{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P38356","secondaryAccessions":["D6VQT5"],"uniProtkbId":"BSD2_YEAST","entryAudit":{"firstPublicDate":"1994-10-01","lastAnnotationUpdateDate":"2026-06-10","lastSequenceUpdateDate":"1994-10-01","entryVersion":168,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)","commonName":"Baker's yeast","taxonId":559292,"lineage":["Eukaryota","Fungi","Dikarya","Ascomycota","Saccharomycotina","Saccharomycetes","Saccharomycetales","Saccharomycetaceae","Saccharomyces"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Metal homeostatis protein BSD2"}},"alternativeNames":[{"fullName":{"value":"Bypass SOD defects protein 2"}}]},"genes":[{"geneName":{"value":"BSD2"},"orderedLocusNames":[{"value":"YBR290W"}],"orfNames":[{"value":"YBR2037"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7935419"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9115231"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9988727"}],"value":"Required for homeostasis of heavy metal ions such as cadmium, cobalt and copper. Controls metal ion transport and prevents metal hyperaccumulation by negatively regulating the SMF1 and SMF2 metal transport systems. Under manganese-replete conditions facilitates trafficking of SMF1 and SMF2 metal transporters to the vacuole where they are degraded"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"value":"Endoplasmic reticulum","id":"SL-0095"}},{"location":{"value":"Vacuole","id":"SL-0272"}},{"location":{"value":"Membrane","id":"SL-0162"},"topology":{"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7935419"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9115231"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9988727"}],"value":"Increased accumulation of copper, cadmium and cobalt ions and enhanced sensitivity to the toxic effects of copper and cadmium. Exhibits no additional sensitivity to manganese. SMF1 fails to enter the vacuole and is stabilized. Reverses the aerobic defects of yeast strains lacking superoxide dismutase (SOD). Concomitant deletion of SMF1 completely abolishes the ability of BSD2 deletion to suppress SOD deficiency and reverses the increased sensitivity to cadmium and copper. However cobalt ion hyperaccumulation is not suppressed"}],"commentType":"DISRUPTION PHENOTYPE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14562106"}],"value":"Present with 3070 molecules/cell in log phase SD medium"}],"commentType":"MISCELLANEOUS"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the BSD2 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":321,"modifier":"EXACT"}},"description":"Metal homeostatis protein BSD2","featureId":"PRO_0000064996"},{"type":"Topological domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":178,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":179,"modifier":"EXACT"},"end":{"value":199,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":200,"modifier":"EXACT"},"end":{"value":211,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":212,"modifier":"EXACT"},"end":{"value":232,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":233,"modifier":"EXACT"},"end":{"value":280,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":281,"modifier":"EXACT"},"end":{"value":301,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":302,"modifier":"EXACT"},"end":{"value":321,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":71,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":11,"modifier":"EXACT"},"end":{"value":23,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":41,"modifier":"EXACT"},"end":{"value":57,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Cross-link","location":{"start":{"value":312,"modifier":"EXACT"},"end":{"value":312,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"22106047"}]},{"type":"Mutagenesis","location":{"start":{"value":149,"modifier":"EXACT"},"end":{"value":149,"modifier":"EXACT"}},"description":"Reverses the aerobic defects of yeast strains lacking superoxide dismutase (SOD). Associated with elevated copper ion accumulation and increased sensitivity to the toxic effects of copper and cadmium. Exhibits no additional sensitivity to manganese.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7935419"}],"alternativeSequence":{"originalSequence":"P","alternativeSequences":["S"]}}],"keywords":[{"id":"KW-0256","category":"Cellular component","name":"Endoplasmic reticulum"},{"id":"KW-1017","category":"PTM","name":"Isopeptide bond"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0346","category":"Biological process","name":"Stress response"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"id":"KW-0813","category":"Biological process","name":"Transport"},{"id":"KW-0832","category":"PTM","name":"Ubl conjugation"},{"id":"KW-0926","category":"Cellular component","name":"Vacuole"}],"references":[{"referenceNumber":1,"citation":{"id":"7935419","citationType":"journal article","authors":["Liu X.F.","Culotta V.C."],"citationCrossReferences":[{"database":"PubMed","id":"7935419"},{"database":"DOI","id":"10.1128/mcb.14.11.7037-7045.1994"}],"title":"The requirement for yeast superoxide dismutase is bypassed through mutations in BSD2, a novel metal homeostasis gene.","publicationDate":"1994","journal":"Mol. Cell. Biol.","firstPage":"7037","lastPage":"7045","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]","FUNCTION","DISRUPTION PHENOTYPE","MUTAGENESIS OF PRO-149"]},{"referenceNumber":2,"citation":{"id":"8091861","citationType":"journal article","authors":["Holmstroem K.","Brandt T.","Kallesoe T."],"citationCrossReferences":[{"database":"PubMed","id":"8091861"},{"database":"DOI","id":"10.1002/yea.320100007"}],"title":"The sequence of a 32,420 bp segment located on the right arm of chromosome II from Saccharomyces cerevisiae.","publicationDate":"1994","journal":"Yeast","firstPage":"S47","lastPage":"S62","volume":"10"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"],"referenceComments":[{"value":"ATCC 204508 / S288c","type":"STRAIN"}]},{"referenceNumber":3,"citation":{"id":"7813418","citationType":"journal article","authors":["Feldmann H.","Aigle M.","Aljinovic G.","Andre B.","Baclet M.C.","Barthe C.","Baur A.","Becam A.-M.","Biteau N.","Boles E.","Brandt T.","Brendel M.","Brueckner M.","Bussereau F.","Christiansen C.","Contreras R.","Crouzet M.","Cziepluch C.","Demolis N.","Delaveau T.","Doignon F.","Domdey H.","Duesterhus S.","Dubois E.","Dujon B.","El Bakkoury M.","Entian K.-D.","Feuermann M.","Fiers W.","Fobo G.M.","Fritz C.","Gassenhuber J.","Glansdorff N.","Goffeau A.","Grivell L.A.","de Haan M.","Hein C.","Herbert C.J.","Hollenberg C.P.","Holmstroem K.","Jacq C.","Jacquet M.","Jauniaux J.-C.","Jonniaux J.-L.","Kallesoee T.","Kiesau P.","Kirchrath L.","Koetter P.","Korol S.","Liebl S.","Logghe M.","Lohan A.J.E.","Louis E.J.","Li Z.Y.","Maat M.J.","Mallet L.","Mannhaupt G.","Messenguy F.","Miosga T.","Molemans F.","Mueller S.","Nasr F.","Obermaier B.","Perea J.","Pierard A.","Piravandi E.","Pohl F.M.","Pohl T.M.","Potier S.","Proft M.","Purnelle B.","Ramezani Rad M.","Rieger M.","Rose M.","Schaaff-Gerstenschlaeger I.","Scherens B.","Schwarzlose C.","Skala J.","Slonimski P.P.","Smits P.H.M.","Souciet J.-L.","Steensma H.Y.","Stucka R.","Urrestarazu L.A.","van der Aart Q.J.M.","Van Dyck L.","Vassarotti A.","Vetter I.","Vierendeels F.","Vissers S.","Wagner G.","de Wergifosse P.","Wolfe K.H.","Zagulski M.","Zimmermann F.K.","Mewes H.-W.","Kleine K."],"citationCrossReferences":[{"database":"PubMed","id":"7813418"},{"database":"DOI","id":"10.1002/j.1460-2075.1994.tb06923.x"}],"title":"Complete DNA sequence of yeast chromosome II.","publicationDate":"1994","journal":"EMBO J.","firstPage":"5795","lastPage":"5809","volume":"13"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"ATCC 204508 / S288c","type":"STRAIN"}]},{"referenceNumber":4,"citation":{"id":"24374639","citationType":"journal article","authors":["Engel S.R.","Dietrich F.S.","Fisk D.G.","Binkley G.","Balakrishnan R.","Costanzo M.C.","Dwight S.S.","Hitz B.C.","Karra K.","Nash R.S.","Weng S.","Wong E.D.","Lloyd P.","Skrzypek M.S.","Miyasato S.R.","Simison M.","Cherry J.M."],"citationCrossReferences":[{"database":"PubMed","id":"24374639"},{"database":"DOI","id":"10.1534/g3.113.008995"}],"title":"The reference genome sequence of Saccharomyces cerevisiae: Then and now.","publicationDate":"2014","journal":"G3 (Bethesda)","firstPage":"389","lastPage":"398","volume":"4"},"referencePositions":["GENOME REANNOTATION"],"referenceComments":[{"value":"ATCC 204508 / S288c","type":"STRAIN"}]},{"referenceNumber":5,"citation":{"id":"9115231","citationType":"journal article","authors":["Liu X.F.","Supek F.","Nelson N.","Culotta V.C."],"citationCrossReferences":[{"database":"PubMed","id":"9115231"},{"database":"DOI","id":"10.1074/jbc.272.18.11763"}],"title":"Negative control of heavy metal uptake by the Saccharomyces cerevisiae BSD2 gene.","publicationDate":"1997","journal":"J. Biol. Chem.","firstPage":"11763","lastPage":"11769","volume":"272"},"referencePositions":["FUNCTION","SUBCELLULAR LOCATION","DISRUPTION PHENOTYPE"]},{"referenceNumber":6,"citation":{"id":"9988727","citationType":"journal article","authors":["Liu X.F.","Culotta V.C."],"citationCrossReferences":[{"database":"PubMed","id":"9988727"},{"database":"DOI","id":"10.1074/jbc.274.8.4863"}],"title":"Post-translation control of Nramp metal transport in yeast. Role of metal ions and the BSD2 gene.","publicationDate":"1999","journal":"J. Biol. Chem.","firstPage":"4863","lastPage":"4868","volume":"274"},"referencePositions":["FUNCTION","DISRUPTION PHENOTYPE"]},{"referenceNumber":7,"citation":{"id":"14562095","citationType":"journal article","authors":["Huh W.-K.","Falvo J.V.","Gerke L.C.","Carroll A.S.","Howson R.W.","Weissman J.S.","O'Shea E.K."],"citationCrossReferences":[{"database":"PubMed","id":"14562095"},{"database":"DOI","id":"10.1038/nature02026"}],"title":"Global analysis of protein localization in budding yeast.","publicationDate":"2003","journal":"Nature","firstPage":"686","lastPage":"691","volume":"425"},"referencePositions":["SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]"]},{"referenceNumber":8,"citation":{"id":"14562106","citationType":"journal article","authors":["Ghaemmaghami S.","Huh W.-K.","Bower K.","Howson R.W.","Belle A.","Dephoure N.","O'Shea E.K.","Weissman J.S."],"citationCrossReferences":[{"database":"PubMed","id":"14562106"},{"database":"DOI","id":"10.1038/nature02046"}],"title":"Global analysis of protein expression in yeast.","publicationDate":"2003","journal":"Nature","firstPage":"737","lastPage":"741","volume":"425"},"referencePositions":["LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS]"]},{"referenceNumber":9,"citation":{"id":"12872131","citationType":"journal article","authors":["Peng J.","Schwartz D.","Elias J.E.","Thoreen C.C.","Cheng D.","Marsischky G.","Roelofs J.","Finley D.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"12872131"},{"database":"DOI","id":"10.1038/nbt849"}],"title":"A proteomics approach to understanding protein ubiquitination.","publicationDate":"2003","journal":"Nat. Biotechnol.","firstPage":"921","lastPage":"926","volume":"21"},"referencePositions":["UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-312","IDENTIFICATION BY MASS SPECTROMETRY"],"referenceComments":[{"value":"SUB592","type":"STRAIN"}]},{"referenceNumber":10,"citation":{"id":"16847258","citationType":"journal article","authors":["Kim H.","Melen K.","Oesterberg M.","von Heijne G."],"citationCrossReferences":[{"database":"PubMed","id":"16847258"},{"database":"DOI","id":"10.1073/pnas.0604075103"}],"title":"A global topology map of the Saccharomyces cerevisiae membrane proteome.","publicationDate":"2006","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"11142","lastPage":"11147","volume":"103"},"referencePositions":["TOPOLOGY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"ATCC 208353 / W303-1A","type":"STRAIN"}]},{"referenceNumber":11,"citation":{"id":"18407956","citationType":"journal article","authors":["Albuquerque C.P.","Smolka M.B.","Payne S.H.","Bafna V.","Eng J.","Zhou H."],"citationCrossReferences":[{"database":"PubMed","id":"18407956"},{"database":"DOI","id":"10.1074/mcp.m700468-mcp200"}],"title":"A multidimensional chromatography technology for in-depth phosphoproteome analysis.","publicationDate":"2008","journal":"Mol. Cell. Proteomics","firstPage":"1389","lastPage":"1396","volume":"7"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":12,"citation":{"id":"22106047","citationType":"journal article","authors":["Starita L.M.","Lo R.S.","Eng J.K.","von Haller P.D.","Fields S."],"citationCrossReferences":[{"database":"PubMed","id":"22106047"},{"database":"DOI","id":"10.1002/pmic.201100166"}],"title":"Sites of ubiquitin attachment in Saccharomyces cerevisiae.","publicationDate":"2012","journal":"Proteomics","firstPage":"236","lastPage":"240","volume":"12"},"referencePositions":["UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-312","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"L33783","properties":[{"key":"ProteinId","value":"AAA65065.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"X76053","properties":[{"key":"ProteinId","value":"CAA53653.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"Z36159","properties":[{"key":"ProteinId","value":"CAA85255.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BK006936","properties":[{"key":"ProteinId","value":"DAA07405.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"S44552","properties":[{"key":"EntryName","value":"S44552"}]},{"database":"RefSeq","id":"NP_009849.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001178638.1"}]},{"database":"AlphaFoldDB","id":"P38356","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P38356","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"32984","properties":[{"key":"Interactions","value":"215"}]},{"database":"DIP","id":"DIP-7753N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"P38356","properties":[{"key":"Number of interactors","value":"76"}]},{"database":"IntAct","id":"P38356","properties":[{"key":"Interactions","value":"39"}]},{"database":"MINT","id":"P38356","properties":[{"key":"Description","value":"-"}]},{"database":"STRING","id":"4932.YBR290W","properties":[{"key":"Description","value":"-"}]},{"database":"TCDB","id":"8.A.30.2.1","properties":[{"key":"FamilyName","value":"the nedd4-family interacting protein-2 (nedd4) family"}]},{"database":"iPTMnet","id":"P38356","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"4932-YBR290W","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"P38356","properties":[{"key":"Description","value":"-"}]},{"database":"EnsemblFungi","id":"YBR290W_mRNA","properties":[{"key":"ProteinId","value":"YBR290W"},{"key":"GeneId","value":"YBR290W"}]},{"database":"GeneID","id":"852593","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"sce:YBR290W","properties":[{"key":"Description","value":"-"}]},{"database":"AGR","id":"SGD:S000000494","properties":[{"key":"Description","value":"-"}]},{"database":"SGD","id":"S000000494","properties":[{"key":"GeneName","value":"BSD2"}]},{"database":"VEuPathDB","id":"FungiDB:YBR290W","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG4812","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"HOGENOM","id":"CLU_041193_2_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P38356","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"YNEICID","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"10003116at2759","properties":[{"key":"Description","value":"-"}]},{"database":"BioCyc","id":"YEAST:G3O-29209-MONOMER","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"852593","properties":[{"key":"hits","value":"9 hits in 10 CRISPR screens"}]},{"database":"PRO","id":"PR:P38356","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000002311","properties":[{"key":"Component","value":"Chromosome II"}]},{"database":"RNAct","id":"P38356","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"GO","id":"GO:0005783","properties":[{"key":"GoTerm","value":"C:endoplasmic reticulum"},{"key":"GoEvidenceType","value":"IDA:SGD"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"9115231"}]},{"database":"GO","id":"GO:0000324","properties":[{"key":"GoTerm","value":"C:fungal-type vacuole"},{"key":"GoEvidenceType","value":"IDA:SGD"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"23708375"}]},{"database":"GO","id":"GO:0000329","properties":[{"key":"GoTerm","value":"C:fungal-type vacuole membrane"},{"key":"GoEvidenceType","value":"IDA:SGD"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"14988731"}]},{"database":"GO","id":"GO:0005794","properties":[{"key":"GoTerm","value":"C:Golgi apparatus"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0048471","properties":[{"key":"GoTerm","value":"C:perinuclear region of cytoplasm"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0030001","properties":[{"key":"GoTerm","value":"P:metal ion transport"},{"key":"GoEvidenceType","value":"IMP:SGD"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"9115231"}]},{"database":"GO","id":"GO:0031398","properties":[{"key":"GoTerm","value":"P:positive regulation of protein ubiquitination"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0006623","properties":[{"key":"GoTerm","value":"P:protein targeting to vacuole"},{"key":"GoEvidenceType","value":"IMP:SGD"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"14988731"},{"evidenceCode":"ECO:0000315","source":"PubMed","id":"9988727"}]},{"database":"GO","id":"GO:0006511","properties":[{"key":"GoTerm","value":"P:ubiquitin-dependent protein catabolic process"},{"key":"GoEvidenceType","value":"IMP:SGD"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"16456538"}]},{"database":"CDD","id":"cd22212","properties":[{"key":"EntryName","value":"NDFIP-like"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR019325","properties":[{"key":"EntryName","value":"NEDD4/Bsd2"}]},{"database":"PANTHER","id":"PTHR13396:SF5","properties":[{"key":"EntryName","value":"NEDD4 FAMILY INTERACTING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR13396","properties":[{"key":"EntryName","value":"NEDD4 FAMILY INTERACTING PROTEIN 1/2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF10176","properties":[{"key":"EntryName","value":"NEDD4_Bsd2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MPEQELLIGQEMNTLHAGSSTDGINVGNAGRTRDTQTGVEGETEIGSDEEDSIEDEGSSSGGNSTTERLVPHQLREQAARHIGKIGRHFNILDRLFKKRTQQSSDIQQGAMFDGVFSNLSAKPDTTETEGNNEQDIPPTYDEAAADMAPSYYGMDLNNSDIYYDEICIEGLPVGNIANLLWNIIVSTSFQFIGFLITYILHTSHAAKQGSRFGLGLTFIGYGYSMIPNDVTSKVGKNKSLNRMELEDPNEFDDVRLNSQSTTQDKFESHLNHGLDEEKQNIPWLAVFVAFLGLFITLKSIYDYIQVKKLEKKYLNQSQNQA","length":321,"molWeight":35764,"crc64":"1C212AED2A249850","md5":"C2C6D2918F08760927E55D9708E979D4"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"DISRUPTION PHENOTYPE":1,"MISCELLANEOUS":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Topological domain":4,"Transmembrane":3,"Region":1,"Compositional bias":2,"Cross-link":1,"Mutagenesis":1},"uniParcId":"UPI0000126AF3"}}