{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P41212","secondaryAccessions":["A3QVP6","A8K076","Q9UMF6","Q9UMF7","Q9UMG0"],"uniProtkbId":"ETV6_HUMAN","entryAudit":{"firstPublicDate":"1995-02-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1995-02-01","entryVersion":238,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Transcription factor ETV6"}},"alternativeNames":[{"fullName":{"value":"ETS translocation variant 6"}},{"fullName":{"value":"ETS-related protein Tel1"},"shortNames":[{"value":"Tel"}]}]},"genes":[{"geneName":{"value":"ETV6"},"synonyms":[{"value":"TEL"},{"value":"TEL1"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25581430"}],"value":"Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'. Plays a role in hematopoiesis and malignant transformation"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12588862"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12590135"}],"value":"Can form homodimers or heterodimers with TEL2 or FLI1. Interacts with L3MBTL1 and HDAC9"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P41212","intActId":"EBI-1372759"},"interactantTwo":{"uniProtKBAccession":"Q9BXS5","geneName":"AP1M1","intActId":"EBI-541426"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P41212","intActId":"EBI-1372759"},"interactantTwo":{"uniProtKBAccession":"A0A0S2Z4M1","geneName":"AXIN1","intActId":"EBI-16429430"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P41212","intActId":"EBI-1372759"},"interactantTwo":{"uniProtKBAccession":"Q9UKV0-3","geneName":"HDAC9","intActId":"EBI-765476"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P41212","intActId":"EBI-1372759"},"interactantTwo":{"uniProtKBAccession":"Q16236","geneName":"NFE2L2","intActId":"EBI-2007911"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P41212","intActId":"EBI-1372759"},"interactantTwo":{"uniProtKBAccession":"Q96HA8","geneName":"NTAQ1","intActId":"EBI-741158"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P41212","intActId":"EBI-1372759"},"interactantTwo":{"uniProtKBAccession":"Q13526","geneName":"PIN1","intActId":"EBI-714158"},"numberOfExperiments":5,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"value":"Nucleus","id":"SL-0191"}}]},{"texts":[{"value":"Ubiquitous"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12435397"}],"value":"Phosphorylation of Ser-257 by MAPK14 (p38) inhibits ETV6 transcriptional repression"}],"commentType":"PTM"},{"commentType":"DISEASE","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8168137"}],"value":"A chromosomal aberration involving ETV6 is found in a form of chronic myelomonocytic leukemia (CMML). Translocation t(5;12)(q33;p13) with PDGFRB. It is characterized by abnormal clonal myeloid proliferation and by progression to acute myelogenous leukemia (AML)"}]}},{"commentType":"DISEASE","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10477709"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7731705"}],"value":"Chromosomal aberrations involving ETV6 are found in acute myeloid leukemia (AML). Translocation t(12;22)(p13;q11) with MN1 (PubMed:7731705). Translocation t(4;12)(q12;p13) with CHIC2 (PubMed:10477709)"}]}},{"commentType":"DISEASE","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7761424"}],"value":"Chromosomal aberrations involving ETV6 are found in childhood acute lymphoblastic leukemia (ALL). Translocations t(12;21)(p12;q22) and t(12;21)(p13;q22) with RUNX1/AML1"}]}},{"commentType":"DISEASE","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9326218"}],"value":"A chromosomal aberration involving ETV6 is found in a form of pre-B acute lymphoid leukemia. Translocation t(9;12)(p24;p13) with JAK2"}]}},{"commentType":"DISEASE","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9326218"}],"value":"A chromosomal aberration involving ETV6 and JAK2 is found in an atypical chronic myelogenous leukemia. Translocation t(9;15;12)(p24;q15;p13)"}]}},{"commentType":"DISEASE","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10502316"}],"value":"A chromosomal aberration involving ETV6 is found in myelodysplastic syndrome (MDS) with basophilia. Translocation t(5;12)(q31;p13) with ACSL6"}]}},{"commentType":"DISEASE","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10502316"}],"value":"A chromosomal aberration involving ETV6 is found in acute eosinophilic leukemia (AEL). Translocation t(5;12)(q31;p13) with ACSL6"}]}},{"commentType":"DISEASE","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12203785"}],"value":"A chromosomal aberration involving ETV6 is found in myelodysplastic syndrome (MDS). Translocation t(1;12)(p36.1;p13) with MDS2"}]}},{"commentType":"DISEASE","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17344859"}],"value":"A chromosomal aberration involving ETV6 is found in acute lymphoblastic leukemia. Translocation t(9;12)(p13;p13) with PAX5"}]}},{"commentType":"DISEASE","disease":{"diseaseId":"Myeloproliferative disorder chronic with eosinophilia","diseaseAccession":"DI-02609","acronym":"MPE","description":"A hematologic disorder characterized by malignant eosinophils proliferation.","diseaseCrossReference":{"database":"MIM","id":"131440"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12181402"}]},"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12181402"}],"value":"The gene represented in this entry is involved in disease pathogenesis. A chromosomal aberration involving ETV6 is found in many instances of myeloproliferative disorder chronic with eosinophilia. Translocation t(5;12) with PDGFRB on chromosome 5 creating an ETV6-PDGFRB fusion protein"}]}},{"commentType":"DISEASE","disease":{"diseaseId":"Leukemia, acute myelogenous","diseaseAccession":"DI-01171","acronym":"AML","description":"A subtype of acute leukemia, a cancer of the white blood cells. AML is a malignant disease of bone marrow characterized by maturational arrest of hematopoietic precursors at an early stage of development. Clonal expansion of myeloid blasts occurs in bone marrow, blood, and other tissue. Myelogenous leukemias develop from changes in cells that normally produce neutrophils, basophils, eosinophils and monocytes.","diseaseCrossReference":{"database":"MIM","id":"601626"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15806161"}]},"note":{"texts":[{"value":"The gene represented in this entry is involved in disease pathogenesis"}]}},{"commentType":"DISEASE","disease":{"diseaseId":"Thrombocytopenia 5","diseaseAccession":"DI-04335","acronym":"THC5","description":"A form of thrombocytopenia, a hematologic disorder defined by a decrease in the number of platelets in circulating blood, resulting in the potential for increased bleeding and decreased ability for clotting. THC5 is an autosomal dominant disorder, associated with an increased susceptibility to the development of hematologic and solid malignancies.","diseaseCrossReference":{"database":"MIM","id":"616216"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25581430"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the ETS family"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"ABI30005.1","note":"Extended N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"WEB RESOURCE","resourceName":"Atlas of Genetics and Cytogenetics in Oncology and Haematology","resourceUrl":"https://atlasgeneticsoncology.org/gene/38/ETV6","ftp":false}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":452,"modifier":"EXACT"}},"description":"Transcription factor ETV6","featureId":"PRO_0000204121"},{"type":"Domain","location":{"start":{"value":40,"modifier":"EXACT"},"end":{"value":124,"modifier":"EXACT"}},"description":"PNT","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00762"}]},{"type":"DNA binding","location":{"start":{"value":339,"modifier":"EXACT"},"end":{"value":420,"modifier":"EXACT"}},"description":"ETS","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00237"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":30,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":158,"modifier":"EXACT"},"end":{"value":262,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":10,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":230,"modifier":"EXACT"},"end":{"value":250,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Site","location":{"start":{"value":11,"modifier":"EXACT"},"end":{"value":12,"modifier":"EXACT"}},"description":"Breakpoint for translocation to form CHIC2-ETV6 in AML"},{"type":"Site","location":{"start":{"value":54,"modifier":"EXACT"},"end":{"value":55,"modifier":"EXACT"}},"description":"Breakpoint for translocation to form ETV6-MDS2 in MDS"},{"type":"Site","location":{"start":{"value":55,"modifier":"EXACT"},"end":{"value":56,"modifier":"EXACT"}},"description":"Breakpoint for translocation to form PAX5-ETV6"},{"type":"Site","location":{"start":{"value":336,"modifier":"EXACT"},"end":{"value":337,"modifier":"EXACT"}},"description":"Breakpoint for translocation to form ETV6-AML1 in ALL"},{"type":"Modified residue","location":{"start":{"value":11,"modifier":"EXACT"},"end":{"value":11,"modifier":"EXACT"}},"description":"N6-acetyllysine; alternate","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19608861"}]},{"type":"Modified residue","location":{"start":{"value":18,"modifier":"EXACT"},"end":{"value":18,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19690332"}]},{"type":"Modified residue","location":{"start":{"value":22,"modifier":"EXACT"},"end":{"value":22,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12435397"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19690332"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"}]},{"type":"Modified residue","location":{"start":{"value":213,"modifier":"EXACT"},"end":{"value":213,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"}]},{"type":"Modified residue","location":{"start":{"value":238,"modifier":"EXACT"},"end":{"value":238,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P97360"}]},{"type":"Modified residue","location":{"start":{"value":257,"modifier":"EXACT"},"end":{"value":257,"modifier":"EXACT"}},"description":"Phosphoserine; by MAPK14","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12435397"}]},{"type":"Modified residue","location":{"start":{"value":302,"modifier":"EXACT"},"end":{"value":302,"modifier":"EXACT"}},"description":"N6-acetyllysine; alternate","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19608861"}]},{"type":"Modified residue","location":{"start":{"value":323,"modifier":"EXACT"},"end":{"value":323,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P97360"}]},{"type":"Cross-link","location":{"start":{"value":11,"modifier":"EXACT"},"end":{"value":11,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"25218447"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"25755297"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"25772364"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":288,"modifier":"EXACT"},"end":{"value":288,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"25755297"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":302,"modifier":"EXACT"},"end":{"value":302,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":403,"modifier":"EXACT"},"end":{"value":403,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":421,"modifier":"EXACT"},"end":{"value":421,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Natural variant","location":{"start":{"value":214,"modifier":"EXACT"},"end":{"value":214,"modifier":"EXACT"}},"description":"in THC5; abrogates DNA binding; alters subcellular location; decreases transcriptional repression in a dominant-negative fashion; dbSNP:rs724159947","featureCrossReferences":[{"database":"dbSNP","id":"rs724159947"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25581430"}],"featureId":"VAR_073322","alternativeSequence":{"originalSequence":"P","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":344,"modifier":"EXACT"},"end":{"value":344,"modifier":"EXACT"}},"description":"in one individual with AML; somatic mutation; unable to repress transcription","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15806161"}],"featureId":"VAR_034600","alternativeSequence":{"originalSequence":"Y","alternativeSequences":["YG"]}},{"type":"Natural variant","location":{"start":{"value":369,"modifier":"EXACT"},"end":{"value":369,"modifier":"EXACT"}},"description":"in THC5; abrogates DNA binding; alters subcellular location; decreases transcriptional repression in a dominant-negative fashion; dbSNP:rs724159946","featureCrossReferences":[{"database":"dbSNP","id":"rs724159946"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25581430"}],"featureId":"VAR_073323","alternativeSequence":{"originalSequence":"R","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":399,"modifier":"EXACT"},"end":{"value":399,"modifier":"EXACT"}},"description":"in THC5; abrogates DNA binding; alters subcellular location; decreases transcriptional repression in a dominant-negative fashion; dbSNP:rs724159945","featureCrossReferences":[{"database":"dbSNP","id":"rs724159945"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25581430"}],"featureId":"VAR_073324","alternativeSequence":{"originalSequence":"R","alternativeSequences":["C"]}},{"type":"Mutagenesis","location":{"start":{"value":22,"modifier":"EXACT"},"end":{"value":22,"modifier":"EXACT"}},"description":"No effect.","alternativeSequence":{"originalSequence":"S","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":213,"modifier":"EXACT"},"end":{"value":213,"modifier":"EXACT"}},"description":"No effect.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12435397"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":238,"modifier":"EXACT"},"end":{"value":238,"modifier":"EXACT"}},"description":"No effect.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12435397"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":257,"modifier":"EXACT"},"end":{"value":257,"modifier":"EXACT"}},"description":"No phosphorylation by MAPK14.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12435397"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["A"]}},{"type":"Helix","location":{"start":{"value":12,"modifier":"EXACT"},"end":{"value":18,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5L0P"}]},{"type":"Turn","location":{"start":{"value":20,"modifier":"EXACT"},"end":{"value":22,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5L0P"}]},{"type":"Helix","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":27,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5L0P"}]},{"type":"Helix","location":{"start":{"value":30,"modifier":"EXACT"},"end":{"value":38,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5L0P"}]},{"type":"Helix","location":{"start":{"value":49,"modifier":"EXACT"},"end":{"value":51,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9DB5"}]},{"type":"Helix","location":{"start":{"value":52,"modifier":"EXACT"},"end":{"value":54,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9DOC"}]},{"type":"Helix","location":{"start":{"value":58,"modifier":"EXACT"},"end":{"value":60,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9DOC"}]},{"type":"Helix","location":{"start":{"value":63,"modifier":"EXACT"},"end":{"value":77,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9DOC"}]},{"type":"Helix","location":{"start":{"value":79,"modifier":"EXACT"},"end":{"value":83,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9DOC"}]},{"type":"Turn","location":{"start":{"value":84,"modifier":"EXACT"},"end":{"value":87,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9DOC"}]},{"type":"Helix","location":{"start":{"value":91,"modifier":"EXACT"},"end":{"value":94,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9DOC"}]},{"type":"Helix","location":{"start":{"value":99,"modifier":"EXACT"},"end":{"value":105,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9DOC"}]},{"type":"Turn","location":{"start":{"value":107,"modifier":"EXACT"},"end":{"value":109,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9DOC"}]},{"type":"Helix","location":{"start":{"value":110,"modifier":"EXACT"},"end":{"value":121,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9DOC"}]},{"type":"Helix","location":{"start":{"value":341,"modifier":"EXACT"},"end":{"value":350,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2DAO"}]},{"type":"Helix","location":{"start":{"value":352,"modifier":"EXACT"},"end":{"value":354,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2DAO"}]},{"type":"Turn","location":{"start":{"value":355,"modifier":"EXACT"},"end":{"value":357,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2DAO"}]},{"type":"Beta strand","location":{"start":{"value":358,"modifier":"EXACT"},"end":{"value":362,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2DAO"}]},{"type":"Helix","location":{"start":{"value":363,"modifier":"EXACT"},"end":{"value":365,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2DAO"}]},{"type":"Beta strand","location":{"start":{"value":367,"modifier":"EXACT"},"end":{"value":371,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2DAO"}]},{"type":"Helix","location":{"start":{"value":373,"modifier":"EXACT"},"end":{"value":383,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2DAO"}]},{"type":"Helix","location":{"start":{"value":391,"modifier":"EXACT"},"end":{"value":404,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2DAO"}]},{"type":"Beta strand","location":{"start":{"value":406,"modifier":"EXACT"},"end":{"value":408,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2DAO"}]},{"type":"Beta strand","location":{"start":{"value":411,"modifier":"EXACT"},"end":{"value":419,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2DAO"}]},{"type":"Helix","location":{"start":{"value":424,"modifier":"EXACT"},"end":{"value":426,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2DAO"}]},{"type":"Beta strand","location":{"start":{"value":430,"modifier":"EXACT"},"end":{"value":432,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2DAO"}]},{"type":"Helix","location":{"start":{"value":434,"modifier":"EXACT"},"end":{"value":438,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2DAO"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0007","category":"PTM","name":"Acetylation"},{"id":"KW-0160","category":"Coding sequence diversity","name":"Chromosomal rearrangement"},{"id":"KW-0225","category":"Disease","name":"Disease variant"},{"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"id":"KW-1017","category":"PTM","name":"Isopeptide bond"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-0656","category":"Disease","name":"Proto-oncogene"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0678","category":"Molecular function","name":"Repressor"},{"id":"KW-0804","category":"Biological process","name":"Transcription"},{"id":"KW-0805","category":"Biological process","name":"Transcription regulation"},{"id":"KW-0832","category":"PTM","name":"Ubl conjugation"}],"references":[{"referenceNumber":1,"citation":{"id":"8168137","citationType":"journal article","authors":["Golub T.R.","Barker G.F.","Lovett M.","Gilliland D.G."],"citationCrossReferences":[{"database":"PubMed","id":"8168137"},{"database":"DOI","id":"10.1016/0092-8674(94)90322-0"}],"title":"Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation.","publicationDate":"1994","journal":"Cell","firstPage":"307","lastPage":"316","volume":"77"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]","CHROMOSOMAL TRANSLOCATION WITH PDGFRB"]},{"referenceNumber":2,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Urinary bladder","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"CI-5GBDQ6B103N1E","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"JUL-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":4,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Testis","type":"TISSUE"}]},{"referenceNumber":5,"citation":{"id":"8743990","citationType":"journal article","authors":["Baens M.","Peeters P.","Guo C.","Aerssens J.","Marynen P."],"citationCrossReferences":[{"database":"PubMed","id":"8743990"},{"database":"DOI","id":"10.1101/gr.6.5.404"}],"title":"Genomic organization of TEL: the human ETS-variant gene 6.","publicationDate":"1996","journal":"Genome Res.","firstPage":"404","lastPage":"413","volume":"6"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 56-109; 111-336 AND 338-452"]},{"referenceNumber":6,"citation":{"id":"17344859","citationType":"journal article","authors":["Mullighan C.G.","Goorha S.","Radtke I.","Miller C.B.","Coustan-Smith E.","Dalton J.D.","Girtman K.","Mathew S.","Ma J.","Pounds S.B.","Su X.","Pui C.-H.","Relling M.V.","Evans W.E.","Shurtleff S.A.","Downing J.R."],"citationCrossReferences":[{"database":"PubMed","id":"17344859"},{"database":"DOI","id":"10.1038/nature05690"}],"title":"Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia.","publicationDate":"2007","journal":"Nature","firstPage":"758","lastPage":"764","volume":"446"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] OF 56-452","CHROMOSOMAL TRANSLOCATION WITH PAX5"]},{"referenceNumber":7,"citation":{"id":"7731705","citationType":"journal article","authors":["Buijs A.","Sherr S.","van Baal S.","van Bezouw S.","van der Plas D.","Geurts van Kessel A.","Riegman P.","Lekanne Deprez R.","Zwarthoff E.","Hagemeijer A."],"citationCrossReferences":[{"database":"PubMed","id":"7731705"}],"title":"Translocation (12;22) (p13;q11) in myeloproliferative disorders results in fusion of the ETS-like TEL gene on 12p13 to the MN1 gene on 22q11.","publicationDate":"1995","journal":"Oncogene","firstPage":"1511","lastPage":"1519","volume":"10"},"referencePositions":["CHROMOSOMAL TRANSLOCATION WITH MN1"]},{"referenceNumber":8,"citation":{"id":"7761424","citationType":"journal article","authors":["Golub T.R.","Barker G.F.","Bohlander S.K.","Hiebert S.W.","Ward D.C.","Bray-Ward P.","Morgan E.","Raimondi S.C.","Rowley J.D.","Gilliland D.G."],"citationCrossReferences":[{"database":"PubMed","id":"7761424"},{"database":"DOI","id":"10.1073/pnas.92.11.4917"}],"title":"Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia.","publicationDate":"1995","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"4917","lastPage":"4921","volume":"92"},"referencePositions":["CHROMOSOMAL TRANSLOCATION WITH AML1"]},{"referenceNumber":9,"citation":{"id":"7780150","citationType":"journal article","authors":["Romana S.P.","Mauchauffe M.","le Coniat M.","Chumakov I.","le Paslier D.","Berger R.","Bernard O.A."],"citationCrossReferences":[{"database":"PubMed","id":"7780150"},{"database":"DOI","id":"10.1182/blood.v85.12.3662.bloodjournal85123662"}],"title":"The t(12;21) of acute lymphoblastic leukemia results in a tel-AML1 gene fusion.","publicationDate":"1995","journal":"Blood","firstPage":"3662","lastPage":"3670","volume":"85"},"referencePositions":["CHROMOSOMAL TRANSLOCATION WITH AML1"]},{"referenceNumber":10,"citation":{"id":"9326218","citationType":"journal article","authors":["Peeters P.","Raynaud S.D.","Cools J.","Wlodarska I.","Grosgeorge J.","Philip P.","Monpoux F.","Van Rompaey L.","Baens M.","Van Den Berghe H.","Marynen P."],"citationCrossReferences":[{"database":"PubMed","id":"9326218"},{"database":"DOI","id":"10.1182/blood.v90.7.2535"}],"title":"Fusion of TEL, the ETS-variant gene 6 (ETV6), to the receptor-associated kinase JAK2 as a result of t(9;12) in a lymphoid and t(9;15;12) in a myeloid leukemia.","publicationDate":"1997","journal":"Blood","firstPage":"2535","lastPage":"2540","volume":"90"},"referencePositions":["CHROMOSOMAL TRANSLOCATIONS WITH JAK2"]},{"referenceNumber":11,"citation":{"id":"10502316","citationType":"journal article","authors":["Yagasaki F.","Jinnai I.","Yoshida S.","Yokoyama Y.","Matsuda A.","Kusumoto S.","Kobayashi H.","Terasaki H.","Ohyashiki K.","Asou N.","Murohashi I.","Bessho M.","Hirashima K."],"citationCrossReferences":[{"database":"PubMed","id":"10502316"},{"database":"DOI","id":"10.1002/(sici)1098-2264(199911)26:3<192::aid-gcc2>3.0.co;2-e"}],"title":"Fusion of TEL/ETV6 to a novel ACS2 in myelodysplastic syndrome and acute myelogenous leukemia with t(5;12)(q31;p13).","publicationDate":"1999","journal":"Genes Chromosomes Cancer","firstPage":"192","lastPage":"202","volume":"26"},"referencePositions":["CHROMOSOMAL TRANSLOCATION WITH ACSL6"]},{"referenceNumber":12,"citation":{"id":"10477709","citationType":"journal article","authors":["Cools J.","Bilhou-Nabera C.","Wlodarska I.","Cabrol C.","Talmant P.","Bernard P.","Hagemeijer A.","Marynen P."],"citationCrossReferences":[{"database":"PubMed","id":"10477709"},{"database":"DOI","id":"10.1182/blood.v94.5.1820"}],"title":"Fusion of a novel gene, BTL, to ETV6 in acute myeloid leukemias with a t(4;12)(q11-q12;p13).","publicationDate":"1999","journal":"Blood","firstPage":"1820","lastPage":"1824","volume":"94"},"referencePositions":["CHROMOSOMAL TRANSLOCATION WITH CHIC2"]},{"referenceNumber":13,"citation":{"id":"12435397","citationType":"journal article","authors":["Arai H.","Maki K.","Waga K.","Sasaki K.","Nakamura Y.","Imai Y.","Kurokawa M.","Hirai H.","Mitani K."],"citationCrossReferences":[{"database":"PubMed","id":"12435397"},{"database":"DOI","id":"10.1016/s0006-291x(02)02588-3"}],"title":"Functional regulation of TEL by p38-induced phosphorylation.","publicationDate":"2002","journal":"Biochem. Biophys. Res. Commun.","firstPage":"116","lastPage":"125","volume":"299"},"referencePositions":["PHOSPHORYLATION AT SER-22 AND SER-257","MUTAGENESIS OF SER-213; SER-238 AND SER-257"]},{"referenceNumber":14,"citation":{"id":"12203785","citationType":"journal article","authors":["Odero M.D.","Vizmanos J.L.","Roman J.P.","Lahortiga I.","Panizo C.","Calasanz M.J.","Zeleznik-Le N.J.","Rowley J.D.","Novo F.J."],"citationCrossReferences":[{"database":"PubMed","id":"12203785"},{"database":"DOI","id":"10.1002/gcc.10090"}],"title":"A novel gene, MDS2, is fused to ETV6/TEL in a t(1;12)(p36.1;p13) in a patient with myelodysplastic syndrome.","publicationDate":"2002","journal":"Genes Chromosomes Cancer","firstPage":"11","lastPage":"19","volume":"35"},"referencePositions":["CHROMOSOMAL TRANSLOCATION WITH MDS2"]},{"referenceNumber":15,"citation":{"id":"12181402","citationType":"journal article","authors":["Apperley J.F.","Gardembas M.","Melo J.V.","Russell-Jones R.","Bain B.J.","Baxter E.J.","Chase A.","Chessells J.M.","Colombat M.","Dearden C.E.","Dimitrijevic S.","Mahon F.-X.","Marin D.","Nikolova Z.","Olavarria E.","Silberman S.","Schultheis B.","Cross N.C.P.","Goldman J.M."],"citationCrossReferences":[{"database":"PubMed","id":"12181402"},{"database":"DOI","id":"10.1056/nejmoa020150"}],"title":"Response to imatinib mesylate in patients with chronic myeloproliferative diseases with rearrangements of the platelet-derived growth factor receptor beta.","publicationDate":"2002","journal":"N. Engl. J. Med.","firstPage":"481","lastPage":"487","volume":"347"},"referencePositions":["INVOLVEMENT IN MPE","CHROMOSOMAL TRANSLOCATION WITH PDGFRB"]},{"referenceNumber":16,"citation":{"id":"12588862","citationType":"journal article","authors":["Boccuni P.","MacGrogan D.","Scandura J.M.","Nimer S.D."],"citationCrossReferences":[{"database":"PubMed","id":"12588862"},{"database":"DOI","id":"10.1074/jbc.m300592200"}],"title":"The human L(3)MBT Polycomb group protein is a transcriptional repressor and interacts physically and functionally with TEL (ETV6).","publicationDate":"2003","journal":"J. Biol. Chem.","firstPage":"15412","lastPage":"15420","volume":"278"},"referencePositions":["INTERACTION WITH L3MBTL1"]},{"referenceNumber":17,"citation":{"id":"12590135","citationType":"journal article","authors":["Petrie K.","Guidez F.","Howell L.","Healy L.","Waxman S.","Greaves M.","Zelent A."],"citationCrossReferences":[{"database":"PubMed","id":"12590135"},{"database":"DOI","id":"10.1074/jbc.m212935200"}],"title":"The histone deacetylase 9 gene encodes multiple protein isoforms.","publicationDate":"2003","journal":"J. Biol. Chem.","firstPage":"16059","lastPage":"16072","volume":"278"},"referencePositions":["INTERACTION WITH HDAC9"]},{"referenceNumber":18,"citation":{"id":"15806161","citationType":"journal article","authors":["Barjesteh van Waalwijk van Doorn-Khosrovani S.","Spensberger D.","de Knegt Y.","Tang M.","Loewenberg B.","Delwel R."],"citationCrossReferences":[{"database":"PubMed","id":"15806161"},{"database":"DOI","id":"10.1038/sj.onc.1208588"}],"title":"Somatic heterozygous mutations in ETV6 (TEL) and frequent absence of ETV6 protein in acute myeloid leukemia.","publicationDate":"2005","journal":"Oncogene","firstPage":"4129","lastPage":"4137","volume":"24"},"referencePositions":["INVOLVEMENT IN AML","VARIANT GLY-344 INS","CHARACTERIZATION OF VARIANT GLY-344 INS"]},{"referenceNumber":19,"citation":{"id":"18669648","citationType":"journal article","authors":["Dephoure N.","Zhou C.","Villen J.","Beausoleil S.A.","Bakalarski C.E.","Elledge S.J.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"18669648"},{"database":"DOI","id":"10.1073/pnas.0805139105"}],"title":"A quantitative atlas of mitotic phosphorylation.","publicationDate":"2008","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"10762","lastPage":"10767","volume":"105"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-22","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":20,"citation":{"id":"19690332","citationType":"journal article","authors":["Mayya V.","Lundgren D.H.","Hwang S.-I.","Rezaul K.","Wu L.","Eng J.K.","Rodionov V.","Han D.K."],"citationCrossReferences":[{"database":"PubMed","id":"19690332"},{"database":"DOI","id":"10.1126/scisignal.2000007"}],"title":"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.","publicationDate":"2009","journal":"Sci. Signal.","firstPage":"RA46","lastPage":"RA46","volume":"2"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-18 AND SER-22","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Leukemic T-cell","type":"TISSUE"}]},{"referenceNumber":21,"citation":{"id":"19608861","citationType":"journal article","authors":["Choudhary C.","Kumar C.","Gnad F.","Nielsen M.L.","Rehman M.","Walther T.C.","Olsen J.V.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"19608861"},{"database":"DOI","id":"10.1126/science.1175371"}],"title":"Lysine acetylation targets protein complexes and co-regulates major cellular functions.","publicationDate":"2009","journal":"Science","firstPage":"834","lastPage":"840","volume":"325"},"referencePositions":["ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-11 AND LYS-302","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":22,"citation":{"id":"20068231","citationType":"journal article","authors":["Olsen J.V.","Vermeulen M.","Santamaria A.","Kumar C.","Miller M.L.","Jensen L.J.","Gnad F.","Cox J.","Jensen T.S.","Nigg E.A.","Brunak S.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"20068231"},{"database":"DOI","id":"10.1126/scisignal.2000475"}],"title":"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.","publicationDate":"2010","journal":"Sci. Signal.","firstPage":"RA3","lastPage":"RA3","volume":"3"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-22","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":23,"citation":{"id":"21406692","citationType":"journal article","authors":["Rigbolt K.T.","Prokhorova T.A.","Akimov V.","Henningsen J.","Johansen P.T.","Kratchmarova I.","Kassem M.","Mann M.","Olsen J.V.","Blagoev B."],"citationCrossReferences":[{"database":"PubMed","id":"21406692"},{"database":"DOI","id":"10.1126/scisignal.2001570"}],"title":"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.","publicationDate":"2011","journal":"Sci. Signal.","firstPage":"RS3","lastPage":"RS3","volume":"4"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-22 AND SER-213","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":24,"citation":{"id":"22814378","citationType":"journal article","authors":["Van Damme P.","Lasa M.","Polevoda B.","Gazquez C.","Elosegui-Artola A.","Kim D.S.","De Juan-Pardo E.","Demeyer K.","Hole K.","Larrea E.","Timmerman E.","Prieto J.","Arnesen T.","Sherman F.","Gevaert K.","Aldabe R."],"citationCrossReferences":[{"database":"PubMed","id":"22814378"},{"database":"DOI","id":"10.1073/pnas.1210303109"}],"title":"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.","publicationDate":"2012","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"12449","lastPage":"12454","volume":"109"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":25,"citation":{"id":"23186163","citationType":"journal article","authors":["Zhou H.","Di Palma S.","Preisinger C.","Peng M.","Polat A.N.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"23186163"},{"database":"DOI","id":"10.1021/pr300630k"}],"title":"Toward a comprehensive characterization of a human cancer cell phosphoproteome.","publicationDate":"2013","journal":"J. Proteome Res.","firstPage":"260","lastPage":"271","volume":"12"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Erythroleukemia","type":"TISSUE"}]},{"referenceNumber":26,"citation":{"id":"25218447","citationType":"journal article","authors":["Hendriks I.A.","D'Souza R.C.","Yang B.","Verlaan-de Vries M.","Mann M.","Vertegaal A.C."],"citationCrossReferences":[{"database":"PubMed","id":"25218447"},{"database":"DOI","id":"10.1038/nsmb.2890"}],"title":"Uncovering global SUMOylation signaling networks in a site-specific manner.","publicationDate":"2014","journal":"Nat. Struct. Mol. Biol.","firstPage":"927","lastPage":"936","volume":"21"},"referencePositions":["SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-11","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":27,"citation":{"id":"25772364","citationType":"journal article","authors":["Hendriks I.A.","Treffers L.W.","Verlaan-de Vries M.","Olsen J.V.","Vertegaal A.C."],"citationCrossReferences":[{"database":"PubMed","id":"25772364"},{"database":"DOI","id":"10.1016/j.celrep.2015.02.033"}],"title":"SUMO-2 orchestrates chromatin modifiers in response to DNA damage.","publicationDate":"2015","journal":"Cell Rep.","firstPage":"1778","lastPage":"1791","volume":"10"},"referencePositions":["SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-11","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":28,"citation":{"id":"25755297","citationType":"journal article","authors":["Xiao Z.","Chang J.G.","Hendriks I.A.","Sigurdsson J.O.","Olsen J.V.","Vertegaal A.C."],"citationCrossReferences":[{"database":"PubMed","id":"25755297"},{"database":"DOI","id":"10.1074/mcp.o114.044792"}],"title":"System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.","publicationDate":"2015","journal":"Mol. Cell. Proteomics","firstPage":"1419","lastPage":"1434","volume":"14"},"referencePositions":["SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-11 AND LYS-288","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":29,"citation":{"id":"25581430","citationType":"journal article","authors":["Zhang M.Y.","Churpek J.E.","Keel S.B.","Walsh T.","Lee M.K.","Loeb K.R.","Gulsuner S.","Pritchard C.C.","Sanchez-Bonilla M.","Delrow J.J.","Basom R.S.","Forouhar M.","Gyurkocza B.","Schwartz B.S.","Neistadt B.","Marquez R.","Mariani C.J.","Coats S.A.","Hofmann I.","Lindsley R.C.","Williams D.A.","Abkowitz J.L.","Horwitz M.S.","King M.C.","Godley L.A.","Shimamura A."],"citationCrossReferences":[{"database":"PubMed","id":"25581430"},{"database":"DOI","id":"10.1038/ng.3177"}],"title":"Germline ETV6 mutations in familial thrombocytopenia and hematologic malignancy.","publicationDate":"2015","journal":"Nat. Genet.","firstPage":"180","lastPage":"185","volume":"47"},"referencePositions":["FUNCTION","INVOLVEMENT IN THC5","VARIANTS THC5 LEU-214; GLN-369 AND CYS-399","CHARACTERIZATION OF VARIANTS THC5 LEU-214; GLN-369 AND CYS-399"]},{"referenceNumber":30,"citation":{"id":"28112733","citationType":"journal article","authors":["Hendriks I.A.","Lyon D.","Young C.","Jensen L.J.","Vertegaal A.C.","Nielsen M.L."],"citationCrossReferences":[{"database":"PubMed","id":"28112733"},{"database":"DOI","id":"10.1038/nsmb.3366"}],"title":"Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.","publicationDate":"2017","journal":"Nat. Struct. Mol. Biol.","firstPage":"325","lastPage":"336","volume":"24"},"referencePositions":["SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-11; LYS-288; LYS-302; LYS-403 AND LYS-421","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":31,"citation":{"id":"CI-BTRE0A31MIM9E","citationType":"submission","authoringGroup":["RIKEN structural genomics initiative (RSGI)"],"title":"Solution structure of ets domain transcriptional factor ETV6 protein.","publicationDate":"DEC-2006","submissionDatabase":"PDB data bank"},"referencePositions":["STRUCTURE BY NMR OF 338-442"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"U11732","properties":[{"key":"ProteinId","value":"AAA19786.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK289441","properties":[{"key":"ProteinId","value":"BAF82130.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"CH471094","properties":[{"key":"ProteinId","value":"EAW96240.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC043399","properties":[{"key":"ProteinId","value":"AAH43399.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"U61375","properties":[{"key":"ProteinId","value":"AAC50690.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"U63312","properties":[{"key":"ProteinId","value":"AAB17134.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"U63313","properties":[{"key":"ProteinId","value":"AAB17135.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"DQ841178","properties":[{"key":"ProteinId","value":"ABI30005.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS8643.1","properties":[{"key":"Description","value":"-"}]},{"database":"RefSeq","id":"NP_001978.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001987.5"}]},{"database":"PDB","id":"1JI7","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.45 A"},{"key":"Chains","value":"A/B/C=47-123"}]},{"database":"PDB","id":"1LKY","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.30 A"},{"key":"Chains","value":"A/B/C/D/E/F=47-123"}]},{"database":"PDB","id":"2DAO","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=338-442"}]},{"database":"PDB","id":"2QAR","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.40 A"},{"key":"Chains","value":"A/B/D/E=47-124"}]},{"database":"PDB","id":"2QB0","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.56 A"},{"key":"Chains","value":"A/C=47-123"}]},{"database":"PDB","id":"2QB1","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.61 A"},{"key":"Chains","value":"A/B=47-123"}]},{"database":"PDB","id":"5L0P","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.30 A"},{"key":"Chains","value":"A=47-356"}]},{"database":"PDB","id":"7JU2","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.85 A"},{"key":"Chains","value":"A/B=43-125"}]},{"database":"PDB","id":"7N1O","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.77 A"},{"key":"Chains","value":"A=46-123"}]},{"database":"PDB","id":"7N2B","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.22 A"},{"key":"Chains","value":"A/B=36-132"}]},{"database":"PDB","id":"7T8J","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.89 A"},{"key":"Chains","value":"A=47-121"}]},{"database":"PDB","id":"7TDY","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.53 A"},{"key":"Chains","value":"A=47-120"}]},{"database":"PDB","id":"7TW7","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.62 A"},{"key":"Chains","value":"A=47-123"}]},{"database":"PDB","id":"7TW8","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.55 A"},{"key":"Chains","value":"A=47-123"}]},{"database":"PDB","id":"7TW9","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.41 A"},{"key":"Chains","value":"A=47-123"}]},{"database":"PDB","id":"7U4W","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.10 A"},{"key":"Chains","value":"A=47-121"}]},{"database":"PDB","id":"7U4Z","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.03 A"},{"key":"Chains","value":"A=47-121"}]},{"database":"PDB","id":"8BWU","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.36 A"},{"key":"Chains","value":"A=47-123"}]},{"database":"PDB","id":"8E1F","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.16 A"},{"key":"Chains","value":"A/B/C/D=47-124"}]},{"database":"PDB","id":"8FRJ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.57 A"},{"key":"Chains","value":"A=47-123"}]},{"database":"PDB","id":"8FRK","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.61 A"},{"key":"Chains","value":"A=47-123"}]},{"database":"PDB","id":"8FT6","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.62 A"},{"key":"Chains","value":"A=47-124"}]},{"database":"PDB","id":"8FT8","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.60 A"},{"key":"Chains","value":"A=47-124"}]},{"database":"PDB","id":"8FZ3","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.78 A"},{"key":"Chains","value":"A/B/C/D=47-123"}]},{"database":"PDB","id":"8FZU","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"A/B/C=47-111"}]},{"database":"PDB","id":"8FZV","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.29 A"},{"key":"Chains","value":"A/B/C=47-111"}]},{"database":"PDB","id":"8THA","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.68 A"},{"key":"Chains","value":"A=47-124"}]},{"database":"PDB","id":"9CPL","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.40 A"},{"key":"Chains","value":"A=47-124, A=132-144"}]},{"database":"PDB","id":"9DB5","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.57 A"},{"key":"Chains","value":"A=47-121"}]},{"database":"PDB","id":"9DOC","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.19 A"},{"key":"Chains","value":"A=47-121"}]},{"database":"PDB","id":"9DP8","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.47 A"},{"key":"Chains","value":"A=47-124"}]},{"database":"PDB","id":"9DVG","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.54 A"},{"key":"Chains","value":"A=47-124"}]},{"database":"PDB","id":"9E4Q","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.58 A"},{"key":"Chains","value":"A=39-124, A=121-132"}]},{"database":"PDB","id":"9FEH","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.99 A"},{"key":"Chains","value":"A=47-123"}]},{"database":"PDB","id":"9NGE","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.02 A"},{"key":"Chains","value":"A/B=47-122"}]},{"database":"PDB","id":"9O0H","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.24 A"},{"key":"Chains","value":"B=10-39, B=47-124, B=132-144"}]},{"database":"PDB","id":"9Q4D","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.30 A"},{"key":"Chains","value":"A=47-125"}]},{"database":"PDB","id":"9Q9E","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.05 A"},{"key":"Chains","value":"A/B/C=47-123"}]},{"database":"PDB","id":"9YKB","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.50 A"},{"key":"Chains","value":"A/B/C=47-123"}]},{"database":"PDB","id":"9Z2L","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.02 A"},{"key":"Chains","value":"A/B=47-122"}]},{"database":"PDB","id":"9ZB7","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.24 A"},{"key":"Chains","value":"A=47-124"}]},{"database":"PDB","id":"9ZNB","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.77 A"},{"key":"Chains","value":"A=47-124"}]},{"database":"PDB","id":"9ZVU","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.96 A"},{"key":"Chains","value":"A/B=47-122"}]},{"database":"PDBsum","id":"1JI7","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1LKY","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2DAO","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2QAR","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2QB0","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2QB1","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5L0P","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7JU2","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7N1O","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7N2B","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7T8J","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7TDY","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7TW7","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7TW8","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7TW9","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7U4W","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7U4Z","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8BWU","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8E1F","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8FRJ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8FRK","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8FT6","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8FT8","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8FZ3","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8FZU","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8FZV","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8THA","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9CPL","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9DB5","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9DOC","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9DP8","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9DVG","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9E4Q","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9FEH","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9NGE","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9O0H","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9Q4D","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9Q9E","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9YKB","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9Z2L","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9ZB7","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9ZNB","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9ZVU","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"P41212","properties":[{"key":"Description","value":"-"}]},{"database":"BMRB","id":"P41212","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P41212","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"108421","properties":[{"key":"Interactions","value":"114"}]},{"database":"CORUM","id":"P41212","properties":[{"key":"Description","value":"-"}]},{"database":"DIP","id":"DIP-17028N","properties":[{"key":"Description","value":"-"}]},{"database":"ELM","id":"P41212","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"P41212","properties":[{"key":"Number of interactors","value":"2403"}]},{"database":"IntAct","id":"P41212","properties":[{"key":"Interactions","value":"83"}]},{"database":"MINT","id":"P41212","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-ETV6","properties":[{"key":"Evidences","value":"3 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000379658","properties":[{"key":"Description","value":"-"}]},{"database":"BindingDB","id":"P41212","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL2401606","properties":[{"key":"Description","value":"-"}]},{"database":"DrugCentral","id":"P41212","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"P41212","properties":[{"key":"glycosylation","value":"1 site, 1 O-linked glycan (1 site)"}]},{"database":"iPTMnet","id":"P41212","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"P41212","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"ETV6","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"730927","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"P41212","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"P41212","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000379658","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"P41212","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"55416","properties":[{"key":"Description","value":"-"}]},{"database":"Pumba","id":"P41212","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"634","properties":[{"key":"antibodies","value":"400 antibodies from 38 providers"}]},{"database":"DNASU","id":"2120","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000396373.9","properties":[{"key":"ProteinId","value":"ENSP00000379658.3"},{"key":"GeneId","value":"ENSG00000139083.12"}]},{"database":"GeneID","id":"2120","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:2120","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000396373.9","properties":[{"key":"ProteinId","value":"ENSP00000379658.3"},{"key":"RefSeqNucleotideId","value":"NM_001987.5"},{"key":"RefSeqProteinId","value":"NP_001978.1"}]},{"database":"UCSC","id":"uc001qzz.4","properties":[{"key":"OrganismName","value":"human"}]},{"database":"AGR","id":"HGNC:3495","properties":[{"key":"Description","value":"-"}]},{"database":"CIViC","id":"2120","properties":[{"key":"Number of evidences","value":"9 evidence items across 8 molecular profiles"}]},{"database":"ClinPGx","id":"PA27909","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"2120","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"2120","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"ETV6","properties":[{"key":"Description","value":"-"}]},{"database":"GeneReviews","id":"ETV6","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:3495","properties":[{"key":"GeneName","value":"ETV6"}]},{"database":"HPA","id":"ENSG00000139083","properties":[{"key":"ExpressionPatterns","value":"Low tissue specificity"}]},{"database":"MalaCards","id":"ETV6","properties":[{"key":"Description","value":"-"}]},{"database":"MIM","id":"131440","properties":[{"key":"Type","value":"phenotype"}]},{"database":"MIM","id":"600618","properties":[{"key":"Type","value":"gene"}]},{"database":"MIM","id":"601626","properties":[{"key":"Type","value":"phenotype"}]},{"database":"MIM","id":"616216","properties":[{"key":"Type","value":"phenotype"}]},{"database":"OpenTargets","id":"ENSG00000139083","properties":[{"key":"Description","value":"-"}]},{"database":"Orphanet","id":"168629","properties":[{"key":"Disease","value":"Autosomal thrombocytopenia with normal platelets size"}]},{"database":"Orphanet","id":"585929","properties":[{"key":"Disease","value":"B-lymphoblastic leukemia/lymphoma with t(12;21)(p13.2;q22.1)"}]},{"database":"Orphanet","id":"98823","properties":[{"key":"Disease","value":"Chronic myelomonocytic leukemia"}]},{"database":"Orphanet","id":"2665","properties":[{"key":"Disease","value":"Congenital mesoblastic nephroma"}]},{"database":"Orphanet","id":"146","properties":[{"key":"Disease","value":"Differentiated thyroid carcinoma"}]},{"database":"Orphanet","id":"2030","properties":[{"key":"Disease","value":"Fibrosarcoma"}]},{"database":"Orphanet","id":"314950","properties":[{"key":"Disease","value":"Primary hypereosinophilic syndrome"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000139083","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG3804","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000159508","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_037998_1_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P41212","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"AFMNHIM","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"6408625at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"P41212","properties":[{"key":"Number of GO annotations","value":"4 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"P41212","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"P41212","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-9673768","properties":[{"key":"PathwayName","value":"Signaling by membrane-tethered fusions of PDGFRA or PDGFRB"}]},{"database":"Reactome","id":"R-HSA-9703465","properties":[{"key":"PathwayName","value":"Signaling by FLT3 fusion proteins"}]},{"database":"SignaLink","id":"P41212","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"P41212","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000139083","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"2120","properties":[{"key":"hits","value":"27 hits in 1189 CRISPR screens"}]},{"database":"ChiTaRS","id":"ETV6","properties":[{"key":"OrganismName","value":"human"}]},{"database":"EvolutionaryTrace","id":"P41212","properties":[{"key":"Description","value":"-"}]},{"database":"GeneWiki","id":"ETV6","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"2120","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"P41212","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:P41212","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 12"}]},{"database":"RNAct","id":"P41212","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000139083","properties":[{"key":"ExpressionPatterns","value":"Expressed in mucosa of paranasal sinus and 172 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"P41212","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0000785","properties":[{"key":"GoTerm","value":"C:chromatin"},{"key":"GoEvidenceType","value":"ISA:NTNU_SB"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0001228","properties":[{"key":"GoTerm","value":"F:DNA-binding transcription activator activity, RNA polymerase II-specific"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0003700","properties":[{"key":"GoTerm","value":"F:DNA-binding transcription factor activity"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"7761424"}]},{"database":"GO","id":"GO:0000981","properties":[{"key":"GoTerm","value":"F:DNA-binding transcription factor activity, RNA polymerase II-specific"},{"key":"GoEvidenceType","value":"ISA:NTNU_SB"}]},{"database":"GO","id":"GO:0001227","properties":[{"key":"GoTerm","value":"F:DNA-binding transcription repressor activity, RNA polymerase II-specific"},{"key":"GoEvidenceType","value":"IDA:NTNU_SB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10514502"}]},{"database":"GO","id":"GO:0019904","properties":[{"key":"GoTerm","value":"F:protein domain specific binding"},{"key":"GoEvidenceType","value":"IPI:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"12588862"}]},{"database":"GO","id":"GO:0000978","properties":[{"key":"GoTerm","value":"F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0000977","properties":[{"key":"GoTerm","value":"F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"},{"key":"GoEvidenceType","value":"IDA:NTNU_SB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"9018121"}]},{"database":"GO","id":"GO:0030154","properties":[{"key":"GoTerm","value":"P:cell differentiation"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0071425","properties":[{"key":"GoTerm","value":"P:hematopoietic stem cell proliferation"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"25581430"}]},{"database":"GO","id":"GO:0000122","properties":[{"key":"GoTerm","value":"P:negative regulation of transcription by RNA polymerase II"},{"key":"GoEvidenceType","value":"IDA:NTNU_SB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10514502"}]},{"database":"GO","id":"GO:0006357","properties":[{"key":"GoTerm","value":"P:regulation of transcription by RNA polymerase II"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"CDD","id":"cd08535","properties":[{"key":"EntryName","value":"SAM_PNT-Tel_Yan"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.150.50:FF:000030","properties":[{"key":"EntryName","value":"transcription factor ETV6"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.10.10:FF:000176","properties":[{"key":"EntryName","value":"transcription factor ETV6 isoform X2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.150.50","properties":[{"key":"EntryName","value":"Transcription Factor, Ets-1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.10.10","properties":[{"key":"EntryName","value":"Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000418","properties":[{"key":"EntryName","value":"Ets_dom"}]},{"database":"InterPro","id":"IPR046328","properties":[{"key":"EntryName","value":"ETS_fam"}]},{"database":"InterPro","id":"IPR003118","properties":[{"key":"EntryName","value":"Pointed_dom"}]},{"database":"InterPro","id":"IPR013761","properties":[{"key":"EntryName","value":"SAM/pointed_sf"}]},{"database":"InterPro","id":"IPR036388","properties":[{"key":"EntryName","value":"WH-like_DNA-bd_sf"}]},{"database":"InterPro","id":"IPR036390","properties":[{"key":"EntryName","value":"WH_DNA-bd_sf"}]},{"database":"PANTHER","id":"PTHR11849","properties":[{"key":"EntryName","value":"ETS"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11849:SF19","properties":[{"key":"EntryName","value":"TRANSCRIPTION FACTOR ETV6"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00178","properties":[{"key":"EntryName","value":"Ets"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02198","properties":[{"key":"EntryName","value":"SAM_PNT"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00454","properties":[{"key":"EntryName","value":"ETSDOMAIN"}]},{"database":"SMART","id":"SM00413","properties":[{"key":"EntryName","value":"ETS"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00251","properties":[{"key":"EntryName","value":"SAM_PNT"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF47769","properties":[{"key":"EntryName","value":"SAM/Pointed domain"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF46785","properties":[{"key":"EntryName","value":"Winged helix' DNA-binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00346","properties":[{"key":"EntryName","value":"ETS_DOMAIN_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50061","properties":[{"key":"EntryName","value":"ETS_DOMAIN_3"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51433","properties":[{"key":"EntryName","value":"PNT"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMNGKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDNCVQRTPRPSVDNVHHNPPTIELLHRSRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSESHPKPSSPRQESTRVIQLMPSPIMHPLILNPRHSVDFKQSRLSEDGLHREGKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIADCRLLWDYVYQLLSDSRYENFIRWEDKESKIFRIVDPNGLARLWGNHKNRTNMTYEKMSRALRHYYKLNIIRKEPGQRLLFRFMKTPDEIMSGRTDRLEHLESQELDEQIYQEDEC","length":452,"molWeight":53000,"crc64":"DEC45682ECADECBB","md5":"7B361E584CD2DB1FC059E57DBF006319"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"INTERACTION":6,"SUBCELLULAR LOCATION":1,"TISSUE SPECIFICITY":1,"PTM":1,"DISEASE":12,"SIMILARITY":1,"SEQUENCE CAUTION":1,"WEB RESOURCE":1},"countByFeatureType":{"Chain":1,"Domain":1,"DNA binding":1,"Region":2,"Compositional bias":2,"Site":4,"Modified residue":8,"Cross-link":5,"Natural variant":4,"Mutagenesis":4,"Helix":18,"Turn":4,"Beta strand":5},"uniParcId":"UPI000000DA45"}}