{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P37759","secondaryAccessions":["P78082"],"uniProtkbId":"RMLB1_ECOLI","entryAudit":{"firstPublicDate":"1994-10-01","lastAnnotationUpdateDate":"2026-01-28","lastSequenceUpdateDate":"1997-11-01","entryVersion":185,"sequenceVersion":2},"annotationScore":4.0,"organism":{"scientificName":"Escherichia coli (strain K12)","taxonId":83333,"lineage":["Bacteria","Pseudomonadati","Pseudomonadota","Gammaproteobacteria","Enterobacterales","Enterobacteriaceae","Escherichia"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P27830"}],"value":"dTDP-glucose 4,6-dehydratase 1"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P27830"}],"value":"4.2.1.46"}]}},"genes":[{"geneName":{"value":"rfbB"},"synonyms":[{"value":"rmlB"}],"orderedLocusNames":[{"value":"b2041"},{"value":"JW2026"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P27830"}],"value":"Catalyzes the dehydration of dTDP-D-glucose to form dTDP-6-deoxy-D-xylo-4-hexulose via a three-step process involving oxidation, dehydration and reduction"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"dTDP-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:17221"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:57477"},{"database":"ChEBI","id":"CHEBI:57649"}],"ecNumber":"4.2.1.46","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P27830"}]}},{"commentType":"COFACTOR","cofactors":[{"name":"NAD(+)","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P27830"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:57540"}}],"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P27830"}],"value":"Binds 1 NAD(+) per subunit."}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7559340"}],"value":"Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7559340"}],"value":"Bacterial outer membrane biogenesis; LPS O-antigen biosynthesis"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P27830"}],"value":"Homodimer"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P27830"}],"value":"Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":361,"modifier":"EXACT"}},"description":"dTDP-glucose 4,6-dehydratase 1","featureId":"PRO_0000183238"},{"type":"Active site","location":{"start":{"value":134,"modifier":"EXACT"},"end":{"value":134,"modifier":"EXACT"}},"description":"Proton donor","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P27830"}]},{"type":"Active site","location":{"start":{"value":135,"modifier":"EXACT"},"end":{"value":135,"modifier":"EXACT"}},"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P27830"}]},{"type":"Active site","location":{"start":{"value":167,"modifier":"EXACT"},"end":{"value":167,"modifier":"EXACT"}},"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P27830"}]},{"type":"Binding site","location":{"start":{"value":11,"modifier":"EXACT"},"end":{"value":12,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:57540"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P27830"}],"ligand":{"name":"NAD(+)","id":"ChEBI:CHEBI:57540"}},{"type":"Binding site","location":{"start":{"value":32,"modifier":"EXACT"},"end":{"value":35,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:57540"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P27830"}],"ligand":{"name":"NAD(+)","id":"ChEBI:CHEBI:57540"}},{"type":"Binding site","location":{"start":{"value":58,"modifier":"EXACT"},"end":{"value":59,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:57540"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P27830"}],"ligand":{"name":"NAD(+)","id":"ChEBI:CHEBI:57540"}},{"type":"Binding site","location":{"start":{"value":80,"modifier":"EXACT"},"end":{"value":84,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:57540"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P27830"}],"ligand":{"name":"NAD(+)","id":"ChEBI:CHEBI:57540"}},{"type":"Binding site","location":{"start":{"value":84,"modifier":"EXACT"},"end":{"value":84,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P26391"}],"ligand":{"name":"substrate"}},{"type":"Binding site","location":{"start":{"value":99,"modifier":"EXACT"},"end":{"value":99,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:57540"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P27830"}],"ligand":{"name":"NAD(+)","id":"ChEBI:CHEBI:57540"}},{"type":"Binding site","location":{"start":{"value":133,"modifier":"EXACT"},"end":{"value":133,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P26391"}],"ligand":{"name":"substrate"}},{"type":"Binding site","location":{"start":{"value":167,"modifier":"EXACT"},"end":{"value":171,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:57540"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P27830"}],"ligand":{"name":"NAD(+)","id":"ChEBI:CHEBI:57540"}},{"type":"Binding site","location":{"start":{"value":196,"modifier":"EXACT"},"end":{"value":196,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P26391"}],"ligand":{"name":"substrate"}},{"type":"Binding site","location":{"start":{"value":197,"modifier":"EXACT"},"end":{"value":197,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:57540"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P27830"}],"ligand":{"name":"NAD(+)","id":"ChEBI:CHEBI:57540"}},{"type":"Binding site","location":{"start":{"value":206,"modifier":"EXACT"},"end":{"value":207,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P26391"}],"ligand":{"name":"substrate"}},{"type":"Binding site","location":{"start":{"value":222,"modifier":"EXACT"},"end":{"value":224,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P26391"}],"ligand":{"name":"substrate"}},{"type":"Binding site","location":{"start":{"value":231,"modifier":"EXACT"},"end":{"value":231,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P26391"}],"ligand":{"name":"substrate"}},{"type":"Binding site","location":{"start":{"value":266,"modifier":"EXACT"},"end":{"value":266,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P26391"}],"ligand":{"name":"substrate"}},{"type":"Binding site","location":{"start":{"value":296,"modifier":"EXACT"},"end":{"value":300,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P26391"}],"ligand":{"name":"substrate"}},{"type":"Sequence conflict","location":{"start":{"value":123,"modifier":"EXACT"},"end":{"value":123,"modifier":"EXACT"}},"description":"in Ref. 1; AAB88398","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["E"]}},{"type":"Sequence conflict","location":{"start":{"value":250,"modifier":"EXACT"},"end":{"value":250,"modifier":"EXACT"}},"description":"in Ref. 1; AAB88398","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"G","alternativeSequences":["V"]}}],"keywords":[{"id":"KW-0448","category":"Biological process","name":"Lipopolysaccharide biosynthesis"},{"id":"KW-0456","category":"Molecular function","name":"Lyase"},{"id":"KW-0520","category":"Ligand","name":"NAD"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"7517391","citationType":"journal article","authors":["Stevenson G.","Neal B.","Liu D.","Hobbs M.","Packer N.H.","Batley M.","Redmond J.W.","Lindquist L.","Reeves P.R."],"citationCrossReferences":[{"database":"PubMed","id":"7517391"},{"database":"DOI","id":"10.1128/jb.176.13.4144-4156.1994"}],"title":"Structure of the O antigen of Escherichia coli K-12 and the sequence of its rfb gene cluster.","publicationDate":"1994","journal":"J. Bacteriol.","firstPage":"4144","lastPage":"4156","volume":"176"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"],"referenceComments":[{"value":"K12 / WG1","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"CI-2DD8HI9E8ANTF","citationType":"submission","authors":["Stevenson G."],"publicationDate":"DEC-1997","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["SEQUENCE REVISION TO 123 AND 250"],"referenceComments":[{"value":"K12 / WG1","type":"STRAIN"}]},{"referenceNumber":3,"citation":{"id":"9097040","citationType":"journal article","authors":["Itoh T.","Aiba H.","Baba T.","Fujita K.","Hayashi K.","Inada T.","Isono K.","Kasai H.","Kimura S.","Kitakawa M.","Kitagawa M.","Makino K.","Miki T.","Mizobuchi K.","Mori H.","Mori T.","Motomura K.","Nakade S.","Nakamura Y.","Nashimoto H.","Nishio Y.","Oshima T.","Saito N.","Sampei G.","Seki Y.","Sivasundaram S.","Tagami H.","Takeda J.","Takemoto K.","Wada C.","Yamamoto Y.","Horiuchi T."],"citationCrossReferences":[{"database":"PubMed","id":"9097040"},{"database":"DOI","id":"10.1093/dnares/3.6.379"}],"title":"A 460-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 40.1-50.0 min region on the linkage map.","publicationDate":"1996","journal":"DNA Res.","firstPage":"379","lastPage":"392","volume":"3"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"K12 / W3110 / ATCC 27325 / DSM 5911","type":"STRAIN"}]},{"referenceNumber":4,"citation":{"id":"9278503","citationType":"journal article","authors":["Blattner F.R.","Plunkett G. III","Bloch C.A.","Perna N.T.","Burland V.","Riley M.","Collado-Vides J.","Glasner J.D.","Rode C.K.","Mayhew G.F.","Gregor J.","Davis N.W.","Kirkpatrick H.A.","Goeden M.A.","Rose D.J.","Mau B.","Shao Y."],"citationCrossReferences":[{"database":"PubMed","id":"9278503"},{"database":"DOI","id":"10.1126/science.277.5331.1453"}],"title":"The complete genome sequence of Escherichia coli K-12.","publicationDate":"1997","journal":"Science","firstPage":"1453","lastPage":"1462","volume":"277"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"K12 / MG1655 / ATCC 47076","type":"STRAIN"}]},{"referenceNumber":5,"citation":{"id":"16738553","citationType":"journal article","authors":["Hayashi K.","Morooka N.","Yamamoto Y.","Fujita K.","Isono K.","Choi S.","Ohtsubo E.","Baba T.","Wanner B.L.","Mori H.","Horiuchi T."],"citationCrossReferences":[{"database":"PubMed","id":"16738553"},{"database":"DOI","id":"10.1038/msb4100049"}],"title":"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.","publicationDate":"2006","journal":"Mol. Syst. Biol.","firstPage":"E1","lastPage":"E5","volume":"2"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"K12 / W3110 / ATCC 27325 / DSM 5911","type":"STRAIN"}]},{"referenceNumber":6,"citation":{"id":"7559340","citationType":"journal article","authors":["Marolda C.L.","Valvano M.A."],"citationCrossReferences":[{"database":"PubMed","id":"7559340"},{"database":"DOI","id":"10.1128/jb.177.19.5539-5546.1995"}],"title":"Genetic analysis of the dTDP-rhamnose biosynthesis region of the Escherichia coli VW187 (O7:K1) rfb gene cluster: identification of functional homologs of rfbB and rfbA in the rff cluster and correct location of the rffE gene.","publicationDate":"1995","journal":"J. Bacteriol.","firstPage":"5539","lastPage":"5546","volume":"177"},"referencePositions":["PATHWAY"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"U09876","properties":[{"key":"ProteinId","value":"AAB88398.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"U00096","properties":[{"key":"ProteinId","value":"AAC75102.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AP009048","properties":[{"key":"ProteinId","value":"BAA15883.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"H64969","properties":[{"key":"EntryName","value":"H64969"}]},{"database":"RefSeq","id":"NP_416545.1","properties":[{"key":"NucleotideSequenceId","value":"NC_000913.3"}]},{"database":"RefSeq","id":"WP_000699460.1","properties":[{"key":"NucleotideSequenceId","value":"NZ_CP009789.1"}]},{"database":"AlphaFoldDB","id":"P37759","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P37759","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"4259679","properties":[{"key":"Interactions","value":"188"}]},{"database":"BioGRID","id":"849655","properties":[{"key":"Interactions","value":"4"}]},{"database":"DIP","id":"DIP-10680N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"P37759","properties":[{"key":"Number of interactors","value":"823"}]},{"database":"IntAct","id":"P37759","properties":[{"key":"Interactions","value":"7"}]},{"database":"STRING","id":"511145.b2041","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"P37759","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"511145-b2041","properties":[{"key":"Description","value":"-"}]},{"database":"EnsemblBacteria","id":"AAC75102","properties":[{"key":"ProteinId","value":"AAC75102"},{"key":"GeneId","value":"b2041"}]},{"database":"GeneID","id":"945276","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"ecj:JW2026","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"eco:b2041","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"ecoc:C3026_11495","properties":[{"key":"Description","value":"-"}]},{"database":"PATRIC","id":"fig|1411691.4.peg.210","properties":[{"key":"GeneDesignation","value":"-"}]},{"database":"EchoBASE","id":"EB2311","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"COG1088","properties":[{"key":"ToxonomicScope","value":"Bacteria"}]},{"database":"HOGENOM","id":"CLU_007383_1_14_6","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P37759","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"EWCQHVQ","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"9803010at2","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"P37759","properties":[{"key":"Description","value":"-"}]},{"database":"BioCyc","id":"EcoCyc:DTDPGLUCDEHYDRAT-MONOMER","properties":[{"key":"Description","value":"-"}]},{"database":"BioCyc","id":"MetaCyc:DTDPGLUCDEHYDRAT-MONOMER","properties":[{"key":"Description","value":"-"}]},{"database":"SABIO-RK","id":"P37759","properties":[{"key":"Description","value":"-"}]},{"database":"UniPathway","id":"UPA00124","properties":[{"key":"RectionId","value":"-"}]},{"database":"UniPathway","id":"UPA00281","properties":[{"key":"RectionId","value":"-"}]},{"database":"PRO","id":"PR:P37759","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000625","properties":[{"key":"Component","value":"Chromosome"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IDA:EcoCyc"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15911532"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18304323"}]},{"database":"GO","id":"GO:0008460","properties":[{"key":"GoTerm","value":"F:dTDP-glucose 4,6-dehydratase activity"},{"key":"GoEvidenceType","value":"IDA:EcoCyc"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"4307450"}]},{"database":"GO","id":"GO:0042802","properties":[{"key":"GoTerm","value":"F:identical protein binding"},{"key":"GoEvidenceType","value":"IDA:EcoCyc"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"4307450"}]},{"database":"GO","id":"GO:0051287","properties":[{"key":"GoTerm","value":"F:NAD binding"},{"key":"GoEvidenceType","value":"IDA:EcoCyc"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"4307450"}]},{"database":"GO","id":"GO:0019305","properties":[{"key":"GoTerm","value":"P:dTDP-rhamnose biosynthetic process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniPathway"}]},{"database":"GO","id":"GO:0009103","properties":[{"key":"GoTerm","value":"P:lipopolysaccharide biosynthetic process"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0009226","properties":[{"key":"GoTerm","value":"P:nucleotide-sugar biosynthetic process"},{"key":"GoEvidenceType","value":"IDA:EcoCyc"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"14235522"}]},{"database":"GO","id":"GO:0009243","properties":[{"key":"GoTerm","value":"P:O antigen biosynthetic process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniPathway"}]},{"database":"GO","id":"GO:0000271","properties":[{"key":"GoTerm","value":"P:polysaccharide biosynthetic process"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"CDD","id":"cd05246","properties":[{"key":"EntryName","value":"dTDP_GD_SDR_e"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.720:FF:000108","properties":[{"key":"EntryName","value":"dTDP-glucose 4,6-dehydratase"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.720","properties":[{"key":"EntryName","value":"NAD(P)-binding Rossmann-like Domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.90.25.10","properties":[{"key":"EntryName","value":"UDP-galactose 4-epimerase, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR005888","properties":[{"key":"EntryName","value":"dTDP_Gluc_deHydtase"}]},{"database":"InterPro","id":"IPR016040","properties":[{"key":"EntryName","value":"NAD(P)-bd_dom"}]},{"database":"InterPro","id":"IPR036291","properties":[{"key":"EntryName","value":"NAD(P)-bd_dom_sf"}]},{"database":"NCBIfam","id":"TIGR01181","properties":[{"key":"EntryName","value":"dTDP_gluc_dehyt"},{"key":"MatchStatus","value":"1"}]},{"database":"NCBIfam","id":"NF007490","properties":[{"key":"EntryName","value":"PRK10084.1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR43000","properties":[{"key":"EntryName","value":"DTDP-D-GLUCOSE 4,6-DEHYDRATASE-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF16363","properties":[{"key":"EntryName","value":"GDP_Man_Dehyd"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF51735","properties":[{"key":"EntryName","value":"NAD(P)-binding Rossmann-fold domains"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MKILVTGGAGFIGSAVVRHIINNTQDSVVNVDKLTYAGNRESLADVSDSERYVFEHADICDAPAMARIFAQHQPDAVMHLAAESHVDRSITGPAAFIETNIVGTYVLLEAARNYWSALDSDKKNSFRFHHISTDEVYGDLPHPDEVNNTEELPLFTETTAYAPSSPYSASKASSDHLVRAWKRTYGLPTIVTNCSNNYGPYHFPEKLIPLVILNALEGKALPIYGKGDQIRDWLYVEDHARALYTVVTEGKAGETYNIGGHNEKKNIDVVLTICDLLDEIVPKEKSYREQITYVADRPGHDRRYAIDAEKIGRALGWKPQETFESGIRKTVEWYLSNTKWVDNVKSGAYQSWIEQNYEGRQ","length":361,"molWeight":40558,"crc64":"C3F64643271C14C7","md5":"1405208AED5CD6F9B3443B549F31DBC1"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"COFACTOR":1,"PATHWAY":2,"SUBUNIT":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Active site":3,"Binding site":15,"Sequence conflict":2},"uniParcId":"UPI0000133189"}}