"ED5D89BF2347E407B119F5DF4193209B"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Transmembrane":9},"uniParcId":"UPI000013BF9E"}}