{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P37173","secondaryAccessions":["B4DTV5","Q15580","Q6DKT6","Q99474"],"uniProtkbId":"TGFR2_HUMAN","entryAudit":{"firstPublicDate":"1994-10-01","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2006-10-17","entryVersion":261,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"TGF-beta receptor type-2"},"shortNames":[{"value":"TGFR-2"}],"ecNumbers":[{"value":"2.7.11.30"}]},"alternativeNames":[{"fullName":{"value":"TGF-beta type II receptor"}},{"fullName":{"value":"Transforming growth factor-beta receptor type II"},"shortNames":[{"value":"TGF-beta receptor type II"},{"value":"TbetaR-II"}]}],"flag":"Precursor"},"genes":[{"geneName":{"value":"TGFBR2"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7774578"}],"value":"Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and thus regulates a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and activation of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8635485"}],"value":"Has transforming growth factor beta-activated receptor activity"}],"commentType":"FUNCTION","molecule":"Isoform 1"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8635485"}],"value":"Has transforming growth factor beta-activated receptor activity"}],"commentType":"FUNCTION","molecule":"Isoform 2"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34568316"}],"value":"Binds TGFB1, TGFB2 and TGFB3 in the picomolar affinity range without the participation of additional receptors. Blocks activation of SMAD2 and SMAD3 by TGFB1"}],"commentType":"FUNCTION","molecule":"Isoform 3"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-threonyl-[receptor-protein] + ATP = O-phospho-L-threonyl-[receptor-protein] + ADP + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:44880"},{"database":"Rhea","id":"RHEA-COMP:11024"},{"database":"Rhea","id":"RHEA-COMP:11025"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30013"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:61977"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"2.7.11.30"}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-seryl-[receptor-protein] + ATP = O-phospho-L-seryl-[receptor-protein] + ADP + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:18673"},{"database":"Rhea","id":"RHEA-COMP:11022"},{"database":"Rhea","id":"RHEA-COMP:11023"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:29999"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:83421"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"2.7.11.30"}},{"commentType":"COFACTOR","cofactors":[{"name":"Mg(2+)","evidences":[{"evidenceCode":"ECO:0000250"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:18420"}},{"name":"Mn(2+)","evidences":[{"evidenceCode":"ECO:0000250"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:29035"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11483955"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11850637"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12941698"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16982625"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18243111"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20207738"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21441952"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21791611"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8555189"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9865696"}],"value":"Homodimer. Heterohexamer; TGFB1, TGFB2 and TGFB3 homodimeric ligands assemble a functional receptor composed of two TGFBR1 and TGFBR2 heterodimers to form a ligand-receptor heterohexamer. The respective affinity of TGFRB1 and TGFRB2 for the ligands may modulate the kinetics of assembly of the receptor and may explain the different biological activities of TGFB1, TGFB2 and TGFB3. Component of a complex composed of TSC22D1 (via N-terminus), TGFBR1 and TGFBR2; the interaction between TSC22D1 and TGFBR1 is inhibited by SMAD7 and promoted by TGFB1 (PubMed:21791611). Interacts with DAXX. Interacts with DYNLT4. Interacts with ZFYVE9; ZFYVE9 recruits SMAD2 and SMAD3 to the TGF-beta receptor. Interacts with and is activated by SCUBE3; this interaction does not affect TGFB1-binding to TGFBR2. Interacts with VPS39; this interaction is independent of the receptor kinase activity and of the presence of TGF-beta. Interacts with CLU (PubMed:8555189)"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34568316"}],"value":"Homodimer; disulfide-linked"}],"commentType":"SUBUNIT","molecule":"Isoform 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