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In the nucleus binds to HNRPA1-associated poly(A) mRNAs and is part of nmRNP complexes at late stages of mRNA maturation which are possibly associated with nuclear mRNA export. Positively modulates nuclear export of mRNAs containing the EIF4E sensitivity element (4ESE) by binding simultaneously to both EIF4E and the 4ESE and acting as a platform for assembly for the RNA export complex (PubMed:19262567, PubMed:28325843). Also binds to exportin XPO1/CRM1 to engage the nuclear pore and traffic the bound mRNAs to the cytoplasm (PubMed:28325843). May bind mature mRNA in the nucleus outer membrane. In mitochondria binds to poly(A) mRNA. Plays a role in translation or stability of mitochondrially encoded cytochrome c oxidase (COX) subunits. May be involved in transcription regulation. Cooperates with PPARGC1A to regulate certain mitochondrially encoded genes and gluconeogenic genes and may regulate docking of PPARGC1A to transcription factors. Seems to be involved in the transcription regulation of the multidrug-related genes MDR1 and MVP. Part of a nuclear factor that binds to the invMED1 element of MDR1 and MVP gene promoters. Binds single-stranded DNA (By similarity). Required for maintaining mitochondrial potential (PubMed:23822101). Suppresses the initiation of basal levels of autophagy and mitophagy by sustaining BCL2 levels (PubMed:23822101)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11585913"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11827465"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15907802"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17050673"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19262567"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23822101"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28325843"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31937766"}],"value":"Component of mRNP complexes associated with HNRPA1 (PubMed:11585913). Component of the complex, at least composed of LRPPRC, BECN1 and BCL2; the interactions prevent BECN1 from forming an autophagy-inducing complex with PIK3C3 (PubMed:23822101). Interacts with CECR2, HEBP2, MAP1S and UXT. Interacts with PPARGC1A. Interacts with FOXO1 (By similarity). Interacts (via N-terminus) with EIF4E; the interaction promotes association of EIF4E with 4ESE-containing mRNAs (PubMed:19262567, PubMed:28325843). Interacts with exportin XPO1/CRM1; interacts both alone and in complex with EIF4E and 4ESE-containing mRNAs to form an EIF4E-dependent mRNA export complex (PubMed:28325843). Interacts with importin IPO8; the interaction occurs when LRPPRC is in its RNA-free form and returns LRPPRC to the nucleus for further export rounds (PubMed:28325843). Interacts with BECN1 (PubMed:31937766). Interacts with Aedes aegypti venom allergen-1; the interaction interrupts BECN1 and LRPPRC association (PubMed:31937766)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P42704","intActId":"EBI-1050853"},"interactantTwo":{"uniProtKBAccession":"P05067","geneName":"APP","intActId":"EBI-77613"},"numberOfExperiments":8,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P42704","intActId":"EBI-1050853"},"interactantTwo":{"uniProtKBAccession":"P06730","geneName":"EIF4E","intActId":"EBI-73440"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P42704","intActId":"EBI-1050853"},"interactantTwo":{"uniProtKBAccession":"O15397","geneName":"IPO8","intActId":"EBI-358808"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P42704","intActId":"EBI-1050853"},"interactantTwo":{"uniProtKBAccession":"Q9UBK2","geneName":"PPARGC1A","intActId":"EBI-765486"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P42704","intActId":"EBI-1050853"},"interactantTwo":{"uniProtKBAccession":"Q9GZT3","geneName":"SLIRP","intActId":"EBI-1050793"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P42704","intActId":"EBI-1050853"},"interactantTwo":{"uniProtKBAccession":"O14980","geneName":"XPO1","intActId":"EBI-355867"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P42704","intActId":"EBI-1050853"},"interactantTwo":{"uniProtKBAccession":"P63104","geneName":"YWHAZ","intActId":"EBI-347088"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P42704","intActId":"EBI-1050853"},"interactantTwo":{"uniProtKBAccession":"P63073","geneName":"Eif4e","intActId":"EBI-2000006"},"numberOfExperiments":3,"organismDiffer":true}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"value":"Seems to be predominantly mitochondrial"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19262567"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23822101"}],"value":"Mitochondrion","id":"SL-0173"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19262567"}],"value":"Nucleus","id":"SL-0191"}},{"location":{"value":"Nucleus, nucleoplasm","id":"SL-0190"}},{"location":{"value":"Nucleus inner membrane","id":"SL-0179"}},{"location":{"value":"Nucleus outer membrane","id":"SL-0183"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11827465"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15139850"}],"value":"Expressed ubiquitously. 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