{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P39408","secondaryAccessions":["P78143","Q2M5T9"],"uniProtkbId":"YJJV_ECOLI","entryAudit":{"firstPublicDate":"1995-02-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1995-11-01","entryVersion":166,"sequenceVersion":2},"annotationScore":3.0,"organism":{"scientificName":"Escherichia coli (strain K12)","taxonId":83333,"lineage":["Bacteria","Pseudomonadati","Pseudomonadota","Gammaproteobacteria","Enterobacterales","Enterobacteriaceae","Escherichia"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Uncharacterized metal-dependent hydrolase YjjV"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"3.1.-.-"}]}},"genes":[{"geneName":{"value":"yjjV"},"orderedLocusNames":[{"value":"b4378"},{"value":"JW4341"}]}],"comments":[{"commentType":"COFACTOR","cofactors":[{"name":"a divalent metal cation","evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.4"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:60240"}}],"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.4"}],"value":"Binds 2 divalent metal cations per subunit."}]}},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P39408","intActId":"EBI-561387"},"interactantTwo":{"uniProtKBAccession":"P0CE47","geneName":"tufA","intActId":"EBI-301077"},"numberOfExperiments":2,"organismDiffer":false}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"AAA97274.1","note":"Truncated N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":259,"modifier":"EXACT"}},"description":"Uncharacterized metal-dependent hydrolase YjjV","featureId":"PRO_0000201999"},{"type":"Binding site","location":{"start":{"value":9,"modifier":"EXACT"},"end":{"value":9,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:60240"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.4"}],"ligand":{"name":"a divalent metal cation","id":"ChEBI:CHEBI:60240","label":"1"}},{"type":"Binding site","location":{"start":{"value":11,"modifier":"EXACT"},"end":{"value":11,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:60240"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.4"}],"ligand":{"name":"a divalent metal cation","id":"ChEBI:CHEBI:60240","label":"1"}},{"type":"Binding site","location":{"start":{"value":97,"modifier":"EXACT"},"end":{"value":97,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:60240"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.4"}],"ligand":{"name":"a divalent metal cation","id":"ChEBI:CHEBI:60240","label":"1"}},{"type":"Binding site","location":{"start":{"value":97,"modifier":"EXACT"},"end":{"value":97,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:60240"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.4"}],"ligand":{"name":"a divalent metal cation","id":"ChEBI:CHEBI:60240","label":"2"}},{"type":"Binding site","location":{"start":{"value":133,"modifier":"EXACT"},"end":{"value":133,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:60240"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.4"}],"ligand":{"name":"a divalent metal cation","id":"ChEBI:CHEBI:60240","label":"2"}},{"type":"Binding site","location":{"start":{"value":157,"modifier":"EXACT"},"end":{"value":157,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:60240"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.4"}],"ligand":{"name":"a divalent metal cation","id":"ChEBI:CHEBI:60240","label":"2"}},{"type":"Binding site","location":{"start":{"value":207,"modifier":"EXACT"},"end":{"value":207,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:60240"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.4"}],"ligand":{"name":"a divalent metal cation","id":"ChEBI:CHEBI:60240","label":"1"}},{"type":"Beta strand","location":{"start":{"value":5,"modifier":"EXACT"},"end":{"value":8,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1ZZM"}]},{"type":"Turn","location":{"start":{"value":15,"modifier":"EXACT"},"end":{"value":19,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1ZZM"}]},{"type":"Helix","location":{"start":{"value":21,"modifier":"EXACT"},"end":{"value":30,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1ZZM"}]},{"type":"Beta strand","location":{"start":{"value":33,"modifier":"EXACT"},"end":{"value":39,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1ZZM"}]},{"type":"Helix","location":{"start":{"value":43,"modifier":"EXACT"},"end":{"value":45,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1ZZM"}]},{"type":"Helix","location":{"start":{"value":46,"modifier":"EXACT"},"end":{"value":55,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1ZZM"}]},{"type":"Beta strand","location":{"start":{"value":59,"modifier":"EXACT"},"end":{"value":63,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1ZZM"}]},{"type":"Helix","location":{"start":{"value":67,"modifier":"EXACT"},"end":{"value":72,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1ZZM"}]},{"type":"Helix","location":{"start":{"value":75,"modifier":"EXACT"},"end":{"value":87,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1ZZM"}]},{"type":"Beta strand","location":{"start":{"value":90,"modifier":"EXACT"},"end":{"value":101,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1ZZM"}]},{"type":"Helix","location":{"start":{"value":109,"modifier":"EXACT"},"end":{"value":125,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1ZZM"}]},{"type":"Beta strand","location":{"start":{"value":130,"modifier":"EXACT"},"end":{"value":136,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1ZZM"}]},{"type":"Helix","location":{"start":{"value":138,"modifier":"EXACT"},"end":{"value":148,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1ZZM"}]},{"type":"Beta strand","location":{"start":{"value":154,"modifier":"EXACT"},"end":{"value":156,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1ZZM"}]},{"type":"Helix","location":{"start":{"value":163,"modifier":"EXACT"},"end":{"value":171,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1ZZM"}]},{"type":"Beta strand","location":{"start":{"value":175,"modifier":"EXACT"},"end":{"value":178,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1ZZM"}]},{"type":"Helix","location":{"start":{"value":180,"modifier":"EXACT"},"end":{"value":183,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1ZZM"}]},{"type":"Turn","location":{"start":{"value":185,"modifier":"EXACT"},"end":{"value":187,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1ZZM"}]},{"type":"Helix","location":{"start":{"value":190,"modifier":"EXACT"},"end":{"value":196,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1ZZM"}]},{"type":"Helix","location":{"start":{"value":199,"modifier":"EXACT"},"end":{"value":201,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1ZZM"}]},{"type":"Beta strand","location":{"start":{"value":202,"modifier":"EXACT"},"end":{"value":204,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1ZZM"}]},{"type":"Helix","location":{"start":{"value":223,"modifier":"EXACT"},"end":{"value":225,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1ZZM"}]},{"type":"Helix","location":{"start":{"value":226,"modifier":"EXACT"},"end":{"value":236,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1ZZM"}]},{"type":"Helix","location":{"start":{"value":241,"modifier":"EXACT"},"end":{"value":256,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1ZZM"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"7610040","citationType":"journal article","authors":["Burland V.D.","Plunkett G. III","Sofia H.J.","Daniels D.L.","Blattner F.R."],"citationCrossReferences":[{"database":"PubMed","id":"7610040"},{"database":"DOI","id":"10.1093/nar/23.12.2105"}],"title":"Analysis of the Escherichia coli genome VI: DNA sequence of the region from 92.8 through 100 minutes.","publicationDate":"1995","journal":"Nucleic Acids Res.","firstPage":"2105","lastPage":"2119","volume":"23"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"K12 / MG1655 / ATCC 47076","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"9278503","citationType":"journal article","authors":["Blattner F.R.","Plunkett G. III","Bloch C.A.","Perna N.T.","Burland V.","Riley M.","Collado-Vides J.","Glasner J.D.","Rode C.K.","Mayhew G.F.","Gregor J.","Davis N.W.","Kirkpatrick H.A.","Goeden M.A.","Rose D.J.","Mau B.","Shao Y."],"citationCrossReferences":[{"database":"PubMed","id":"9278503"},{"database":"DOI","id":"10.1126/science.277.5331.1453"}],"title":"The complete genome sequence of Escherichia coli K-12.","publicationDate":"1997","journal":"Science","firstPage":"1453","lastPage":"1462","volume":"277"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"K12 / MG1655 / ATCC 47076","type":"STRAIN"}]},{"referenceNumber":3,"citation":{"id":"16738553","citationType":"journal article","authors":["Hayashi K.","Morooka N.","Yamamoto Y.","Fujita K.","Isono K.","Choi S.","Ohtsubo E.","Baba T.","Wanner B.L.","Mori H.","Horiuchi T."],"citationCrossReferences":[{"database":"PubMed","id":"16738553"},{"database":"DOI","id":"10.1038/msb4100049"}],"title":"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.","publicationDate":"2006","journal":"Mol. Syst. Biol.","firstPage":"E1","lastPage":"E5","volume":"2"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"K12 / W3110 / ATCC 27325 / DSM 5911","type":"STRAIN"}]},{"referenceNumber":4,"citation":{"id":"CI-2R897RTG739N6","citationType":"submission","authoringGroup":["New York structural genomics research consortium (NYSGRC)"],"title":"Crystal structure of yjjV, tatD homolog from Escherichia coli K12, at 1.8 A resolution.","publicationDate":"FEB-2009","submissionDatabase":"PDB data bank"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) IN COMPLEX WITH ZINC IONS"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"U14003","properties":[{"key":"ProteinId","value":"AAA97274.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"U00096","properties":[{"key":"ProteinId","value":"AAC77331.2"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AP009048","properties":[{"key":"ProteinId","value":"BAE78367.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"S56602","properties":[{"key":"EntryName","value":"S56602"}]},{"database":"RefSeq","id":"WP_000563040.1","properties":[{"key":"NucleotideSequenceId","value":"NZ_CP009789.1"}]},{"database":"RefSeq","id":"YP_026291.2","properties":[{"key":"NucleotideSequenceId","value":"NC_000913.3"}]},{"database":"PDB","id":"1ZZM","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"A=1-259"}]},{"database":"PDBsum","id":"1ZZM","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"P39408","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P39408","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"4261644","properties":[{"key":"Interactions","value":"74"}]},{"database":"DIP","id":"DIP-12661N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"P39408","properties":[{"key":"Number of interactors","value":"55"}]},{"database":"IntAct","id":"P39408","properties":[{"key":"Interactions","value":"4"}]},{"database":"STRING","id":"511145.b4378","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"P39408","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"511145-b4378","properties":[{"key":"Description","value":"-"}]},{"database":"EnsemblBacteria","id":"AAC77331","properties":[{"key":"ProteinId","value":"AAC77331"},{"key":"GeneId","value":"b4378"}]},{"database":"GeneID","id":"2847741","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"ecj:JW4341","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"eco:b4378","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"ecoc:C3026_23655","properties":[{"key":"Description","value":"-"}]},{"database":"PATRIC","id":"fig|511145.12.peg.4524","properties":[{"key":"GeneDesignation","value":"-"}]},{"database":"EchoBASE","id":"EB2483","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"COG0084","properties":[{"key":"ToxonomicScope","value":"Bacteria"}]},{"database":"HOGENOM","id":"CLU_031506_0_1_6","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P39408","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"HDAKSWE","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"9810005at2","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"P39408","properties":[{"key":"Description","value":"-"}]},{"database":"BioCyc","id":"EcoCyc:G7952-MONOMER","properties":[{"key":"Description","value":"-"}]},{"database":"EvolutionaryTrace","id":"P39408","properties":[{"key":"Description","value":"-"}]},{"database":"PRO","id":"PR:P39408","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000625","properties":[{"key":"Component","value":"Chromosome"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0016788","properties":[{"key":"GoTerm","value":"F:hydrolase activity, acting on ester bonds"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd01310","properties":[{"key":"EntryName","value":"TatD_DNAse"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.20.20.140:FF:000005","properties":[{"key":"EntryName","value":"TatD family hydrolase"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.20.20.140","properties":[{"key":"EntryName","value":"Metal-dependent hydrolases"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR018228","properties":[{"key":"EntryName","value":"DNase_TatD-rel_CS"}]},{"database":"InterPro","id":"IPR032466","properties":[{"key":"EntryName","value":"Metal_Hydrolase"}]},{"database":"InterPro","id":"IPR001130","properties":[{"key":"EntryName","value":"TatD-like"}]},{"database":"NCBIfam","id":"NF008522","properties":[{"key":"EntryName","value":"PRK11449.1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR46124","properties":[{"key":"EntryName","value":"D-AMINOACYL-TRNA DEACYLASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR46124:SF3","properties":[{"key":"EntryName","value":"HYDROLASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01026","properties":[{"key":"EntryName","value":"TatD_DNase"},{"key":"MatchStatus","value":"1"}]},{"database":"PIRSF","id":"PIRSF005902","properties":[{"key":"EntryName","value":"DNase_TatD"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF51556","properties":[{"key":"EntryName","value":"Metallo-dependent hydrolases"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS01137","properties":[{"key":"EntryName","value":"TATD_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS01090","properties":[{"key":"EntryName","value":"TATD_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS01091","properties":[{"key":"EntryName","value":"TATD_3"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MICRFIDTHCHFDFPPFSGDEEASLQRAAQAGVGKIIVPATEAENFARVLALAENYQPLYAALGLHPGMLEKHSDVSLEQLQQALERRPAKVVAVGEIGLDLFGDDPQFERQQWLLDEQLKLAKRYDLPVILHSRRTHDKLAMHLKRHDLPRTGVVHGFSGSLQQAERFVQLGYKIGVGGTITYPRASKTRDVIAKLPLASLLLETDAPDMPLNGFQGQPNRPEQAARVFAVLCELRREPADEIAQALLNNTYTLFNVP","length":259,"molWeight":28909,"crc64":"9BFB42FAA760DC67","md5":"957EBA51673707BEF346D48959C876EE"},"extraAttributes":{"countByCommentType":{"COFACTOR":1,"INTERACTION":1,"SIMILARITY":1,"SEQUENCE CAUTION":1},"countByFeatureType":{"Chain":1,"Binding site":7,"Beta strand":8,"Turn":2,"Helix":14},"uniParcId":"UPI000013B5D6"}}