{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P37613","secondaryAccessions":["Q2M7C2"],"uniProtkbId":"PANZ_ECOLI","entryAudit":{"firstPublicDate":"1994-10-01","lastAnnotationUpdateDate":"2026-01-28","lastSequenceUpdateDate":"1994-10-01","entryVersion":156,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Escherichia coli (strain K12)","taxonId":83333,"lineage":["Bacteria","Pseudomonadati","Pseudomonadota","Gammaproteobacteria","Enterobacterales","Enterobacteriaceae","Escherichia"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_02018"},{"evidenceCode":"ECO:0000305"}],"value":"PanD regulatory factor"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_02018"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"23170229"}],"value":"panZ"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q7CPJ9"}],"value":"panM"},{"value":"yhhK"}],"orderedLocusNames":[{"value":"b3459"},{"value":"JW3424"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23170229"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25910242"}],"value":"Controls both the activation and catalytic activity of PanD in a coenzyme A (CoA)-dependent fashion. Binding of CoA or a derivative to PanZ leads to interaction with PanD, which promotes the processing and activation of pro-PanD, and subsequent substrate-mediated inhibition of the active form of PanD (PubMed:23170229, PubMed:25910242). Inhibition of PanD activity is probably the primary metabolic role of PanZ, allowing negative feedback regulation of pantothenate biosynthesis by CoA (PubMed:25910242)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25910242"}],"value":"Activation of PanD processing occurs even at low CoA concentrations. In contrast, full inhibition of PanD catalytic activity only occurs at sufficiently high CoA concentrations"}],"commentType":"ACTIVITY REGULATION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22940551"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23170229"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25910242"}],"value":"Interacts with PanD in the presence of CoA (PubMed:22940551, PubMed:23170229, PubMed:25910242). Forms a heterooctameric complex composed of four PanD subunits and four PanZ subunits (PubMed:22940551, PubMed:25910242). Monomer in solution (PubMed:22940551)"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23170229"}],"value":"Deletion mutants are deficient in the biosynthetic pathway for pantothenate"}],"commentType":"DISRUPTION PHENOTYPE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_02018"},{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the PanZ/PanM family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q7CPJ9"}],"value":"Lacks the conserved catalytic glutamate found in many enzymatically active members of the Gcn5-like N-acetyltransferase (GNAT) family"}],"commentType":"CAUTION"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":127,"modifier":"EXACT"}},"description":"PanD regulatory factor","featureId":"PRO_0000169553"},{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":127,"modifier":"EXACT"}},"description":"N-acetyltransferase","evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_02018"}]},{"type":"Region","location":{"start":{"value":43,"modifier":"EXACT"},"end":{"value":48,"modifier":"EXACT"}},"description":"Interaction with PanD","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25910242"}]},{"type":"Region","location":{"start":{"value":66,"modifier":"EXACT"},"end":{"value":76,"modifier":"EXACT"}},"description":"Interaction with PanD","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25910242"}]},{"type":"Binding site","location":{"start":{"value":66,"modifier":"EXACT"},"end":{"value":68,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:57287"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_02018"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25910242"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.6"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.7"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"2K5T"}],"ligand":{"name":"CoA","id":"ChEBI:CHEBI:57287"}},{"type":"Binding site","location":{"start":{"value":72,"modifier":"EXACT"},"end":{"value":79,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:57287"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_02018"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25910242"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.6"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.7"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"2K5T"}],"ligand":{"name":"CoA","id":"ChEBI:CHEBI:57287"}},{"type":"Mutagenesis","location":{"start":{"value":45,"modifier":"EXACT"},"end":{"value":45,"modifier":"EXACT"}},"description":"Loss of affinity for PanD. Is still able to activate but not regulate the PanD protein.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25910242"}],"alternativeSequence":{"originalSequence":"N","alternativeSequences":["A"]}},{"type":"Beta strand","location":{"start":{"value":4,"modifier":"EXACT"},"end":{"value":10,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5LS7"}]},{"type":"Helix","location":{"start":{"value":13,"modifier":"EXACT"},"end":{"value":22,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5LS7"}]},{"type":"Helix","location":{"start":{"value":28,"modifier":"EXACT"},"end":{"value":30,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5LS7"}]},{"type":"Beta strand","location":{"start":{"value":37,"modifier":"EXACT"},"end":{"value":44,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5LS7"}]},{"type":"Beta strand","location":{"start":{"value":47,"modifier":"EXACT"},"end":{"value":57,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5LS7"}]},{"type":"Beta strand","location":{"start":{"value":60,"modifier":"EXACT"},"end":{"value":68,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5LS7"}]},{"type":"Helix","location":{"start":{"value":70,"modifier":"EXACT"},"end":{"value":72,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5LS7"}]},{"type":"Beta strand","location":{"start":{"value":74,"modifier":"EXACT"},"end":{"value":76,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5LS7"}]},{"type":"Helix","location":{"start":{"value":77,"modifier":"EXACT"},"end":{"value":88,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5LS7"}]},{"type":"Beta strand","location":{"start":{"value":94,"modifier":"EXACT"},"end":{"value":98,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5LS7"}]},{"type":"Helix","location":{"start":{"value":105,"modifier":"EXACT"},"end":{"value":114,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5LS7"}]},{"type":"Beta strand","location":{"start":{"value":118,"modifier":"EXACT"},"end":{"value":120,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5LS7"}]},{"type":"Beta strand","location":{"start":{"value":123,"modifier":"EXACT"},"end":{"value":127,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5LS7"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0566","category":"Biological process","name":"Pantothenate biosynthesis"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"8041620","citationType":"journal article","authors":["Sofia H.J.","Burland V.","Daniels D.L.","Plunkett G. III","Blattner F.R."],"citationCrossReferences":[{"database":"PubMed","id":"8041620"},{"database":"DOI","id":"10.1093/nar/22.13.2576"}],"title":"Analysis of the Escherichia coli genome. V. DNA sequence of the region from 76.0 to 81.5 minutes.","publicationDate":"1994","journal":"Nucleic Acids Res.","firstPage":"2576","lastPage":"2586","volume":"22"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"K12 / MG1655 / ATCC 47076","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"9278503","citationType":"journal article","authors":["Blattner F.R.","Plunkett G. III","Bloch C.A.","Perna N.T.","Burland V.","Riley M.","Collado-Vides J.","Glasner J.D.","Rode C.K.","Mayhew G.F.","Gregor J.","Davis N.W.","Kirkpatrick H.A.","Goeden M.A.","Rose D.J.","Mau B.","Shao Y."],"citationCrossReferences":[{"database":"PubMed","id":"9278503"},{"database":"DOI","id":"10.1126/science.277.5331.1453"}],"title":"The complete genome sequence of Escherichia coli K-12.","publicationDate":"1997","journal":"Science","firstPage":"1453","lastPage":"1462","volume":"277"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"K12 / MG1655 / ATCC 47076","type":"STRAIN"}]},{"referenceNumber":3,"citation":{"id":"16738553","citationType":"journal article","authors":["Hayashi K.","Morooka N.","Yamamoto Y.","Fujita K.","Isono K.","Choi S.","Ohtsubo E.","Baba T.","Wanner B.L.","Mori H.","Horiuchi T."],"citationCrossReferences":[{"database":"PubMed","id":"16738553"},{"database":"DOI","id":"10.1038/msb4100049"}],"title":"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.","publicationDate":"2006","journal":"Mol. Syst. Biol.","firstPage":"E1","lastPage":"E5","volume":"2"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"K12 / W3110 / ATCC 27325 / DSM 5911","type":"STRAIN"}]},{"referenceNumber":4,"citation":{"id":"22940551","citationType":"journal article","authors":["Monteiro D.C.","Rugen M.D.","Shepherd D.","Nozaki S.","Niki H.","Webb M.E."],"citationCrossReferences":[{"database":"PubMed","id":"22940551"},{"database":"DOI","id":"10.1016/j.bbrc.2012.08.084"}],"title":"Formation of a heterooctameric complex between aspartate alpha-decarboxylase and its cognate activating factor, PanZ, is CoA-dependent.","publicationDate":"2012","journal":"Biochem. Biophys. Res. Commun.","firstPage":"350","lastPage":"355","volume":"426"},"referencePositions":["INTERACTION WITH PAND","SUBUNIT"]},{"referenceNumber":5,"citation":{"id":"23170229","citationType":"journal article","authors":["Nozaki S.","Webb M.E.","Niki H."],"citationCrossReferences":[{"database":"PubMed","id":"23170229"},{"database":"DOI","id":"10.1002/mbo3.34"}],"title":"An activator for pyruvoyl-dependent l-aspartate alpha-decarboxylase is conserved in a small group of the gamma-proteobacteria including Escherichia coli.","publicationDate":"2012","journal":"MicrobiologyOpen","firstPage":"298","lastPage":"310","volume":"1"},"referencePositions":["FUNCTION","INTERACTION WITH PAND","DISRUPTION PHENOTYPE"],"referenceComments":[{"value":"K12 / MG1655 / ATCC 47076","type":"STRAIN"}]},{"referenceNumber":6,"citation":{"id":"CI-BFURG3963F36F","citationType":"submission","authors":["Cort J.R.","Yee A.","Arrowsmith C.H.","Kennedy M.A."],"title":"Solution NMR structure of putative N-acetyl transferase YhhK from E. coli bound to coenzyme A.","publicationDate":"JUN-2008","submissionDatabase":"PDB data bank"},"referencePositions":["STRUCTURE BY NMR IN COMPLEX WITH COENZYME A"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"2K5T"}]},{"referenceNumber":7,"citation":{"id":"CI-26T4P8L5FSSG7","citationType":"submission","authors":["Monteiro D.C.F.","Patel V.","Bartlett C.P.","Grant T.D.","Nozaki S.","Gowdy J.A.","Snell E.H.","Niki H.","Pearson A.R.","Webb M.E."],"title":"Direct visualisation of strain-induced protein post-translational modification.","publicationDate":"MAR-2014","submissionDatabase":"PDB data bank"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (1.61 ANGSTROMS) IN COMPLEX WITH PAND AND ACETYL COENZYME A"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"4CRY"}]},{"referenceNumber":8,"citation":{"id":"25910242","citationType":"journal article","authors":["Monteiro D.C.","Patel V.","Bartlett C.P.","Nozaki S.","Grant T.D.","Gowdy J.A.","Thompson G.S.","Kalverda A.P.","Snell E.H.","Niki H.","Pearson A.R.","Webb M.E."],"citationCrossReferences":[{"database":"PubMed","id":"25910242"},{"database":"DOI","id":"10.1016/j.chembiol.2015.03.017"}],"title":"The structure of the PanD/PanZ protein complex reveals negative feedback regulation of pantothenate biosynthesis by coenzyme A.","publicationDate":"2015","journal":"Chem. Biol.","firstPage":"492","lastPage":"503","volume":"22"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) IN COMPLEXES WITH PAND AND ACETYL COENZYME A","FUNCTION","ACTIVITY REGULATION","INTERACTION WITH PAND","SUBUNIT","MUTAGENESIS OF ASN-45"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"4CRZ"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4CS0"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"U00039","properties":[{"key":"ProteinId","value":"AAB18434.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"U00096","properties":[{"key":"ProteinId","value":"AAC76484.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AP009048","properties":[{"key":"ProteinId","value":"BAE77834.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"S47678","properties":[{"key":"EntryName","value":"S47678"}]},{"database":"RefSeq","id":"NP_417916.1","properties":[{"key":"NucleotideSequenceId","value":"NC_000913.3"}]},{"database":"RefSeq","id":"WP_000778768.1","properties":[{"key":"NucleotideSequenceId","value":"NZ_CP009789.1"}]},{"database":"PDB","id":"2K5T","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=1-127"}]},{"database":"PDB","id":"4CRY","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.61 A"},{"key":"Chains","value":"B=1-127"}]},{"database":"PDB","id":"4CRZ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.70 A"},{"key":"Chains","value":"B=1-127"}]},{"database":"PDB","id":"4CS0","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.10 A"},{"key":"Chains","value":"B=1-127"}]},{"database":"PDB","id":"5LS7","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.16 A"},{"key":"Chains","value":"B=1-127"}]},{"database":"PDBsum","id":"2K5T","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4CRY","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4CRZ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4CS0","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5LS7","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"P37613","properties":[{"key":"Description","value":"-"}]},{"database":"BMRB","id":"P37613","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P37613","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"4262496","properties":[{"key":"Interactions","value":"9"}]},{"database":"FunCoup","id":"P37613","properties":[{"key":"Number of interactors","value":"38"}]},{"database":"IntAct","id":"P37613","properties":[{"key":"Interactions","value":"2"}]},{"database":"STRING","id":"511145.b3459","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"P37613","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"511145-b3459","properties":[{"key":"Description","value":"-"}]},{"database":"DNASU","id":"947963","properties":[{"key":"Description","value":"-"}]},{"database":"EnsemblBacteria","id":"AAC76484","properties":[{"key":"ProteinId","value":"AAC76484"},{"key":"GeneId","value":"b3459"}]},{"database":"GeneID","id":"947963","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"ecj:JW3424","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"eco:b3459","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"ecoc:C3026_18735","properties":[{"key":"Description","value":"-"}]},{"database":"PATRIC","id":"fig|1411691.4.peg.3266","properties":[{"key":"GeneDesignation","value":"-"}]},{"database":"EchoBASE","id":"EB2125","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"COG0456","properties":[{"key":"ToxonomicScope","value":"Bacteria"}]},{"database":"HOGENOM","id":"CLU_135649_0_0_6","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P37613","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"KIWPSQD","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"5736859at2","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"P37613","properties":[{"key":"Description","value":"-"}]},{"database":"BioCyc","id":"EcoCyc:EG12211-MONOMER","properties":[{"key":"Description","value":"-"}]},{"database":"BioCyc","id":"MetaCyc:EG12211-MONOMER","properties":[{"key":"Description","value":"-"}]},{"database":"EvolutionaryTrace","id":"P37613","properties":[{"key":"Description","value":"-"}]},{"database":"PRO","id":"PR:P37613","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000625","properties":[{"key":"Component","value":"Chromosome"}]},{"database":"GO","id":"GO:1905502","properties":[{"key":"GoTerm","value":"F:acetyl-CoA binding"},{"key":"GoEvidenceType","value":"IDA:EcoCyc"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"25910242"}]},{"database":"GO","id":"GO:0016747","properties":[{"key":"GoTerm","value":"F:acyltransferase activity, transferring groups other than amino-acyl groups"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0015940","properties":[{"key":"GoTerm","value":"P:pantothenate biosynthetic process"},{"key":"GoEvidenceType","value":"IMP:EcoCyc"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"2195019"},{"evidenceCode":"ECO:0000315","source":"PubMed","id":"23170229"}]},{"database":"GO","id":"GO:0016485","properties":[{"key":"GoTerm","value":"P:protein processing"},{"key":"GoEvidenceType","value":"ISO:EcoCyc"}],"evidences":[{"evidenceCode":"ECO:0000266","source":"PubMed","id":"22497218"}]},{"database":"GO","id":"GO:0031638","properties":[{"key":"GoTerm","value":"P:zymogen activation"},{"key":"GoEvidenceType","value":"IDA:EcoCyc"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"23170229"}]},{"database":"FunFam","id":"3.40.630.30:FF:000038","properties":[{"key":"EntryName","value":"PanD regulatory factor"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.630.30","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"HAMAP","id":"MF_02018","properties":[{"key":"EntryName","value":"PanZ_PanM"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR016181","properties":[{"key":"EntryName","value":"Acyl_CoA_acyltransferase"}]},{"database":"InterPro","id":"IPR000182","properties":[{"key":"EntryName","value":"GNAT_dom"}]},{"database":"InterPro","id":"IPR032900","properties":[{"key":"EntryName","value":"PanZ"}]},{"database":"InterPro","id":"IPR040448","properties":[{"key":"EntryName","value":"PanZ_GNAT"}]},{"database":"NCBIfam","id":"NF033213","properties":[{"key":"EntryName","value":"matur_PanM"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF12568","properties":[{"key":"EntryName","value":"PanZ"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF55729","properties":[{"key":"EntryName","value":"Acyl-CoA N-acyltransferases (Nat)"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51186","properties":[{"key":"EntryName","value":"GNAT"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MKLTIIRLEKFSDQDRIDLQKIWPEYSPSSLQVDDNHRIYAARFNERLLAAVRVTLSGTEGALDSLRVREVTRRRGVGQYLLEEVLRNNPGVSCWWMADAGVEDRGVMTAFMQALGFTAQQGGWEKC","length":127,"molWeight":14506,"crc64":"EF054A30D294519A","md5":"C6182CE9FAFA6CA12A98731074EE9A10"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"ACTIVITY REGULATION":1,"SUBUNIT":1,"DISRUPTION PHENOTYPE":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Chain":1,"Domain":1,"Region":2,"Binding site":2,"Mutagenesis":1,"Beta strand":8,"Helix":5},"uniParcId":"UPI000013B24D"}}