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Specific to 5'-phosphorylated single-stranded guanine-rich sequences (PubMed:22999958, PubMed:8349627). May play a role in RNA metabolism, ribosome biogenesis or initiation of translation (PubMed:19158098, PubMed:19299493). May play a role in regulation of transcription (By similarity). Interacts with tRNA-Tyr (PubMed:19299493). Has low processivity (PubMed:30218034)"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.","ecNumber":"5.6.2.3","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19158098"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30218034"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"ATP + H2O = ADP + phosphate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:13065"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"5.6.2.3","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19158098"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30218034"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"n ATP + n H2O + wound RNA = n ADP + n phosphate + unwound RNA.","ecNumber":"5.6.2.5","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19158098"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"22965130"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19158098"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19299493"}],"value":"Homooligomer (PubMed:19299493). Interacts with RUVBL1 (PubMed:19299493). Interacts with RUVBL2 (PubMed:19299493). Interacts with GTF3C1 (PubMed:19299493). Interacts with ABT1 (PubMed:19299493). Interacts with ribosomes (PubMed:19158098)"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19299493"}],"value":"Nucleus","id":"SL-0191"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19158098"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19299493"}],"value":"Cytoplasm","id":"SL-0086"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P40694"}],"value":"Cell projection, axon","id":"SL-0279"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25439726"}],"value":"Expressed in all tissues examined. Expressed in the developing and adult human brain, with highest expression in the cerebellum. Moderately expressed in fibroblasts"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30218034"}],"value":"Helicase subdomains 1B (residues 5-157) and 1C (residues 270-347) impact nucleic acid substrate-binding and processivity; swapping them with the equivalent domains from yeast NAM7 (Upf1) individually or together increases binding and helicase activity. The swapped IGHMBP2 protein has decreased substrate-binding and processivity"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22965130"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22999958"}],"value":"The R3H domain recognizes phosphorylated 5'-ends of single-stranded nucleic acids which promotes binding of nucleic acids and stimulates ATPase activity"}],"commentType":"DOMAIN"},{"commentType":"DISEASE","disease":{"diseaseId":"Neuronopathy, distal hereditary motor, autosomal recessive 1","diseaseAccession":"DI-00403","acronym":"HMNR1","description":"A form of distal hereditary motor neuronopathy, a heterogeneous group of neuromuscular disorders caused by selective degeneration of motor neurons in the anterior horn of the spinal cord, without sensory deficit in the posterior horn. The overall clinical picture consists of a classical distal muscular atrophy syndrome in the legs without clinical sensory loss. The disease starts with weakness and wasting of distal muscles of the anterior tibial and peroneal compartments of the legs. Later on, weakness and atrophy may expand to the proximal muscles of the lower limbs and/or to the distal upper limbs.","diseaseCrossReference":{"database":"MIM","id":"604320"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11528396"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14681881"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15108294"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15290238"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17431882"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18802676"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19158098"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"commentType":"DISEASE","disease":{"diseaseId":"Charcot-Marie-Tooth disease, axonal, type 2S","diseaseAccession":"DI-04308","acronym":"CMT2S","description":"An axonal form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral axonal neuropathies (CMT2). Neuropathies of the CMT2 group are characterized by signs of axonal degeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy.","diseaseCrossReference":{"database":"MIM","id":"616155"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25439726"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the DNA2/NAM7 helicase family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Initiator 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