{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P38804","secondaryAccessions":["D3DL39"],"uniProtkbId":"SDO1L_YEAST","entryAudit":{"firstPublicDate":"1995-02-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1995-02-01","entryVersion":161,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)","commonName":"Baker's yeast","taxonId":559292,"lineage":["Eukaryota","Fungi","Dikarya","Ascomycota","Saccharomycotina","Saccharomycetes","Saccharomycetales","Saccharomycetaceae","Saccharomyces"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Restriction of telomere capping protein 3"}}},"genes":[{"geneName":{"value":"RTC3"},"orderedLocusNames":[{"value":"YHR087W"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18845848"}],"value":"May play a role in RNA metabolism, rRNA-processing, and in a process influencing telomere capping"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14562095"}],"value":"Cytoplasm","id":"SL-0086"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14562095"}],"value":"Nucleus","id":"SL-0191"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14562106"}],"value":"Present with 2430 molecules/cell in log phase SD medium"}],"commentType":"MISCELLANEOUS"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the SDO1-like family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":111,"modifier":"EXACT"}},"description":"Restriction of telomere capping protein 3","featureId":"PRO_0000202905"},{"type":"Region","location":{"start":{"value":89,"modifier":"EXACT"},"end":{"value":111,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":90,"modifier":"EXACT"},"end":{"value":99,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Beta strand","location":{"start":{"value":5,"modifier":"EXACT"},"end":{"value":10,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1NYN"}]},{"type":"Beta strand","location":{"start":{"value":12,"modifier":"EXACT"},"end":{"value":21,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1NYN"}]},{"type":"Helix","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":31,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1NYN"}]},{"type":"Helix","location":{"start":{"value":35,"modifier":"EXACT"},"end":{"value":41,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1NYN"}]},{"type":"Beta strand","location":{"start":{"value":52,"modifier":"EXACT"},"end":{"value":54,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1NYN"}]},{"type":"Beta strand","location":{"start":{"value":56,"modifier":"EXACT"},"end":{"value":58,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1NYN"}]},{"type":"Helix","location":{"start":{"value":65,"modifier":"EXACT"},"end":{"value":72,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1NYN"}]},{"type":"Helix","location":{"start":{"value":79,"modifier":"EXACT"},"end":{"value":87,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1NYN"}]},{"type":"Beta strand","location":{"start":{"value":107,"modifier":"EXACT"},"end":{"value":109,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1NYN"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0690","category":"Biological process","name":"Ribosome biogenesis"},{"id":"KW-0698","category":"Biological process","name":"rRNA processing"}],"references":[{"referenceNumber":1,"citation":{"id":"8091229","citationType":"journal article","authors":["Johnston M.","Andrews S.","Brinkman R.","Cooper J.","Ding H.","Dover J.","Du Z.","Favello A.","Fulton L.","Gattung S.","Geisel C.","Kirsten J.","Kucaba T.","Hillier L.W.","Jier M.","Johnston L.","Langston Y.","Latreille P.","Louis E.J.","Macri C.","Mardis E.","Menezes S.","Mouser L.","Nhan M.","Rifkin L.","Riles L.","St Peter H.","Trevaskis E.","Vaughan K.","Vignati D.","Wilcox L.","Wohldman P.","Waterston R.","Wilson R.","Vaudin M."],"citationCrossReferences":[{"database":"PubMed","id":"8091229"},{"database":"DOI","id":"10.1126/science.8091229"}],"title":"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII.","publicationDate":"1994","journal":"Science","firstPage":"2077","lastPage":"2082","volume":"265"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"ATCC 204508 / S288c","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"24374639","citationType":"journal article","authors":["Engel S.R.","Dietrich F.S.","Fisk D.G.","Binkley G.","Balakrishnan R.","Costanzo M.C.","Dwight S.S.","Hitz B.C.","Karra K.","Nash R.S.","Weng S.","Wong E.D.","Lloyd P.","Skrzypek M.S.","Miyasato S.R.","Simison M.","Cherry J.M."],"citationCrossReferences":[{"database":"PubMed","id":"24374639"},{"database":"DOI","id":"10.1534/g3.113.008995"}],"title":"The reference genome sequence of Saccharomyces cerevisiae: Then and now.","publicationDate":"2014","journal":"G3 (Bethesda)","firstPage":"389","lastPage":"398","volume":"4"},"referencePositions":["GENOME REANNOTATION"],"referenceComments":[{"value":"ATCC 204508 / S288c","type":"STRAIN"}]},{"referenceNumber":3,"citation":{"id":"17322287","citationType":"journal article","authors":["Hu Y.","Rolfs A.","Bhullar B.","Murthy T.V.S.","Zhu C.","Berger M.F.","Camargo A.A.","Kelley F.","McCarron S.","Jepson D.","Richardson A.","Raphael J.","Moreira D.","Taycher E.","Zuo D.","Mohr S.","Kane M.F.","Williamson J.","Simpson A.J.G.","Bulyk M.L.","Harlow E.","Marsischky G.","Kolodner R.D.","LaBaer J."],"citationCrossReferences":[{"database":"PubMed","id":"17322287"},{"database":"DOI","id":"10.1101/gr.6037607"}],"title":"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae.","publicationDate":"2007","journal":"Genome Res.","firstPage":"536","lastPage":"543","volume":"17"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"],"referenceComments":[{"value":"ATCC 204508 / S288c","type":"STRAIN"}]},{"referenceNumber":4,"citation":{"id":"14562095","citationType":"journal article","authors":["Huh W.-K.","Falvo J.V.","Gerke L.C.","Carroll A.S.","Howson R.W.","Weissman J.S.","O'Shea E.K."],"citationCrossReferences":[{"database":"PubMed","id":"14562095"},{"database":"DOI","id":"10.1038/nature02026"}],"title":"Global analysis of protein localization in budding yeast.","publicationDate":"2003","journal":"Nature","firstPage":"686","lastPage":"691","volume":"425"},"referencePositions":["SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]"]},{"referenceNumber":5,"citation":{"id":"14562106","citationType":"journal article","authors":["Ghaemmaghami S.","Huh W.-K.","Bower K.","Howson R.W.","Belle A.","Dephoure N.","O'Shea E.K.","Weissman J.S."],"citationCrossReferences":[{"database":"PubMed","id":"14562106"},{"database":"DOI","id":"10.1038/nature02046"}],"title":"Global analysis of protein expression in yeast.","publicationDate":"2003","journal":"Nature","firstPage":"737","lastPage":"741","volume":"425"},"referencePositions":["LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS]"]},{"referenceNumber":6,"citation":{"id":"18845848","citationType":"journal article","authors":["Addinall S.G.","Downey M.","Yu M.","Zubko M.K.","Dewar J.","Leake A.","Hallinan J.","Shaw O.","James K.","Wilkinson D.J.","Wipat A.","Durocher D.","Lydall D."],"citationCrossReferences":[{"database":"PubMed","id":"18845848"},{"database":"DOI","id":"10.1534/genetics.108.092577"}],"title":"A genomewide suppressor and enhancer analysis of cdc13-1 reveals varied cellular processes influencing telomere capping in Saccharomyces cerevisiae.","publicationDate":"2008","journal":"Genetics","firstPage":"2251","lastPage":"2266","volume":"180"},"referencePositions":["FUNCTION"]},{"referenceNumber":7,"citation":{"id":"18407956","citationType":"journal article","authors":["Albuquerque C.P.","Smolka M.B.","Payne S.H.","Bafna V.","Eng J.","Zhou H."],"citationCrossReferences":[{"database":"PubMed","id":"18407956"},{"database":"DOI","id":"10.1074/mcp.m700468-mcp200"}],"title":"A multidimensional chromatography technology for in-depth phosphoproteome analysis.","publicationDate":"2008","journal":"Mol. Cell. Proteomics","firstPage":"1389","lastPage":"1396","volume":"7"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":8,"citation":{"id":"15701634","citationType":"journal article","authors":["Savchenko A.","Krogan N.","Cort J.R.","Evdokimova E.","Lew J.M.","Yee A.A.","Sanchez-Pulido L.","Andrade M.A.","Bochkarev A.","Watson J.D.","Kennedy M.A.","Greenblatt J.","Hughes T.","Arrowsmith C.H.","Rommens J.M.","Edwards A.M."],"citationCrossReferences":[{"database":"PubMed","id":"15701634"},{"database":"DOI","id":"10.1074/jbc.m414421200"}],"title":"The Shwachman-Bodian-Diamond syndrome protein family is involved in RNA metabolism.","publicationDate":"2005","journal":"J. Biol. Chem.","firstPage":"19213","lastPage":"19220","volume":"280"},"referencePositions":["STRUCTURE BY NMR"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"U00060","properties":[{"key":"ProteinId","value":"AAB68927.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AY557845","properties":[{"key":"ProteinId","value":"AAS56171.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BK006934","properties":[{"key":"ProteinId","value":"DAA06783.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"S46719","properties":[{"key":"EntryName","value":"S46719"}]},{"database":"RefSeq","id":"NP_011955.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001179217.1"}]},{"database":"PDB","id":"1NYN","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=1-111"}]},{"database":"PDBsum","id":"1NYN","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"P38804","properties":[{"key":"Description","value":"-"}]},{"database":"BMRB","id":"P38804","properties":[{"key":"Description","value":"-"}]},{"database":"MDposit","id":"P38804","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P38804","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"36522","properties":[{"key":"Interactions","value":"146"}]},{"database":"DIP","id":"DIP-2925N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"P38804","properties":[{"key":"Number of interactors","value":"250"}]},{"database":"IntAct","id":"P38804","properties":[{"key":"Interactions","value":"25"}]},{"database":"MINT","id":"P38804","properties":[{"key":"Description","value":"-"}]},{"database":"STRING","id":"4932.YHR087W","properties":[{"key":"Description","value":"-"}]},{"database":"iPTMnet","id":"P38804","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"4932-YHR087W","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"P38804","properties":[{"key":"Description","value":"-"}]},{"database":"TopDownProteomics","id":"P38804","properties":[{"key":"Description","value":"-"}]},{"database":"DNASU","id":"856487","properties":[{"key":"Description","value":"-"}]},{"database":"EnsemblFungi","id":"YHR087W_mRNA","properties":[{"key":"ProteinId","value":"YHR087W"},{"key":"GeneId","value":"YHR087W"}]},{"database":"GeneID","id":"856487","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"sce:YHR087W","properties":[{"key":"Description","value":"-"}]},{"database":"AGR","id":"SGD:S000001129","properties":[{"key":"Description","value":"-"}]},{"database":"SGD","id":"S000001129","properties":[{"key":"GeneName","value":"RTC3"}]},{"database":"VEuPathDB","id":"FungiDB:YHR087W","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502S9SB","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"HOGENOM","id":"CLU_137480_1_1_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P38804","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"HYKGKDD","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"2567806at2759","properties":[{"key":"Description","value":"-"}]},{"database":"BioCyc","id":"YEAST:G3O-31134-MONOMER","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"856487","properties":[{"key":"hits","value":"0 hits in 10 CRISPR screens"}]},{"database":"EvolutionaryTrace","id":"P38804","properties":[{"key":"Description","value":"-"}]},{"database":"PRO","id":"PR:P38804","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000002311","properties":[{"key":"Component","value":"Chromosome VIII"}]},{"database":"RNAct","id":"P38804","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"HDA:SGD"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"14562095"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"HDA:SGD"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"14562095"}]},{"database":"Gene3D","id":"3.30.1250.10","properties":[{"key":"EntryName","value":"Ribosome maturation protein SBDS, N-terminal domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR036786","properties":[{"key":"EntryName","value":"Ribosome_mat_SBDS_N_sf"}]},{"database":"InterPro","id":"IPR019783","properties":[{"key":"EntryName","value":"SDO1/SBDS_N"}]},{"database":"Pfam","id":"PF01172","properties":[{"key":"EntryName","value":"SBDS_N"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF89895","properties":[{"key":"EntryName","value":"FYSH domain"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSTVTKYFYKGENTDLIVFAASEELVDEYLKNPSIGKLSEVVELFEVFTPQDGRGAEGELGAASKAQVENEFGKGKKIEEVIDLILRNGKPNSTTSSLKTKGGNAGTKAYN","length":111,"molWeight":12009,"crc64":"34A95645CAFB51BD","md5":"EA7CB012D8214D3BFD38E99CD7C3E4F2"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"MISCELLANEOUS":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Region":1,"Compositional bias":1,"Beta strand":5,"Helix":4},"uniParcId":"UPI000013B2B4"}}