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Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria (PubMed:27469264, PubMed:8089172, PubMed:9628893). The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex (PubMed:17410204). Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids (PubMed:11266455, PubMed:12454062, PubMed:14981098)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"C5DRQ1"},{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03103"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"13679517"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17410204"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19556461"}],"value":"Homodimer (By similarity). Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34 (PubMed:13679517, PubMed:17410204, PubMed:19556461). A MMM1 homodimer associates with one molecule of MDM12 on each side in a pairwise head-to-tail manner, and the SMP-LTD domains of MMM1 and MDM12 generate a continuous hydrophobic tunnel for phospholipid trafficking (By similarity)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P41800","intActId":"EBI-11029"},"interactantTwo":{"uniProtKBAccession":"Q92328","geneName":"MDM12","intActId":"EBI-10584"},"numberOfExperiments":5,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03103"}],"value":"The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. 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Abolishes growth on non-fermentable carbon source (glycerol with ethanol) (PubMed:26370498, PubMed:27280386). Slow growth on fermentable carbon source (glucose) (PubMed:26370498, PubMed:27280386). Synthetic lethal with VPS13 (PubMed:26370498, PubMed:27280386)"}],"commentType":"DISRUPTION PHENOTYPE"},{"texts":[{"value":"Normal levels of MMM1 require MDM34"}],"commentType":"MISCELLANEOUS"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14562106"}],"value":"Present with 2490 molecules/cell in log phase SD medium"}],"commentType":"MISCELLANEOUS"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03103"}],"value":"Belongs to the MMM1 family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"19556461"}],"value":"Was originally proposed to be inserted into either the outer or inner mitochondrial membrane (PubMed:12972421, PubMed:8089172). 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