{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P42858","secondaryAccessions":["Q9UQB7"],"uniProtkbId":"HD_HUMAN","entryAudit":{"firstPublicDate":"1995-11-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2010-05-18","entryVersion":237,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Huntingtin"}},"alternativeNames":[{"fullName":{"value":"Huntington disease protein"},"shortNames":[{"value":"HD protein"}]}],"contains":[{"recommendedName":{"fullName":{"value":"Huntingtin, myristoylated N-terminal fragment"}}}]},"genes":[{"geneName":{"value":"HTT"},"synonyms":[{"value":"HD"},{"value":"IT15"}]}],"comments":[{"texts":[{"value":"May play a role in microtubule-mediated transport or vesicle function"}],"commentType":"FUNCTION","molecule":"Huntingtin"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24459296"}],"value":"Promotes the formation of autophagic vesicles"}],"commentType":"FUNCTION","molecule":"Huntingtin, myristoylated N-terminal fragment"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P42859"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10332029"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10958656"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11461154"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15654337"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16476778"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17141218"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18573880"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26198635"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28757145"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28882895"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29466333"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9700202"}],"value":"Interacts with PFN1 (PubMed:18573880). Interacts through its N-terminus with PRPF40A (PubMed:9700202). Interacts with PQBP1 (PubMed:10332029). Interacts with SETD2 (PubMed:10958656, PubMed:11461154, PubMed:9700202). Interacts with SH3GLB1 (By similarity). Interacts with SYVN (PubMed:17141218). Interacts with TPR; the interaction is inhibited by forms of Huntingtin with expanded polyglutamine stretch (PubMed:15654337). Interacts with ZDHHC13 (via ANK repeats) (PubMed:26198635). Interacts with ZDHHC17 (via ANK repeats) (PubMed:26198635, PubMed:28757145, PubMed:28882895). Interacts with F8A1/F8A2/F8A3 (PubMed:16476778, PubMed:29466333). Found in a complex with F8A1/F8A2/F8A3, HTT and RAB5A; mediates the recruitment of HTT by RAB5A (PubMed:16476778)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P42858","intActId":"EBI-466029"},"interactantTwo":{"uniProtKBAccession":"Q9H7C9","geneName":"AAMDC","intActId":"EBI-10308705"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P42858","intActId":"EBI-466029"},"interactantTwo":{"uniProtKBAccession":"Q6PCB6","geneName":"ABHD17C","intActId":"EBI-22011868"},"numberOfExperiments":21,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P42858","intActId":"EBI-466029"},"interactantTwo":{"uniProtKBAccession":"Q9ULW3","geneName":"ABT1","intActId":"EBI-2602396"},"numberOfExperiments":9,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P42858","intActId":"EBI-466029"},"interactantTwo":{"uniProtKBAccession":"P60709","geneName":"ACTB","intActId":"EBI-353944"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P42858","intActId":"EBI-466029"},"interactantTwo":{"uniProtKBAccession":"P63261","geneName":"ACTG1","intActId":"EBI-351292"},"numberOfExperiments":16,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P42858","intActId":"EBI-466029"},"interactantTwo":{"uniProtKBAccession":"P42025","geneName":"ACTR1B","intActId":"EBI-367493"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P42858","intActId":"EBI-466029"},"interactantTwo":{"uniProtKBAccession":"Q15848","geneName":"ADIPOQ","intActId":"EBI-10827839"},"numberOfExperiments":9,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P42858","intActId":"EBI-466029"},"interactantTwo":{"uniProtKBAccession":"Q9Y4W6","geneName":"AFG3L2","intActId":"EBI-358755"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P42858","intActId":"EBI-466029"},"interactantTwo":{"uniProtKBAccession":"Q53H12","geneName":"AGK","intActId":"EBI-2269837"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P42858","intActId":"EBI-466029"},"interactantTwo":{"uniProtKBAccession":"Q53H12-2","geneName":"AGK","intActId":"EBI-25944242"},"numberOfExperiments":12,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P42858","intActId":"EBI-466029"},"interactantTwo":{"uniProtKBAccession":"Q5TGY3","geneName":"AHDC1","intActId":"EBI-948813"},"numberOfExperiments":12,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P42858","intActId":"EBI-466029"},"interactantTwo":{"uniProtKBAccession":"Q9UIJ7","geneName":"AK3","intActId":"EBI-3916527"},"numberOfExperiments":9,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P42858","intActId":"EBI-466029"},"interactantTwo":{"uniProtKBAccession":"P14550","geneName":"AKR1A1","intActId":"EBI-372388"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P42858","intActId":"EBI-466029"},"interactantTwo":{"uniProtKBAccession":"P31749","geneName":"AKT1","intActId":"EBI-296087"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P42858","intActId":"EBI-466029"},"interactantTwo":{"uniProtKBAccession":"Q3SY69","geneName":"ALDH1L2","intActId":"EBI-6916128"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P42858","intActId":"EBI-466029"},"interactantTwo":{"uniProtKBAccession":"P04075-2","geneName":"ALDOA","intActId":"EBI-10194102"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P42858","intActId":"EBI-466029"},"interactantTwo":{"uniProtKBAccession":"Q9H553","geneName":"ALG2","intActId":"EBI-25806804"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P42858","intActId":"EBI-466029"},"interactantTwo":{"uniProtKBAccession":"Q8IWZ3-3","geneName":"ANKHD1","intActId":"EBI-25833200"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P42858","intActId":"EBI-466029"},"interactantTwo":{"uniProtKBAccession":"Q6ZTN6-2","geneName":"ANKRD13D","intActId":"EBI-25840993"},"numberOfExperiments":9,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P42858","intActId":"EBI-466029"},"interactantTwo":{"uniProtKBAccession":"Q5TZF3-1","geneName":"ANKRD45","intActId":"EBI-22011535"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P42858","intActId":"EBI-466029"},"interactantTwo":{"uniProtKBAccession":"Q16853","geneName":"AOC3","intActId":"EBI-3921628"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P42858","intActId":"EBI-466029"},"interactantTwo":{"uniProtKBAccession":"P63010-2","geneName":"AP2B1","intActId":"EBI-11529439"},"numberOfExperiments":18,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P42858","intActId":"EBI-466029"},"interactantTwo":{"uniProtKBAccession":"O00203","geneName":"AP3B1","intActId":"EBI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