{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P40182","uniProtkbId":"Y2127_STRCO","entryAudit":{"firstPublicDate":"1995-02-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1995-02-01","entryVersion":108,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)","taxonId":100226,"lineage":["Bacteria","Bacillati","Actinomycetota","Actinomycetes","Kitasatosporales","Streptomycetaceae","Streptomyces","Streptomyces albidoflavus group"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Uncharacterized protein SCO2127"}}},"genes":[{"orderedLocusNames":[{"value":"SCO2127"}],"orfNames":[{"value":"SC6E10.21c"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"1435260"}],"value":"May be involved in glucose transport or metabolism"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"1435260"}],"value":"It may form a heterotetramer of two glucokinase subunits (glk) with two ORF2 proteins"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1435260"}],"value":"Transcribed at low levels from its own promoter. Transcript includes downstream gene glk. Expressed when grown on glucose or galactose, levels decrease as cells enter stationary phase"}],"commentType":"INDUCTION"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":191,"modifier":"EXACT"}},"description":"Uncharacterized protein SCO2127","featureId":"PRO_0000205345"},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":42,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":145,"modifier":"EXACT"},"end":{"value":191,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":11,"modifier":"EXACT"},"end":{"value":26,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":147,"modifier":"EXACT"},"end":{"value":178,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"id":"KW-0119","category":"Biological process","name":"Carbohydrate metabolism"},{"id":"KW-0313","category":"Biological process","name":"Glucose metabolism"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0762","category":"Biological process","name":"Sugar transport"},{"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"1435260","citationType":"journal article","authors":["Angell S.","Schwarz E.","Bibb M.J."],"citationCrossReferences":[{"database":"PubMed","id":"1435260"},{"database":"DOI","id":"10.1111/j.1365-2958.1992.tb01463.x"}],"title":"The glucose kinase gene of Streptomyces coelicolor A3(2): its nucleotide sequence, transcriptional analysis and role in glucose repression.","publicationDate":"1992","journal":"Mol. Microbiol.","firstPage":"2833","lastPage":"2844","volume":"6"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]","POSSIBLE FUNCTION","POSSIBLE SUBUNIT","INDUCTION"],"referenceComments":[{"value":"A3(2) / NRRL B-16638","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"12000953","citationType":"journal article","authors":["Bentley S.D.","Chater K.F.","Cerdeno-Tarraga A.-M.","Challis G.L.","Thomson N.R.","James K.D.","Harris D.E.","Quail M.A.","Kieser H.","Harper D.","Bateman A.","Brown S.","Chandra G.","Chen C.W.","Collins M.","Cronin A.","Fraser A.","Goble A.","Hidalgo J.","Hornsby T.","Howarth S.","Huang C.-H.","Kieser T.","Larke L.","Murphy L.D.","Oliver K.","O'Neil S.","Rabbinowitsch E.","Rajandream M.A.","Rutherford K.M.","Rutter S.","Seeger K.","Saunders D.","Sharp S.","Squares R.","Squares S.","Taylor K.","Warren T.","Wietzorrek A.","Woodward J.R.","Barrell B.G.","Parkhill J.","Hopwood D.A."],"citationCrossReferences":[{"database":"PubMed","id":"12000953"},{"database":"DOI","id":"10.1038/417141a"}],"title":"Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).","publicationDate":"2002","journal":"Nature","firstPage":"141","lastPage":"147","volume":"417"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"ATCC BAA-471 / A3(2) / M145","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"X65932","properties":[{"key":"ProteinId","value":"CAA46726.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL939111","properties":[{"key":"ProteinId","value":"CAB51975.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"T35508","properties":[{"key":"EntryName","value":"T35508"}]},{"database":"RefSeq","id":"WP_011028152.1","properties":[{"key":"NucleotideSequenceId","value":"NC_003888.3"}]},{"database":"AlphaFoldDB","id":"P40182","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P40182","properties":[{"key":"Description","value":"-"}]},{"database":"STRING","id":"100226.gene:17759725","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"100226-gene:17759725","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"91386879","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"sco:SCO2127","properties":[{"key":"Description","value":"-"}]},{"database":"PATRIC","id":"fig|100226.15.peg.2162","properties":[{"key":"GeneDesignation","value":"-"}]},{"database":"eggNOG","id":"ENOG50340VK","properties":[{"key":"ToxonomicScope","value":"Bacteria"}]},{"database":"HOGENOM","id":"CLU_120031_0_0_11","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P40182","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"3853386at2","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000001973","properties":[{"key":"Component","value":"Chromosome"}]},{"database":"AbasyAtlas","id":"P40182","properties":[{"key":"Description","value":"-"}]},{"database":"InterPro","id":"IPR035183","properties":[{"key":"EntryName","value":"DUF5304"}]},{"database":"Pfam","id":"PF17230","properties":[{"key":"EntryName","value":"DUF5304"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSEELPPSEAPRPDEADAVDETRATGETRGAAQEPGASDADAWATACAEDLEAEKARRRAAYGPPPGSAAEELRRLVDTVADKLSGLQSPLLGQVAGPAAQQVVRQVVQQAKAAVEPVIERNPDLFDHLAAAGGELLAAYRSAVQNQERRWTTGDTAPKDPSDPRDLDERGTDGRDEGDGGTGPGQRIDLD","length":191,"molWeight":20131,"crc64":"7CF36B2A7AC20044","md5":"6E5335B8DD7521E908D06657961CECEA"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"INDUCTION":1},"countByFeatureType":{"Chain":1,"Region":2,"Compositional bias":2},"uniParcId":"UPI000013B7AC"}}