{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P40818","secondaryAccessions":["B4DKA8","Q2TB31","Q7Z3U2","Q86VA0","Q8IWI7"],"uniProtkbId":"UBP8_HUMAN","entryAudit":{"firstPublicDate":"1995-02-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1995-02-01","entryVersion":243,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Ubiquitin carboxyl-terminal hydrolase 8"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9628861"}],"value":"3.4.19.12"}]},"alternativeNames":[{"fullName":{"value":"Deubiquitinating enzyme 8"}},{"fullName":{"value":"Ubiquitin isopeptidase Y"},"shortNames":[{"value":"hUBPy"}]},{"fullName":{"value":"Ubiquitin thioesterase 8"}},{"fullName":{"value":"Ubiquitin-specific-processing protease 8"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:12631"}],"value":"USP8"},"synonyms":[{"value":"KIAA0055"},{"value":"UBPY"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16520378"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17711858"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18329369"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27302062"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9628861"}],"value":"Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Probably regulates the stability of STAM2 and RASGRF1. Regulates endosomal ubiquitin dynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level of protein ubiquitination on endosomes is essential for maintaining the morphology of the organelle. Deubiquitinates EPS15 and controls tyrosine kinase stability. Removes conjugated ubiquitin from EGFR thus regulating EGFR degradation and downstream MAPK signaling. Involved in acrosome biogenesis through interaction with the spermatid ESCRT-0 complex and microtubules. Deubiquitinates BIRC6/bruce and KIF23/MKLP1. Deubiquitinates BACE1 which inhibits BACE1 lysosomal degradation and modulates BACE-mediated APP cleavage and amyloid-beta formation (PubMed:27302062)"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).","ecNumber":"3.4.19.12","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9628861"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17035239"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17711858"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18329369"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19129480"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19427866"}],"value":"Forms a ternary complex with RNF128 and OTUB1. Interacts (via C-terminal UCH catalytic domain) with OTUB1 isoform 1. Interacts with STAM2 (via SH3 domain). Interacts with DNAJB3, EGFR, EPS15, RASGRF1, RNF41, YWHAE, YWHAG and YWHAZ (By similarity). Interacts with NBR1, RASGRF1, RNF41 and IST1. Associates with the ESCRT-0 complex and with microtubules (By similarity). Interacts with BIRC6/bruce and KIF23/MKLP1"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30065070"}],"value":"(Microbial infection) Interacts with Zika virus non-structural protein 1"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P40818","intActId":"EBI-1050865"},"interactantTwo":{"uniProtKBAccession":"Q9HD42","geneName":"CHMP1A","intActId":"EBI-1057156"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P40818","intActId":"EBI-1050865"},"interactantTwo":{"uniProtKBAccession":"Q7LBR1","geneName":"CHMP1B","intActId":"EBI-2118090"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P40818","intActId":"EBI-1050865"},"interactantTwo":{"uniProtKBAccession":"Q96CF2","geneName":"CHMP4C","intActId":"EBI-1221015"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P40818","intActId":"EBI-1050865"},"interactantTwo":{"uniProtKBAccession":"Q99814","geneName":"EPAS1","intActId":"EBI-447470"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P40818","intActId":"EBI-1050865"},"interactantTwo":{"uniProtKBAccession":"Q16665","geneName":"HIF1A","intActId":"EBI-447269"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P40818","intActId":"EBI-1050865"},"interactantTwo":{"uniProtKBAccession":"Q14596","geneName":"NBR1","intActId":"EBI-742698"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P40818","intActId":"EBI-1050865"},"interactantTwo":{"uniProtKBAccession":"P31947","geneName":"SFN","intActId":"EBI-476295"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P40818","intActId":"EBI-1050865"},"interactantTwo":{"uniProtKBAccession":"P62258","geneName":"YWHAE","intActId":"EBI-356498"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P40818","intActId":"EBI-1050865"},"interactantTwo":{"uniProtKBAccession":"P63104","geneName":"YWHAZ","intActId":"EBI-347088"},"numberOfExperiments":5,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16520378"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17711858"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19427866"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28505279"}],"value":"Cytoplasm","id":"SL-0086"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q80U87"}],"value":"Nucleus","id":"SL-0191"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16520378"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17711858"}],"value":"Endosome membrane","id":"SL-0100"},"topology":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Peripheral membrane protein","id":"SL-9903"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16520378"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Peripheral membrane protein","id":"SL-9903"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["P40818-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["P40818-2"],"sequenceIds":["VSP_054594","VSP_054595"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9628861"}],"value":"Upon growth stimulation in starved human fibroblasts. Decreases in response to growth arrest induced by cell-cell contact"}],"commentType":"INDUCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17711858"}],"value":"The MIT domain is required for endosomal localization, CHMP1B-binding, maintenance of ESCRT-0 stability and EGFR degradation"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"The rhodanese domain is sufficient for RNF41-binding"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Phosphorylation of Ser-718 is essential for interaction with YWHAE and for cytosol localization. Undergoes dephosphorylation at Ser-718 in the M phase. Tyrosine-phosphorylated in its N-terminal half in an EGFR-dependent manner"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Ubiquitinated. Inactive form is mostly monoubiquitinated, but polyubiquitination happens too. Ubiquitination is increased in EGF-stimulated cells. Ubiquitination of active form is undetectable, suggesting a possibility that USP8 deubiquitinates itself, thereby regulating its own function (By similarity)"}],"commentType":"PTM"},{"commentType":"DISEASE","disease":{"diseaseId":"Pituitary adenoma 4, ACTH-secreting","diseaseAccession":"DI-01168","acronym":"PITA4","description":"A form of pituitary adenoma, a neoplasm of the pituitary gland and one of the most common neuroendocrine tumors. Pituitary adenomas are clinically classified as functional and non-functional tumors, and manifest with a variety of features, including local invasion of surrounding structures and excessive hormone secretion. Functional pituitary adenomas are further classified by the type of hormone they secrete. PITA4 results in excessive production of adrenocorticotropic hormone. This leads to hypersecretion of cortisol by the adrenal glands and ACTH-dependent Cushing syndrome. Clinical manifestations of Cushing syndrome include facial and truncal obesity, abdominal striae, muscular weakness, osteoporosis, arterial hypertension, diabetes.","diseaseCrossReference":{"database":"MIM","id":"219090"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28505279"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the peptidase C19 family"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Miscellaneous discrepancy","sequence":"AAH38801.1","note":"Contaminating sequence. Potential poly-A sequence.","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Miscellaneous discrepancy","sequence":"AAH51345.1","note":"Contaminating sequence. Potential poly-A sequence.","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1118,"modifier":"EXACT"}},"description":"Ubiquitin carboxyl-terminal hydrolase 8","featureId":"PRO_0000080627"},{"type":"Domain","location":{"start":{"value":33,"modifier":"EXACT"},"end":{"value":116,"modifier":"EXACT"}},"description":"MIT"},{"type":"Domain","location":{"start":{"value":195,"modifier":"EXACT"},"end":{"value":313,"modifier":"EXACT"}},"description":"Rhodanese","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00173"}]},{"type":"Domain","location":{"start":{"value":777,"modifier":"EXACT"},"end":{"value":1109,"modifier":"EXACT"}},"description":"USP"},{"type":"Region","location":{"start":{"value":120,"modifier":"EXACT"},"end":{"value":177,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":402,"modifier":"EXACT"},"end":{"value":447,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":475,"modifier":"EXACT"},"end":{"value":648,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":679,"modifier":"EXACT"},"end":{"value":746,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Motif","location":{"start":{"value":405,"modifier":"EXACT"},"end":{"value":413,"modifier":"EXACT"}},"description":"SH3-binding","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Compositional bias","location":{"start":{"value":120,"modifier":"EXACT"},"end":{"value":146,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":158,"modifier":"EXACT"},"end":{"value":177,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":417,"modifier":"EXACT"},"end":{"value":429,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":475,"modifier":"EXACT"},"end":{"value":573,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":618,"modifier":"EXACT"},"end":{"value":645,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":716,"modifier":"EXACT"},"end":{"value":726,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Active site","location":{"start":{"value":786,"modifier":"EXACT"},"end":{"value":786,"modifier":"EXACT"}},"description":"Nucleophile","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU10092"},{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU10093"}]},{"type":"Active site","location":{"start":{"value":1067,"modifier":"EXACT"},"end":{"value":1067,"modifier":"EXACT"}},"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU10092"},{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU10093"}]},{"type":"Modified residue","location":{"start":{"value":160,"modifier":"EXACT"},"end":{"value":160,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":392,"modifier":"EXACT"},"end":{"value":392,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":400,"modifier":"EXACT"},"end":{"value":400,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":452,"modifier":"EXACT"},"end":{"value":452,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":577,"modifier":"EXACT"},"end":{"value":577,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":718,"modifier":"EXACT"},"end":{"value":718,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":719,"modifier":"EXACT"},"end":{"value":719,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"}]},{"type":"Modified residue","location":{"start":{"value":945,"modifier":"EXACT"},"end":{"value":945,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q80U87"}]},{"type":"Alternative sequence","location":{"start":{"value":35,"modifier":"EXACT"},"end":{"value":111,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"}],"featureId":"VSP_054594","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":601,"modifier":"EXACT"},"end":{"value":629,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"}],"featureId":"VSP_054595","alternativeSequence":{}},{"type":"Natural variant","location":{"start":{"value":310,"modifier":"EXACT"},"end":{"value":310,"modifier":"EXACT"}},"description":"found in a patient with spastic paraplegia; uncertain significance; dbSNP:rs587777201","featureCrossReferences":[{"database":"dbSNP","id":"rs587777201"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24482476"}],"featureId":"VAR_077850","alternativeSequence":{"originalSequence":"Q","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":443,"modifier":"EXACT"},"end":{"value":443,"modifier":"EXACT"}},"description":"in dbSNP:rs3743044","featureCrossReferences":[{"database":"dbSNP","id":"rs3743044"}],"featureId":"VAR_017796","alternativeSequence":{"originalSequence":"D","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":718,"modifier":"EXACT"},"end":{"value":723,"modifier":"EXACT"}},"description":"in PITA4; uncertain significance; somatic mutation","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28505279"}],"featureId":"VAR_079717","alternativeSequence":{}},{"type":"Natural variant","location":{"start":{"value":718,"modifier":"EXACT"},"end":{"value":718,"modifier":"EXACT"}},"description":"in PITA4; uncertain significance; somatic mutation; dbSNP:rs672601308","featureCrossReferences":[{"database":"dbSNP","id":"rs672601308"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28505279"}],"featureId":"VAR_079718","alternativeSequence":{"originalSequence":"S","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":718,"modifier":"EXACT"},"end":{"value":718,"modifier":"EXACT"}},"description":"in PITA4; uncertain significance; somatic mutation; localizes to nucleus instead of cytoplasm; dbSNP:rs672601307","featureCrossReferences":[{"database":"dbSNP","id":"rs672601307"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28505279"}],"featureId":"VAR_079719","alternativeSequence":{"originalSequence":"S","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":718,"modifier":"EXACT"},"end":{"value":718,"modifier":"EXACT"}},"description":"in PITA4; uncertain significance; somatic mutation","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28505279"}],"featureId":"VAR_079720","alternativeSequence":{}},{"type":"Natural variant","location":{"start":{"value":720,"modifier":"EXACT"},"end":{"value":720,"modifier":"EXACT"}},"description":"in PITA4; uncertain significance; somatic mutation; dbSNP:rs672601311","featureCrossReferences":[{"database":"dbSNP","id":"rs672601311"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28505279"}],"featureId":"VAR_079721","alternativeSequence":{"originalSequence":"P","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":739,"modifier":"EXACT"},"end":{"value":739,"modifier":"EXACT"}},"description":"in dbSNP:rs11638390","featureCrossReferences":[{"database":"dbSNP","id":"rs11638390"}],"featureId":"VAR_051525","alternativeSequence":{"originalSequence":"T","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":827,"modifier":"EXACT"},"end":{"value":827,"modifier":"EXACT"}},"description":"in dbSNP:rs1056577","featureCrossReferences":[{"database":"dbSNP","id":"rs1056577"}],"featureId":"VAR_017797","alternativeSequence":{"originalSequence":"A","alternativeSequences":["G"]}},{"type":"Mutagenesis","location":{"start":{"value":786,"modifier":"EXACT"},"end":{"value":786,"modifier":"EXACT"}},"description":"Impairs deubiquitination activity and leads to endosome membrane accumulation.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16520378"}],"alternativeSequence":{"originalSequence":"C","alternativeSequences":["S"]}},{"type":"Sequence conflict","location":{"start":{"value":526,"modifier":"EXACT"},"end":{"value":526,"modifier":"EXACT"}},"description":"in Ref. 3; CAD97662","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["G"]}},{"type":"Sequence conflict","location":{"start":{"value":717,"modifier":"EXACT"},"end":{"value":717,"modifier":"EXACT"}},"description":"in Ref. 3; CAD97662","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"Y","alternativeSequences":["H"]}},{"type":"Sequence conflict","location":{"start":{"value":945,"modifier":"EXACT"},"end":{"value":945,"modifier":"EXACT"}},"description":"in Ref. 3; CAD97662","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"T","alternativeSequences":["A"]}},{"type":"Helix","location":{"start":{"value":7,"modifier":"EXACT"},"end":{"value":11,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2A9U"}]},{"type":"Helix","location":{"start":{"value":17,"modifier":"EXACT"},"end":{"value":21,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2A9U"}]},{"type":"Helix","location":{"start":{"value":22,"modifier":"EXACT"},"end":{"value":24,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2A9U"}]},{"type":"Helix","location":{"start":{"value":28,"modifier":"EXACT"},"end":{"value":30,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2A9U"}]},{"type":"Helix","location":{"start":{"value":33,"modifier":"EXACT"},"end":{"value":52,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2A9U"}]},{"type":"Helix","location":{"start":{"value":56,"modifier":"EXACT"},"end":{"value":73,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2A9U"}]},{"type":"Helix","location":{"start":{"value":77,"modifier":"EXACT"},"end":{"value":81,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2A9U"}]},{"type":"Helix","location":{"start":{"value":83,"modifier":"EXACT"},"end":{"value":90,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2A9U"}]},{"type":"Helix","location":{"start":{"value":92,"modifier":"EXACT"},"end":{"value":138,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2A9U"}]},{"type":"Beta strand","location":{"start":{"value":181,"modifier":"EXACT"},"end":{"value":183,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1WHB"}]},{"type":"Helix","location":{"start":{"value":185,"modifier":"EXACT"},"end":{"value":193,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2GWF"}]},{"type":"Beta strand","location":{"start":{"value":195,"modifier":"EXACT"},"end":{"value":197,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1WHB"}]},{"type":"Beta strand","location":{"start":{"value":199,"modifier":"EXACT"},"end":{"value":203,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2GWF"}]},{"type":"Helix","location":{"start":{"value":207,"modifier":"EXACT"},"end":{"value":212,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2GWF"}]},{"type":"Beta strand","location":{"start":{"value":219,"modifier":"EXACT"},"end":{"value":221,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1WHB"}]},{"type":"Helix","location":{"start":{"value":223,"modifier":"EXACT"},"end":{"value":225,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2GWF"}]},{"type":"Helix","location":{"start":{"value":232,"modifier":"EXACT"},"end":{"value":237,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2GWF"}]},{"type":"Helix","location":{"start":{"value":241,"modifier":"EXACT"},"end":{"value":248,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2GWF"}]},{"type":"Turn","location":{"start":{"value":249,"modifier":"EXACT"},"end":{"value":252,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2GWF"}]},{"type":"Beta strand","location":{"start":{"value":253,"modifier":"EXACT"},"end":{"value":259,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2GWF"}]},{"type":"Helix","location":{"start":{"value":265,"modifier":"EXACT"},"end":{"value":267,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2GWF"}]},{"type":"Helix","location":{"start":{"value":273,"modifier":"EXACT"},"end":{"value":282,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2GWF"}]},{"type":"Beta strand","location":{"start":{"value":295,"modifier":"EXACT"},"end":{"value":297,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2GWF"}]},{"type":"Helix","location":{"start":{"value":300,"modifier":"EXACT"},"end":{"value":307,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2GWF"}]},{"type":"Helix","location":{"start":{"value":309,"modifier":"EXACT"},"end":{"value":311,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2GWF"}]},{"type":"Helix","location":{"start":{"value":763,"modifier":"EXACT"},"end":{"value":765,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2GFO"}]},{"type":"Beta strand","location":{"start":{"value":782,"modifier":"EXACT"},"end":{"value":784,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2GFO"}]},{"type":"Helix","location":{"start":{"value":786,"modifier":"EXACT"},"end":{"value":796,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2GFO"}]},{"type":"Helix","location":{"start":{"value":799,"modifier":"EXACT"},"end":{"value":806,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2GFO"}]},{"type":"Turn","location":{"start":{"value":807,"modifier":"EXACT"},"end":{"value":809,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2GFO"}]},{"type":"Helix","location":{"start":{"value":810,"modifier":"EXACT"},"end":{"value":813,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2GFO"}]},{"type":"Turn","location":{"start":{"value":819,"modifier":"EXACT"},"end":{"value":824,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8XPN"}]},{"type":"Helix","location":{"start":{"value":825,"modifier":"EXACT"},"end":{"value":839,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2GFO"}]},{"type":"Beta strand","location":{"start":{"value":842,"modifier":"EXACT"},"end":{"value":845,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2GFO"}]},{"type":"Helix","location":{"start":{"value":848,"modifier":"EXACT"},"end":{"value":857,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2GFO"}]},{"type":"Helix","location":{"start":{"value":859,"modifier":"EXACT"},"end":{"value":861,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2GFO"}]},{"type":"Beta strand","location":{"start":{"value":862,"modifier":"EXACT"},"end":{"value":865,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2GFO"}]},{"type":"Helix","location":{"start":{"value":869,"modifier":"EXACT"},"end":{"value":884,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2GFO"}]},{"type":"Helix","location":{"start":{"value":903,"modifier":"EXACT"},"end":{"value":917,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2GFO"}]},{"type":"Helix","location":{"start":{"value":921,"modifier":"EXACT"},"end":{"value":926,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2GFO"}]},{"type":"Beta strand","location":{"start":{"value":928,"modifier":"EXACT"},"end":{"value":936,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2GFO"}]},{"type":"Turn","location":{"start":{"value":937,"modifier":"EXACT"},"end":{"value":939,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2GFO"}]},{"type":"Beta strand","location":{"start":{"value":942,"modifier":"EXACT"},"end":{"value":954,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2GFO"}]},{"type":"Beta strand","location":{"start":{"value":959,"modifier":"EXACT"},"end":{"value":963,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2GFO"}]},{"type":"Helix","location":{"start":{"value":964,"modifier":"EXACT"},"end":{"value":971,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2GFO"}]},{"type":"Beta strand","location":{"start":{"value":975,"modifier":"EXACT"},"end":{"value":977,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2GFO"}]},{"type":"Helix","location":{"start":{"value":979,"modifier":"EXACT"},"end":{"value":981,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8XPN"}]},{"type":"Beta strand","location":{"start":{"value":983,"modifier":"EXACT"},"end":{"value":985,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2GFO"}]},{"type":"Turn","location":{"start":{"value":986,"modifier":"EXACT"},"end":{"value":989,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2GFO"}]},{"type":"Beta strand","location":{"start":{"value":990,"modifier":"EXACT"},"end":{"value":992,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2GFO"}]},{"type":"Beta strand","location":{"start":{"value":994,"modifier":"EXACT"},"end":{"value":1002,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2GFO"}]},{"type":"Beta strand","location":{"start":{"value":1005,"modifier":"EXACT"},"end":{"value":1011,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2GFO"}]},{"type":"Beta strand","location":{"start":{"value":1014,"modifier":"EXACT"},"end":{"value":1016,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2GFO"}]},{"type":"Beta strand","location":{"start":{"value":1018,"modifier":"EXACT"},"end":{"value":1023,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2GFO"}]},{"type":"Beta strand","location":{"start":{"value":1027,"modifier":"EXACT"},"end":{"value":1029,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2GFO"}]},{"type":"Helix","location":{"start":{"value":1038,"modifier":"EXACT"},"end":{"value":1040,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2GFO"}]},{"type":"Beta strand","location":{"start":{"value":1051,"modifier":"EXACT"},"end":{"value":1061,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2GFO"}]},{"type":"Turn","location":{"start":{"value":1063,"modifier":"EXACT"},"end":{"value":1065,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2GFO"}]},{"type":"Beta strand","location":{"start":{"value":1067,"modifier":"EXACT"},"end":{"value":1074,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2GFO"}]},{"type":"Turn","location":{"start":{"value":1075,"modifier":"EXACT"},"end":{"value":1078,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2GFO"}]},{"type":"Beta strand","location":{"start":{"value":1079,"modifier":"EXACT"},"end":{"value":1084,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2GFO"}]},{"type":"Beta strand","location":{"start":{"value":1087,"modifier":"EXACT"},"end":{"value":1090,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2GFO"}]},{"type":"Helix","location":{"start":{"value":1093,"modifier":"EXACT"},"end":{"value":1096,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2GFO"}]},{"type":"Beta strand","location":{"start":{"value":1101,"modifier":"EXACT"},"end":{"value":1107,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2GFO"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0131","category":"Biological process","name":"Cell cycle"},{"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"id":"KW-1062","category":"Disease","name":"Cushing syndrome"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0225","category":"Disease","name":"Disease variant"},{"id":"KW-0967","category":"Cellular component","name":"Endosome"},{"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-0645","category":"Molecular function","name":"Protease"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0729","category":"Domain","name":"SH3-binding"},{"id":"KW-0788","category":"Molecular function","name":"Thiol protease"},{"id":"KW-0832","category":"PTM","name":"Ubl conjugation"},{"id":"KW-0833","category":"Biological process","name":"Ubl conjugation pathway"}],"references":[{"referenceNumber":1,"citation":{"id":"7584044","citationType":"journal article","authors":["Nomura N.","Nagase T.","Miyajima N.","Sazuka T.","Tanaka A.","Sato S.","Seki N.","Kawarabayasi Y.","Ishikawa K.","Tabata S."],"citationCrossReferences":[{"database":"PubMed","id":"7584044"},{"database":"DOI","id":"10.1093/dnares/1.5.223"}],"title":"Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1.","publicationDate":"1994","journal":"DNA Res.","firstPage":"223","lastPage":"229","volume":"1"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"],"referenceComments":[{"value":"Bone marrow","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)"],"referenceComments":[{"value":"Thalamus","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"17974005","citationType":"journal article","authors":["Bechtel S.","Rosenfelder H.","Duda A.","Schmidt C.P.","Ernst U.","Wellenreuther R.","Mehrle A.","Schuster C.","Bahr A.","Bloecker H.","Heubner D.","Hoerlein A.","Michel G.","Wedler H.","Koehrer K.","Ottenwaelder B.","Poustka A.","Wiemann S.","Schupp I."],"citationCrossReferences":[{"database":"PubMed","id":"17974005"},{"database":"DOI","id":"10.1186/1471-2164-8-399"}],"title":"The full-ORF clone resource of the German cDNA consortium.","publicationDate":"2007","journal":"BMC Genomics","firstPage":"399","lastPage":"399","volume":"8"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"],"referenceComments":[{"value":"Testis","type":"TISSUE"}]},{"referenceNumber":4,"citation":{"id":"16572171","citationType":"journal article","authors":["Zody M.C.","Garber M.","Sharpe T.","Young S.K.","Rowen L.","O'Neill K.","Whittaker C.A.","Kamal M.","Chang J.L.","Cuomo C.A.","Dewar K.","FitzGerald M.G.","Kodira C.D.","Madan A.","Qin S.","Yang X.","Abbasi N.","Abouelleil A.","Arachchi H.M.","Baradarani L.","Birditt B.","Bloom S.","Bloom T.","Borowsky M.L.","Burke J.","Butler J.","Cook A.","DeArellano K.","DeCaprio D.","Dorris L. III","Dors M.","Eichler E.E.","Engels R.","Fahey J.","Fleetwood P.","Friedman C.","Gearin G.","Hall J.L.","Hensley G.","Johnson E.","Jones C.","Kamat A.","Kaur A.","Locke D.P.","Madan A.","Munson G.","Jaffe D.B.","Lui A.","Macdonald P.","Mauceli E.","Naylor J.W.","Nesbitt R.","Nicol R.","O'Leary S.B.","Ratcliffe A.","Rounsley S.","She X.","Sneddon K.M.B.","Stewart S.","Sougnez C.","Stone S.M.","Topham K.","Vincent D.","Wang S.","Zimmer A.R.","Birren B.W.","Hood L.","Lander E.S.","Nusbaum C."],"citationCrossReferences":[{"database":"PubMed","id":"16572171"},{"database":"DOI","id":"10.1038/nature04601"}],"title":"Analysis of the DNA sequence and duplication history of human chromosome 15.","publicationDate":"2006","journal":"Nature","firstPage":"671","lastPage":"675","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":5,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"],"referenceComments":[{"value":"Lung","type":"TISSUE"},{"value":"Lymph","type":"TISSUE"}]},{"referenceNumber":6,"citation":{"id":"9628861","citationType":"journal article","authors":["Naviglio S.","Mattecucci C.","Matoskova B.","Nagase T.","Nomura N.","Di Fiore P.P.","Draetta G.F."],"citationCrossReferences":[{"database":"PubMed","id":"9628861"},{"database":"DOI","id":"10.1093/emboj/17.12.3241"}],"title":"UBPY: a growth-regulated human ubiquitin isopeptidase.","publicationDate":"1998","journal":"EMBO J.","firstPage":"3241","lastPage":"3250","volume":"17"},"referencePositions":["FUNCTION","CATALYTIC ACTIVITY","INDUCTION"]},{"referenceNumber":7,"citation":{"id":"16520378","citationType":"journal article","authors":["Row P.E.","Prior I.A.","McCullough J.","Clague M.J.","Urbe S."],"citationCrossReferences":[{"database":"PubMed","id":"16520378"},{"database":"DOI","id":"10.1074/jbc.m512615200"}],"title":"The ubiquitin isopeptidase UBPY regulates endosomal ubiquitin dynamics and is essential for receptor down-regulation.","publicationDate":"2006","journal":"J. Biol. Chem.","firstPage":"12618","lastPage":"12624","volume":"281"},"referencePositions":["FUNCTION","SUBCELLULAR LOCATION","MUTAGENESIS OF CYS-786"]},{"referenceNumber":8,"citation":{"id":"16964243","citationType":"journal article","authors":["Beausoleil S.A.","Villen J.","Gerber S.A.","Rush J.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"16964243"},{"database":"DOI","id":"10.1038/nbt1240"}],"title":"A probability-based approach for high-throughput protein phosphorylation analysis and site localization.","publicationDate":"2006","journal":"Nat. Biotechnol.","firstPage":"1285","lastPage":"1292","volume":"24"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":9,"citation":{"id":"17711858","citationType":"journal article","authors":["Row P.E.","Liu H.","Hayes S.","Welchman R.","Charalabous P.","Hofmann K.","Clague M.J.","Sanderson C.M.","Urbe S."],"citationCrossReferences":[{"database":"PubMed","id":"17711858"},{"database":"DOI","id":"10.1074/jbc.m704009200"}],"title":"The MIT domain of UBPY constitutes a CHMP binding and endosomal localization signal required for efficient epidermal growth factor receptor degradation.","publicationDate":"2007","journal":"J. Biol. Chem.","firstPage":"30929","lastPage":"30937","volume":"282"},"referencePositions":["DOMAIN","INTERACTION WITH CHMP1A; CHMP1B AND CHMP7","FUNCTION","SUBCELLULAR LOCATION"]},{"referenceNumber":10,"citation":{"id":"18329369","citationType":"journal article","authors":["Pohl C.","Jentsch S."],"citationCrossReferences":[{"database":"PubMed","id":"18329369"},{"database":"DOI","id":"10.1016/j.cell.2008.01.012"}],"title":"Final stages of cytokinesis and midbody ring formation are controlled by BRUCE.","publicationDate":"2008","journal":"Cell","firstPage":"832","lastPage":"845","volume":"132"},"referencePositions":["FUNCTION","INTERACTION WITH BIRC6/BRUCE AND KIF23/MKLP1"]},{"referenceNumber":11,"citation":{"id":"18669648","citationType":"journal article","authors":["Dephoure N.","Zhou C.","Villen J.","Beausoleil S.A.","Bakalarski C.E.","Elledge S.J.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"18669648"},{"database":"DOI","id":"10.1073/pnas.0805139105"}],"title":"A quantitative atlas of mitotic phosphorylation.","publicationDate":"2008","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"10762","lastPage":"10767","volume":"105"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-452; SER-718 AND SER-719","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":12,"citation":{"id":"19413330","citationType":"journal article","authors":["Gauci S.","Helbig A.O.","Slijper M.","Krijgsveld J.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"19413330"},{"database":"DOI","id":"10.1021/ac9004309"}],"title":"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.","publicationDate":"2009","journal":"Anal. Chem.","firstPage":"4493","lastPage":"4501","volume":"81"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":13,"citation":{"id":"19427866","citationType":"journal article","authors":["Waters S.","Marchbank K.","Solomon E.","Whitehouse C.","Gautel M."],"citationCrossReferences":[{"database":"PubMed","id":"19427866"},{"database":"DOI","id":"10.1016/j.febslet.2009.04.049"}],"title":"Interactions with LC3 and polyubiquitin chains link nbr1 to autophagic protein turnover.","publicationDate":"2009","journal":"FEBS Lett.","firstPage":"1846","lastPage":"1852","volume":"583"},"referencePositions":["INTERACTION WITH NBR1","SUBCELLULAR LOCATION"]},{"referenceNumber":14,"citation":{"id":"19129480","citationType":"journal article","authors":["Agromayor M.","Carlton J.G.","Phelan J.P.","Matthews D.R.","Carlin L.M.","Ameer-Beg S.","Bowers K.","Martin-Serrano J."],"citationCrossReferences":[{"database":"PubMed","id":"19129480"},{"database":"DOI","id":"10.1091/mbc.e08-05-0474"}],"title":"Essential role of hIST1 in cytokinesis.","publicationDate":"2009","journal":"Mol. Biol. Cell","firstPage":"1374","lastPage":"1387","volume":"20"},"referencePositions":["INTERACTION WITH IST1"]},{"referenceNumber":15,"citation":{"id":"19690332","citationType":"journal article","authors":["Mayya V.","Lundgren D.H.","Hwang S.-I.","Rezaul K.","Wu L.","Eng J.K.","Rodionov V.","Han D.K."],"citationCrossReferences":[{"database":"PubMed","id":"19690332"},{"database":"DOI","id":"10.1126/scisignal.2000007"}],"title":"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.","publicationDate":"2009","journal":"Sci. Signal.","firstPage":"RA46","lastPage":"RA46","volume":"2"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Leukemic T-cell","type":"TISSUE"}]},{"referenceNumber":16,"citation":{"id":"20068231","citationType":"journal article","authors":["Olsen J.V.","Vermeulen M.","Santamaria A.","Kumar C.","Miller M.L.","Jensen L.J.","Gnad F.","Cox J.","Jensen T.S.","Nigg E.A.","Brunak S.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"20068231"},{"database":"DOI","id":"10.1126/scisignal.2000475"}],"title":"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.","publicationDate":"2010","journal":"Sci. Signal.","firstPage":"RA3","lastPage":"RA3","volume":"3"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-160 AND SER-718","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":17,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Buerckstuemmer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":18,"citation":{"id":"21406692","citationType":"journal article","authors":["Rigbolt K.T.","Prokhorova T.A.","Akimov V.","Henningsen J.","Johansen P.T.","Kratchmarova I.","Kassem M.","Mann M.","Olsen J.V.","Blagoev B."],"citationCrossReferences":[{"database":"PubMed","id":"21406692"},{"database":"DOI","id":"10.1126/scisignal.2001570"}],"title":"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.","publicationDate":"2011","journal":"Sci. Signal.","firstPage":"RS3","lastPage":"RS3","volume":"4"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-577 AND SER-718","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":19,"citation":{"id":"23186163","citationType":"journal article","authors":["Zhou H.","Di Palma S.","Preisinger C.","Peng M.","Polat A.N.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"23186163"},{"database":"DOI","id":"10.1021/pr300630k"}],"title":"Toward a comprehensive characterization of a human cancer cell phosphoproteome.","publicationDate":"2013","journal":"J. Proteome Res.","firstPage":"260","lastPage":"271","volume":"12"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-160; SER-392; SER-400; SER-452; THR-577 AND SER-718","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"},{"value":"Erythroleukemia","type":"TISSUE"}]},{"referenceNumber":20,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":21,"citation":{"id":"27302062","citationType":"journal article","authors":["Yeates E.F.","Tesco G."],"citationCrossReferences":[{"database":"PubMed","id":"27302062"},{"database":"DOI","id":"10.1074/jbc.m116.718023"}],"title":"The Endosome-associated Deubiquitinating Enzyme USP8 Regulates BACE1 Enzyme Ubiquitination and Degradation.","publicationDate":"2016","journal":"J. Biol. Chem.","firstPage":"15753","lastPage":"15766","volume":"291"},"referencePositions":["FUNCTION"]},{"referenceNumber":22,"citation":{"id":"30065070","citationType":"journal article","authors":["Zheng Y.","Liu Q.","Wu Y.","Ma L.","Zhang Z.","Liu T.","Jin S.","She Y.","Li Y.P.","Cui J."],"citationCrossReferences":[{"database":"PubMed","id":"30065070"},{"database":"DOI","id":"10.15252/embj.201899347"}],"title":"Zika virus elicits inflammation to evade antiviral response by cleaving cGAS via NS1-caspase-1 axis.","publicationDate":"2018","journal":"EMBO J.","firstPage":"0","lastPage":"0","volume":"37"},"referencePositions":["INTERACTION WITH ZIKA VIRUS NON-STRUCTURAL PROTEIN 1 (MICROBIAL INFECTION)"]},{"referenceNumber":23,"citation":{"id":"CI-ENANV4NUPFSB5","citationType":"submission","authoringGroup":["RIKEN structural genomics initiative (RSGI)"],"title":"Solution structure of the rhodanese-like domain in human ubiquitin specific protease 8 (UBP8).","publicationDate":"NOV-2004","submissionDatabase":"PDB data bank"},"referencePositions":["STRUCTURE BY NMR OF 174-317"]},{"referenceNumber":24,"citation":{"id":"17035239","citationType":"journal article","authors":["Avvakumov G.V.","Walker J.R.","Xue S.","Finerty P.J. Jr.","Mackenzie F.","Newman E.M.","Dhe-Paganon S."],"citationCrossReferences":[{"database":"PubMed","id":"17035239"},{"database":"DOI","id":"10.1074/jbc.m606704200"}],"title":"Amino-terminal dimerization, NRDP1-rhodanese interaction, and inhibited catalytic domain conformation of the ubiquitin-specific protease 8 (USP8).","publicationDate":"2006","journal":"J. Biol. Chem.","firstPage":"38061","lastPage":"38070","volume":"281"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 181-318 IN COMPLEX WITH RNF41"]},{"referenceNumber":25,"citation":{"id":"24482476","citationType":"journal article","authors":["Novarino G.","Fenstermaker A.G.","Zaki M.S.","Hofree M.","Silhavy J.L.","Heiberg A.D.","Abdellateef M.","Rosti B.","Scott E.","Mansour L.","Masri A.","Kayserili H.","Al-Aama J.Y.","Abdel-Salam G.M.","Karminejad A.","Kara M.","Kara B.","Bozorgmehri B.","Ben-Omran T.","Mojahedi F.","Mahmoud I.G.","Bouslam N.","Bouhouche A.","Benomar A.","Hanein S.","Raymond L.","Forlani S.","Mascaro M.","Selim L.","Shehata N.","Al-Allawi N.","Bindu P.S.","Azam M.","Gunel M.","Caglayan A.","Bilguvar K.","Tolun A.","Issa M.Y.","Schroth J.","Spencer E.G.","Rosti R.O.","Akizu N.","Vaux K.K.","Johansen A.","Koh A.A.","Megahed H.","Durr A.","Brice A.","Stevanin G.","Gabriel S.B.","Ideker T.","Gleeson J.G."],"citationCrossReferences":[{"database":"PubMed","id":"24482476"},{"database":"DOI","id":"10.1126/science.1247363"}],"title":"Exome sequencing links corticospinal motor neuron disease to common neurodegenerative disorders.","publicationDate":"2014","journal":"Science","firstPage":"506","lastPage":"511","volume":"343"},"referencePositions":["VARIANT LYS-310"]},{"referenceNumber":26,"citation":{"id":"28505279","citationType":"journal article","authors":["Faucz F.R.","Tirosh A.","Tatsi C.","Berthon A.","Hernandez-Ramirez L.C.","Settas N.","Angelousi A.","Correa R.","Papadakis G.Z.","Chittiboina P.","Quezado M.","Pankratz N.","Lane J.","Dimopoulos A.","Mills J.L.","Lodish M.","Stratakis C.A."],"citationCrossReferences":[{"database":"PubMed","id":"28505279"},{"database":"DOI","id":"10.1210/jc.2017-00161"}],"title":"Somatic USP8 gene mutations are a common cause of pediatric Cushing disease.","publicationDate":"2017","journal":"J. Clin. Endocrinol. Metab.","firstPage":"2836","lastPage":"2843","volume":"102"},"referencePositions":["VARIANTS PITA4 718-SER--THR-723 DEL; CYS-718; PRO-718; SER-718 DEL AND ARG-720","CHARACTERIZATION OF VARIANT PITA4 PRO-718","SUBCELLULAR LOCATION"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"D29956","properties":[{"key":"ProteinId","value":"BAA06225.2"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK296480","properties":[{"key":"ProteinId","value":"BAG59120.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BX537420","properties":[{"key":"ProteinId","value":"CAD97662.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AC012170","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC038801","properties":[{"key":"ProteinId","value":"AAH38801.1"},{"key":"Status","value":"ALT_SEQ"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC051345","properties":[{"key":"ProteinId","value":"AAH51345.1"},{"key":"Status","value":"ALT_SEQ"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC110590","properties":[{"key":"ProteinId","value":"AAI10591.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS10137.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P40818-1"},{"database":"CCDS","id":"CCDS61632.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P40818-2"},{"database":"RefSeq","id":"NP_001122082.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001128610.3"}],"isoformId":"P40818-1"},{"database":"RefSeq","id":"NP_001269978.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001283049.2"}],"isoformId":"P40818-2"},{"database":"RefSeq","id":"NP_005145.3","properties":[{"key":"NucleotideSequenceId","value":"NM_005154.5"}],"isoformId":"P40818-1"},{"database":"PDB","id":"1WHB","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=174-317"}]},{"database":"PDB","id":"2A9U","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.10 A"},{"key":"Chains","value":"A/B=1-142"}]},{"database":"PDB","id":"2GFO","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"A=734-1110"}]},{"database":"PDB","id":"2GWF","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.30 A"},{"key":"Chains","value":"A/C/E=181-318"}]},{"database":"PDB","id":"3N3K","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.60 A"},{"key":"Chains","value":"A=734-1110"}]},{"database":"PDB","id":"6F09","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.59 A"},{"key":"Chains","value":"A/B/C/D=712-724"}]},{"database":"PDB","id":"8ADM","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.70 A"},{"key":"Chains","value":"P=715-722"}]},{"database":"PDB","id":"8XPN","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.10 A"},{"key":"Chains","value":"A/B/C=734-1110"}]},{"database":"PDB","id":"8Y9A","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.10 A"},{"key":"Chains","value":"A=1-142"}]},{"database":"PDBsum","id":"1WHB","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2A9U","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2GFO","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2GWF","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3N3K","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6F09","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8ADM","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8XPN","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8Y9A","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"P40818","properties":[{"key":"Description","value":"-"}]},{"database":"MDRepo","id":"P40818","properties":[{"key":"Description","value":"-"}]},{"database":"SASBDB","id":"P40818","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P40818","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"114555","properties":[{"key":"Interactions","value":"171"}]},{"database":"CORUM","id":"P40818","properties":[{"key":"Description","value":"-"}]},{"database":"DIP","id":"DIP-40365N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"P40818","properties":[{"key":"Number of interactors","value":"2457"}]},{"database":"IntAct","id":"P40818","properties":[{"key":"Interactions","value":"60"}]},{"database":"MINT","id":"P40818","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-USP8","properties":[{"key":"Evidences","value":"4 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000379721","properties":[{"key":"Description","value":"-"}]},{"database":"BindingDB","id":"P40818","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL2157854","properties":[{"key":"Description","value":"-"}]},{"database":"GuidetoPHARMACOLOGY","id":"3209","properties":[{"key":"Description","value":"-"}]},{"database":"MEROPS","id":"C19.011","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"P40818","properties":[{"key":"glycosylation","value":"3 sites, 1 O-linked glycan (2 sites)"}]},{"database":"iPTMnet","id":"P40818","properties":[{"key":"Description","value":"-"}]},{"database":"MetOSite","id":"P40818","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"P40818","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"P40818","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"USP8","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"731046","properties":[{"key":"Description","value":"-"}]},{"database":"CPTAC","id":"CPTAC-1733","properties":[{"key":"Description","value":"-"}]},{"database":"CPTAC","id":"CPTAC-1734","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"P40818","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"P40818","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000379721","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"P40818","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"4442","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"55380","properties":[{"key":"Description","value":"-"}],"isoformId":"P40818-1"},{"database":"Pumba","id":"P40818","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"1385","properties":[{"key":"antibodies","value":"277 antibodies from 29 providers"}]},{"database":"DNASU","id":"9101","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000307179.9","properties":[{"key":"ProteinId","value":"ENSP00000302239.4"},{"key":"GeneId","value":"ENSG00000138592.16"}],"isoformId":"P40818-1"},{"database":"Ensembl","id":"ENST00000396444.7","properties":[{"key":"ProteinId","value":"ENSP00000379721.3"},{"key":"GeneId","value":"ENSG00000138592.16"}],"isoformId":"P40818-1"},{"database":"Ensembl","id":"ENST00000425032.7","properties":[{"key":"ProteinId","value":"ENSP00000412682.3"},{"key":"GeneId","value":"ENSG00000138592.16"}],"isoformId":"P40818-2"},{"database":"Ensembl","id":"ENST00000919051.1","properties":[{"key":"ProteinId","value":"ENSP00000589110.1"},{"key":"GeneId","value":"ENSG00000138592.16"}],"isoformId":"P40818-1"},{"database":"Ensembl","id":"ENST00000919052.1","properties":[{"key":"ProteinId","value":"ENSP00000589111.1"},{"key":"GeneId","value":"ENSG00000138592.16"}],"isoformId":"P40818-1"},{"database":"GeneID","id":"9101","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:9101","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000307179.9","properties":[{"key":"ProteinId","value":"ENSP00000302239.4"},{"key":"RefSeqNucleotideId","value":"NM_005154.5"},{"key":"RefSeqProteinId","value":"NP_005145.3"}]},{"database":"UCSC","id":"uc001zyl.6","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"P40818-1"},{"database":"AGR","id":"HGNC:12631","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA37256","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"9101","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"9101","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"USP8","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:12631","properties":[{"key":"GeneName","value":"USP8"}]},{"database":"HPA","id":"ENSG00000138592","properties":[{"key":"ExpressionPatterns","value":"Low tissue specificity"}]},{"database":"MalaCards","id":"USP8","properties":[{"key":"Description","value":"-"}]},{"database":"MIM","id":"219090","properties":[{"key":"Type","value":"phenotype"}]},{"database":"MIM","id":"603158","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000138592","properties":[{"key":"Description","value":"-"}]},{"database":"Orphanet","id":"401795","properties":[{"key":"Disease","value":"Autosomal recessive spastic paraplegia type 59"}]},{"database":"Orphanet","id":"96253","properties":[{"key":"Disease","value":"Cushing disease"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000138592","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG1868","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000157542","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_009980_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P40818","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"YKYDDHE","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"292964at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"P40818","properties":[{"key":"Number of GO annotations","value":"6 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"P40818","properties":[{"key":"Description","value":"-"}]},{"database":"BRENDA","id":"3.4.19.12","properties":[{"key":"OrganismId","value":"2681"}]},{"database":"PathwayCommons","id":"P40818","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-1358803","properties":[{"key":"PathwayName","value":"Downregulation of ERBB2:ERBB3 signaling"}]},{"database":"Reactome","id":"R-HSA-4641263","properties":[{"key":"PathwayName","value":"Regulation of FZD by ubiquitination"}]},{"database":"Reactome","id":"R-HSA-5689880","properties":[{"key":"PathwayName","value":"Ub-specific processing proteases"}]},{"database":"Reactome","id":"R-HSA-6807004","properties":[{"key":"PathwayName","value":"Negative regulation of MET activity"}]},{"database":"SignaLink","id":"P40818","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"P40818","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000138592","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"9101","properties":[{"key":"hits","value":"564 hits in 1172 CRISPR screens"}]},{"database":"ChiTaRS","id":"USP8","properties":[{"key":"OrganismName","value":"human"}]},{"database":"EvolutionaryTrace","id":"P40818","properties":[{"key":"Description","value":"-"}]},{"database":"GeneWiki","id":"USP8","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"9101","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"P40818","properties":[{"key":"DevelopmentLevel","value":"Tchem"}]},{"database":"PRO","id":"PR:P40818","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 15"}]},{"database":"RNAct","id":"P40818","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000138592","properties":[{"key":"ExpressionPatterns","value":"Expressed in calcaneal tendon and 195 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"P40818","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0002080","properties":[{"key":"GoTerm","value":"C:acrosomal membrane"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18388320"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16520378"}]},{"database":"GO","id":"GO:0005769","properties":[{"key":"GoTerm","value":"C:early endosome"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16520378"}]},{"database":"GO","id":"GO:0010008","properties":[{"key":"GoTerm","value":"C:endosome membrane"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16520378"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17711858"}]},{"database":"GO","id":"GO:0098978","properties":[{"key":"GoTerm","value":"C:glutamatergic synapse"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0030496","properties":[{"key":"GoTerm","value":"C:midbody"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18388320"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16520378"}]},{"database":"GO","id":"GO:0014069","properties":[{"key":"GoTerm","value":"C:postsynaptic density"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0045296","properties":[{"key":"GoTerm","value":"F:cadherin binding"},{"key":"GoEvidenceType","value":"HDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"25468996"}]},{"database":"GO","id":"GO:0004843","properties":[{"key":"GoTerm","value":"F:cysteine-type deubiquitinase activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16520378"}]},{"database":"GO","id":"GO:0004197","properties":[{"key":"GoTerm","value":"F:cysteine-type endopeptidase activity"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"9827704"}]},{"database":"GO","id":"GO:1990380","properties":[{"key":"GoTerm","value":"F:K48-linked deubiquitinase activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16520378"}]},{"database":"GO","id":"GO:0061578","properties":[{"key":"GoTerm","value":"F:K63-linked deubiquitinase activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16520378"}]},{"database":"GO","id":"GO:0071549","properties":[{"key":"GoTerm","value":"P:cellular response to dexamethasone stimulus"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:1990090","properties":[{"key":"GoTerm","value":"P:cellular response to nerve growth factor stimulus"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0007032","properties":[{"key":"GoTerm","value":"P:endosome organization"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0000281","properties":[{"key":"GoTerm","value":"P:mitotic cytokinesis"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"18388320"}]},{"database":"GO","id":"GO:1905166","properties":[{"key":"GoTerm","value":"P:negative regulation of lysosomal protein catabolic process"},{"key":"GoEvidenceType","value":"IMP:FlyBase"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"27444016"}]},{"database":"GO","id":"GO:1905908","properties":[{"key":"GoTerm","value":"P:positive regulation of amyloid fibril formation"},{"key":"GoEvidenceType","value":"IMP:FlyBase"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"27444016"}]},{"database":"GO","id":"GO:0090263","properties":[{"key":"GoTerm","value":"P:positive regulation of canonical Wnt signaling pathway"},{"key":"GoEvidenceType","value":"IMP:FlyBase"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"20495530"}]},{"database":"GO","id":"GO:0016579","properties":[{"key":"GoTerm","value":"P:protein deubiquitination"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"27302062"}]},{"database":"GO","id":"GO:0071108","properties":[{"key":"GoTerm","value":"P:protein K48-linked deubiquitination"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16520378"}]},{"database":"GO","id":"GO:0070536","properties":[{"key":"GoTerm","value":"P:protein K63-linked deubiquitination"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16520378"}]},{"database":"GO","id":"GO:0007265","properties":[{"key":"GoTerm","value":"P:Ras protein signal transduction"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0099576","properties":[{"key":"GoTerm","value":"P:regulation of protein catabolic process at postsynapse, modulating synaptic transmission"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0032880","properties":[{"key":"GoTerm","value":"P:regulation of protein localization"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"27302062"}]},{"database":"GO","id":"GO:0031647","properties":[{"key":"GoTerm","value":"P:regulation of protein stability"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"27302062"}]},{"database":"CDD","id":"cd02674","properties":[{"key":"EntryName","value":"Peptidase_C19R"},{"key":"MatchStatus","value":"1"}]},{"database":"DisProt","id":"DP03012","properties":[{"key":"Description","value":"-"}]},{"database":"FunFam","id":"3.90.70.10:FF:000025","properties":[{"key":"EntryName","value":"Putative ubiquitin carboxyl-terminal hydrolase 8"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.80:FF:000011","properties":[{"key":"EntryName","value":"Ubiquitin carboxyl-terminal hydrolase 8"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.250.10:FF:000017","properties":[{"key":"EntryName","value":"ubiquitin carboxyl-terminal hydrolase 8"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.90.70.10","properties":[{"key":"EntryName","value":"Cysteine proteinases"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.58.80","properties":[{"key":"EntryName","value":"Phosphotransferase system, lactose/cellobiose-type IIA subunit"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.250.10","properties":[{"key":"EntryName","value":"Rhodanese-like domain"},{"key":"MatchStatus","value":"1"}]},{"database":"IDEAL","id":"IID00801","properties":[{"key":"Description","value":"-"}]},{"database":"InterPro","id":"IPR038765","properties":[{"key":"EntryName","value":"Papain-like_cys_pep_sf"}]},{"database":"InterPro","id":"IPR001394","properties":[{"key":"EntryName","value":"Peptidase_C19_UCH"}]},{"database":"InterPro","id":"IPR001763","properties":[{"key":"EntryName","value":"Rhodanese-like_dom"}]},{"database":"InterPro","id":"IPR036873","properties":[{"key":"EntryName","value":"Rhodanese-like_dom_sf"}]},{"database":"InterPro","id":"IPR050185","properties":[{"key":"EntryName","value":"Ub_carboxyl-term_hydrolase"}]},{"database":"InterPro","id":"IPR028889","properties":[{"key":"EntryName","value":"USP"}]},{"database":"InterPro","id":"IPR015063","properties":[{"key":"EntryName","value":"USP8_dimer"}]},{"database":"InterPro","id":"IPR018200","properties":[{"key":"EntryName","value":"USP_CS"}]},{"database":"InterPro","id":"IPR048498","properties":[{"key":"EntryName","value":"WW_USP8"}]},{"database":"PANTHER","id":"PTHR21646","properties":[{"key":"EntryName","value":"UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR21646:SF27","properties":[{"key":"EntryName","value":"UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 8"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00581","properties":[{"key":"EntryName","value":"Rhodanese"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00443","properties":[{"key":"EntryName","value":"UCH"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08969","properties":[{"key":"EntryName","value":"USP8_dimer"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF20625","properties":[{"key":"EntryName","value":"WW_USP8"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF54001","properties":[{"key":"EntryName","value":"Cysteine proteinases"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52821","properties":[{"key":"EntryName","value":"Rhodanese/Cell cycle control phosphatase"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF140856","properties":[{"key":"EntryName","value":"USP8 N-terminal domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50206","properties":[{"key":"EntryName","value":"RHODANESE_3"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00972","properties":[{"key":"EntryName","value":"USP_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00973","properties":[{"key":"EntryName","value":"USP_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50235","properties":[{"key":"EntryName","value":"USP_3"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MPAVASVPKELYLSSSLKDLNKKTEVKPEKISTKSYVHSALKIFKTAEECRLDRDEERAYVLYMKYVTVYNLIKKRPDFKQQQDYFHSILGPGNIKKAVEEAERLSESLKLRYEEAEVRKKLEEKDRQEEAQRLQQKRQETGREDGGTLAKGSLENVLDSKDKTQKSNGEKNEKCETKEKGAITAKELYTMMTDKNISLIIMDARRMQDYQDSCILHSLSVPEEAISPGVTASWIEAHLPDDSKDTWKKRGNVEYVVLLDWFSSAKDLQIGTTLRSLKDALFKWESKTVLRNEPLVLEGGYENWLLCYPQYTTNAKVTPPPRRQNEEVSISLDFTYPSLEESIPSKPAAQTPPASIEVDENIELISGQNERMGPLNISTPVEPVAASKSDVSPIIQPVPSIKNVPQIDRTKKPAVKLPEEHRIKSESTNHEQQSPQSGKVIPDRSTKPVVFSPTLMLTDEEKARIHAETALLMEKNKQEKELRERQQEEQKEKLRKEEQEQKAKKKQEAEENEITEKQQKAKEEMEKKESEQAKKEDKETSAKRGKEITGVKRQSKSEHETSDAKKSVEDRGKRCPTPEIQKKSTGDVPHTSVTGDSGSGKPFKIKGQPESGILRTGTFREDTDDTERNKAQREPLTRARSEEMGRIVPGLPSGWAKFLDPITGTFRYYHSPTNTVHMYPPEMAPSSAPPSTPPTHKAKPQIPAERDREPSKLKRSYSSPDITQAIQEEEKRKPTVTPTVNRENKPTCYPKAEISRLSASQIRNLNPVFGGSGPALTGLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKGEVAEEFGIIMKALWTGQYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDLNKADNRKRYKEENNDHLDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAFMYLSLPLASTSKCTLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFSYDGRWKQKLQTSVDFPLENLDLSQYVIGPKNNLKKYNLFSVSNHYGGLDGGHYTAYCKNAARQRWFKFDDHEVSDISVSSVKSSAAYILFYTSLGPRVTDVAT","length":1118,"molWeight":127523,"crc64":"8B884B7A842F9A9A","md5":"595327C21D3546627C47C8D4634C0FE0"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"SUBUNIT":2,"INTERACTION":9,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":2,"INDUCTION":1,"DOMAIN":2,"PTM":2,"DISEASE":1,"SIMILARITY":1,"SEQUENCE CAUTION":2},"countByFeatureType":{"Chain":1,"Domain":3,"Region":4,"Motif":1,"Compositional bias":6,"Active site":2,"Modified residue":8,"Alternative sequence":2,"Natural variant":9,"Mutagenesis":1,"Sequence conflict":3,"Helix":32,"Beta strand":25,"Turn":7},"uniParcId":"UPI0000030306"}}