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May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P42567"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10393179"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10757979"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11062555"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12551915"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16159959"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16314522"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16325581"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16903783"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18199683"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18200045"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18362181"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20448150"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21762413"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22484487"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22648170"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24768539"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26822536"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8662907"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9721102"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9723620"}],"value":"Interacts with SGIP1 (PubMed:26822536). Interacts with HGS; the interaction bridges the interaction of STAM or STAM2 with EPS15. Isoform 2 interacts with HGS and AP2A2. Part of a complex at least composed of EPS15, HGS, and either STAM or STAM2. Binds AP2A2. Interacts with AP2B1; clathrin competes with EPS15. Binds STON2. Interacts (via its SH3-binding sites) with CRK. Interacts with SH3BP4/TTP. Interacts with ERBB2. Interacts with FCHO1. Interacts with FCHO2. Interacts (via EH domains) with DAB2. Interacts (via UIM repeats) with CORO7 (when ubiquitinated at 'Lys-472'). Interacts (via UIM domains) with UBQLN1 (via ubiquitin-like domain) and can interact with both the ubiquitinated and the non-ubiquitinated forms of UBQLN1. Interacts with UBQLN2 (By similarity) (PubMed:10757979, PubMed:11062555, PubMed:12551915, PubMed:16159959, PubMed:16314522, PubMed:16325581, PubMed:16903783, PubMed:18199683, PubMed:18200045, PubMed:18362181, PubMed:20448150, PubMed:21762413, PubMed:22484487, PubMed:22648170, PubMed:24768539, PubMed:8662907, PubMed:9721102, PubMed:9723620). Interacts with REPS2; the interaction is direct (PubMed:10393179). 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