{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P39165","secondaryAccessions":["P46124","P76022"],"uniProtkbId":"YCHO_ECOLI","entryAudit":{"firstPublicDate":"1995-02-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2007-06-26","entryVersion":136,"sequenceVersion":3},"annotationScore":2.0,"organism":{"scientificName":"Escherichia coli (strain K12)","taxonId":83333,"lineage":["Bacteria","Pseudomonadati","Pseudomonadota","Gammaproteobacteria","Enterobacterales","Enterobacteriaceae","Escherichia"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"value":"Uncharacterized protein YchO"}},"flag":"Precursor"},"genes":[{"geneName":{"value":"ychO"},"synonyms":[{"value":"ychP"}],"orderedLocusNames":[{"value":"b1220"},{"value":"JW1211"}]}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Periplasm","id":"SL-0200"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the intimin/invasin family"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Frameshift","sequence":"X69189","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":24,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Chain","location":{"start":{"value":25,"modifier":"EXACT"},"end":{"value":464,"modifier":"EXACT"}},"description":"Uncharacterized protein YchO","featureId":"PRO_0000211832"}],"keywords":[{"id":"KW-0574","category":"Cellular component","name":"Periplasm"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"8905232","citationType":"journal article","authors":["Oshima T.","Aiba H.","Baba T.","Fujita K.","Hayashi K.","Honjo A.","Ikemoto K.","Inada T.","Itoh T.","Kajihara M.","Kanai K.","Kashimoto K.","Kimura S.","Kitagawa M.","Makino K.","Masuda S.","Miki T.","Mizobuchi K.","Mori H.","Motomura K.","Nakamura Y.","Nashimoto H.","Nishio Y.","Saito N.","Sampei G.","Seki Y.","Tagami H.","Takemoto K.","Wada C.","Yamamoto Y.","Yano M.","Horiuchi T."],"citationCrossReferences":[{"database":"PubMed","id":"8905232"},{"database":"DOI","id":"10.1093/dnares/3.3.137"}],"title":"A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map.","publicationDate":"1996","journal":"DNA Res.","firstPage":"137","lastPage":"155","volume":"3"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"K12 / W3110 / ATCC 27325 / DSM 5911","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"9278503","citationType":"journal article","authors":["Blattner F.R.","Plunkett G. III","Bloch C.A.","Perna N.T.","Burland V.","Riley M.","Collado-Vides J.","Glasner J.D.","Rode C.K.","Mayhew G.F.","Gregor J.","Davis N.W.","Kirkpatrick H.A.","Goeden M.A.","Rose D.J.","Mau B.","Shao Y."],"citationCrossReferences":[{"database":"PubMed","id":"9278503"},{"database":"DOI","id":"10.1126/science.277.5331.1453"}],"title":"The complete genome sequence of Escherichia coli K-12.","publicationDate":"1997","journal":"Science","firstPage":"1453","lastPage":"1462","volume":"277"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"K12 / MG1655 / ATCC 47076","type":"STRAIN"}]},{"referenceNumber":3,"citation":{"id":"16738553","citationType":"journal article","authors":["Hayashi K.","Morooka N.","Yamamoto Y.","Fujita K.","Isono K.","Choi S.","Ohtsubo E.","Baba T.","Wanner B.L.","Mori H.","Horiuchi T."],"citationCrossReferences":[{"database":"PubMed","id":"16738553"},{"database":"DOI","id":"10.1038/msb4100049"}],"title":"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.","publicationDate":"2006","journal":"Mol. Syst. Biol.","firstPage":"E1","lastPage":"E5","volume":"2"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"K12 / W3110 / ATCC 27325 / DSM 5911","type":"STRAIN"}]},{"referenceNumber":4,"citation":{"id":"CI-9H61KLFQG7AEF","citationType":"submission","authors":["Ivey D.M.","Guffanti A.A.","Zemsky J.","Pinner E.","Karpel R.","Padan E.","Schuldiner S.","Krulwich T.A."],"publicationDate":"JUL-1994","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-37"],"referenceComments":[{"value":"NM8191","type":"STRAIN"}]},{"referenceNumber":5,"citation":{"id":"2657652","citationType":"journal article","authors":["Nohno T.","Noji S.","Taniguchi S.","Saito T."],"citationCrossReferences":[{"database":"PubMed","id":"2657652"},{"database":"DOI","id":"10.1093/nar/17.8.2947"}],"title":"The narX and narL genes encoding the nitrate-sensing regulators of Escherichia coli are homologous to a family of prokaryotic two-component regulatory genes.","publicationDate":"1989","journal":"Nucleic Acids Res.","firstPage":"2947","lastPage":"2957","volume":"17"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 306-417"],"referenceComments":[{"value":"K12","type":"STRAIN"}]},{"referenceNumber":6,"citation":{"id":"2649492","citationType":"journal article","authors":["Stewart V.","Parales J. Jr.","Merkel S.M."],"citationCrossReferences":[{"database":"PubMed","id":"2649492"},{"database":"DOI","id":"10.1128/jb.171.4.2229-2234.1989"}],"title":"Structure of genes narL and narX of the nar (nitrate reductase) locus in Escherichia coli K-12.","publicationDate":"1989","journal":"J. Bacteriol.","firstPage":"2229","lastPage":"2234","volume":"171"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 364-417"],"referenceComments":[{"value":"K12","type":"STRAIN"}]},{"referenceNumber":7,"citation":{"id":"7567469","citationType":"journal article","authors":["Borodovsky M.","McIninch J.","Koonin E.V.","Rudd K.E.","Medigue C.","Danchin A."],"citationCrossReferences":[{"database":"PubMed","id":"7567469"},{"database":"DOI","id":"10.1093/nar/23.17.3554"}],"title":"Detection of new genes in a bacterial genome using Markov models for three gene classes.","publicationDate":"1995","journal":"Nucleic Acids Res.","firstPage":"3554","lastPage":"3562","volume":"23"},"referencePositions":["IDENTIFICATION"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"U00096","properties":[{"key":"ProteinId","value":"AAC74304.2"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AP009048","properties":[{"key":"ProteinId","value":"BAA36088.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"L28709","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"X13360","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M24910","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"X69189","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"A64869","properties":[{"key":"EntryName","value":"A64869"}]},{"database":"RefSeq","id":"NP_415738.2","properties":[{"key":"NucleotideSequenceId","value":"NC_000913.3"}]},{"database":"RefSeq","id":"WP_000086217.1","properties":[{"key":"NucleotideSequenceId","value":"NZ_CP009789.1"}]},{"database":"AlphaFoldDB","id":"P39165","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P39165","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"4263269","properties":[{"key":"Interactions","value":"175"}]},{"database":"FunCoup","id":"P39165","properties":[{"key":"Number of interactors","value":"33"}]},{"database":"IntAct","id":"P39165","properties":[{"key":"Interactions","value":"7"}]},{"database":"STRING","id":"511145.b1220","properties":[{"key":"Description","value":"-"}]},{"database":"TCDB","id":"1.B.54.1.9","properties":[{"key":"FamilyName","value":"the intimin/invasin (int/inv) or autotransporter-3 (at-3) family"}]},{"database":"PaxDb","id":"511145-b1220","properties":[{"key":"Description","value":"-"}]},{"database":"EnsemblBacteria","id":"AAC74304","properties":[{"key":"ProteinId","value":"AAC74304"},{"key":"GeneId","value":"b1220"}]},{"database":"GeneID","id":"945801","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"ecj:JW1211","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"eco:b1220","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"ecoc:C3026_07175","properties":[{"key":"Description","value":"-"}]},{"database":"PATRIC","id":"fig|1411691.4.peg.1062","properties":[{"key":"GeneDesignation","value":"-"}]},{"database":"EchoBASE","id":"EB2305","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"COG4932","properties":[{"key":"ToxonomicScope","value":"Bacteria"}]},{"database":"HOGENOM","id":"CLU_000210_6_0_6","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P39165","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"YHNPVAV","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"8320584at2","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"P39165","properties":[{"key":"Description","value":"-"}]},{"database":"BioCyc","id":"EcoCyc:EG12405-MONOMER","properties":[{"key":"Description","value":"-"}]},{"database":"PHI-base","id":"PHI:6184","properties":[{"key":"Description","value":"-"}]},{"database":"PRO","id":"PR:P39165","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000625","properties":[{"key":"Component","value":"Chromosome"}]},{"database":"AbasyAtlas","id":"P39165","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0009279","properties":[{"key":"GoTerm","value":"C:cell outer membrane"},{"key":"GoEvidenceType","value":"HDA:EcoCyc"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"32127419"}]},{"database":"GO","id":"GO:0042597","properties":[{"key":"GoTerm","value":"C:periplasmic space"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"FunFam","id":"2.40.160.160:FF:000001","properties":[{"key":"EntryName","value":"Intimin-like inverse autotransporter SinH"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.40.160.160","properties":[{"key":"EntryName","value":"Inverse autotransporter, beta-domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR024519","properties":[{"key":"EntryName","value":"IAT_beta"}]},{"database":"InterPro","id":"IPR038177","properties":[{"key":"EntryName","value":"IAT_beta_sf"}]},{"database":"InterPro","id":"IPR051715","properties":[{"key":"EntryName","value":"Intimin-Invasin_domain"}]},{"database":"InterPro","id":"IPR063183","properties":[{"key":"EntryName","value":"YchO_Ig"}]},{"database":"NCBIfam","id":"NF007556","properties":[{"key":"EntryName","value":"PRK10177.1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR39576","properties":[{"key":"EntryName","value":"ATTACHING AND EFFACING PROTEIN HOMOLOG-RELATED-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR39576:SF1","properties":[{"key":"EntryName","value":"INVASIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF11924","properties":[{"key":"EntryName","value":"IAT_beta"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF30369","properties":[{"key":"EntryName","value":"YchO_Ig"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSRFVPRIIPFYLLLLVAGGTANAQSTFEQKAANPFDNNNDGLPDLGMAPENHDGEKHFAEIVKDFGETSMNDNGLDTGEQAKAFALGKVRDALSQQVNQHVESWLSPWGNASVDVKVDNEGHFTGSRGSWFVPLQDNDRYLTWSQLGLTQQDNGLVSNVGVGQRWARGNWLVGYNTFYDNLLDENLQRAGFGAEAWGEYLRLSANFYQPFAAWHEQTATQEQRMARGYDLTARMRMPFYQHLNTSVSLEQYFGDRVDLFNSGTGYHNPVALSLGLNYTPVPLVTVTAQHKQGESGENQNNLGLNLNYRFGVPLKKQLSAGEVAESQSLRGSRYDNPQRNNLPTLEYRQRKTLTVFLATPPWDLKPGETVPLKLQIRSRYGIRQLIWQGDTQILSLTPGAQANSAEGWTLIMPDWQNGEGASNHWRLSVVVEDNQGQRVSSNEITLTLVEPFDALSNDELRWEP","length":464,"molWeight":52100,"crc64":"FF826965DE18B630","md5":"B5CDEB2139FB7DF3EBC607FCBAA1B418"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"SEQUENCE CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1},"uniParcId":"UPI0001505B8D"}}