{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P37047","secondaryAccessions":["Q8KJQ0"],"uniProtkbId":"CDAR_ECOLI","entryAudit":{"firstPublicDate":"1994-06-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1998-12-15","entryVersion":166,"sequenceVersion":2},"annotationScore":3.0,"organism":{"scientificName":"Escherichia coli (strain K12)","taxonId":83333,"lineage":["Bacteria","Pseudomonadati","Pseudomonadota","Gammaproteobacteria","Enterobacterales","Enterobacteriaceae","Escherichia"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Carbohydrate diacid regulator"}},"alternativeNames":[{"fullName":{"value":"Sugar diacid regulator"}}]},"genes":[{"geneName":{"value":"cdaR"},"synonyms":[{"value":"sdaR"},{"value":"yaeG"}],"orderedLocusNames":[{"value":"b0162"},{"value":"JW5013"}]}],"comments":[{"texts":[{"value":"Seems to regulate the expression of the operons for the enzymes involved in D-galactarate, D-glucarate and D-glycerate utilization"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the CdaR family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":385,"modifier":"EXACT"}},"description":"Carbohydrate diacid regulator","featureId":"PRO_0000165944"},{"type":"Natural variant","location":{"start":{"value":292,"modifier":"EXACT"},"end":{"value":292,"modifier":"EXACT"}},"description":"in strain: JA176; unable to grow on galactarate, glucarate and glycerate","featureId":"","alternativeSequence":{"originalSequence":"P","alternativeSequences":["S"]}}],"keywords":[{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0804","category":"Biological process","name":"Transcription"},{"id":"KW-0805","category":"Biological process","name":"Transcription regulation"}],"references":[{"referenceNumber":1,"citation":{"id":"8202364","citationType":"journal article","authors":["Fujita N.","Mori H.","Yura T.","Ishihama A."],"citationCrossReferences":[{"database":"PubMed","id":"8202364"},{"database":"DOI","id":"10.1093/nar/22.9.1637"}],"title":"Systematic sequencing of the Escherichia coli genome: analysis of the 2.4-4.1 min (110,917-193,643 bp) region.","publicationDate":"1994","journal":"Nucleic Acids Res.","firstPage":"1637","lastPage":"1639","volume":"22"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"K12 / W3110 / ATCC 27325 / DSM 5911","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"CI-B1UJ6TNQ0SAS1","citationType":"submission","authors":["Chung E.","Allen E.","Araujo R.","Aparicio A.M.","Davis K.","Duncan M.","Federspiel N.","Hyman R.","Kalman S.","Komp C.","Kurdi O.","Lew H.","Lin D.","Namath A.","Oefner P.","Roberts D.","Schramm S.","Davis R.W."],"title":"Sequence of minutes 4-25 of Escherichia coli.","publicationDate":"JAN-1997","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"K12 / MG1655 / ATCC 47076","type":"STRAIN"}]},{"referenceNumber":3,"citation":{"id":"9278503","citationType":"journal article","authors":["Blattner F.R.","Plunkett G. III","Bloch C.A.","Perna N.T.","Burland V.","Riley M.","Collado-Vides J.","Glasner J.D.","Rode C.K.","Mayhew G.F.","Gregor J.","Davis N.W.","Kirkpatrick H.A.","Goeden M.A.","Rose D.J.","Mau B.","Shao Y."],"citationCrossReferences":[{"database":"PubMed","id":"9278503"},{"database":"DOI","id":"10.1126/science.277.5331.1453"}],"title":"The complete genome sequence of Escherichia coli K-12.","publicationDate":"1997","journal":"Science","firstPage":"1453","lastPage":"1462","volume":"277"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"K12 / MG1655 / ATCC 47076","type":"STRAIN"}]},{"referenceNumber":4,"citation":{"id":"16738553","citationType":"journal article","authors":["Hayashi K.","Morooka N.","Yamamoto Y.","Fujita K.","Isono K.","Choi S.","Ohtsubo E.","Baba T.","Wanner B.L.","Mori H.","Horiuchi T."],"citationCrossReferences":[{"database":"PubMed","id":"16738553"},{"database":"DOI","id":"10.1038/msb4100049"}],"title":"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.","publicationDate":"2006","journal":"Mol. Syst. Biol.","firstPage":"E1","lastPage":"E5","volume":"2"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"K12 / W3110 / ATCC 27325 / DSM 5911","type":"STRAIN"}]},{"referenceNumber":5,"citation":{"id":"10762278","citationType":"journal article","authors":["Monterrubio R.","Baldoma L.","Obradors N.","Aguilar J.","Badia J."],"citationCrossReferences":[{"database":"PubMed","id":"10762278"},{"database":"DOI","id":"10.1128/jb.182.9.2672-2674.2000"}],"title":"A common regulator for the operons encoding the enzymes involved in D-galactarate, D-glucarate, and D-glycerate utilization in Escherichia coli.","publicationDate":"2000","journal":"J. Bacteriol.","firstPage":"2672","lastPage":"2674","volume":"182"},"referencePositions":["CHARACTERIZATION"],"referenceComments":[{"value":"K12 / MC4100 / ATCC 35695 / DSM 6574","type":"STRAIN"},{"value":"K12 / MC4100 / JA176","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"U70214","properties":[{"key":"ProteinId","value":"AAB08592.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"U00096","properties":[{"key":"ProteinId","value":"AAC73273.2"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AP009048","properties":[{"key":"ProteinId","value":"BAB96739.2"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"B64740","properties":[{"key":"EntryName","value":"B64740"}]},{"database":"RefSeq","id":"NP_414704.4","properties":[{"key":"NucleotideSequenceId","value":"NC_000913.3"}]},{"database":"RefSeq","id":"WP_000929443.1","properties":[{"key":"NucleotideSequenceId","value":"NZ_CP009789.1"}]},{"database":"AlphaFoldDB","id":"P37047","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P37047","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"4260992","properties":[{"key":"Interactions","value":"118"}]},{"database":"DIP","id":"DIP-9258N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"P37047","properties":[{"key":"Number of interactors","value":"66"}]},{"database":"STRING","id":"511145.b0162","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"P37047","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"511145-b0162","properties":[{"key":"Description","value":"-"}]},{"database":"EnsemblBacteria","id":"AAC73273","properties":[{"key":"ProteinId","value":"AAC73273"},{"key":"GeneId","value":"b0162"}]},{"database":"GeneID","id":"944860","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"ecj:JW5013","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"eco:b0162","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"ecoc:C3026_00740","properties":[{"key":"Description","value":"-"}]},{"database":"PATRIC","id":"fig|1411691.4.peg.2118","properties":[{"key":"GeneDesignation","value":"-"}]},{"database":"EchoBASE","id":"EB2239","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"COG3835","properties":[{"key":"ToxonomicScope","value":"Bacteria"}]},{"database":"HOGENOM","id":"CLU_043769_1_0_6","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P37047","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"VRMTAEM","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"9792148at2","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"P37047","properties":[{"key":"Description","value":"-"}]},{"database":"BioCyc","id":"EcoCyc:EG12335-MONOMER","properties":[{"key":"Description","value":"-"}]},{"database":"PRO","id":"PR:P37047","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000625","properties":[{"key":"Component","value":"Chromosome"}]},{"database":"AbasyAtlas","id":"P37047","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0003700","properties":[{"key":"GoTerm","value":"F:DNA-binding transcription factor activity"},{"key":"GoEvidenceType","value":"IMP:EcoCyc"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"10762278"}]},{"database":"GO","id":"GO:0045893","properties":[{"key":"GoTerm","value":"P:positive regulation of DNA-templated transcription"},{"key":"GoEvidenceType","value":"IMP:EcoCyc"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"10762278"}]},{"database":"FunFam","id":"1.10.10.2840:FF:000001","properties":[{"key":"EntryName","value":"Carbohydrate diacid transcriptional regulator"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.10.2840","properties":[{"key":"EntryName","value":"PucR C-terminal helix-turn-helix domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR051448","properties":[{"key":"EntryName","value":"CdaR-like_regulators"}]},{"database":"InterPro","id":"IPR041522","properties":[{"key":"EntryName","value":"CdaR_GGDEF"}]},{"database":"InterPro","id":"IPR008599","properties":[{"key":"EntryName","value":"Diacid_rec"}]},{"database":"InterPro","id":"IPR025736","properties":[{"key":"EntryName","value":"PucR_C-HTH_dom"}]},{"database":"InterPro","id":"IPR042070","properties":[{"key":"EntryName","value":"PucR_C-HTH_sf"}]},{"database":"NCBIfam","id":"NF008550","properties":[{"key":"EntryName","value":"PRK11477.1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR33744","properties":[{"key":"EntryName","value":"CARBOHYDRATE DIACID REGULATOR"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR33744:SF15","properties":[{"key":"EntryName","value":"CARBOHYDRATE DIACID REGULATOR"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF05651","properties":[{"key":"EntryName","value":"Diacid_rec"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF17853","properties":[{"key":"EntryName","value":"GGDEF_2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF13556","properties":[{"key":"EntryName","value":"HTH_30"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MAGWHLDTKMAQDIVARTMRIIDTNINVMDARGRIIGSGDRERIGELHEGALLVLSQGRVVDIDDAVARHLHGVRQGINLPLRLEGEIVGVIGLTGEPENLRKYGELVCMTAEMMLEQSRLMHLLAQDSRLREELVMNLIQAEENTPALTEWAQRLGIDLNQPRVVAIVEVDSGQLGVDSAMAELQQLQNALTTPERNNLVAIVSLTEMVVLKPALNSFGRWDAEDHRKRVEQLITRMKEYGQLRFRVSLGNYFTGPGSIARSYRTAKTTMVVGKQRMPESRCYFYQDLMLPVLLDSLRGDWQANELARPLARLKTMDNNGLLRRTLAAWFRHNVQPLATSKALFIHRNTLEYRLNRISELTGLDLGNFDDRLLLYVALQLDEER","length":385,"molWeight":43687,"crc64":"5FD4EEFB33C44DBB","md5":"6351CEC6A6C59D9787FEE4E6E170BF47"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Natural variant":1},"uniParcId":"UPI00001273D7"}}